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D2NSL4

- D2NSL4_ROTMD

UniProt

D2NSL4 - D2NSL4_ROTMD

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Protein

3-isopropylmalate dehydratase small subunit

Gene
leuD, RMDY18_08080
Organism
Rothia mucilaginosa (strain DY-18) (Stomatococcus mucilaginosus)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate By similarity.UniRule annotationSAAS annotations

Catalytic activityi

(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate.UniRule annotationSAAS annotations

Pathwayi

GO - Molecular functioni

  1. 3-isopropylmalate dehydratase activity Source: UniProtKB-EC

GO - Biological processi

  1. leucine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotations

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Leucine biosynthesisUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciRMUC680646:GH63-796-MONOMER.
UniPathwayiUPA00048; UER00071.

Names & Taxonomyi

Protein namesi
Recommended name:
3-isopropylmalate dehydratase small subunitUniRule annotation (EC:4.2.1.33UniRule annotation)
Alternative name(s):
Alpha-IPM isomerase
Isopropylmalate isomerase
Gene namesi
Name:leuDUniRule annotation
Ordered Locus Names:RMDY18_08080Imported
OrganismiRothia mucilaginosa (strain DY-18) (Stomatococcus mucilaginosus)
Taxonomic identifieri680646 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeRothia
ProteomesiUP000001883: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. 3-isopropylmalate dehydratase complex Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Heterodimer of LeuC and LeuD By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Belongs to the LeuD family. LeuD type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000222939.
KOiK01704.
OMAiYQDNSKR.
OrthoDBiEOG661HCP.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
HAMAPiMF_01031. LeuD_type1.
InterProiIPR004431. 3-IsopropMal_deHydase_ssu.
IPR015937. Acoase/IPM_deHydtase.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 1 hit.
PfamiPF00694. Aconitase_C. 1 hit.
[Graphical view]
SUPFAMiSSF52016. SSF52016. 1 hit.
TIGRFAMsiTIGR00171. leuD. 1 hit.

Sequencei

Sequence statusi: Complete.

D2NSL4-1 [UniParc]FASTAAdd to Basket

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MEPIIKHTGI GVPLRSSNVD TDQIIPAVYL KRVTKTGFDD ALFANWRKDP    50
EFILNQEPYK HGSVLVAGPD FGTGSSREHA VWALRDYGFK VVISARFADI 100
FRGNSGKQGL VTAQVAQDDI ELIWKALEHE PGTEITVDLE SKTVTVGALV 150
VPFEIDDYVR WRLMEGLDDI GLTLQNLEAI EAYEAKRPSW MPHTQEL 197
Length:197
Mass (Da):22,079
Last modified:March 2, 2010 - v1
Checksum:iB716420E1EC915DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP011540 Genomic DNA. Translation: BAI64640.1.
RefSeqiWP_012903330.1. NC_013715.1.
YP_003362460.1. NC_013715.1.

Genome annotation databases

EnsemblBacteriaiBAI64640; BAI64640; RMDY18_08080.
GeneIDi8693800.
KEGGirmu:RMDY18_08080.
PATRICi35272301. VBIRotMuc152186_0697.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP011540 Genomic DNA. Translation: BAI64640.1 .
RefSeqi WP_012903330.1. NC_013715.1.
YP_003362460.1. NC_013715.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAI64640 ; BAI64640 ; RMDY18_08080 .
GeneIDi 8693800.
KEGGi rmu:RMDY18_08080.
PATRICi 35272301. VBIRotMuc152186_0697.

Phylogenomic databases

HOGENOMi HOG000222939.
KOi K01704.
OMAi YQDNSKR.
OrthoDBi EOG661HCP.

Enzyme and pathway databases

UniPathwayi UPA00048 ; UER00071 .
BioCyci RMUC680646:GH63-796-MONOMER.

Family and domain databases

Gene3Di 3.20.19.10. 1 hit.
HAMAPi MF_01031. LeuD_type1.
InterProi IPR004431. 3-IsopropMal_deHydase_ssu.
IPR015937. Acoase/IPM_deHydtase.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view ]
PANTHERi PTHR11670. PTHR11670. 1 hit.
Pfami PF00694. Aconitase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF52016. SSF52016. 1 hit.
TIGRFAMsi TIGR00171. leuD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Rothia mucilaginosa DJ."
    Yamane K., Nambu T., Mashimo C., Sugimori C., Yamanaka T., Leung K., Fukushima H.
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DY-18.

Entry informationi

Entry nameiD2NSL4_ROTMD
AccessioniPrimary (citable) accession number: D2NSL4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: September 3, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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