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Protein

Sodium channel protein

Gene

PANDA_018637

Organism
Ailuropoda melanoleuca (Giant panda)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
ORF Names:PANDA_018637Imported
OrganismiAiluropoda melanoleuca (Giant panda)Imported
Taxonomic identifieri9646 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeAiluropoda

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei136 – 155HelicalUniRule annotationAdd BLAST20
Transmembranei231 – 252HelicalUniRule annotationAdd BLAST22
Transmembranei258 – 278HelicalUniRule annotationAdd BLAST21
Transmembranei407 – 434HelicalUniRule annotationAdd BLAST28
Transmembranei776 – 794HelicalUniRule annotationAdd BLAST19
Transmembranei806 – 824HelicalUniRule annotationAdd BLAST19
Transmembranei886 – 914HelicalUniRule annotationAdd BLAST29
Transmembranei973 – 999HelicalUniRule annotationAdd BLAST27
Transmembranei1226 – 1244HelicalUniRule annotationAdd BLAST19
Transmembranei1265 – 1284HelicalUniRule annotationAdd BLAST20
Transmembranei1340 – 1368HelicalUniRule annotationAdd BLAST29
Transmembranei1466 – 1490HelicalUniRule annotationAdd BLAST25
Transmembranei1561 – 1579HelicalUniRule annotationAdd BLAST19
Transmembranei1591 – 1609HelicalUniRule annotationAdd BLAST19
Transmembranei1621 – 1641HelicalUniRule annotationAdd BLAST21
Transmembranei1678 – 1706HelicalUniRule annotationAdd BLAST29
Transmembranei1782 – 1805HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini139 – 441Ion_transInterPro annotationAdd BLAST303
Domaini512 – 725Na_trans_cytoplInterPro annotationAdd BLAST214
Domaini776 – 1003Ion_transInterPro annotationAdd BLAST228
Domaini1013 – 1220Na_trans_assocInterPro annotationAdd BLAST208
Domaini1224 – 1498Ion_transInterPro annotationAdd BLAST275
Domaini1560 – 1815Ion_transInterPro annotationAdd BLAST256

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili431 – 476Sequence analysisAdd BLAST46

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiENOG410INF8. Eukaryota.
COG1226. LUCA.
HOGENOMiHOG000231755.

Family and domain databases

InterProiView protein in InterPro
IPR005821. Ion_trans_dom.
IPR008051. Na_channel_a1su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR024583. Na_trans_cytopl.
PfamiView protein in Pfam
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
PF11933. Na_trans_cytopl. 1 hit.
PRINTSiPR00170. NACHANNEL.
PR01664. NACHANNEL1.

Sequencei

Sequence statusi: Fragment.

