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D2KF13

- D2KF13_HUMAN

UniProt

D2KF13 - D2KF13_HUMAN

Protein
Submitted name:

Androgen receptor variant 5,6,7es

Gene

AR

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (09 Feb 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. androgen receptor activity Source: InterPro
    2. sequence-specific DNA binding Source: InterPro
    3. steroid binding Source: InterPro
    4. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    ReceptorImported

    Keywords - Biological processi

    Transcription, Transcription regulationSAAS annotation

    Keywords - Ligandi

    DNA-bindingSAAS annotation, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Androgen receptor variant 5,6,7esImported
    Gene namesi
    Name:ARImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-KW

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiD2KF13.
    BgeeiD2KF13.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the nuclear hormone receptor family.UniRule annotation
    Contains nuclear receptor DNA-binding domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerSAAS annotation

    Family and domain databases

    Gene3Di1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProiIPR001103. Andrgn_rcpt.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF02166. Androgen_recep. 2 hits.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR00521. ANDROGENR.
    PR00047. STROIDFINGER.
    SMARTiSM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D2KF13-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEVQLGLGRV YPRPPSKTYR GAFQNLFQSV REVIQNPGPR HPEAASAAPP    50
    GASLLLLQQQ QQQQQQQQQQ QQQQQQQQQQ QETSPRQQQQ QQGEDGSPQA 100
    HRRGPTGYLV LDEEQQPSQP QSALECHPER GCVPEPGAAV AASKGLPQQL 150
    PAPPDEDDSA APSTLSLLGP TFPGLSSCSA DLKDILSEAS TMQLLQQQQQ 200
    EAVSEGSSSG RAREASGAPT SSKDNYLGGT STISDNAKEL CKAVSVSMGL 250
    GVEALEHLSP GEQLRGDCMY APLLGVPPAV RPTPCAPLAE CKGSLLDDSA 300
    GKSTEDTAEY SPFKGGYTKG LEGESLGCSG SAAAGSSGTL ELPSTLSLYK 350
    SGALDEAAAY QSRDYYNFPL ALAGPPPPPP PPHPHARIKL ENPLDYGSAW 400
    AAAAAQCRYG DLASLHGAGA AGPGSGSPSA AASSSWHTLF TAEEGQLYGP 450
    CGGGGGGGGG GGGGGGGGGG GGGGGGGGEA GAVAPYGYTR PPQGLAGQES 500
    DFTAPDVWYP GGMVSRVPYP SPTCVKSEMG PWMDSYSGPY GDMRLETARD 550
    HVLPIDYYFP PQKTCLICGD EASGCHYGAL TCGSCKVFFK RAAEGKQKYL 600
    CASRNDCTID KFRRKNCPSC RLRKCYEAGM TLGARKLKKL GNLKLQEEGE 650
    ASSTTSPTEE TTQKLTVSHI EGYECQPIFL NVLEAIEPGV VCAGHDNNQP 700
    DSFAALLSSL NELGERQLVH VVKWAKALPD CERAASVHF 739
    Length:739
    Mass (Da):77,372
    Last modified:February 9, 2010 - v1
    Checksum:i4495C9F9D3C860DD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GU208210 mRNA. Translation: ACZ81436.1.
    UniGeneiHs.76704.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GU208210 mRNA. Translation: ACZ81436.1 .
    UniGenei Hs.76704.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    ChiTaRSi AR. human.
    NextBioi 35489622.

    Gene expression databases

    ArrayExpressi D2KF13.
    Bgeei D2KF13.

    Family and domain databases

    Gene3Di 1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProi IPR001103. Andrgn_rcpt.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF02166. Androgen_recep. 2 hits.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR00521. ANDROGENR.
    PR00047. STROIDFINGER.
    SMARTi SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A Novel, Frequently Occurring Androgen Receptor Splice Variant Confers Castration Resistance in Prostate Cancer."
      Sun S., Vessella R., Sprenger C., Haugk K., Soriano K., Mostaghel E., Page S., Coleman I., Nelson P., Nguyen H., Plymate S.
      Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiD2KF13_HUMAN
    AccessioniPrimary (citable) accession number: D2KF13
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 9, 2010
    Last sequence update: February 9, 2010
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.