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D2NSL4

- D2NSL4_ROTMD

UniProt

D2NSL4 - D2NSL4_ROTMD

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Protein

3-isopropylmalate dehydratase small subunit

Gene

leuD

Organism
Rothia mucilaginosa (strain DY-18) (Stomatococcus mucilaginosus)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.UniRule annotationSAAS annotation

Catalytic activityi

(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate.UniRule annotationSAAS annotation

Pathwayi

GO - Molecular functioni

  1. 3-isopropylmalate dehydratase activity Source: UniProtKB-EC

GO - Biological processi

  1. leucine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Leucine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciRMUC680646:GH63-796-MONOMER.
UniPathwayiUPA00048; UER00071.

Names & Taxonomyi

Protein namesi
Recommended name:
3-isopropylmalate dehydratase small subunitUniRule annotation (EC:4.2.1.33UniRule annotation)
Alternative name(s):
Alpha-IPM isomeraseUniRule annotation
Isopropylmalate isomeraseUniRule annotation
Gene namesi
Name:leuDUniRule annotation
Ordered Locus Names:RMDY18_08080Imported
OrganismiRothia mucilaginosa (strain DY-18) (Stomatococcus mucilaginosus)Imported
Taxonomic identifieri680646 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeRothia
ProteomesiUP000001883: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. 3-isopropylmalate dehydratase complex Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Heterodimer of LeuC and LeuD.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the LeuD family. LeuD type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000222939.
KOiK01704.
OMAiYQDNSKR.
OrthoDBiEOG661HCP.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
HAMAPiMF_01031. LeuD_type1.
InterProiIPR004431. 3-IsopropMal_deHydase_ssu.
IPR015937. Acoase/IPM_deHydtase.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 1 hit.
PfamiPF00694. Aconitase_C. 1 hit.
[Graphical view]
SUPFAMiSSF52016. SSF52016. 1 hit.
TIGRFAMsiTIGR00171. leuD. 1 hit.

Sequencei

Sequence statusi: Complete.

D2NSL4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPIIKHTGI GVPLRSSNVD TDQIIPAVYL KRVTKTGFDD ALFANWRKDP
60 70 80 90 100
EFILNQEPYK HGSVLVAGPD FGTGSSREHA VWALRDYGFK VVISARFADI
110 120 130 140 150
FRGNSGKQGL VTAQVAQDDI ELIWKALEHE PGTEITVDLE SKTVTVGALV
160 170 180 190
VPFEIDDYVR WRLMEGLDDI GLTLQNLEAI EAYEAKRPSW MPHTQEL
Length:197
Mass (Da):22,079
Last modified:March 2, 2010 - v1
Checksum:iB716420E1EC915DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011540 Genomic DNA. Translation: BAI64640.1.
RefSeqiYP_003362460.1. NC_013715.1.

Genome annotation databases

EnsemblBacteriaiBAI64640; BAI64640; RMDY18_08080.
GeneIDi8693800.
KEGGirmu:RMDY18_08080.
PATRICi35272301. VBIRotMuc152186_0697.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011540 Genomic DNA. Translation: BAI64640.1 .
RefSeqi YP_003362460.1. NC_013715.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAI64640 ; BAI64640 ; RMDY18_08080 .
GeneIDi 8693800.
KEGGi rmu:RMDY18_08080.
PATRICi 35272301. VBIRotMuc152186_0697.

Phylogenomic databases

HOGENOMi HOG000222939.
KOi K01704.
OMAi YQDNSKR.
OrthoDBi EOG661HCP.

Enzyme and pathway databases

UniPathwayi UPA00048 ; UER00071 .
BioCyci RMUC680646:GH63-796-MONOMER.

Family and domain databases

Gene3Di 3.20.19.10. 1 hit.
HAMAPi MF_01031. LeuD_type1.
InterProi IPR004431. 3-IsopropMal_deHydase_ssu.
IPR015937. Acoase/IPM_deHydtase.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view ]
PANTHERi PTHR11670. PTHR11670. 1 hit.
Pfami PF00694. Aconitase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF52016. SSF52016. 1 hit.
TIGRFAMsi TIGR00171. leuD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Rothia mucilaginosa DJ."
    Yamane K., Nambu T., Mashimo C., Sugimori C., Yamanaka T., Leung K., Fukushima H.
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DY-18Imported.

Entry informationi

Entry nameiD2NSL4_ROTMD
AccessioniPrimary (citable) accession number: D2NSL4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: October 29, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3