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D2H2R3

- D2H2R3_AILME

UniProt

D2H2R3 - D2H2R3_AILME

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Protein
DNA ligase
Gene
PANDA_003934
Organism
Ailuropoda melanoleuca (Giant panda)
Status
Unreviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: Ensembl
  3. DNA ligase (ATP) activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. DNA ligation involved in DNA recombination Source: Ensembl
  2. DNA ligation involved in DNA repair Source: Ensembl
  3. DNA replication Source: UniProtKB-KW
  4. T cell differentiation in thymus Source: Ensembl
  5. T cell receptor V(D)J recombination Source: Ensembl
  6. cell proliferation Source: Ensembl
  7. central nervous system development Source: Ensembl
  8. chromosome organization Source: Ensembl
  9. double-strand break repair via nonhomologous end joining Source: Ensembl
  10. immunoglobulin V(D)J recombination Source: Ensembl
  11. in utero embryonic development Source: Ensembl
  12. isotype switching Source: Ensembl
  13. negative regulation of neuron apoptotic process Source: Ensembl
  14. neuron apoptotic process Source: Ensembl
  15. nucleotide-excision repair, DNA gap filling Source: Ensembl
  16. positive regulation of fibroblast proliferation Source: Ensembl
  17. positive regulation of neurogenesis Source: Ensembl
  18. pro-B cell differentiation Source: Ensembl
  19. response to X-ray Source: Ensembl
  20. response to gamma radiation Source: Ensembl
  21. single strand break repair Source: Ensembl
  22. somatic stem cell maintenance Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:PANDA_003934Imported
OrganismiAiluropoda melanoleuca (Giant panda)
Taxonomic identifieri9646 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeAiluropoda

Subcellular locationi

GO - Cellular componenti

  1. DNA ligase IV complex Source: Ensembl
  2. DNA-dependent protein kinase-DNA ligase 4 complex Source: Ensembl
  3. condensed chromosome Source: Ensembl
  4. cytoplasm Source: Ensembl
  5. focal adhesion Source: Ensembl
  6. plasma membrane Source: Ensembl
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000007831.
KOiK10777.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR021536. DNA_ligase_IV_dom.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF00533. BRCT. 2 hits.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF11411. DNA_ligase_IV. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D2H2R3-1 [UniParc]FASTAAdd to Basket

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MAASHTSPTV ASRVPFADLC STLERIQRSR ERAAKIRHFR EFLDSWRRFH    50
DALHKNQRDV SDSFYPAMRL ILPQLERERM AYGIKETMLA KLYIELLNLP 100
RGGKDALKLL NYRTPTGTRA DAGDFATIAY FVLKPRCLQK GSLTIQQVND 150
ILDSIASNNS ARRKDLIKKS LLQLISQSSA LEQKWLIRMI VKDLKLGFSE 200
QSVFSVFHND AAELHNVTTD LEKVCRQLHD PSIGLSDISI TLFSAFKPML 250
AAIADIERIE KDMKHQSFYI ETKLDGERMQ MHRQGDVYQY FSRNGYNYTD 300
QFGDSPREGS LTPFIHSAFK TDVQICILDG EMMAFNPNTQ TFMQKGNKFD 350
IKRMVEDSDL QTCYCVFDVL MVNNKKLGRE TLKKRHEILT SVFTPIPGRI 400
EIVQKTQAHT QKEVIDALNE AIDKREEGIM IKHPLSIYKP DKRGEGWLKI 450
KPEYVDGLMD ELDILIVGGY WGKGSRGGMM SHFLCAVAEK PPPGEKPSVF 500
HTLCRVGSGY TMKELYDLGL KLAKHWKPFH KKAPPSSILC GTEKPEVYIE 550
PCHSVIVQVK ATEIVSSDMY KAGCTLRFPR IERIREDKEW HECTTVDDLE 600
QLRGKASGKL ASKHLYVGDD DEPQEKKRKA APKVKKVIGI IEHLKAPNLS 650
NVNKVCNIFE DVEFCVMSGT GSHPKPDLEN RIAEFGGYIV QNPGPDTYCV 700
IAGSENIRVK NIISSNKHDV VKPEWLLECF KTKSCVPWQP RFMIHMCPST 750
KEHFAREYDH YGDSYFIDTD LNQLKEVFSG IKNSGEQTPG EMASVIAHLE 800
FRYSWDRCPL SMFRQHIIYV DVYAVINDLS TKIEGTRLAV MGLELRFHGA 850
KVVSRLAQGV SHVIVGEDRS RVADLKAFRR TLKRKFKILQ QDWVTDSIDK 900
CELQEENRYL V 911
Length:911
Mass (Da):104,150
Last modified:February 9, 2010 - v1
Checksum:i103EDFCADBE593E1
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei911 – 9111Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GL192446 Genomic DNA. Translation: EFB27082.1.
RefSeqiXP_002915906.1. XM_002915860.1.

Genome annotation databases

GeneIDi100476294.
KEGGiaml:100476294.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GL192446 Genomic DNA. Translation: EFB27082.1 .
RefSeqi XP_002915906.1. XM_002915860.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100476294.
KEGGi aml:100476294.

Organism-specific databases

CTDi 3981.

Phylogenomic databases

HOGENOMi HOG000007831.
KOi K10777.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProi IPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR021536. DNA_ligase_IV_dom.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF00533. BRCT. 2 hits.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF11411. DNA_ligase_IV. 1 hit.
[Graphical view ]
SMARTi SM00292. BRCT. 2 hits.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sequence and de novo assembly of the giant panda genome."
    Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.
    , Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L., Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J., Wang J.
    Nature 463:311-317(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiD2H2R3_AILME
AccessioniPrimary (citable) accession number: D2H2R3
Entry historyi
Integrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: September 3, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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