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D2H2R3

- D2H2R3_AILME

UniProt

D2H2R3 - D2H2R3_AILME

Protein

DNA ligase

Gene

PANDA_003934

Organism
Ailuropoda melanoleuca (Giant panda)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (09 Feb 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: Ensembl
    3. DNA ligase (ATP) activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell proliferation Source: Ensembl
    2. central nervous system development Source: Ensembl
    3. chromosome organization Source: Ensembl
    4. DNA ligation involved in DNA recombination Source: Ensembl
    5. DNA ligation involved in DNA repair Source: Ensembl
    6. DNA replication Source: UniProtKB-KW
    7. double-strand break repair via nonhomologous end joining Source: Ensembl
    8. immunoglobulin V(D)J recombination Source: Ensembl
    9. in utero embryonic development Source: Ensembl
    10. isotype switching Source: Ensembl
    11. negative regulation of neuron apoptotic process Source: Ensembl
    12. neuron apoptotic process Source: Ensembl
    13. nucleotide-excision repair, DNA gap filling Source: Ensembl
    14. positive regulation of fibroblast proliferation Source: Ensembl
    15. positive regulation of neurogenesis Source: Ensembl
    16. pro-B cell differentiation Source: Ensembl
    17. response to gamma radiation Source: Ensembl
    18. response to X-ray Source: Ensembl
    19. single strand break repair Source: Ensembl
    20. somatic stem cell maintenance Source: Ensembl
    21. T cell differentiation in thymus Source: Ensembl
    22. T cell receptor V(D)J recombination Source: Ensembl

    Keywords - Molecular functioni

    LigaseUniRule annotation

    Keywords - Biological processi

    DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Gene namesi
    ORF Names:PANDA_003934Imported
    OrganismiAiluropoda melanoleuca (Giant panda)
    Taxonomic identifieri9646 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeAiluropoda

    Subcellular locationi

    GO - Cellular componenti

    1. condensed chromosome Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. DNA-dependent protein kinase-DNA ligase 4 complex Source: Ensembl
    4. DNA ligase IV complex Source: Ensembl
    5. focal adhesion Source: Ensembl
    6. plasma membrane Source: Ensembl

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000007831.
    KOiK10777.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    3.40.50.10190. 2 hits.
    InterProiIPR001357. BRCT_dom.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR021536. DNA_ligase_IV_dom.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF00533. BRCT. 2 hits.
    PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    PF11411. DNA_ligase_IV. 1 hit.
    [Graphical view]
    SMARTiSM00292. BRCT. 2 hits.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF52113. SSF52113. 2 hits.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS50172. BRCT. 2 hits.
    PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    D2H2R3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAASHTSPTV ASRVPFADLC STLERIQRSR ERAAKIRHFR EFLDSWRRFH    50
    DALHKNQRDV SDSFYPAMRL ILPQLERERM AYGIKETMLA KLYIELLNLP 100
    RGGKDALKLL NYRTPTGTRA DAGDFATIAY FVLKPRCLQK GSLTIQQVND 150
    ILDSIASNNS ARRKDLIKKS LLQLISQSSA LEQKWLIRMI VKDLKLGFSE 200
    QSVFSVFHND AAELHNVTTD LEKVCRQLHD PSIGLSDISI TLFSAFKPML 250
    AAIADIERIE KDMKHQSFYI ETKLDGERMQ MHRQGDVYQY FSRNGYNYTD 300
    QFGDSPREGS LTPFIHSAFK TDVQICILDG EMMAFNPNTQ TFMQKGNKFD 350
    IKRMVEDSDL QTCYCVFDVL MVNNKKLGRE TLKKRHEILT SVFTPIPGRI 400
    EIVQKTQAHT QKEVIDALNE AIDKREEGIM IKHPLSIYKP DKRGEGWLKI 450
    KPEYVDGLMD ELDILIVGGY WGKGSRGGMM SHFLCAVAEK PPPGEKPSVF 500
    HTLCRVGSGY TMKELYDLGL KLAKHWKPFH KKAPPSSILC GTEKPEVYIE 550
    PCHSVIVQVK ATEIVSSDMY KAGCTLRFPR IERIREDKEW HECTTVDDLE 600
    QLRGKASGKL ASKHLYVGDD DEPQEKKRKA APKVKKVIGI IEHLKAPNLS 650
    NVNKVCNIFE DVEFCVMSGT GSHPKPDLEN RIAEFGGYIV QNPGPDTYCV 700
    IAGSENIRVK NIISSNKHDV VKPEWLLECF KTKSCVPWQP RFMIHMCPST 750
    KEHFAREYDH YGDSYFIDTD LNQLKEVFSG IKNSGEQTPG EMASVIAHLE 800
    FRYSWDRCPL SMFRQHIIYV DVYAVINDLS TKIEGTRLAV MGLELRFHGA 850
    KVVSRLAQGV SHVIVGEDRS RVADLKAFRR TLKRKFKILQ QDWVTDSIDK 900
    CELQEENRYL V 911
    Length:911
    Mass (Da):104,150
    Last modified:February 9, 2010 - v1
    Checksum:i103EDFCADBE593E1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei911 – 9111Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GL192446 Genomic DNA. Translation: EFB27082.1.
    RefSeqiXP_002915906.1. XM_002915860.1.

    Genome annotation databases

    GeneIDi100476294.
    KEGGiaml:100476294.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GL192446 Genomic DNA. Translation: EFB27082.1 .
    RefSeqi XP_002915906.1. XM_002915860.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100476294.
    KEGGi aml:100476294.

    Organism-specific databases

    CTDi 3981.

    Phylogenomic databases

    HOGENOMi HOG000007831.
    KOi K10777.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    3.40.50.10190. 2 hits.
    InterProi IPR001357. BRCT_dom.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR021536. DNA_ligase_IV_dom.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF00533. BRCT. 2 hits.
    PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    PF11411. DNA_ligase_IV. 1 hit.
    [Graphical view ]
    SMARTi SM00292. BRCT. 2 hits.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF52113. SSF52113. 2 hits.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS50172. BRCT. 2 hits.
    PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence and de novo assembly of the giant panda genome."
      Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.
      , Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L., Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J., Wang J.
      Nature 463:311-317(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiD2H2R3_AILME
    AccessioniPrimary (citable) accession number: D2H2R3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 9, 2010
    Last sequence update: February 9, 2010
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)