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Protein
Submitted name:

Peroxisome proliferative activated receptor gamma

Gene

PPARG

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotationImported

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Peroxisome proliferative activated receptor gammaImported
Submitted name:
Peroxisome proliferative activated receptor gamma isoform 6 variantImported
Submitted name:
Peroxisome proliferative activated receptor, gamma, isoform CRA_aImported
Submitted name:
Peroxisome proliferator-activated nuclear receptor gamma variant 1Imported
Submitted name:
Peroxisome proliferator-activated receptor gamma isoform 1Imported
Gene namesi
Name:PPARGImported
Synonyms:NR1C3Imported, PPAR gammaImported
ORF Names:hCG_26772Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA281.

Expressioni

Gene expression databases

BgeeiENSG00000132170.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000287820.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini108 – 18275Nuclear receptor DNA-bindingInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation
Contains 1 Nuclear receptor DNA-binding domain.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotation

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR003074. 1Cnucl_rcpt.
IPR003077. 1Cnucl_rcpt_G.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR022590. PPARgamma_N.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF12577. PPARgamma_N. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01288. PROXISOMEPAR.
PR01291. PROXISOMPAGR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2KUA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMVDTEMPF WPTNFGISSV DLSVMEDHSH SFDIKPFTTV DFSSISTPHY
60 70 80 90 100
EDIPFTRTDP VVADYKYDLK LQEYQSAIKV EPASPPYYSE KTQLYNKPHE
110 120 130 140 150
EPSNSLMAIE CRVCGDKASG FHYGVHACEG CKGFFRRTIR LKLIYDRCDL
160 170 180 190 200
NCRIHKKSRN KCQYCRFQKC LAVGMSHNAI RFGRMPQAEK EKLLAEISSD
210 220 230 240 250
IDQLNPESAD LRALAKHLYD SYIKSFPLTK AKARAILTGK TTDKSPFVIY
260 270 280 290 300
DMNSLMMGED KIKFKHITPL QEQSKEVAIR IFQGCQFRSV EAVQEITEYA
310 320 330 340 350
KSIPGFVNLD LNDQVTLLKY GVHEIIYTML ASLMNKDGVL ISEGQGFMTR
360 370 380 390 400
EFLKSLRKPF GDFMEPKFEF AVKFNALELD DSDLAIFIAV IILSGDRPGL
410 420 430 440 450
LNVKPIEDIQ DNLLQALELQ LKLNHPESSQ LFAKLLQKMT DLRQIVTEHV
460 470
QLLQVIKKTE TDMSLHPLLQ EIYKDLY
Length:477
Mass (Da):54,681
Last modified:March 2, 2010 - v1
Checksum:i1061C2074B739E0A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei477 – 4771Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ692866 mRNA. Translation: ADZ17377.1.
KU178267 mRNA. Translation: ALQ33725.1.
AB472042 mRNA. Translation: BAI63629.1.
AB565476 mRNA. Translation: BAM71699.1.
CH471055 Genomic DNA. Translation: EAW64123.1.
RefSeqiNP_005028.4. NM_005037.5.
NP_619725.2. NM_138711.3.
NP_619726.2. NM_138712.3.
XP_011532143.1. XM_011533841.2.
UniGeneiHs.162646.

Genome annotation databases

GeneIDi5468.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ692866 mRNA. Translation: ADZ17377.1.
KU178267 mRNA. Translation: ALQ33725.1.
AB472042 mRNA. Translation: BAI63629.1.
AB565476 mRNA. Translation: BAM71699.1.
CH471055 Genomic DNA. Translation: EAW64123.1.
RefSeqiNP_005028.4. NM_005037.5.
NP_619725.2. NM_138711.3.
NP_619726.2. NM_138712.3.
XP_011532143.1. XM_011533841.2.
UniGeneiHs.162646.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000287820.

Protocols and materials databases

DNASUi5468.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5468.

Organism-specific databases

CTDi5468.
PharmGKBiPA281.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.

Miscellaneous databases

ChiTaRSiPPARG. human.
GenomeRNAii5468.

Gene expression databases

BgeeiENSG00000132170.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR003074. 1Cnucl_rcpt.
IPR003077. 1Cnucl_rcpt_G.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR022590. PPARgamma_N.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF12577. PPARgamma_N. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01288. PROXISOMEPAR.
PR01291. PROXISOMPAGR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD2KUA6_HUMAN
AccessioniPrimary (citable) accession number: D2KUA6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: September 7, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.