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Protein

Conotoxin Pu6.1

Gene
N/A
Organism
Conus pulicarius (Flea-bite cone)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionToxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin Pu6.1
OrganismiConus pulicarius (Flea-bite cone)
Taxonomic identifieri93154 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000039216020 – 42Sequence analysisAdd BLAST23
PeptideiPRO_000039216143 – 83Conotoxin Pu6.1Add BLAST41

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 57By similarity
Disulfide bondi50 ↔ 62By similarity
Disulfide bondi56 ↔ 78By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiD2DGD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity
The cysteine framework is VI/VII (C-C-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin I3 superfamily.Curated

Keywords - Domaini

Knottin, Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D2DGD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLVLAIVLI LMLVSLSTGA EESGQEISMV GPPLYIWDPI PPCKQLDEDC
60 70 80
GYGYSCCEDL SCQPLIEPDT MEITALVCQI ESA
Length:83
Mass (Da):9,023
Last modified:February 9, 2010 - v1
Checksum:i9E51092876D27BA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ531699 mRNA. Translation: ACU30045.1.

Entry informationi

Entry nameiCI361_CONPL
AccessioniPrimary (citable) accession number: D2DGD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: February 9, 2010
Last modified: November 22, 2017
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families