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Protein

Phosphopentomutase

Gene

drm

Organism
Listeria monocytogenes serotype 1/2a (strain 08-5923)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Phosphotransfer between the C1 and C5 carbon atoms of pentose.UniRule annotationSAAS annotation

Catalytic activityi

2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-alpha-D-ribose 5-phosphate.UniRule annotationSAAS annotation
Alpha-D-ribose 1-phosphate = D-ribose 5-phosphate.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mn2+UniRule annotationSAAS annotationNote: Binds 1 or 2 manganese ions.UniRule annotationSAAS annotation
  • Mn2+Note: Binds 1 or 2 manganese ions.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi14 – 141ManganeseUniRule annotation
Metal bindingi292 – 2921ManganeseUniRule annotation
Metal bindingi328 – 3281ManganeseUniRule annotation
Metal bindingi329 – 3291ManganeseUniRule annotation
Metal bindingi340 – 3401ManganeseUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphopentomutase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 5-phosphoribose 1-diphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. cellular metabolic compound salvage Source: InterPro
  3. deoxyribonucleotide catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciLMON637381:GH7Z-2142-MONOMER.
UniPathwayiUPA00087; UER00173.

Names & Taxonomyi

Protein namesi
Recommended name:
PhosphopentomutaseUniRule annotationSAAS annotation (EC:5.4.2.7UniRule annotationSAAS annotation)
Alternative name(s):
PhosphodeoxyribomutaseUniRule annotation
Gene namesi
Name:drmImported
Synonyms:deoBUniRule annotation
Ordered Locus Names:LM5923_2106Imported
OrganismiListeria monocytogenes serotype 1/2a (strain 08-5923)Imported
Taxonomic identifieri637381 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000006922 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliD2P6R2.
SMRiD2P6R2. Positions 3-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphopentomutase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000008159.
KOiK01839.
OMAiYLGNCHA.

Family and domain databases

Gene3Di3.30.70.1250. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_00740. Phosphopentomut.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR010045. DeoB.
IPR006124. Metalloenzyme.
IPR024052. Phosphopentomutase_DeoB_cap.
[Graphical view]
PfamiPF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001491. Ppentomutase. 1 hit.
SUPFAMiSSF143856. SSF143856. 1 hit.
SSF53649. SSF53649. 2 hits.
TIGRFAMsiTIGR01696. deoB. 1 hit.

Sequencei

Sequence statusi: Complete.

D2P6R2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDKFKRVHV VVMDSVGIGE APDAAKFGDF DVDTFGHIAK HVGGLKMPEM
60 70 80 90 100
GKLGLSNIRE IEGIKKAEKP LAYYTKMQEA SNGKDTMTGH WEIMGLYIDT
110 120 130 140 150
PFRVFPDGFP DDLINQIEEK TGRKVIGNKP ASGTEIMAEL GEEHVKTGAL
160 170 180 190 200
IVYTSADSVL QIAAHEDVVP LEELYEICEF CRKITLDDPY MLGRIIARPF
210 220 230 240 250
VGEPGAFVRT PNRHDYALKP FKPTVMDALK DGGKDVIAIG KISDIFDGEG
260 270 280 290 300
VTESIRTKSN MDGMDQFIAV LDKDFNGMSF LNLVDFDALF GHRRDPQGYA
310 320 330 340 350
DALVDFDGRL VEVMEKLTDD DLLIITADHG NDPTYTGTDH TREFVPLLVY
360 370 380 390
SPRFKNGGSE LELRKTFADL GATVADNFDV KMPEYGTSFL RDLK
Length:394
Mass (Da):43,746
Last modified:March 2, 2010 - v1
Checksum:i1D2D6202D2C95D23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001604 Genomic DNA. Translation: ADB71947.1.
RefSeqiYP_003417309.1. NC_013768.1.

Genome annotation databases

EnsemblBacteriaiADB71947; ADB71947; LM5923_2106.
KEGGilmy:LM5923_2106.
PATRICi32258044. VBILisMon5116_2123.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001604 Genomic DNA. Translation: ADB71947.1.
RefSeqiYP_003417309.1. NC_013768.1.

3D structure databases

ProteinModelPortaliD2P6R2.
SMRiD2P6R2. Positions 3-393.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADB71947; ADB71947; LM5923_2106.
KEGGilmy:LM5923_2106.
PATRICi32258044. VBILisMon5116_2123.

Phylogenomic databases

HOGENOMiHOG000008159.
KOiK01839.
OMAiYLGNCHA.

Enzyme and pathway databases

UniPathwayiUPA00087; UER00173.
BioCyciLMON637381:GH7Z-2142-MONOMER.

Family and domain databases

Gene3Di3.30.70.1250. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_00740. Phosphopentomut.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR010045. DeoB.
IPR006124. Metalloenzyme.
IPR024052. Phosphopentomutase_DeoB_cap.
[Graphical view]
PfamiPF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001491. Ppentomutase. 1 hit.
SUPFAMiSSF143856. SSF143856. 1 hit.
SSF53649. SSF53649. 2 hits.
TIGRFAMsiTIGR01696. deoB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "High-throughput genome sequencing of two Listeria monocytogenes clinical isolates during a large foodborne outbreak."
    Gilmour M.W., Graham M., Van Domselaar G., Tyler S., Kent H., Trout-Yakel K.M., Larios O., Allen V., Lee B., Nadon C.
    BMC Genomics 11:120-120(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 08-5923Imported.

Entry informationi

Entry nameiD2P6R2_LISM2
AccessioniPrimary (citable) accession number: D2P6R2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: April 1, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.