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Protein

3-isopropylmalate dehydratase small subunit

Gene

leuD

Organism
Rothia mucilaginosa (strain DY-18) (Stomatococcus mucilaginosus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.UniRule annotationSAAS annotation

Catalytic activityi

(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate.UniRule annotationSAAS annotation

Pathwayi: L-leucine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-leucine from 3-methyl-2-oxobutanoate.UniRule annotationSAAS annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. 2-isopropylmalate synthase (leuA)
  2. 3-isopropylmalate dehydratase small subunit (leuD), 3-isopropylmalate dehydratase large subunit (leuC)
  3. no protein annotated in this organism
  4. Branched-chain-amino-acid aminotransferase (RMDY18_07670)
This subpathway is part of the pathway L-leucine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-leucine from 3-methyl-2-oxobutanoate, the pathway L-leucine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotation
Biological processAmino-acid biosynthesis, Branched-chain amino acid biosynthesis, Leucine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00048; UER00071.

Names & Taxonomyi

Protein namesi
Recommended name:
3-isopropylmalate dehydratase small subunitUniRule annotation (EC:4.2.1.33UniRule annotation)
Alternative name(s):
Alpha-IPM isomeraseUniRule annotation
Short name:
IPMIUniRule annotation
Isopropylmalate isomeraseUniRule annotation
Gene namesi
Name:leuDUniRule annotation
Ordered Locus Names:RMDY18_08080Imported
OrganismiRothia mucilaginosa (strain DY-18) (Stomatococcus mucilaginosus)Imported
Taxonomic identifieri680646 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeRothia
Proteomesi
  • UP000001883 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Subunit structurei

Heterodimer of LeuC and LeuD.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi680646.RMDY18_08080.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 116Aconitase_CInterPro annotationAdd BLAST116

Sequence similaritiesi

Belongs to the LeuD family. LeuD type 1 subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105MQS. Bacteria.
COG0066. LUCA.
HOGENOMiHOG000222939.
KOiK01704.
OMAiAFTTHTG.

Family and domain databases

CDDicd01577. IPMI_Swivel. 1 hit.
Gene3Di3.20.19.10. 1 hit.
HAMAPiMF_01031. LeuD_type1. 1 hit.
InterProiView protein in InterPro
IPR004431. 3-IsopropMal_deHydase_ssu.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
IPR033940. IPMI_Swivel.
PfamiView protein in Pfam
PF00694. Aconitase_C. 1 hit.
TIGRFAMsiTIGR00171. leuD. 1 hit.

Sequencei

Sequence statusi: Complete.

D2NSL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPIIKHTGI GVPLRSSNVD TDQIIPAVYL KRVTKTGFDD ALFANWRKDP
60 70 80 90 100
EFILNQEPYK HGSVLVAGPD FGTGSSREHA VWALRDYGFK VVISARFADI
110 120 130 140 150
FRGNSGKQGL VTAQVAQDDI ELIWKALEHE PGTEITVDLE SKTVTVGALV
160 170 180 190
VPFEIDDYVR WRLMEGLDDI GLTLQNLEAI EAYEAKRPSW MPHTQEL
Length:197
Mass (Da):22,079
Last modified:March 2, 2010 - v1
Checksum:iB716420E1EC915DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011540 Genomic DNA. Translation: BAI64640.1.
RefSeqiWP_012903330.1. NC_013715.1.

Genome annotation databases

EnsemblBacteriaiBAI64640; BAI64640; RMDY18_08080.
GeneIDi25056471.
KEGGirmu:RMDY18_08080.

Similar proteinsi

Entry informationi

Entry nameiD2NSL4_ROTMD
AccessioniPrimary (citable) accession number: D2NSL4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: November 22, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported