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Protein

Conotoxin Ca11a

Gene
N/A
Organism
Conus caracteristicus (Characteristic cone)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionToxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin Ca11a
Alternative name(s):
Ca11.1
OrganismiConus caracteristicus (Characteristic cone)
Taxonomic identifieri89440 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000039215020 – 421 PublicationAdd BLAST23
PeptideiPRO_000039215143 – 80Conotoxin Ca11aAdd BLAST38

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 60By similarity
Disulfide bondi53 ↔ 65By similarity
Disulfide bondi59 ↔ 72By similarity
Disulfide bondi64 ↔ 79By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiD2DGD3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XI (C-C-CC-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin I3 superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR004214. Conotoxin.
PfamiView protein in Pfam
PF02950. Conotoxin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D2DGD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLVLAIVVI LMLLSLSTGA EMSDNHASRS ATARRDRHLS PKAWPCGGVR
60 70 80
ASCSRHDDCC GSLCCFGTST GCRVAVRPCW
Length:80
Mass (Da):8,581
Last modified:February 9, 2010 - v1
Checksum:i66C19C7BB6CB880F
GO

Mass spectrometryi

Molecular mass is 4000 Da from positions 43 - 80. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ531694 mRNA. Translation: ACU30040.1.

Similar proteinsi

Entry informationi

Entry nameiCI3BA_CONCB
AccessioniPrimary (citable) accession number: D2DGD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: February 9, 2010
Last modified: November 22, 2017
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families