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D2P4H0

- D2P4H0_LISM2

UniProt

D2P4H0 - D2P4H0_LISM2

Protein

Glutamate 5-kinase

Gene

proB

Organism
Listeria monocytogenes serotype 1/2a (strain 08-5923)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (02 Mar 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.SAAS annotation
    Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5-oxoproline.UniRule annotation

    Catalytic activityi

    ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei14 – 141ATPUniRule annotation
    Binding sitei54 – 541SubstrateUniRule annotation
    Binding sitei141 – 1411SubstrateUniRule annotation
    Binding sitei157 – 1571Substrate; via amide nitrogenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi177 – 1782ATPUniRule annotation
    Nucleotide bindingi219 – 2257ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate 5-kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-proline biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Proline biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLMON637381:GH7Z-1360-MONOMER.
    UniPathwayiUPA00098; UER00359.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate 5-kinaseUniRule annotation (EC:2.7.2.11UniRule annotation)
    Alternative name(s):
    Gamma-glutamyl kinaseUniRule annotation
    Gene namesi
    Name:proBUniRule annotationImported
    Ordered Locus Names:LM5923_1351Imported
    OrganismiListeria monocytogenes serotype 1/2a (strain 08-5923)Imported
    Taxonomic identifieri637381 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
    ProteomesiUP000006922: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD2P4H0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamate 5-kinase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000246368.
    KOiK00931.
    OMAiDIHYRQA.

    Family and domain databases

    Gene3Di3.40.1160.10. 1 hit.
    HAMAPiMF_00456. ProB.
    InterProiIPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    IPR011529. Glu_5kinase.
    IPR005715. Glu_5kinase/COase_Synthase.
    IPR019797. Glutamate_5-kinase_CS.
    [Graphical view]
    PfamiPF00696. AA_kinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000729. GK. 1 hit.
    PRINTSiPR00474. GLU5KINASE.
    SUPFAMiSSF53633. SSF53633. 1 hit.
    TIGRFAMsiTIGR01027. proB. 1 hit.
    PROSITEiPS00902. GLUTAMATE_5_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D2P4H0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRESLKNSKR LVIKVGTSTL MYGNGHINLR TIEKLAMVLS DLRNEGKEVI    50
    LVSSGAIGVG CHKLQLPVRP TSIPEQQAVA SVGQSELMHI YSKFFGEYGQ 100
    VVGQVLLTRD VTDFPISREN VMNTLESLLE RGIIPIVNEN DTVAVEELEH 150
    VTKYGDNDLL SAIVAKLVQA DLLIMLSDID GFYGSNPSTD PDAVMFSEIN 200
    QITPEIEALA GGKGSKFGTG GMLTKLSAAS YCMNANQKMI LTNGKNPTII 250
    FDIMQGEQIG TLFASKKEEF SHDGTH 276
    Length:276
    Mass (Da):30,034
    Last modified:March 2, 2010 - v1
    Checksum:iF9A94811AFC5AD06
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001604 Genomic DNA. Translation: ADB71193.1.
    RefSeqiYP_003416555.1. NC_013768.1.

    Genome annotation databases

    EnsemblBacteriaiADB71193; ADB71193; LM5923_1351.
    GeneIDi8758146.
    KEGGilmy:LM5923_1351.
    PATRICi32256474. VBILisMon5116_1366.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001604 Genomic DNA. Translation: ADB71193.1 .
    RefSeqi YP_003416555.1. NC_013768.1.

    3D structure databases

    ProteinModelPortali D2P4H0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADB71193 ; ADB71193 ; LM5923_1351 .
    GeneIDi 8758146.
    KEGGi lmy:LM5923_1351.
    PATRICi 32256474. VBILisMon5116_1366.

    Phylogenomic databases

    HOGENOMi HOG000246368.
    KOi K00931.
    OMAi DIHYRQA.

    Enzyme and pathway databases

    UniPathwayi UPA00098 ; UER00359 .
    BioCyci LMON637381:GH7Z-1360-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1160.10. 1 hit.
    HAMAPi MF_00456. ProB.
    InterProi IPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    IPR011529. Glu_5kinase.
    IPR005715. Glu_5kinase/COase_Synthase.
    IPR019797. Glutamate_5-kinase_CS.
    [Graphical view ]
    Pfami PF00696. AA_kinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000729. GK. 1 hit.
    PRINTSi PR00474. GLU5KINASE.
    SUPFAMi SSF53633. SSF53633. 1 hit.
    TIGRFAMsi TIGR01027. proB. 1 hit.
    PROSITEi PS00902. GLUTAMATE_5_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-throughput genome sequencing of two Listeria monocytogenes clinical isolates during a large foodborne outbreak."
      Gilmour M.W., Graham M., Van Domselaar G., Tyler S., Kent H., Trout-Yakel K.M., Larios O., Allen V., Lee B., Nadon C.
      BMC Genomics 11:120-120(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 08-5923Imported.

    Entry informationi

    Entry nameiD2P4H0_LISM2
    AccessioniPrimary (citable) accession number: D2P4H0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 2, 2010
    Last sequence update: March 2, 2010
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3