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D2NRR5

- D2NRR5_ROTMD

UniProt

D2NRR5 - D2NRR5_ROTMD

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Protein
tRNA pseudouridine synthase A
Gene
truA, RMDY18_05090
Organism
Rothia mucilaginosa (strain DY-18) (Stomatococcus mucilaginosus)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs By similarity.UniRule annotationSAAS annotations

Catalytic activityi

tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei96 – 961Nucleophile By similarityUniRule annotation
Binding sitei187 – 1871Substrate By similarityUniRule annotation

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. pseudouridine synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tRNA pseudouridine synthesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotations

Keywords - Biological processi

tRNA processingUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciRMUC680646:GH63-505-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase AUniRule annotation (EC:5.4.99.12UniRule annotation)
Alternative name(s):
tRNA pseudouridine(38-40) synthase
tRNA pseudouridylate synthase I
tRNA-uridine isomerase I
Gene namesi
Name:truAUniRule annotation
Ordered Locus Names:RMDY18_05090Imported
OrganismiRothia mucilaginosa (strain DY-18) (Stomatococcus mucilaginosus)
Taxonomic identifieri680646 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeRothia
ProteomesiUP000001883: Chromosome

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000248674.
KOiK06173.
OMAiCRPREGA.
OrthoDBiEOG6Z9B4R.

Family and domain databases

Gene3Di3.30.70.580. 2 hits.
3.30.70.660. 1 hit.
HAMAPiMF_00171. TruA.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view]
PANTHERiPTHR11142. PTHR11142. 1 hit.
PfamiPF01416. PseudoU_synth_1. 2 hits.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 2 hits.
TIGRFAMsiTIGR00071. hisT_truA. 1 hit.

Sequencei

Sequence statusi: Complete.

D2NRR5-1 [UniParc]FASTAAdd to Basket

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MELFLRAPSL QEPCQCFRTL SPLKGTPMQN ATALENHEEQ LFIATHRVRI    50
DCAYDGSLFS GWAAQPNLVT VQGVIENALE LILRAPHRVV VAGRTDAGVH 100
AEAQTLHCDL SDEDWTRLQG RTGEDDPTAA LGRRLTGALQ RCLYDAEEQL 150
NLPKNVRGIL QGAIQIHRVA EVPFDFDARF SATGRRYVYR IADGAADGLN 200
PLHRTYTWAV PEHLDCADLN ESAQQLLGLR DFLSFCKPRE GATTIRELRE 250
LSFTRTESAL IEVCVVADAF CHHMVRSLVG ALVLYGTGKR DAAWLRERIE 300
NPGREASLTL APPHALALAE IYYPAPELYG EQAERARAKR EDDEAQSA 348
Length:348
Mass (Da):38,696
Last modified:March 2, 2010 - v1
Checksum:iAD367ED3C0F33A0D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP011540 Genomic DNA. Translation: BAI64341.1.
RefSeqiWP_012903065.1. NC_013715.1.
YP_003362161.1. NC_013715.1.

Genome annotation databases

EnsemblBacteriaiBAI64341; BAI64341; RMDY18_05090.
GeneIDi8693518.
KEGGirmu:RMDY18_05090.
PATRICi35271763. VBIRotMuc152186_0437.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP011540 Genomic DNA. Translation: BAI64341.1 .
RefSeqi WP_012903065.1. NC_013715.1.
YP_003362161.1. NC_013715.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAI64341 ; BAI64341 ; RMDY18_05090 .
GeneIDi 8693518.
KEGGi rmu:RMDY18_05090.
PATRICi 35271763. VBIRotMuc152186_0437.

Phylogenomic databases

HOGENOMi HOG000248674.
KOi K06173.
OMAi CRPREGA.
OrthoDBi EOG6Z9B4R.

Enzyme and pathway databases

BioCyci RMUC680646:GH63-505-MONOMER.

Family and domain databases

Gene3Di 3.30.70.580. 2 hits.
3.30.70.660. 1 hit.
HAMAPi MF_00171. TruA.
InterProi IPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view ]
PANTHERi PTHR11142. PTHR11142. 1 hit.
Pfami PF01416. PseudoU_synth_1. 2 hits.
[Graphical view ]
SUPFAMi SSF55120. SSF55120. 2 hits.
TIGRFAMsi TIGR00071. hisT_truA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Rothia mucilaginosa DJ."
    Yamane K., Nambu T., Mashimo C., Sugimori C., Yamanaka T., Leung K., Fukushima H.
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DY-18.

Entry informationi

Entry nameiD2NRR5_ROTMD
AccessioniPrimary (citable) accession number: D2NRR5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: September 3, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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