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D2P4H0

- D2P4H0_LISM2

UniProt

D2P4H0 - D2P4H0_LISM2

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Protein
Glutamate 5-kinase
Gene
proB, LM5923_1351
Organism
Listeria monocytogenes serotype 1/2a (strain 08-5923)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5-oxoproline By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141ATP By similarityUniRule annotation
Binding sitei54 – 541Substrate By similarityUniRule annotation
Binding sitei141 – 1411Substrate By similarityUniRule annotation
Binding sitei157 – 1571Substrate; via amide nitrogen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi177 – 1782ATP By similarityUniRule annotation
Nucleotide bindingi219 – 2257ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate 5-kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciLMON637381:GH7Z-1360-MONOMER.
UniPathwayiUPA00098; UER00359.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate 5-kinaseUniRule annotation (EC:2.7.2.11UniRule annotation)
Alternative name(s):
Gamma-glutamyl kinase
Gene namesi
Name:proBUniRule annotationImported
Ordered Locus Names:LM5923_1351Imported
OrganismiListeria monocytogenes serotype 1/2a (strain 08-5923)Imported
Taxonomic identifieri637381 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000006922: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliD2P4H0.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamate 5-kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000246368.
KOiK00931.
OMAiDIHYRQA.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
HAMAPiMF_00456. ProB.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000729. GK. 1 hit.
PRINTSiPR00474. GLU5KINASE.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR01027. proB. 1 hit.
PROSITEiPS00902. GLUTAMATE_5_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2P4H0-1 [UniParc]FASTAAdd to Basket

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MRESLKNSKR LVIKVGTSTL MYGNGHINLR TIEKLAMVLS DLRNEGKEVI    50
LVSSGAIGVG CHKLQLPVRP TSIPEQQAVA SVGQSELMHI YSKFFGEYGQ 100
VVGQVLLTRD VTDFPISREN VMNTLESLLE RGIIPIVNEN DTVAVEELEH 150
VTKYGDNDLL SAIVAKLVQA DLLIMLSDID GFYGSNPSTD PDAVMFSEIN 200
QITPEIEALA GGKGSKFGTG GMLTKLSAAS YCMNANQKMI LTNGKNPTII 250
FDIMQGEQIG TLFASKKEEF SHDGTH 276
Length:276
Mass (Da):30,034
Last modified:March 2, 2010 - v1
Checksum:iF9A94811AFC5AD06
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001604 Genomic DNA. Translation: ADB71193.1.
RefSeqiYP_003416555.1. NC_013768.1.

Genome annotation databases

EnsemblBacteriaiADB71193; ADB71193; LM5923_1351.
GeneIDi8758146.
KEGGilmy:LM5923_1351.
PATRICi32256474. VBILisMon5116_1366.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001604 Genomic DNA. Translation: ADB71193.1 .
RefSeqi YP_003416555.1. NC_013768.1.

3D structure databases

ProteinModelPortali D2P4H0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADB71193 ; ADB71193 ; LM5923_1351 .
GeneIDi 8758146.
KEGGi lmy:LM5923_1351.
PATRICi 32256474. VBILisMon5116_1366.

Phylogenomic databases

HOGENOMi HOG000246368.
KOi K00931.
OMAi DIHYRQA.

Enzyme and pathway databases

UniPathwayi UPA00098 ; UER00359 .
BioCyci LMON637381:GH7Z-1360-MONOMER.

Family and domain databases

Gene3Di 3.40.1160.10. 1 hit.
HAMAPi MF_00456. ProB.
InterProi IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
[Graphical view ]
Pfami PF00696. AA_kinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000729. GK. 1 hit.
PRINTSi PR00474. GLU5KINASE.
SUPFAMi SSF53633. SSF53633. 1 hit.
TIGRFAMsi TIGR01027. proB. 1 hit.
PROSITEi PS00902. GLUTAMATE_5_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-throughput genome sequencing of two Listeria monocytogenes clinical isolates during a large foodborne outbreak."
    Gilmour M.W., Graham M., Van Domselaar G., Tyler S., Kent H., Trout-Yakel K.M., Larios O., Allen V., Lee B., Nadon C.
    BMC Genomics 11:120-120(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 08-5923Imported.

Entry informationi

Entry nameiD2P4H0_LISM2
AccessioniPrimary (citable) accession number: D2P4H0
Entry historyi
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: June 11, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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