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Protein

tRNA pseudouridine synthase A

Gene

truA

Organism
Rothia mucilaginosa (strain DY-18) (Stomatococcus mucilaginosus)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.UniRule annotationSAAS annotation

Catalytic activityi

tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei96 – 961NucleophileUniRule annotation
Binding sitei187 – 1871SubstrateUniRule annotation

GO - Molecular functioni

  1. pseudouridine synthase activity Source: UniProtKB-HAMAP
  2. RNA binding Source: InterPro

GO - Biological processi

  1. tRNA pseudouridine synthesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Keywords - Biological processi

tRNA processingUniRule annotation

Enzyme and pathway databases

BioCyciRMUC680646:GH63-505-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase AUniRule annotation (EC:5.4.99.12UniRule annotation)
Alternative name(s):
tRNA pseudouridine(38-40) synthaseUniRule annotation
tRNA pseudouridylate synthase IUniRule annotation
tRNA-uridine isomerase IUniRule annotation
Gene namesi
Name:truAUniRule annotation
Ordered Locus Names:RMDY18_05090Imported
OrganismiRothia mucilaginosa (strain DY-18) (Stomatococcus mucilaginosus)Imported
Taxonomic identifieri680646 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeRothia
ProteomesiUP000001883 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the tRNA pseudouridine synthase TruA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000248674.
KOiK06173.
OMAiRTIYNVE.
OrthoDBiEOG6Z9B4R.

Family and domain databases

Gene3Di3.30.70.580. 2 hits.
3.30.70.660. 1 hit.
HAMAPiMF_00171. TruA.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view]
PANTHERiPTHR11142. PTHR11142. 1 hit.
PfamiPF01416. PseudoU_synth_1. 2 hits.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 2 hits.
TIGRFAMsiTIGR00071. hisT_truA. 1 hit.

Sequencei

Sequence statusi: Complete.

D2NRR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELFLRAPSL QEPCQCFRTL SPLKGTPMQN ATALENHEEQ LFIATHRVRI
60 70 80 90 100
DCAYDGSLFS GWAAQPNLVT VQGVIENALE LILRAPHRVV VAGRTDAGVH
110 120 130 140 150
AEAQTLHCDL SDEDWTRLQG RTGEDDPTAA LGRRLTGALQ RCLYDAEEQL
160 170 180 190 200
NLPKNVRGIL QGAIQIHRVA EVPFDFDARF SATGRRYVYR IADGAADGLN
210 220 230 240 250
PLHRTYTWAV PEHLDCADLN ESAQQLLGLR DFLSFCKPRE GATTIRELRE
260 270 280 290 300
LSFTRTESAL IEVCVVADAF CHHMVRSLVG ALVLYGTGKR DAAWLRERIE
310 320 330 340
NPGREASLTL APPHALALAE IYYPAPELYG EQAERARAKR EDDEAQSA
Length:348
Mass (Da):38,696
Last modified:March 2, 2010 - v1
Checksum:iAD367ED3C0F33A0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011540 Genomic DNA. Translation: BAI64341.1.
RefSeqiYP_003362161.1. NC_013715.1.

Genome annotation databases

EnsemblBacteriaiBAI64341; BAI64341; RMDY18_05090.
GeneIDi8693518.
KEGGirmu:RMDY18_05090.
PATRICi35271763. VBIRotMuc152186_0437.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011540 Genomic DNA. Translation: BAI64341.1.
RefSeqiYP_003362161.1. NC_013715.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAI64341; BAI64341; RMDY18_05090.
GeneIDi8693518.
KEGGirmu:RMDY18_05090.
PATRICi35271763. VBIRotMuc152186_0437.

Phylogenomic databases

HOGENOMiHOG000248674.
KOiK06173.
OMAiRTIYNVE.
OrthoDBiEOG6Z9B4R.

Enzyme and pathway databases

BioCyciRMUC680646:GH63-505-MONOMER.

Family and domain databases

Gene3Di3.30.70.580. 2 hits.
3.30.70.660. 1 hit.
HAMAPiMF_00171. TruA.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view]
PANTHERiPTHR11142. PTHR11142. 1 hit.
PfamiPF01416. PseudoU_synth_1. 2 hits.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 2 hits.
TIGRFAMsiTIGR00071. hisT_truA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Rothia mucilaginosa DJ."
    Yamane K., Nambu T., Mashimo C., Sugimori C., Yamanaka T., Leung K., Fukushima H.
    Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DY-18Imported.

Entry informationi

Entry nameiD2NRR5_ROTMD
AccessioniPrimary (citable) accession number: D2NRR5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: March 4, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.