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D2KF13

- D2KF13_HUMAN

UniProt

D2KF13 - D2KF13_HUMAN

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Protein
Submitted name:

Androgen receptor variant 5,6,7es

Gene
AR
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. androgen receptor activity Source: InterPro
  2. sequence-specific DNA binding Source: InterPro
  3. steroid binding Source: InterPro
  4. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotations

Keywords - Ligandi

DNA-bindingSAAS annotations, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Androgen receptor variant 5,6,7esImported
Gene namesi
Name:ARImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotations

Expressioni

Gene expression databases

ArrayExpressiD2KF13.
BgeeiD2KF13.

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotations

Keywords - Domaini

Zinc-fingerSAAS annotations

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR001103. Andrgn_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF02166. Androgen_recep. 2 hits.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00521. ANDROGENR.
PR00047. STROIDFINGER.
SMARTiSM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2KF13-1 [UniParc]FASTAAdd to Basket

« Hide

MEVQLGLGRV YPRPPSKTYR GAFQNLFQSV REVIQNPGPR HPEAASAAPP    50
GASLLLLQQQ QQQQQQQQQQ QQQQQQQQQQ QETSPRQQQQ QQGEDGSPQA 100
HRRGPTGYLV LDEEQQPSQP QSALECHPER GCVPEPGAAV AASKGLPQQL 150
PAPPDEDDSA APSTLSLLGP TFPGLSSCSA DLKDILSEAS TMQLLQQQQQ 200
EAVSEGSSSG RAREASGAPT SSKDNYLGGT STISDNAKEL CKAVSVSMGL 250
GVEALEHLSP GEQLRGDCMY APLLGVPPAV RPTPCAPLAE CKGSLLDDSA 300
GKSTEDTAEY SPFKGGYTKG LEGESLGCSG SAAAGSSGTL ELPSTLSLYK 350
SGALDEAAAY QSRDYYNFPL ALAGPPPPPP PPHPHARIKL ENPLDYGSAW 400
AAAAAQCRYG DLASLHGAGA AGPGSGSPSA AASSSWHTLF TAEEGQLYGP 450
CGGGGGGGGG GGGGGGGGGG GGGGGGGGEA GAVAPYGYTR PPQGLAGQES 500
DFTAPDVWYP GGMVSRVPYP SPTCVKSEMG PWMDSYSGPY GDMRLETARD 550
HVLPIDYYFP PQKTCLICGD EASGCHYGAL TCGSCKVFFK RAAEGKQKYL 600
CASRNDCTID KFRRKNCPSC RLRKCYEAGM TLGARKLKKL GNLKLQEEGE 650
ASSTTSPTEE TTQKLTVSHI EGYECQPIFL NVLEAIEPGV VCAGHDNNQP 700
DSFAALLSSL NELGERQLVH VVKWAKALPD CERAASVHF 739
Length:739
Mass (Da):77,372
Last modified:February 9, 2010 - v1
Checksum:i4495C9F9D3C860DD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GU208210 mRNA. Translation: ACZ81436.1.
UniGeneiHs.76704.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GU208210 mRNA. Translation: ACZ81436.1 .
UniGenei Hs.76704.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

ChiTaRSi AR. human.
NextBioi 35489622.

Gene expression databases

ArrayExpressi D2KF13.
Bgeei D2KF13.

Family and domain databases

Gene3Di 1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProi IPR001103. Andrgn_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF02166. Androgen_recep. 2 hits.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR00521. ANDROGENR.
PR00047. STROIDFINGER.
SMARTi SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A Novel, Frequently Occurring Androgen Receptor Splice Variant Confers Castration Resistance in Prostate Cancer."
    Sun S., Vessella R., Sprenger C., Haugk K., Soriano K., Mostaghel E., Page S., Coleman I., Nelson P., Nguyen H., Plymate S.
    Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiD2KF13_HUMAN
AccessioniPrimary (citable) accession number: D2KF13
Entry historyi
Integrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: May 14, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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