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D2P4H0 (D2P4H0_LISM2) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutamate 5-kinase HAMAP-Rule MF_00456
EC=2.7.2.11 HAMAP-Rule MF_00456
Alternative name(s):
Gamma-glutamyl kinase HAMAP-Rule MF_00456
Gene names
Name:proB HAMAP-Rule MF_00456
Ordered Locus Names:LM5923_1351
OrganismListeria monocytogenes serotype 1/2a (strain 08-5923) [Complete proteome] [HAMAP] EMBL ADB71193.1
Taxonomic identifier637381 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Listeriaceae › Listeria ›

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5-oxoproline By similarity. HAMAP-Rule MF_00456 SAAS SAAS011529

Catalytic activity

ATP + L-glutamate = ADP + L-glutamate 5-phosphate. HAMAP-Rule MF_00456

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2. HAMAP-Rule MF_00456 SAAS SAAS011529

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00456 SAAS SAAS011529.

Sequence similarities

Belongs to the glutamate 5-kinase family. HAMAP-Rule MF_00456

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding177 – 1782ATP By similarity HAMAP-Rule MF_00456
Nucleotide binding219 – 2257ATP By similarity HAMAP-Rule MF_00456

Sites

Binding site141ATP By similarity HAMAP-Rule MF_00456
Binding site541Substrate By similarity HAMAP-Rule MF_00456
Binding site1411Substrate By similarity HAMAP-Rule MF_00456
Binding site1571Substrate; via amide nitrogen By similarity HAMAP-Rule MF_00456

Sequences

Sequence LengthMass (Da)Tools
D2P4H0 [UniParc].

Last modified March 2, 2010. Version 1.
Checksum: F9A94811AFC5AD06

FASTA27630,034
        10         20         30         40         50         60 
MRESLKNSKR LVIKVGTSTL MYGNGHINLR TIEKLAMVLS DLRNEGKEVI LVSSGAIGVG 

        70         80         90        100        110        120 
CHKLQLPVRP TSIPEQQAVA SVGQSELMHI YSKFFGEYGQ VVGQVLLTRD VTDFPISREN 

       130        140        150        160        170        180 
VMNTLESLLE RGIIPIVNEN DTVAVEELEH VTKYGDNDLL SAIVAKLVQA DLLIMLSDID 

       190        200        210        220        230        240 
GFYGSNPSTD PDAVMFSEIN QITPEIEALA GGKGSKFGTG GMLTKLSAAS YCMNANQKMI 

       250        260        270 
LTNGKNPTII FDIMQGEQIG TLFASKKEEF SHDGTH

« Hide

References

[1]"High-throughput genome sequencing of two Listeria monocytogenes clinical isolates during a large foodborne outbreak."
Gilmour M.W., Graham M., Van Domselaar G., Tyler S., Kent H., Trout-Yakel K.M., Larios O., Allen V., Lee B., Nadon C.
BMC Genomics 11:120-120(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 08-5923 EMBL ADB71193.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001604 Genomic DNA. Translation: ADB71193.1.
RefSeqYP_003416555.1. NC_013768.1.

3D structure databases

ProteinModelPortalD2P4H0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADB71193; ADB71193; LM5923_1351.
GeneID8758146.
KEGGlmy:LM5923_1351.
PATRIC32256474. VBILisMon5116_1366.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000246368.
KOK00931.
OMAVYTGNPK.

Enzyme and pathway databases

BioCycLMON637381:GH7Z-1348-MONOMER.
UniPathwayUPA00098; UER00359.

Family and domain databases

Gene3D3.40.1160.10. 1 hit.
HAMAPMF_00456. ProB.
InterProIPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
[Graphical view]
PfamPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFPIRSF000729. GK. 1 hit.
PRINTSPR00474. GLU5KINASE.
SUPFAMSSF53633. Aa_kinase. 1 hit.
TIGRFAMsTIGR01027. proB. 1 hit.
PROSITEPS00902. GLUTAMATE_5_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD2P4H0_LISM2
AccessionPrimary (citable) accession number: D2P4H0
Entry history
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: May 1, 2013
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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