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D2NSL4

- D2NSL4_ROTMD

UniProt

D2NSL4 - D2NSL4_ROTMD

Protein

3-isopropylmalate dehydratase small subunit

Gene

leuD

Organism
Rothia mucilaginosa (strain DY-18) (Stomatococcus mucilaginosus)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (02 Mar 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.UniRule annotationSAAS annotation

    Catalytic activityi

    (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate.UniRule annotationSAAS annotation

    Pathwayi

    GO - Molecular functioni

    1. 3-isopropylmalate dehydratase activity Source: UniProtKB-EC

    GO - Biological processi

    1. leucine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    LyaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Leucine biosynthesisUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciRMUC680646:GH63-796-MONOMER.
    UniPathwayiUPA00048; UER00071.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-isopropylmalate dehydratase small subunitUniRule annotation (EC:4.2.1.33UniRule annotation)
    Alternative name(s):
    Alpha-IPM isomeraseUniRule annotation
    Isopropylmalate isomeraseUniRule annotation
    Gene namesi
    Name:leuDUniRule annotation
    Ordered Locus Names:RMDY18_08080Imported
    OrganismiRothia mucilaginosa (strain DY-18) (Stomatococcus mucilaginosus)Imported
    Taxonomic identifieri680646 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeRothia
    ProteomesiUP000001883: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. 3-isopropylmalate dehydratase complex Source: InterPro

    Interactioni

    Subunit structurei

    Heterodimer of LeuC and LeuD.UniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LeuD family. LeuD type 1 subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000222939.
    KOiK01704.
    OMAiYQDNSKR.
    OrthoDBiEOG661HCP.

    Family and domain databases

    Gene3Di3.20.19.10. 1 hit.
    HAMAPiMF_01031. LeuD_type1.
    InterProiIPR004431. 3-IsopropMal_deHydase_ssu.
    IPR015937. Acoase/IPM_deHydtase.
    IPR015928. Aconitase/3IPM_dehydase_swvl.
    IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
    [Graphical view]
    PANTHERiPTHR11670. PTHR11670. 1 hit.
    PfamiPF00694. Aconitase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52016. SSF52016. 1 hit.
    TIGRFAMsiTIGR00171. leuD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D2NSL4-1 [UniParc]FASTAAdd to Basket

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    MEPIIKHTGI GVPLRSSNVD TDQIIPAVYL KRVTKTGFDD ALFANWRKDP    50
    EFILNQEPYK HGSVLVAGPD FGTGSSREHA VWALRDYGFK VVISARFADI 100
    FRGNSGKQGL VTAQVAQDDI ELIWKALEHE PGTEITVDLE SKTVTVGALV 150
    VPFEIDDYVR WRLMEGLDDI GLTLQNLEAI EAYEAKRPSW MPHTQEL 197
    Length:197
    Mass (Da):22,079
    Last modified:March 2, 2010 - v1
    Checksum:iB716420E1EC915DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011540 Genomic DNA. Translation: BAI64640.1.
    RefSeqiWP_012903330.1. NC_013715.1.
    YP_003362460.1. NC_013715.1.

    Genome annotation databases

    EnsemblBacteriaiBAI64640; BAI64640; RMDY18_08080.
    GeneIDi8693800.
    KEGGirmu:RMDY18_08080.
    PATRICi35272301. VBIRotMuc152186_0697.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011540 Genomic DNA. Translation: BAI64640.1 .
    RefSeqi WP_012903330.1. NC_013715.1.
    YP_003362460.1. NC_013715.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAI64640 ; BAI64640 ; RMDY18_08080 .
    GeneIDi 8693800.
    KEGGi rmu:RMDY18_08080.
    PATRICi 35272301. VBIRotMuc152186_0697.

    Phylogenomic databases

    HOGENOMi HOG000222939.
    KOi K01704.
    OMAi YQDNSKR.
    OrthoDBi EOG661HCP.

    Enzyme and pathway databases

    UniPathwayi UPA00048 ; UER00071 .
    BioCyci RMUC680646:GH63-796-MONOMER.

    Family and domain databases

    Gene3Di 3.20.19.10. 1 hit.
    HAMAPi MF_01031. LeuD_type1.
    InterProi IPR004431. 3-IsopropMal_deHydase_ssu.
    IPR015937. Acoase/IPM_deHydtase.
    IPR015928. Aconitase/3IPM_dehydase_swvl.
    IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
    [Graphical view ]
    PANTHERi PTHR11670. PTHR11670. 1 hit.
    Pfami PF00694. Aconitase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52016. SSF52016. 1 hit.
    TIGRFAMsi TIGR00171. leuD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Rothia mucilaginosa DJ."
      Yamane K., Nambu T., Mashimo C., Sugimori C., Yamanaka T., Leung K., Fukushima H.
      Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DY-18Imported.

    Entry informationi

    Entry nameiD2NSL4_ROTMD
    AccessioniPrimary (citable) accession number: D2NSL4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 2, 2010
    Last sequence update: March 2, 2010
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3