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Protein

tRNA pseudouridine synthase A

Gene

truA

Organism
Rothia mucilaginosa (strain DY-18) (Stomatococcus mucilaginosus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.UniRule annotationSAAS annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei96NucleophileUniRule annotation1
Binding sitei187SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
Biological processtRNA processingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase AUniRule annotation (EC:5.4.99.12UniRule annotation)
Alternative name(s):
tRNA pseudouridine(38-40) synthaseUniRule annotation
tRNA pseudouridylate synthase IUniRule annotation
tRNA-uridine isomerase IUniRule annotation
Gene namesi
Name:truAUniRule annotation
Ordered Locus Names:RMDY18_05090Imported
OrganismiRothia mucilaginosa (strain DY-18) (Stomatococcus mucilaginosus)Imported
Taxonomic identifieri680646 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeRothia
Proteomesi
  • UP000001883 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi680646.RMDY18_05090

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini223 – 324PseudoU_synth_1InterPro annotationAdd BLAST102

Sequence similaritiesi

Belongs to the tRNA pseudouridine synthase TruA family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DI7 Bacteria
COG0101 LUCA
HOGENOMiHOG000248674
KOiK06173
OMAiFLYGMVR

Family and domain databases

Gene3Di3.30.70.660, 1 hit
HAMAPiMF_00171 TruA, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001406 PsdUridine_synth_TruA
IPR020097 PsdUridine_synth_TruA_a/b_dom
IPR020095 PsdUridine_synth_TruA_C
PANTHERiPTHR11142 PTHR11142, 1 hit
PfamiView protein in Pfam
PF01416 PseudoU_synth_1, 1 hit
SUPFAMiSSF55120 SSF55120, 2 hits
TIGRFAMsiTIGR00071 hisT_truA, 1 hit

Sequencei

Sequence statusi: Complete.

D2NRR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELFLRAPSL QEPCQCFRTL SPLKGTPMQN ATALENHEEQ LFIATHRVRI
60 70 80 90 100
DCAYDGSLFS GWAAQPNLVT VQGVIENALE LILRAPHRVV VAGRTDAGVH
110 120 130 140 150
AEAQTLHCDL SDEDWTRLQG RTGEDDPTAA LGRRLTGALQ RCLYDAEEQL
160 170 180 190 200
NLPKNVRGIL QGAIQIHRVA EVPFDFDARF SATGRRYVYR IADGAADGLN
210 220 230 240 250
PLHRTYTWAV PEHLDCADLN ESAQQLLGLR DFLSFCKPRE GATTIRELRE
260 270 280 290 300
LSFTRTESAL IEVCVVADAF CHHMVRSLVG ALVLYGTGKR DAAWLRERIE
310 320 330 340
NPGREASLTL APPHALALAE IYYPAPELYG EQAERARAKR EDDEAQSA
Length:348
Mass (Da):38,696
Last modified:March 2, 2010 - v1
Checksum:iAD367ED3C0F33A0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011540 Genomic DNA Translation: BAI64341.1

Genome annotation databases

EnsemblBacteriaiBAI64341; BAI64341; RMDY18_05090
KEGGirmu:RMDY18_05090

Similar proteinsi

Entry informationi

Entry nameiD2NRR5_ROTMD
AccessioniPrimary (citable) accession number: D2NRR5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: March 28, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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