Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Androgen receptor variant 5,6,7es

Gene

AR

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. androgen receptor activity Source: InterPro
  2. sequence-specific DNA binding Source: InterPro
  3. steroid binding Source: InterPro
  4. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Keywords - Ligandi

DNA-bindingSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Androgen receptor variant 5,6,7esImported
Gene namesi
Name:ARImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Expressioni

Gene expression databases

BgeeiD2KF13.
ExpressionAtlasiD2KF13. baseline and differential.

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR001103. Andrgn_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF02166. Androgen_recep. 2 hits.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00521. ANDROGENR.
PR00047. STROIDFINGER.
SMARTiSM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2KF13-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEVQLGLGRV YPRPPSKTYR GAFQNLFQSV REVIQNPGPR HPEAASAAPP
60 70 80 90 100
GASLLLLQQQ QQQQQQQQQQ QQQQQQQQQQ QETSPRQQQQ QQGEDGSPQA
110 120 130 140 150
HRRGPTGYLV LDEEQQPSQP QSALECHPER GCVPEPGAAV AASKGLPQQL
160 170 180 190 200
PAPPDEDDSA APSTLSLLGP TFPGLSSCSA DLKDILSEAS TMQLLQQQQQ
210 220 230 240 250
EAVSEGSSSG RAREASGAPT SSKDNYLGGT STISDNAKEL CKAVSVSMGL
260 270 280 290 300
GVEALEHLSP GEQLRGDCMY APLLGVPPAV RPTPCAPLAE CKGSLLDDSA
310 320 330 340 350
GKSTEDTAEY SPFKGGYTKG LEGESLGCSG SAAAGSSGTL ELPSTLSLYK
360 370 380 390 400
SGALDEAAAY QSRDYYNFPL ALAGPPPPPP PPHPHARIKL ENPLDYGSAW
410 420 430 440 450
AAAAAQCRYG DLASLHGAGA AGPGSGSPSA AASSSWHTLF TAEEGQLYGP
460 470 480 490 500
CGGGGGGGGG GGGGGGGGGG GGGGGGGGEA GAVAPYGYTR PPQGLAGQES
510 520 530 540 550
DFTAPDVWYP GGMVSRVPYP SPTCVKSEMG PWMDSYSGPY GDMRLETARD
560 570 580 590 600
HVLPIDYYFP PQKTCLICGD EASGCHYGAL TCGSCKVFFK RAAEGKQKYL
610 620 630 640 650
CASRNDCTID KFRRKNCPSC RLRKCYEAGM TLGARKLKKL GNLKLQEEGE
660 670 680 690 700
ASSTTSPTEE TTQKLTVSHI EGYECQPIFL NVLEAIEPGV VCAGHDNNQP
710 720 730
DSFAALLSSL NELGERQLVH VVKWAKALPD CERAASVHF
Length:739
Mass (Da):77,372
Last modified:February 9, 2010 - v1
Checksum:i4495C9F9D3C860DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU208210 mRNA. Translation: ACZ81436.1.
UniGeneiHs.76704.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU208210 mRNA. Translation: ACZ81436.1.
UniGeneiHs.76704.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

ChiTaRSiAR. human.
NextBioi35489622.

Gene expression databases

BgeeiD2KF13.
ExpressionAtlasiD2KF13. baseline and differential.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR001103. Andrgn_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF02166. Androgen_recep. 2 hits.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00521. ANDROGENR.
PR00047. STROIDFINGER.
SMARTiSM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A Novel, Frequently Occurring Androgen Receptor Splice Variant Confers Castration Resistance in Prostate Cancer."
    Sun S., Vessella R., Sprenger C., Haugk K., Soriano K., Mostaghel E., Page S., Coleman I., Nelson P., Nguyen H., Plymate S.
    Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiD2KF13_HUMAN
AccessioniPrimary (citable) accession number: D2KF13
Entry historyi
Integrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: February 4, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.