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D2IYK3

- D2IYK3_HUMAN

UniProt

D2IYK3 - D2IYK3_HUMAN

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Protein

POU domain protein

Gene

POU5F1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

TranscriptionUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain proteinUniRule annotation
Gene namesi
Name:POU5F1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33545.

Family & Domainsi

Sequence similaritiesi

Belongs to the POU transcription factor family.UniRule annotation
Contains 1 POU-specific domain.UniRule annotation
Contains 1 homeobox DNA-binding domain.UniRule annotation
Contains POU-specific domain.SAAS annotation
Contains homeobox DNA-binding domain.SAAS annotation

Keywords - Domaini

HomeoboxUniRule annotationSAAS annotation

Phylogenomic databases

KOiK09367.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR015585. POU_dom_5.
IPR000327. POU_specific.
[Graphical view]
PANTHERiPTHR11636:SF15. PTHR11636:SF15. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2IYK3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGHLASDFA FSPPPGGGGD GPGGPEPGWV DPRTWLSFQG PPGGPGIGPG
60 70 80 90 100
VGPGSEVWGI PPCPPPYEFC GGMAYCGPQV GVGLVPQGGL ETSQPEGEAG
110 120 130 140 150
VGVESNSDGA SPEPCTVTPG AVKLEKEKLE QNPEESQDIK ALQKELEQFA
160 170 180 190 200
KLLKQKRITL GYTQADVGLT LGVLFGKVFS QTTICRFEAL QLSFKNMCKL
210 220 230 240 250
RPLLQKWVEE ADNNENLQEI CKAETLVQAR KRKRTSIENR VRGNLENLFL
260 270 280 290 300
QCPKPTLQQI SHIAQQLGLE KDVVRVWFCN RRQKGKRSSS DYAQREDFEA
310 320 330 340 350
AGSPFSGGPV SFPLAPGPHF GTPGYGSPHF TALYSSVPFP EGEAFPPVSV
360
TTLGSPMHSN
Length:360
Mass (Da):38,571
Last modified:February 9, 2010 - v1
Checksum:i934C58DAEA0C535B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ472773 Genomic DNA. Translation: ACZ95699.1.
GU480808 mRNA. Translation: ADE48539.1.
GU480811 mRNA. Translation: ADE48541.1.
GU480812 mRNA. Translation: ADE48542.1.
GU480816 mRNA. Translation: ADE48545.1.
GU480818 mRNA. Translation: ADE48547.1.
GU480824 mRNA. Translation: ADE48553.1.
GU480828 mRNA. Translation: ADE48557.1.
GU480830 mRNA. Translation: ADE48559.1.
HQ122660 mRNA. Translation: ADW77314.1.
HQ122662 mRNA. Translation: ADW77316.1.
HQ122664 mRNA. Translation: ADW77318.1.
HQ122667 mRNA. Translation: ADW77320.1.
HQ122668 mRNA. Translation: ADW77321.1.
HQ122669 mRNA. Translation: ADW77322.1.
HQ122670 mRNA. Translation: ADW77323.1.
HQ122672 mRNA. Translation: ADW77324.1.
HQ122673 mRNA. Translation: ADW77325.1.
HQ122674 mRNA. Translation: ADW77326.1.
HQ122675 mRNA. Translation: ADW77327.1.
KC312698 Genomic DNA. Translation: AGG40970.1.
RefSeqiNP_002692.2. NM_002701.5.
UniGeneiHs.249184.

Genome annotation databases

GeneIDi5460.
KEGGihsa:5460.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ472773 Genomic DNA. Translation: ACZ95699.1 .
GU480808 mRNA. Translation: ADE48539.1 .
GU480811 mRNA. Translation: ADE48541.1 .
GU480812 mRNA. Translation: ADE48542.1 .
GU480816 mRNA. Translation: ADE48545.1 .
GU480818 mRNA. Translation: ADE48547.1 .
GU480824 mRNA. Translation: ADE48553.1 .
GU480828 mRNA. Translation: ADE48557.1 .
GU480830 mRNA. Translation: ADE48559.1 .
HQ122660 mRNA. Translation: ADW77314.1 .
HQ122662 mRNA. Translation: ADW77316.1 .
HQ122664 mRNA. Translation: ADW77318.1 .
HQ122667 mRNA. Translation: ADW77320.1 .
HQ122668 mRNA. Translation: ADW77321.1 .
HQ122669 mRNA. Translation: ADW77322.1 .
HQ122670 mRNA. Translation: ADW77323.1 .
HQ122672 mRNA. Translation: ADW77324.1 .
HQ122673 mRNA. Translation: ADW77325.1 .
HQ122674 mRNA. Translation: ADW77326.1 .
HQ122675 mRNA. Translation: ADW77327.1 .
KC312698 Genomic DNA. Translation: AGG40970.1 .
RefSeqi NP_002692.2. NM_002701.5.
UniGenei Hs.249184.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

DNASUi 5460.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5460.
KEGGi hsa:5460.

Organism-specific databases

CTDi 5460.
PharmGKBi PA33545.

Phylogenomic databases

KOi K09367.

Miscellaneous databases

GenomeRNAii 5460.
NextBioi 21135.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR015585. POU_dom_5.
IPR000327. POU_specific.
[Graphical view ]
PANTHERi PTHR11636:SF15. PTHR11636:SF15. 1 hit.
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparison of MHC class I risk haplotypes in Thai and Caucasian psoriatics shows locus heterogeneity at PSORS1."
    Stuart P.E., Nair R.P., Hiremagalore R., Kullavanijaya P., Kullavanijaya P., Tejasvi T., Lim H.W., Voorhees J.J., Elder J.T.
    Tissue Antigens 76:387-397(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BloodImported.
  2. "Expression of OCT4 Pseudogenes in Human Somatic Tumors."
    Zhao S., Yuan Q., Liu S., Zhang Y., Liu H., Wang F., Liu K., Hao A.
    Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Expression of OCT4 pseudogenes in two human somatic tumours: glioma and breast carcinoma."
    Zhao S., Yuan Q., Guo Y., Liu S., Zhang Y., Wang J., Liu H., Wang F., Liu K., Ling E.-A., Hao A.
    Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: SeminomaImported.
  4. "An In-Depth Characterization of the Major Psoriasis Susceptibility Locus Identifies Candidate Susceptibility Alleles within an HLA-C Enhancer Element."
    Clop A., Bertoni A., Spain S.L., Simpson M.A., Pullabhatla V., Tonda R., Hundhausen C., Di Meglio P., De Jong P., Hayday A.C., Nestle F.O., Barker J.N., Bell R.J., Capon F., Trembath R.C.
    PLoS ONE 8:E71690-E71690(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiD2IYK3_HUMAN
AccessioniPrimary (citable) accession number: D2IYK3
Entry historyi
Integrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: November 26, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.