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D2IYK3

- D2IYK3_HUMAN

UniProt

D2IYK3 - D2IYK3_HUMAN

Protein
Submitted name:

POU class 5 homeobox 1 transcript variant 1

Gene

POU5F1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (09 Feb 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    POU class 5 homeobox 1 transcript variant 1Imported
    Submitted name:
    POU domain class 5 transcription factor 1 isoform 1Imported
    Submitted name:
    POU domain transcription factor OCT4Imported
    Gene namesi
    Name:POU5F1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotationSAAS annotation

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33545.

    Structurei

    3D structure databases

    SMRiD2IYK3. Positions 138-289.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains POU-specific domain.SAAS annotation
    Contains homeobox DNA-binding domain.SAAS annotation

    Keywords - Domaini

    HomeoboxUniRule annotationSAAS annotationImported

    Phylogenomic databases

    KOiK09367.
    PhylomeDBiD2IYK3.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR015585. POU_dom_5.
    IPR000327. POU_specific.
    [Graphical view]
    PANTHERiPTHR11636:SF15. PTHR11636:SF15. 1 hit.
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D2IYK3-1 [UniParc]FASTAAdd to Basket

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    MAGHLASDFA FSPPPGGGGD GPGGPEPGWV DPRTWLSFQG PPGGPGIGPG    50
    VGPGSEVWGI PPCPPPYEFC GGMAYCGPQV GVGLVPQGGL ETSQPEGEAG 100
    VGVESNSDGA SPEPCTVTPG AVKLEKEKLE QNPEESQDIK ALQKELEQFA 150
    KLLKQKRITL GYTQADVGLT LGVLFGKVFS QTTICRFEAL QLSFKNMCKL 200
    RPLLQKWVEE ADNNENLQEI CKAETLVQAR KRKRTSIENR VRGNLENLFL 250
    QCPKPTLQQI SHIAQQLGLE KDVVRVWFCN RRQKGKRSSS DYAQREDFEA 300
    AGSPFSGGPV SFPLAPGPHF GTPGYGSPHF TALYSSVPFP EGEAFPPVSV 350
    TTLGSPMHSN 360
    Length:360
    Mass (Da):38,571
    Last modified:February 9, 2010 - v1
    Checksum:i934C58DAEA0C535B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GQ472773 Genomic DNA. Translation: ACZ95699.1.
    GU480808 mRNA. Translation: ADE48539.1.
    GU480811 mRNA. Translation: ADE48541.1.
    GU480812 mRNA. Translation: ADE48542.1.
    GU480816 mRNA. Translation: ADE48545.1.
    GU480818 mRNA. Translation: ADE48547.1.
    GU480824 mRNA. Translation: ADE48553.1.
    GU480828 mRNA. Translation: ADE48557.1.
    GU480830 mRNA. Translation: ADE48559.1.
    HQ122660 mRNA. Translation: ADW77314.1.
    HQ122662 mRNA. Translation: ADW77316.1.
    HQ122664 mRNA. Translation: ADW77318.1.
    HQ122667 mRNA. Translation: ADW77320.1.
    HQ122668 mRNA. Translation: ADW77321.1.
    HQ122669 mRNA. Translation: ADW77322.1.
    HQ122670 mRNA. Translation: ADW77323.1.
    HQ122672 mRNA. Translation: ADW77324.1.
    HQ122673 mRNA. Translation: ADW77325.1.
    HQ122674 mRNA. Translation: ADW77326.1.
    HQ122675 mRNA. Translation: ADW77327.1.
    KC312698 Genomic DNA. Translation: AGG40970.1.
    RefSeqiNP_002692.2. NM_002701.5.
    UniGeneiHs.249184.

    Genome annotation databases

    GeneIDi5460.
    KEGGihsa:5460.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GQ472773 Genomic DNA. Translation: ACZ95699.1 .
    GU480808 mRNA. Translation: ADE48539.1 .
    GU480811 mRNA. Translation: ADE48541.1 .
    GU480812 mRNA. Translation: ADE48542.1 .
    GU480816 mRNA. Translation: ADE48545.1 .
    GU480818 mRNA. Translation: ADE48547.1 .
    GU480824 mRNA. Translation: ADE48553.1 .
    GU480828 mRNA. Translation: ADE48557.1 .
    GU480830 mRNA. Translation: ADE48559.1 .
    HQ122660 mRNA. Translation: ADW77314.1 .
    HQ122662 mRNA. Translation: ADW77316.1 .
    HQ122664 mRNA. Translation: ADW77318.1 .
    HQ122667 mRNA. Translation: ADW77320.1 .
    HQ122668 mRNA. Translation: ADW77321.1 .
    HQ122669 mRNA. Translation: ADW77322.1 .
    HQ122670 mRNA. Translation: ADW77323.1 .
    HQ122672 mRNA. Translation: ADW77324.1 .
    HQ122673 mRNA. Translation: ADW77325.1 .
    HQ122674 mRNA. Translation: ADW77326.1 .
    HQ122675 mRNA. Translation: ADW77327.1 .
    KC312698 Genomic DNA. Translation: AGG40970.1 .
    RefSeqi NP_002692.2. NM_002701.5.
    UniGenei Hs.249184.

    3D structure databases

    SMRi D2IYK3. Positions 138-289.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 5460.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5460.
    KEGGi hsa:5460.

    Organism-specific databases

    CTDi 5460.
    PharmGKBi PA33545.

    Phylogenomic databases

    KOi K09367.
    PhylomeDBi D2IYK3.

    Miscellaneous databases

    GenomeRNAii 5460.
    NextBioi 21135.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR015585. POU_dom_5.
    IPR000327. POU_specific.
    [Graphical view ]
    PANTHERi PTHR11636:SF15. PTHR11636:SF15. 1 hit.
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of MHC class I risk haplotypes in Thai and Caucasian psoriatics shows locus heterogeneity at PSORS1."
      Stuart P.E., Nair R.P., Hiremagalore R., Kullavanijaya P., Kullavanijaya P., Tejasvi T., Lim H.W., Voorhees J.J., Elder J.T.
      Tissue Antigens 76:387-397(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BloodImported.
    2. "Expression of OCT4 Pseudogenes in Human Somatic Tumors."
      Zhao S., Yuan Q., Liu S., Zhang Y., Liu H., Wang F., Liu K., Hao A.
      Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Expression of OCT4 pseudogenes in two human somatic tumours: glioma and breast carcinoma."
      Zhao S., Yuan Q., Guo Y., Liu S., Zhang Y., Wang J., Liu H., Wang F., Liu K., Ling E.-A., Hao A.
      Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: SeminomaImported.
    4. "An In-Depth Characterization of the Major Psoriasis Susceptibility Locus Identifies Candidate Susceptibility Alleles within an HLA-C Enhancer Element."
      Clop A., Bertoni A., Spain S.L., Simpson M.A., Pullabhatla V., Tonda R., Hundhausen C., Di Meglio P., De Jong P., Hayday A.C., Nestle F.O., Barker J.N., Bell R.J., Capon F., Trembath R.C.
      PLoS ONE 8:E71690-E71690(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiD2IYK3_HUMAN
    AccessioniPrimary (citable) accession number: D2IYK3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 9, 2010
    Last sequence update: February 9, 2010
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.