ID   D2KF13_HUMAN            Unreviewed;       739 AA.
AC   D2KF13;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   27-MAR-2024, entry version 85.
DE   SubName: Full=Androgen receptor variant 5,6,7es {ECO:0000313|EMBL:ACZ81436.1};
GN   Name=AR {ECO:0000313|EMBL:ACZ81436.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ACZ81436.1};
RN   [1] {ECO:0000313|EMBL:ACZ81436.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Sun S., Vessella R., Sprenger C., Haugk K., Soriano K., Mostaghel E.,
RA   Page S., Coleman I., Nelson P., Nguyen H., Plymate S.;
RT   "A Novel, Frequently Occurring Androgen Receptor Splice Variant Confers
RT   Castration Resistance in Prostate Cancer.";
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GU208210; ACZ81436.1; -; mRNA.
DR   AlphaFoldDB; D2KF13; -.
DR   SMR; D2KF13; -.
DR   PeptideAtlas; D2KF13; -.
DR   ChiTaRS; AR; human.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR   GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0005496; F:steroid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0030521; P:androgen receptor signaling pathway; IEA:InterPro.
DR   CDD; cd07173; NR_DBD_AR; 1.
DR   Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR   Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR   InterPro; IPR001103; Andrgn_rcpt.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR48092:SF31; ANDROGEN RECEPTOR; 1.
DR   PANTHER; PTHR48092; KNIRPS-RELATED PROTEIN-RELATED; 1.
DR   Pfam; PF02166; Androgen_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00521; ANDROGENR.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:ACZ81436.1};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          562..637
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000259|PROSITE:PS51030"
FT   REGION          36..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          196..229
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..97
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   739 AA;  77372 MW;  4495C9F9D3C860DD CRC64;
     MEVQLGLGRV YPRPPSKTYR GAFQNLFQSV REVIQNPGPR HPEAASAAPP GASLLLLQQQ
     QQQQQQQQQQ QQQQQQQQQQ QETSPRQQQQ QQGEDGSPQA HRRGPTGYLV LDEEQQPSQP
     QSALECHPER GCVPEPGAAV AASKGLPQQL PAPPDEDDSA APSTLSLLGP TFPGLSSCSA
     DLKDILSEAS TMQLLQQQQQ EAVSEGSSSG RAREASGAPT SSKDNYLGGT STISDNAKEL
     CKAVSVSMGL GVEALEHLSP GEQLRGDCMY APLLGVPPAV RPTPCAPLAE CKGSLLDDSA
     GKSTEDTAEY SPFKGGYTKG LEGESLGCSG SAAAGSSGTL ELPSTLSLYK SGALDEAAAY
     QSRDYYNFPL ALAGPPPPPP PPHPHARIKL ENPLDYGSAW AAAAAQCRYG DLASLHGAGA
     AGPGSGSPSA AASSSWHTLF TAEEGQLYGP CGGGGGGGGG GGGGGGGGGG GGGGGGGGEA
     GAVAPYGYTR PPQGLAGQES DFTAPDVWYP GGMVSRVPYP SPTCVKSEMG PWMDSYSGPY
     GDMRLETARD HVLPIDYYFP PQKTCLICGD EASGCHYGAL TCGSCKVFFK RAAEGKQKYL
     CASRNDCTID KFRRKNCPSC RLRKCYEAGM TLGARKLKKL GNLKLQEEGE ASSTTSPTEE
     TTQKLTVSHI EGYECQPIFL NVLEAIEPGV VCAGHDNNQP DSFAALLSSL NELGERQLVH
     VVKWAKALPD CERAASVHF
//