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Protein

DNA-binding protein RFX6

Gene

RFX6

Organism
Ailuropoda melanoleuca (Giant panda)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes. Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi124 – 199RFX-type winged-helixPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein RFX6
Alternative name(s):
Regulatory factor X 6
Gene namesi
Name:RFX6
ORF Names:PANDA_013423
OrganismiAiluropoda melanoleuca (Giant panda)
Taxonomic identifieri9646 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeAiluropoda
Proteomesi
  • UP000008912 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003929971 – 928DNA-binding protein RFX6Add BLAST928

Interactioni

Subunit structurei

Interacts with RFX3.By similarity

Protein-protein interaction databases

STRINGi9646.ENSAMEP00000006158.

Family & Domainsi

Sequence similaritiesi

Belongs to the RFX family.PROSITE-ProRule annotation
Contains 1 RFX-type winged-helix DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3712. Eukaryota.
ENOG410XSKJ. LUCA.
GeneTreeiENSGT00550000074532.
HOGENOMiHOG000154105.
InParanoidiD2HNW6.
KOiK19521.
OMAiIHDPLNI.
OrthoDBiEOG091G01JI.
TreeFamiTF321340.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR003150. DNA-bd_RFX.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF02257. RFX_DNA_binding. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS51526. RFX_DBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2HNW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVPVLEDA FLPAQPSPQV SPEAQEECCV QLLGKGLLLY PEERVYLAAE
60 70 80 90 100
AQPGGARGSA ERGEHPELPV GVKSEMHLSN GNFSSEEEDG ESHDSKTKAA
110 120 130 140 150
DLHLSQKKTI TQMMKDKKKQ TQLTLQWLEE NYIVCEGVCL PRCILYAHYL
160 170 180 190 200
DFCRKEKLEP ACAATFGKTI RQKFPLLTTR RLGTRGHSKY HYYGIGIKES
210 220 230 240 250
SAYYHSVYSG KGLTRFSGSK LKNEGGFTRK YSLSSKTGTL LPEFPSAQHL
260 270 280 290 300
VYQGCISKDK VDTLIMMYKT HCQCILDNAI NGNFEEIQHF LLHFWQGMPD
310 320 330 340 350
HLLPLLENPV IIDIFCVCDS ILYKVLTDVL IPATMQEMPE SLLADIRNFA
360 370 380 390 400
KNWEQWVVSS LENLPEALTD KKIPIVRRFV SSLKRQTSFL HLAQIARPAL
410 420 430 440 450
FDQHVVNSMV SDIEKVDLNS IGSQALLTIS GSTDTESDIY TEHDSITVFQ
460 470 480 490 500
ELKDLLKKNA TVEAFIEWLD TVVEQRVIKT SKQNGRSLKK RAQDFLLKWS
510 520 530 540 550
FFGARVMHNL TLNNASSFGS FHLIRMLLDE YILLAMETQF NNDKEQELQN
560 570 580 590 600
LLDKYMKNSD ASKAAFTASP SSCFLANRNK GSTASSDTVK NESHVETAYL
610 620 630 640 650
PLSSSHPGGF PSALHPFPAG NTDTMPLTGQ MELSQSTGHL MTPPISPAMA
660 670 680 690 700
SRGSVINQGP MAGRPPSVGP VLSAPSHCST FPESIYPTHP QTNQDFYGTN
710 720 730 740 750
SNYQTVFRAQ PHPPSGLYPH RPEHGRCMAW SEQQLSRDFF SGSCAGSPYN
760 770 780 790 800
SRPPSSYGPS SHSQDSHSMQ FLNTGSFNFL SSTGAASCQG ATLPPSSPNG
810 820 830 840 850
YYGSSINYPE SHRLGSMVNQ HVSVISSVRS LPPYSDIHDP LNILDDSSRK
860 870 880 890 900
QTSSFYADTS PSVACRTPVV ASSLQTSIPS SSSQCMYGTS NQYPAQETLD
910 920
SHGANSREMV SSLPPINTVF MGTAAGGT
Length:928
Mass (Da):102,414
Last modified:March 23, 2010 - v2
Checksum:iA41888418DBCBDCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL193101 Genomic DNA. Translation: EFB21427.1.
RefSeqiXP_002924145.1. XM_002924099.1.

Genome annotation databases

EnsembliENSAMET00000006412; ENSAMEP00000006158; ENSAMEG00000005843.
GeneIDi100476328.
KEGGiaml:100476328.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL193101 Genomic DNA. Translation: EFB21427.1.
RefSeqiXP_002924145.1. XM_002924099.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9646.ENSAMEP00000006158.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSAMET00000006412; ENSAMEP00000006158; ENSAMEG00000005843.
GeneIDi100476328.
KEGGiaml:100476328.

Organism-specific databases

CTDi222546.

Phylogenomic databases

eggNOGiKOG3712. Eukaryota.
ENOG410XSKJ. LUCA.
GeneTreeiENSGT00550000074532.
HOGENOMiHOG000154105.
InParanoidiD2HNW6.
KOiK19521.
OMAiIHDPLNI.
OrthoDBiEOG091G01JI.
TreeFamiTF321340.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR003150. DNA-bd_RFX.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF02257. RFX_DNA_binding. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS51526. RFX_DBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRFX6_AILME
AccessioniPrimary (citable) accession number: D2HNW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 23, 2010
Last modified: September 7, 2016
This is version 41 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.