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D2P9Y5

- D2P9Y5_LISM2

UniProt

D2P9Y5 - D2P9Y5_LISM2

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Protein

Thymidine kinase

Gene

tdk

Organism
Listeria monocytogenes serotype 1/2a (strain 08-5923)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Proton acceptorUniRule annotation
Metal bindingi143 – 1431ZincUniRule annotation
Metal bindingi146 – 1461ZincUniRule annotation
Metal bindingi181 – 1811ZincUniRule annotation
Metal bindingi184 – 1841ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATPUniRule annotation
Nucleotide bindingi85 – 884ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciLMON637381:GH7Z-2750-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:LM5923_2688Imported
OrganismiListeria monocytogenes serotype 1/2a (strain 08-5923)Imported
Taxonomic identifieri637381 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000006922: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliD2P9Y5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076391.
KOiK00857.
OMAiELKTVCH.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2P9Y5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQLFFRYGS MNSGKTIEIL KVAHNYEEQN KTVAIFTSGI DDRDQVGFIS
60 70 80 90 100
SRIGLKREAT PIFSDTDIFE IVANIKPKPN CVLLDESQFL EKEHVFQLAK
110 120 130 140 150
IVDELNIPVI AYGLKNDFRN ELFEGSKYLL LYADKLEEMK TICWFCAKKA
160 170 180 190
TMVLRVDDKG KPVYTGEQIM IGGNDHYYPV CRKCHANPPI K
Length:191
Mass (Da):21,850
Last modified:March 2, 2010 - v1
Checksum:i08E8D07B0DA2AA88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001604 Genomic DNA. Translation: ADB72529.1.
RefSeqiYP_003417891.1. NC_013768.1.

Genome annotation databases

EnsemblBacteriaiADB72529; ADB72529; LM5923_2688.
GeneIDi8759482.
KEGGilmy:LM5923_2688.
PATRICi32259280. VBILisMon5116_2715.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001604 Genomic DNA. Translation: ADB72529.1 .
RefSeqi YP_003417891.1. NC_013768.1.

3D structure databases

ProteinModelPortali D2P9Y5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADB72529 ; ADB72529 ; LM5923_2688 .
GeneIDi 8759482.
KEGGi lmy:LM5923_2688.
PATRICi 32259280. VBILisMon5116_2715.

Phylogenomic databases

HOGENOMi HOG000076391.
KOi K00857.
OMAi ELKTVCH.

Enzyme and pathway databases

BioCyci LMON637381:GH7Z-2750-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-throughput genome sequencing of two Listeria monocytogenes clinical isolates during a large foodborne outbreak."
    Gilmour M.W., Graham M., Van Domselaar G., Tyler S., Kent H., Trout-Yakel K.M., Larios O., Allen V., Lee B., Nadon C.
    BMC Genomics 11:120-120(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 08-5923Imported.

Entry informationi

Entry nameiD2P9Y5_LISM2
AccessioniPrimary (citable) accession number: D2P9Y5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: November 26, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3