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D2H2R3

- D2H2R3_AILME

UniProt

D2H2R3 - D2H2R3_AILME

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Protein

DNA ligase

Gene

PANDA_003934

Organism
Ailuropoda melanoleuca (Giant panda)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: Ensembl
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. cell proliferation Source: Ensembl
  2. central nervous system development Source: Ensembl
  3. chromosome organization Source: Ensembl
  4. DNA biosynthetic process Source: InterPro
  5. DNA ligation involved in DNA recombination Source: Ensembl
  6. DNA ligation involved in DNA repair Source: Ensembl
  7. DNA replication Source: UniProtKB-KW
  8. double-strand break repair via nonhomologous end joining Source: Ensembl
  9. immunoglobulin V(D)J recombination Source: Ensembl
  10. in utero embryonic development Source: Ensembl
  11. isotype switching Source: Ensembl
  12. negative regulation of neuron apoptotic process Source: Ensembl
  13. neuron apoptotic process Source: Ensembl
  14. nucleotide-excision repair, DNA gap filling Source: Ensembl
  15. positive regulation of fibroblast proliferation Source: Ensembl
  16. positive regulation of neurogenesis Source: Ensembl
  17. pro-B cell differentiation Source: Ensembl
  18. response to gamma radiation Source: Ensembl
  19. response to X-ray Source: Ensembl
  20. single strand break repair Source: Ensembl
  21. somatic stem cell maintenance Source: Ensembl
  22. T cell differentiation in thymus Source: Ensembl
  23. T cell receptor V(D)J recombination Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:PANDA_003934Imported
OrganismiAiluropoda melanoleuca (Giant panda)
Taxonomic identifieri9646 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeAiluropoda

Subcellular locationi

GO - Cellular componenti

  1. condensed chromosome Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. DNA-dependent protein kinase-DNA ligase 4 complex Source: Ensembl
  4. DNA ligase IV complex Source: Ensembl
  5. focal adhesion Source: Ensembl
  6. plasma membrane Source: Ensembl
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000007831.
KOiK10777.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR021536. DNA_ligase_IV_dom.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PANTHERiPTHR10459:SF7. PTHR10459:SF7. 1 hit.
PfamiPF00533. BRCT. 2 hits.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF11411. DNA_ligase_IV. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D2H2R3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAASHTSPTV ASRVPFADLC STLERIQRSR ERAAKIRHFR EFLDSWRRFH
60 70 80 90 100
DALHKNQRDV SDSFYPAMRL ILPQLERERM AYGIKETMLA KLYIELLNLP
110 120 130 140 150
RGGKDALKLL NYRTPTGTRA DAGDFATIAY FVLKPRCLQK GSLTIQQVND
160 170 180 190 200
ILDSIASNNS ARRKDLIKKS LLQLISQSSA LEQKWLIRMI VKDLKLGFSE
210 220 230 240 250
QSVFSVFHND AAELHNVTTD LEKVCRQLHD PSIGLSDISI TLFSAFKPML
260 270 280 290 300
AAIADIERIE KDMKHQSFYI ETKLDGERMQ MHRQGDVYQY FSRNGYNYTD
310 320 330 340 350
QFGDSPREGS LTPFIHSAFK TDVQICILDG EMMAFNPNTQ TFMQKGNKFD
360 370 380 390 400
IKRMVEDSDL QTCYCVFDVL MVNNKKLGRE TLKKRHEILT SVFTPIPGRI
410 420 430 440 450
EIVQKTQAHT QKEVIDALNE AIDKREEGIM IKHPLSIYKP DKRGEGWLKI
460 470 480 490 500
KPEYVDGLMD ELDILIVGGY WGKGSRGGMM SHFLCAVAEK PPPGEKPSVF
510 520 530 540 550
HTLCRVGSGY TMKELYDLGL KLAKHWKPFH KKAPPSSILC GTEKPEVYIE
560 570 580 590 600
PCHSVIVQVK ATEIVSSDMY KAGCTLRFPR IERIREDKEW HECTTVDDLE
610 620 630 640 650
QLRGKASGKL ASKHLYVGDD DEPQEKKRKA APKVKKVIGI IEHLKAPNLS
660 670 680 690 700
NVNKVCNIFE DVEFCVMSGT GSHPKPDLEN RIAEFGGYIV QNPGPDTYCV
710 720 730 740 750
IAGSENIRVK NIISSNKHDV VKPEWLLECF KTKSCVPWQP RFMIHMCPST
760 770 780 790 800
KEHFAREYDH YGDSYFIDTD LNQLKEVFSG IKNSGEQTPG EMASVIAHLE
810 820 830 840 850
FRYSWDRCPL SMFRQHIIYV DVYAVINDLS TKIEGTRLAV MGLELRFHGA
860 870 880 890 900
KVVSRLAQGV SHVIVGEDRS RVADLKAFRR TLKRKFKILQ QDWVTDSIDK
910
CELQEENRYL V
Length:911
Mass (Da):104,150
Last modified:February 9, 2010 - v1
Checksum:i103EDFCADBE593E1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei911 – 9111Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GL192446 Genomic DNA. Translation: EFB27082.1.
RefSeqiXP_002915906.1. XM_002915860.1.

Genome annotation databases

GeneIDi100476294.
KEGGiaml:100476294.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GL192446 Genomic DNA. Translation: EFB27082.1 .
RefSeqi XP_002915906.1. XM_002915860.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100476294.
KEGGi aml:100476294.

Organism-specific databases

CTDi 3981.

Phylogenomic databases

HOGENOMi HOG000007831.
KOi K10777.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.10190. 2 hits.
InterProi IPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR021536. DNA_ligase_IV_dom.
IPR029710. LIG4.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
PANTHERi PTHR10459:SF7. PTHR10459:SF7. 1 hit.
Pfami PF00533. BRCT. 2 hits.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF11411. DNA_ligase_IV. 1 hit.
[Graphical view ]
SMARTi SM00292. BRCT. 2 hits.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 2 hits.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sequence and de novo assembly of the giant panda genome."
    Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.
    , Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L., Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J., Wang J.
    Nature 463:311-317(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiD2H2R3_AILME
AccessioniPrimary (citable) accession number: D2H2R3
Entry historyi
Integrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: October 29, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)