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Protein

Nucleolar GTP-binding protein 1

Gene

GTPBP4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the biogenesis of the 60S ribosomal subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRibosome biogenesisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar GTP-binding protein 1UniRule annotation
Gene namesi
Name:GTPBP4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000107937.18.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134922009.

PTM / Processingi

Proteomic databases

PaxDbiD2CFK9.
PRIDEiD2CFK9.

Expressioni

Gene expression databases

BgeeiENSG00000107937.
ExpressionAtlasiD2CFK9. baseline and differential.
GenevisibleiD2CFK9. HS.

Structurei

3D structure databases

ProteinModelPortaliD2CFK9.
SMRiD2CFK9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini169 – 340OBG-type GInterPro annotationAdd BLAST172

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1490. Eukaryota.
COG1084. LUCA.
KOiK06943.
OMAiSAIMYFM.
OrthoDBiEOG091G0476.
PhylomeDBiD2CFK9.

Family and domain databases

InterProiView protein in InterPro
IPR031167. G_OBG.
IPR006073. GTP_binding_domain.
IPR024926. NOG1.
IPR010674. NOG1_Rossman_fold_dom.
IPR012973. NOG_C.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
PANTHERiPTHR11702:SF32. PTHR11702:SF32. 1 hit.
PfamiView protein in Pfam
PF06858. NOG1. 1 hit.
PF08155. NOGCT. 1 hit.
PIRSFiPIRSF038919. NOG1. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51710. G_OBG. 1 hit.

Sequencei

Sequence statusi: Complete.

D2CFK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHYNFKKIT VVPSAKDFID LTLSKTQRKT PTVIHKHYQI HRIRHFYMRK
60 70 80 90 100
VKFTQQNYHD RLSQILTDFP KLDDIHPFYA DLMNILYDKD HYKLALGQIN
110 120 130 140 150
IAKNLVDNVA KDYVRLMKYG DSLYRCKQLK RAALGRMCTV IKRQKQSLEY
160 170 180 190 200
LEQVRQHLSR LPTIDPNTRT LLLCGYPNVG KSSFINKVTR ADVDVQPYAF
210 220 230 240 250
TTKSLFVGHM DYKYLRWQVV DTPGILDHPL EDRNTIEMQA ITALAHLRAA
260 270 280 290 300
VLYVMDLSEQ CGHGLREQLE LFQNIRPLFI NKPLIVVANK CDVKRIAELS
310 320 330 340 350
EDDQKIFTDL QSEGFPVIET STLTEEGVIK VKTEACDRLL AHRVETKMKG
360 370 380 390 400
NKVNEVLNRL HLAIPTRRDD KERPPFIPEG VVARRKRMET EESRKKRERD
410 420 430 440 450
LELEMGDDYI LDLQKYWDLM NLSEKHDKIP EIWEGHNIAD YIDPAIMKKL
460 470 480 490 500
EELEKEEELR TAAGEYDSVS ESEDEEMLEI RQLAKQIREK KKLKILESKE
510 520 530 540 550
KNTQGPRMPR TAKKVQRTVL EKEMRSLGVD MDDKDDAHYA VQARRSRSIT
560 570 580 590 600
RKRKREDSAP PSSVARSGSC SRTPRDVSGL RDVKMVKKAK TMMKNAQKKM
610 620 630
NRLGKKGEAD RHVFDMKPKH LLSGKRKAGK KDRR
Length:634
Mass (Da):73,964
Last modified:February 9, 2010 - v1
Checksum:i0A05E65E65D6DB62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ496111 Genomic DNA. Translation: ABF55254.1.
RefSeqiNP_036473.2. NM_012341.2.
UniGeneiHs.215766.

Genome annotation databases

GeneIDi23560.
KEGGihsa:23560.

Similar proteinsi

Entry informationi

Entry nameiD2CFK9_HUMAN
AccessioniPrimary (citable) accession number: D2CFK9
Entry historyiIntegrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: September 27, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.