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D2NSL4 (D2NSL4_ROTMD) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-isopropylmalate dehydratase small subunit HAMAP-Rule MF_01031
EC=4.2.1.33 HAMAP-Rule MF_01031
Alternative name(s):
Alpha-IPM isomerase HAMAP-Rule MF_01031
Isopropylmalate isomerase HAMAP-Rule MF_01031
Gene names
Name:leuD HAMAP-Rule MF_01031
Ordered Locus Names:RMDY18_08080
OrganismRothia mucilaginosa (strain DY-18) (Stomatococcus mucilaginosus) [Complete proteome] [HAMAP]
Taxonomic identifier680646 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Rothia ›

Protein attributes

Sequence length197 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate By similarity. HAMAP-Rule MF_01031 SAAS SAAS004431

Catalytic activity

(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate. HAMAP-Rule MF_01031 SAAS SAAS004431

Pathway

Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4. HAMAP-Rule MF_01031 SAAS SAAS004431

Subunit structure

Heterodimer of LeuC and LeuD By similarity. HAMAP-Rule MF_01031 SAAS SAAS004431

Sequence similarities

Belongs to the LeuD family. LeuD type 1 subfamily. HAMAP-Rule MF_01031

Sequences

Sequence LengthMass (Da)Tools
D2NSL4 [UniParc].

Last modified March 2, 2010. Version 1.
Checksum: B716420E1EC915DF

FASTA19722,079
        10         20         30         40         50         60 
MEPIIKHTGI GVPLRSSNVD TDQIIPAVYL KRVTKTGFDD ALFANWRKDP EFILNQEPYK 

        70         80         90        100        110        120 
HGSVLVAGPD FGTGSSREHA VWALRDYGFK VVISARFADI FRGNSGKQGL VTAQVAQDDI 

       130        140        150        160        170        180 
ELIWKALEHE PGTEITVDLE SKTVTVGALV VPFEIDDYVR WRLMEGLDDI GLTLQNLEAI 

       190 
EAYEAKRPSW MPHTQEL

« Hide

References

[1]"Complete genome sequence of Rothia mucilaginosa DJ."
Yamane K., Nambu T., Mashimo C., Sugimori C., Yamanaka T., Leung K., Fukushima H.
Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DY-18.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP011540 Genomic DNA. Translation: BAI64640.1.
RefSeqYP_003362460.1. NC_013715.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAI64640; BAI64640; RMDY18_08080.
GeneID8693800.
KEGGrmu:RMDY18_08080.
PATRIC35272301. VBIRotMuc152186_0697.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000222939.
KOK01704.
OMAYQDNSKR.

Enzyme and pathway databases

BioCycRMUC680646:GH63-830-MONOMER.
UniPathwayUPA00048; UER00071.

Family and domain databases

Gene3D3.20.19.10. 1 hit.
HAMAPMF_01031. LeuD_type1.
InterProIPR004431. 3-IsopropMal_deHydase_ssu.
IPR015937. Acoase/IPM_deHydtase.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
PANTHERPTHR11670. PTHR11670. 1 hit.
PTHR11670:SF2. PTHR11670:SF2. 1 hit.
PfamPF00694. Aconitase_C. 1 hit.
[Graphical view]
SUPFAMSSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit.
TIGRFAMsTIGR00171. leuD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD2NSL4_ROTMD
AccessionPrimary (citable) accession number: D2NSL4
Entry history
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: May 1, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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