D2KF13 (D2KF13_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Androgen receptor variant 5,6,7es EMBL ACZ81436.1

Gene names

Name:

AR EMBL ACZ81436.1

Organism

Homo sapiens (Human) EMBL ACZ81436.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	739 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the nuclear hormone receptor family. RuleBase RU000377 Contains 1 nuclear receptor DNA-binding domain. SAAS SAAS001628

Ontologies

Keywords
Biological process	Transcription Transcription regulation SAAS SAAS001628
Cellular component	Nucleus SAAS SAAS001628
Domain	Zinc-finger SAAS SAAS001628
Ligand	DNA-binding SAAS SAAS001628 Metal-binding Zinc
Molecular function	Receptor EMBL ACZ81436.1
Gene Ontology (GO)
Biological_process	steroid hormone mediated signaling pathway Inferred from electronic annotation. Source: GOC
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	androgen receptor activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro steroid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	D2KF13 [UniParc]. Last modified February 9, 2010. Version 1. Checksum: 4495C9F9D3C860DD	FASTA	739	77,372
	10 20 30 40 50 60 MEVQLGLGRV YPRPPSKTYR GAFQNLFQSV REVIQNPGPR HPEAASAAPP GASLLLLQQQ 70 80 90 100 110 120 QQQQQQQQQQ QQQQQQQQQQ QETSPRQQQQ QQGEDGSPQA HRRGPTGYLV LDEEQQPSQP 130 140 150 160 170 180 QSALECHPER GCVPEPGAAV AASKGLPQQL PAPPDEDDSA APSTLSLLGP TFPGLSSCSA 190 200 210 220 230 240 DLKDILSEAS TMQLLQQQQQ EAVSEGSSSG RAREASGAPT SSKDNYLGGT STISDNAKEL 250 260 270 280 290 300 CKAVSVSMGL GVEALEHLSP GEQLRGDCMY APLLGVPPAV RPTPCAPLAE CKGSLLDDSA 310 320 330 340 350 360 GKSTEDTAEY SPFKGGYTKG LEGESLGCSG SAAAGSSGTL ELPSTLSLYK SGALDEAAAY 370 380 390 400 410 420 QSRDYYNFPL ALAGPPPPPP PPHPHARIKL ENPLDYGSAW AAAAAQCRYG DLASLHGAGA 430 440 450 460 470 480 AGPGSGSPSA AASSSWHTLF TAEEGQLYGP CGGGGGGGGG GGGGGGGGGG GGGGGGGGEA 490 500 510 520 530 540 GAVAPYGYTR PPQGLAGQES DFTAPDVWYP GGMVSRVPYP SPTCVKSEMG PWMDSYSGPY 550 560 570 580 590 600 GDMRLETARD HVLPIDYYFP PQKTCLICGD EASGCHYGAL TCGSCKVFFK RAAEGKQKYL 610 620 630 640 650 660 CASRNDCTID KFRRKNCPSC RLRKCYEAGM TLGARKLKKL GNLKLQEEGE ASSTTSPTEE 670 680 690 700 710 720 TTQKLTVSHI EGYECQPIFL NVLEAIEPGV VCAGHDNNQP DSFAALLSSL NELGERQLVH 730 VVKWAKALPD CERAASVHF

References

[1]	"A Novel, Frequently Occurring Androgen Receptor Splice Variant Confers Castration Resistance in Prostate Cancer." Sun S., Vessella R., Sprenger C., Haugk K., Soriano K., Mostaghel E., Page S., Coleman I., Nelson P., Nguyen H., Plymate S. Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GU208210 mRNA. Translation: ACZ81436.1.
IPI	IPI01010342.
UniGene	Hs.76704.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Gene expression databases
ArrayExpress	D2KF13.
Bgee	D2KF13.
Family and domain databases
Gene3D	1.10.565.10. 2 hits. 3.30.50.10. 1 hit.
InterPro	IPR001103. Andrgn_rcpt. IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Pfam	PF02166. Androgen_recep. 2 hits. PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR00521. ANDROGENR. PR00047. STROIDFINGER.
SMART	SM00399. ZnF_C4. 1 hit. [Graphical view]
SUPFAM	SSF48508. Str_ncl_receptor. 1 hit.
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	AR. human.
NextBio	35489622.

Entry information

Entry name

D2KF13_HUMAN

Accession

Primary (citable) accession number: D2KF13

Entry history

Integrated into UniProtKB/TrEMBL:	February 9, 2010
Last sequence update:	February 9, 2010
Last modified:	May 1, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.