D2I0F4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQTVLVPPG PDSFNFFTRE SLAAIERRIA EEKAKNPKPD KKDDDENGPK
60 70 80 90 100
PNSDLEAGKN LPFIYGDIPP EMVSEPLEDL DPYYINKKTF IVLNKGKAIF
110 120 130 140 150
RFSATSALYI LTPFNPLRKI AIKILVHSYP FQVININYFM LIMCTILTNC
160 170 180 190 200
VFMTMSNPPD WTKNVEYTFT GIYTFESLIK IIARGFCLED FTFLRDPWNW
210 220 230 240 250
LDFTVITFAY VTEFVDLGNV SALRTFRVLR ALKTISVIPG LKTIVGALIQ
260 270 280 290 300
SVKKLSDVMI LTVFCLSVFA LIGLQLFMGN LRNKCVQWPP TNASLEEHSI
310 320 330 340 350
ERNVTTNYNG TLVNETRFEF DWKSYIQDTR YHYFLEGVLD ALLCGNSSDA
360 370 380 390 400
GQCPEGYVCV KAGRNPNYGY TSFDTFSWAF LSLFRLMTQD FWENLYQLTL
410 420 430 440 450
RAAGKTYMIF FVLVIFLGSF YLINLILAVV AMAYEEQNQA TLEEAEQKEA
460 470 480 490 500
EFQQMLEQLK KQQEAAQAAA VTASEHSREP SAAGGLSDSS SEASKLSSKS
510 520 530 540 550
AKERRNRRKK RKQKEQSGGE EKDEDEFHKS ESEDSIRRKG FRFSIEGNRL
560 570 580 590 600
TYEKRYSSPH QSLLSIRGSL FSPRRNSRTS LFSFRGRGKD VGSENDFADD
610 620 630 640 650
EHSTFEDNES RRDSLFVPRR HGERRNSNLS QTSRSSRMLA VFPANGKMHS
660 670 680 690 700
TVDCNGVVSL VGGPSVPTSP VGQLLPEVII DKPATDDNGT TTETEMRKRR
710 720 730 740 750
SSSFHVSMDF LEDPSQRQRA MSIASILTNT VEELEESRQK CPPCWYKFSN
760 770 780 790 800
IFLIWDCSPY WLKVKHIVNL VVMDPFVDLA ITICIVLNTL FMAMEHYPMT
810 820 830 840 850
EHFNNVLAVG NLVFTGIFTA EMFLKIIAMD PYYYFQEGWN IFDGFIVTLS
860 870 880 890 900
LVELGLANVE GLSVLRSFRL LRVFKLAKSW PTLNMLIKII GNSVGALGNL
910 920 930 940 950
TLVLAIIVFI FAVVGMQLFG KSYKDCVCKI STSCELPRWH MNDFFHSFLI
960 970 980 990 1000
VFRVLCGEWI ETMWDCMEVA GQAMCLTVFM MVMVIGNLVV LNLFLALLLS
1010 1020 1030 1040 1050
SFSADNLAAT DDDNEMNNLQ IAVDRMHKGI AYVKRKIYEF IQQSFVRKQK
1060 1070 1080 1090 1100
ILDEIKPLDD LNNKKDSCMS NHTTEIGKDL DYLRDVNGTT SGIGTGSSVE
1110 1120 1130 1140 1150
KYIIDESDYM SFINNPSLTV TVPIAVGESD FENLNTEDFS SESDLEESKE
1160 1170 1180 1190 1200
KLNESSSSSE GSTVDIGAPA EEQPVVEPEE TLEPEACFTE GCVQRFKCCQ
1210 1220 1230 1240 1250
ISVEEGRGKQ WWNLRRTCFR IVEHNWFETF IVFMILLSSG ALAFEDIYID
1260 1270 1280 1290 1300
QRKTIKTMLE YADKVFTYIF ILEMLLKWVA YGYQTYFTNA WCWLDFLIVD
1310 1320 1330 1340 1350
VSLVSLTANA LGYSELGAIK SLRTLRALRP LRALSRFEGM RVVVNALLGA
1360 1370 1380 1390 1400
IPSIMNVLLV CLIFWLIFSI MGVNLFAGKF YHCINTTTGD MFDISEVNNH
1410 1420 1430 1440 1450
SDCLKLIERN ETARWKNVKV NFDNVGFGYL SLLQVATFKG WMDIMYAAVD
1460 1470 1480 1490 1500
SRNVELQPKY EESLYMYLYF VIFIIFGSFF TLNLFIGVII DNFNQQKKKI
1510 1520 1530 1540 1550
ILTSFYFSFL YFGGQDIFMT EEQKKYYNAM KKLGSKKPQK PIPRPGNKFQ
1560 1570 1580 1590 1600
GMVFDFVTRQ VFDISIMILI CLNMVTMMVE TDDQSEYVTS ILSRINLVFI
1610 1620 1630 1640 1650
VLFTGECVLK LISLRHYYFT IGWNIFDFVV VILSIVGMFL AELIEKYFVS
1660 1670 1680 1690 1700
PTLFRVIRLA RIGRILRLIK GAKGIRTLLF ALMMSLPALF NIGLLLFLVM
1710 1720 1730 1740 1750
FIYAIFGMSN FAYVKREVGI DDMFNFETFG NSMICLFQIT TSAGWDGLLA
1760 1770 1780 1790 1800
PILNSKPPDC DPNKVNPGSS VKGDCGNPSV GIFFFVSYII ISFLVVVNMY
1810 1820 1830 1840 1850
IAVILENFSV ATEESAEPLS EDDFEMFYEV WEKFDPDATQ FMEFEKLSQF
1860 1870 1880 1890 1900
AAALEPPLNL PQPNKLQLIA MDLPMVSGDR IHCLDILFAF TKRVLGESGE
1910 1920 1930 1940 1950
MDALRIQMEE RFMASNPSKV SYQPITTTLK RKQEEVSAVI IQRAYRRHLL
1960 1970 1980 1990 2000
KRTVKQASFT YNKNKIKGGA NLLVKEDMII DRIHENSITE KTDLTMSTAA
2010 2020
CPPSYDRITK PIVEKHEQEG KDEKAKGK
Length:2,028
Mass (Da):231,210
Last modified:February 9, 2010 - v1
Checksum:i31FFBE97672288B7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei2028Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL193883 Genomic DNA. Translation: EFB20836.1.

Similar proteinsi

Entry informationi

Entry nameiD2I0F4_AILME
AccessioniPrimary (citable) accession number: D2I0F4
Entry historyiIntegrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: October 25, 2017
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation