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D2NRR5

- D2NRR5_ROTMD

UniProt

D2NRR5 - D2NRR5_ROTMD

Protein

tRNA pseudouridine synthase A

Gene

truA

Organism
Rothia mucilaginosa (strain DY-18) (Stomatococcus mucilaginosus)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (02 Mar 2010)
      Previous versions | rss
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    Functioni

    Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.UniRule annotationSAAS annotation

    Catalytic activityi

    tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei96 – 961NucleophileUniRule annotation
    Binding sitei187 – 1871SubstrateUniRule annotation

    GO - Molecular functioni

    1. pseudouridine synthase activity Source: UniProtKB-HAMAP
    2. RNA binding Source: InterPro

    GO - Biological processi

    1. tRNA pseudouridine synthesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Biological processi

    tRNA processingUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciRMUC680646:GH63-505-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA pseudouridine synthase AUniRule annotation (EC:5.4.99.12UniRule annotation)
    Alternative name(s):
    tRNA pseudouridine(38-40) synthaseUniRule annotation
    tRNA pseudouridylate synthase IUniRule annotation
    tRNA-uridine isomerase IUniRule annotation
    Gene namesi
    Name:truAUniRule annotation
    Ordered Locus Names:RMDY18_05090Imported
    OrganismiRothia mucilaginosa (strain DY-18) (Stomatococcus mucilaginosus)Imported
    Taxonomic identifieri680646 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeRothia
    ProteomesiUP000001883: Chromosome

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tRNA pseudouridine synthase TruA family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000248674.
    KOiK06173.
    OMAiCRPREGA.
    OrthoDBiEOG6Z9B4R.

    Family and domain databases

    Gene3Di3.30.70.580. 2 hits.
    3.30.70.660. 1 hit.
    HAMAPiMF_00171. TruA.
    InterProiIPR020103. PsdUridine_synth_cat_dom.
    IPR001406. PsdUridine_synth_TruA.
    IPR020097. PsdUridine_synth_TruA_a/b_dom.
    IPR020095. PsdUridine_synth_TruA_C.
    IPR020094. PsdUridine_synth_TruA_N.
    [Graphical view]
    PANTHERiPTHR11142. PTHR11142. 1 hit.
    PfamiPF01416. PseudoU_synth_1. 2 hits.
    [Graphical view]
    SUPFAMiSSF55120. SSF55120. 2 hits.
    TIGRFAMsiTIGR00071. hisT_truA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D2NRR5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELFLRAPSL QEPCQCFRTL SPLKGTPMQN ATALENHEEQ LFIATHRVRI    50
    DCAYDGSLFS GWAAQPNLVT VQGVIENALE LILRAPHRVV VAGRTDAGVH 100
    AEAQTLHCDL SDEDWTRLQG RTGEDDPTAA LGRRLTGALQ RCLYDAEEQL 150
    NLPKNVRGIL QGAIQIHRVA EVPFDFDARF SATGRRYVYR IADGAADGLN 200
    PLHRTYTWAV PEHLDCADLN ESAQQLLGLR DFLSFCKPRE GATTIRELRE 250
    LSFTRTESAL IEVCVVADAF CHHMVRSLVG ALVLYGTGKR DAAWLRERIE 300
    NPGREASLTL APPHALALAE IYYPAPELYG EQAERARAKR EDDEAQSA 348
    Length:348
    Mass (Da):38,696
    Last modified:March 2, 2010 - v1
    Checksum:iAD367ED3C0F33A0D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011540 Genomic DNA. Translation: BAI64341.1.
    RefSeqiWP_012903065.1. NC_013715.1.
    YP_003362161.1. NC_013715.1.

    Genome annotation databases

    EnsemblBacteriaiBAI64341; BAI64341; RMDY18_05090.
    GeneIDi8693518.
    KEGGirmu:RMDY18_05090.
    PATRICi35271763. VBIRotMuc152186_0437.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011540 Genomic DNA. Translation: BAI64341.1 .
    RefSeqi WP_012903065.1. NC_013715.1.
    YP_003362161.1. NC_013715.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAI64341 ; BAI64341 ; RMDY18_05090 .
    GeneIDi 8693518.
    KEGGi rmu:RMDY18_05090.
    PATRICi 35271763. VBIRotMuc152186_0437.

    Phylogenomic databases

    HOGENOMi HOG000248674.
    KOi K06173.
    OMAi CRPREGA.
    OrthoDBi EOG6Z9B4R.

    Enzyme and pathway databases

    BioCyci RMUC680646:GH63-505-MONOMER.

    Family and domain databases

    Gene3Di 3.30.70.580. 2 hits.
    3.30.70.660. 1 hit.
    HAMAPi MF_00171. TruA.
    InterProi IPR020103. PsdUridine_synth_cat_dom.
    IPR001406. PsdUridine_synth_TruA.
    IPR020097. PsdUridine_synth_TruA_a/b_dom.
    IPR020095. PsdUridine_synth_TruA_C.
    IPR020094. PsdUridine_synth_TruA_N.
    [Graphical view ]
    PANTHERi PTHR11142. PTHR11142. 1 hit.
    Pfami PF01416. PseudoU_synth_1. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55120. SSF55120. 2 hits.
    TIGRFAMsi TIGR00071. hisT_truA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Rothia mucilaginosa DJ."
      Yamane K., Nambu T., Mashimo C., Sugimori C., Yamanaka T., Leung K., Fukushima H.
      Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DY-18Imported.

    Entry informationi

    Entry nameiD2NRR5_ROTMD
    AccessioniPrimary (citable) accession number: D2NRR5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 2, 2010
    Last sequence update: March 2, 2010
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3