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D2H2R3 (D2H2R3_AILME) Unreviewed, UniProtKB/TrEMBL

Last modified October 16, 2013. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
DNA ligase RuleBase RU000617

EC=6.5.1.1 RuleBase RU000617
Gene names
ORF Names:PANDA_003934 EMBL EFB27082.1
OrganismAiluropoda melanoleuca (Giant panda)
Taxonomic identifier9646 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeAiluropoda

Protein attributes

Sequence length911 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). RuleBase RU000617

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Ontologies

Keywords
   Biological processDNA damage
DNA recombination RuleBase RU000617
DNA repair RuleBase RU000617
DNA replication RuleBase RU000617
   LigandATP-binding RuleBase RU000617
Nucleotide-binding
   Molecular functionLigase RuleBase RU000617
Gene Ontology (GO)
   Biological_processDNA ligation involved in DNA recombination

Inferred from electronic annotation. Source: Ensembl

DNA ligation involved in DNA repair

Inferred from electronic annotation. Source: Ensembl

DNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

T cell differentiation in thymus

Inferred from electronic annotation. Source: Ensembl

T cell receptor V(D)J recombination

Inferred from electronic annotation. Source: Ensembl

cell proliferation

Inferred from electronic annotation. Source: Ensembl

central nervous system development

Inferred from electronic annotation. Source: Ensembl

chromosome organization

Inferred from electronic annotation. Source: Ensembl

double-strand break repair via nonhomologous end joining

Inferred from electronic annotation. Source: Ensembl

immunoglobulin V(D)J recombination

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from electronic annotation. Source: Ensembl

isotype switching

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

nucleotide-excision repair, DNA gap filling

Inferred from electronic annotation. Source: Ensembl

positive regulation of fibroblast proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of neurogenesis

Inferred from electronic annotation. Source: Ensembl

pro-B cell differentiation

Inferred from electronic annotation. Source: Ensembl

response to X-ray

Inferred from electronic annotation. Source: Ensembl

response to gamma radiation

Inferred from electronic annotation. Source: Ensembl

single strand break repair

Inferred from electronic annotation. Source: Ensembl

somatic stem cell maintenance

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentDNA ligase IV complex

Inferred from electronic annotation. Source: Ensembl

DNA-dependent protein kinase-DNA ligase 4 complex

Inferred from electronic annotation. Source: Ensembl

condensed chromosome

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from electronic annotation. Source: Ensembl

focal adhesion

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

DNA binding

Inferred from electronic annotation. Source: Ensembl

DNA ligase (ATP) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue9111 EMBL EFB27082.1

Sequences

Sequence LengthMass (Da)Tools
D2H2R3 [UniParc].

Last modified February 9, 2010. Version 1.
Checksum: 103EDFCADBE593E1

FASTA911104,150
        10         20         30         40         50         60 
MAASHTSPTV ASRVPFADLC STLERIQRSR ERAAKIRHFR EFLDSWRRFH DALHKNQRDV 

        70         80         90        100        110        120 
SDSFYPAMRL ILPQLERERM AYGIKETMLA KLYIELLNLP RGGKDALKLL NYRTPTGTRA 

       130        140        150        160        170        180 
DAGDFATIAY FVLKPRCLQK GSLTIQQVND ILDSIASNNS ARRKDLIKKS LLQLISQSSA 

       190        200        210        220        230        240 
LEQKWLIRMI VKDLKLGFSE QSVFSVFHND AAELHNVTTD LEKVCRQLHD PSIGLSDISI 

       250        260        270        280        290        300 
TLFSAFKPML AAIADIERIE KDMKHQSFYI ETKLDGERMQ MHRQGDVYQY FSRNGYNYTD 

       310        320        330        340        350        360 
QFGDSPREGS LTPFIHSAFK TDVQICILDG EMMAFNPNTQ TFMQKGNKFD IKRMVEDSDL 

       370        380        390        400        410        420 
QTCYCVFDVL MVNNKKLGRE TLKKRHEILT SVFTPIPGRI EIVQKTQAHT QKEVIDALNE 

       430        440        450        460        470        480 
AIDKREEGIM IKHPLSIYKP DKRGEGWLKI KPEYVDGLMD ELDILIVGGY WGKGSRGGMM 

       490        500        510        520        530        540 
SHFLCAVAEK PPPGEKPSVF HTLCRVGSGY TMKELYDLGL KLAKHWKPFH KKAPPSSILC 

       550        560        570        580        590        600 
GTEKPEVYIE PCHSVIVQVK ATEIVSSDMY KAGCTLRFPR IERIREDKEW HECTTVDDLE 

       610        620        630        640        650        660 
QLRGKASGKL ASKHLYVGDD DEPQEKKRKA APKVKKVIGI IEHLKAPNLS NVNKVCNIFE 

       670        680        690        700        710        720 
DVEFCVMSGT GSHPKPDLEN RIAEFGGYIV QNPGPDTYCV IAGSENIRVK NIISSNKHDV 

       730        740        750        760        770        780 
VKPEWLLECF KTKSCVPWQP RFMIHMCPST KEHFAREYDH YGDSYFIDTD LNQLKEVFSG 

       790        800        810        820        830        840 
IKNSGEQTPG EMASVIAHLE FRYSWDRCPL SMFRQHIIYV DVYAVINDLS TKIEGTRLAV 

       850        860        870        880        890        900 
MGLELRFHGA KVVSRLAQGV SHVIVGEDRS RVADLKAFRR TLKRKFKILQ QDWVTDSIDK 

       910 
CELQEENRYL V 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GL192446 Genomic DNA. Translation: EFB27082.1.
RefSeqXP_002915906.1. XM_002915860.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100476294.
KEGGaml:100476294.

Organism-specific databases

CTD3981.

Phylogenomic databases

HOGENOMHOG000007831.
KOK10777.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR021536. DNA_ligase_IV.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF00533. BRCT. 2 hits.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF11411. DNA_ligase_IV. 1 hit.
[Graphical view]
SMARTSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD2H2R3_AILME
AccessionPrimary (citable) accession number: D2H2R3
Entry history
Integrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: October 16, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)