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Protein

POU domain protein

Gene

POU5F1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

TranscriptionUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain proteinUniRule annotation
Gene namesi
Name:POU5F1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33545.

PTM / Processingi

Proteomic databases

PRIDEiD2IYK3.

Expressioni

Gene expression databases

BgeeiD2IYK3.
ExpressionAtlasiD2IYK3. baseline.
GenevisibleiD2IYK3. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000259915.

Structurei

3D structure databases

ProteinModelPortaliD2IYK3.
SMRiD2IYK3. Positions 138-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the POU transcription factor family.UniRule annotation
Contains 1 POU-specific domain.UniRule annotation
Contains 1 homeobox DNA-binding domain.UniRule annotation

Keywords - Domaini

HomeoboxUniRule annotationSAAS annotation

Phylogenomic databases

PhylomeDBiD2IYK3.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR015585. POU_dom_5.
IPR000327. POU_specific.
[Graphical view]
PANTHERiPTHR11636:SF15. PTHR11636:SF15. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2IYK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGHLASDFA FSPPPGGGGD GPGGPEPGWV DPRTWLSFQG PPGGPGIGPG
60 70 80 90 100
VGPGSEVWGI PPCPPPYEFC GGMAYCGPQV GVGLVPQGGL ETSQPEGEAG
110 120 130 140 150
VGVESNSDGA SPEPCTVTPG AVKLEKEKLE QNPEESQDIK ALQKELEQFA
160 170 180 190 200
KLLKQKRITL GYTQADVGLT LGVLFGKVFS QTTICRFEAL QLSFKNMCKL
210 220 230 240 250
RPLLQKWVEE ADNNENLQEI CKAETLVQAR KRKRTSIENR VRGNLENLFL
260 270 280 290 300
QCPKPTLQQI SHIAQQLGLE KDVVRVWFCN RRQKGKRSSS DYAQREDFEA
310 320 330 340 350
AGSPFSGGPV SFPLAPGPHF GTPGYGSPHF TALYSSVPFP EGEAFPPVSV
360
TTLGSPMHSN
Length:360
Mass (Da):38,571
Last modified:February 9, 2010 - v1
Checksum:i934C58DAEA0C535B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ472773 Genomic DNA. Translation: ACZ95699.1.
GU480808 mRNA. Translation: ADE48539.1.
GU480811 mRNA. Translation: ADE48541.1.
GU480812 mRNA. Translation: ADE48542.1.
GU480816 mRNA. Translation: ADE48545.1.
GU480818 mRNA. Translation: ADE48547.1.
GU480824 mRNA. Translation: ADE48553.1.
GU480828 mRNA. Translation: ADE48557.1.
GU480830 mRNA. Translation: ADE48559.1.
HQ122660 mRNA. Translation: ADW77314.1.
HQ122662 mRNA. Translation: ADW77316.1.
HQ122664 mRNA. Translation: ADW77318.1.
HQ122667 mRNA. Translation: ADW77320.1.
HQ122668 mRNA. Translation: ADW77321.1.
HQ122669 mRNA. Translation: ADW77322.1.
HQ122670 mRNA. Translation: ADW77323.1.
HQ122672 mRNA. Translation: ADW77324.1.
HQ122673 mRNA. Translation: ADW77325.1.
HQ122674 mRNA. Translation: ADW77326.1.
HQ122675 mRNA. Translation: ADW77327.1.
KC312698 Genomic DNA. Translation: AGG40970.1.
RefSeqiNP_002692.2. NM_002701.5.
UniGeneiHs.249184.

Genome annotation databases

GeneIDi5460.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ472773 Genomic DNA. Translation: ACZ95699.1.
GU480808 mRNA. Translation: ADE48539.1.
GU480811 mRNA. Translation: ADE48541.1.
GU480812 mRNA. Translation: ADE48542.1.
GU480816 mRNA. Translation: ADE48545.1.
GU480818 mRNA. Translation: ADE48547.1.
GU480824 mRNA. Translation: ADE48553.1.
GU480828 mRNA. Translation: ADE48557.1.
GU480830 mRNA. Translation: ADE48559.1.
HQ122660 mRNA. Translation: ADW77314.1.
HQ122662 mRNA. Translation: ADW77316.1.
HQ122664 mRNA. Translation: ADW77318.1.
HQ122667 mRNA. Translation: ADW77320.1.
HQ122668 mRNA. Translation: ADW77321.1.
HQ122669 mRNA. Translation: ADW77322.1.
HQ122670 mRNA. Translation: ADW77323.1.
HQ122672 mRNA. Translation: ADW77324.1.
HQ122673 mRNA. Translation: ADW77325.1.
HQ122674 mRNA. Translation: ADW77326.1.
HQ122675 mRNA. Translation: ADW77327.1.
KC312698 Genomic DNA. Translation: AGG40970.1.
RefSeqiNP_002692.2. NM_002701.5.
UniGeneiHs.249184.

3D structure databases

ProteinModelPortaliD2IYK3.
SMRiD2IYK3. Positions 138-289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000259915.

Proteomic databases

PRIDEiD2IYK3.

Protocols and materials databases

DNASUi5460.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5460.

Organism-specific databases

CTDi5460.
PharmGKBiPA33545.

Phylogenomic databases

PhylomeDBiD2IYK3.

Miscellaneous databases

GenomeRNAii5460.
NextBioi21135.

Gene expression databases

BgeeiD2IYK3.
ExpressionAtlasiD2IYK3. baseline.
GenevisibleiD2IYK3. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR015585. POU_dom_5.
IPR000327. POU_specific.
[Graphical view]
PANTHERiPTHR11636:SF15. PTHR11636:SF15. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparison of MHC class I risk haplotypes in Thai and Caucasian psoriatics shows locus heterogeneity at PSORS1."
    Stuart P.E., Nair R.P., Hiremagalore R., Kullavanijaya P., Kullavanijaya P., Tejasvi T., Lim H.W., Voorhees J.J., Elder J.T.
    Tissue Antigens 76:387-397(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BloodImported.
  2. "Expression of OCT4 Pseudogenes in Human Somatic Tumors."
    Zhao S., Yuan Q., Liu S., Zhang Y., Liu H., Wang F., Liu K., Hao A.
    Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Expression of OCT4 pseudogenes in two human somatic tumours: glioma and breast carcinoma."
    Zhao S., Yuan Q., Guo Y., Liu S., Zhang Y., Wang J., Liu H., Wang F., Liu K., Ling E.-A., Hao A.
    Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: SeminomaImported.
  4. "An In-Depth Characterization of the Major Psoriasis Susceptibility Locus Identifies Candidate Susceptibility Alleles within an HLA-C Enhancer Element."
    Clop A., Bertoni A., Spain S.L., Simpson M.A., Pullabhatla V., Tonda R., Hundhausen C., Di Meglio P., De Jong P., Hayday A.C., Nestle F.O., Barker J.N., Bell R.J., Capon F., Trembath R.C.
    PLoS ONE 8:E71690-E71690(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiD2IYK3_HUMAN
AccessioniPrimary (citable) accession number: D2IYK3
Entry historyi
Integrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: July 22, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.