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Protein

Peroxisome proliferator-activated receptor gamma

Gene

PPARG

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi108 – 182Nuclear receptorPROSITE-ProRule annotationAdd BLAST75

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation, DNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotationImported
Biological processBiological rhythmsUniRule annotation, Transcription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor gammaUniRule annotation
Short name:
PPAR-gammaUniRule annotation
Alternative name(s):
Nuclear receptor subfamily 1 group C member 3UniRule annotation
Gene namesi
Name:PPARGUniRule annotationImported
Synonyms:NR1C3Imported, PPAR gammaImported
ORF Names:hCG_26772Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000132170.19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusPROSITE-ProRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA281

PTM / Processingi

Proteomic databases

PRIDEiD2KUA6

Expressioni

Gene expression databases

BgeeiENSG00000132170
ExpressionAtlasiD2KUA6 baseline and differential

Interactioni

Subunit structurei

Heterodimer with other nuclear receptors.UniRule annotation

Structurei

3D structure databases

SMRiD2KUA6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 182Nuclear receptorInterPro annotationAdd BLAST75
Domaini210 – 475NR LBDInterPro annotationAdd BLAST266

Sequence similaritiesi

Belongs to the nuclear hormone receptor family. NR1 subfamily.UniRule annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR003074 1Cnucl_rcpt
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR003077 PPAR-gamma
IPR022590 PPARgamma_N
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF12577 PPARgamma_N, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01288 PROXISOMEPAR
PR01291 PROXISOMPAGR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

D2KUA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMVDTEMPF WPTNFGISSV DLSVMEDHSH SFDIKPFTTV DFSSISTPHY
60 70 80 90 100
EDIPFTRTDP VVADYKYDLK LQEYQSAIKV EPASPPYYSE KTQLYNKPHE
110 120 130 140 150
EPSNSLMAIE CRVCGDKASG FHYGVHACEG CKGFFRRTIR LKLIYDRCDL
160 170 180 190 200
NCRIHKKSRN KCQYCRFQKC LAVGMSHNAI RFGRMPQAEK EKLLAEISSD
210 220 230 240 250
IDQLNPESAD LRALAKHLYD SYIKSFPLTK AKARAILTGK TTDKSPFVIY
260 270 280 290 300
DMNSLMMGED KIKFKHITPL QEQSKEVAIR IFQGCQFRSV EAVQEITEYA
310 320 330 340 350
KSIPGFVNLD LNDQVTLLKY GVHEIIYTML ASLMNKDGVL ISEGQGFMTR
360 370 380 390 400
EFLKSLRKPF GDFMEPKFEF AVKFNALELD DSDLAIFIAV IILSGDRPGL
410 420 430 440 450
LNVKPIEDIQ DNLLQALELQ LKLNHPESSQ LFAKLLQKMT DLRQIVTEHV
460 470
QLLQVIKKTE TDMSLHPLLQ EIYKDLY
Length:477
Mass (Da):54,681
Last modified:March 2, 2010 - v1
Checksum:i1061C2074B739E0A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei477Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ692866 mRNA Translation: ADZ17377.1
KU178267 mRNA Translation: ALQ33725.1
AB472042 mRNA Translation: BAI63629.1
AB565476 mRNA Translation: BAM71699.1
CH471055 Genomic DNA Translation: EAW64123.1
RefSeqiNP_005028.4, NM_005037.5
NP_619725.2, NM_138711.3
NP_619726.2, NM_138712.3
XP_011532143.1, XM_011533841.2
UniGeneiHs.162646

Genome annotation databases

GeneIDi5468

Similar proteinsi

Entry informationi

Entry nameiD2KUA6_HUMAN
AccessioniPrimary (citable) accession number: D2KUA6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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