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Protein

Nucleolar GTP-binding protein 1

Gene

GTPBP4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the biogenesis of the 60S ribosomal subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar GTP-binding protein 1UniRule annotation
Gene namesi
Name:GTPBP4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleusnucleolus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134922009.

PTM / Processingi

Proteomic databases

PaxDbiD2CFK9.
PRIDEiD2CFK9.

Expressioni

Gene expression databases

BgeeiENSG00000107937.
ExpressionAtlasiD2CFK9. baseline and differential.
GenevisibleiD2CFK9. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000354040.

Structurei

3D structure databases

ProteinModelPortaliD2CFK9.
SMRiD2CFK9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini169 – 340OBG-type G (guanine nucleotide-binding)InterPro annotationAdd BLAST172

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1490. Eukaryota.
COG1084. LUCA.
KOiK06943.
OMAiDYRYMRW.
OrthoDBiEOG091G0476.
PhylomeDBiD2CFK9.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR031167. G_OBG.
IPR006073. GTP_binding_domain.
IPR024926. NOG1.
IPR010674. NOG1_Rossman_fold_dom.
IPR012973. NOG_C.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PfamiPF06858. NOG1. 1 hit.
PF08155. NOGCT. 1 hit.
[Graphical view]
PIRSFiPIRSF038919. NOG1. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2CFK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHYNFKKIT VVPSAKDFID LTLSKTQRKT PTVIHKHYQI HRIRHFYMRK
60 70 80 90 100
VKFTQQNYHD RLSQILTDFP KLDDIHPFYA DLMNILYDKD HYKLALGQIN
110 120 130 140 150
IAKNLVDNVA KDYVRLMKYG DSLYRCKQLK RAALGRMCTV IKRQKQSLEY
160 170 180 190 200
LEQVRQHLSR LPTIDPNTRT LLLCGYPNVG KSSFINKVTR ADVDVQPYAF
210 220 230 240 250
TTKSLFVGHM DYKYLRWQVV DTPGILDHPL EDRNTIEMQA ITALAHLRAA
260 270 280 290 300
VLYVMDLSEQ CGHGLREQLE LFQNIRPLFI NKPLIVVANK CDVKRIAELS
310 320 330 340 350
EDDQKIFTDL QSEGFPVIET STLTEEGVIK VKTEACDRLL AHRVETKMKG
360 370 380 390 400
NKVNEVLNRL HLAIPTRRDD KERPPFIPEG VVARRKRMET EESRKKRERD
410 420 430 440 450
LELEMGDDYI LDLQKYWDLM NLSEKHDKIP EIWEGHNIAD YIDPAIMKKL
460 470 480 490 500
EELEKEEELR TAAGEYDSVS ESEDEEMLEI RQLAKQIREK KKLKILESKE
510 520 530 540 550
KNTQGPRMPR TAKKVQRTVL EKEMRSLGVD MDDKDDAHYA VQARRSRSIT
560 570 580 590 600
RKRKREDSAP PSSVARSGSC SRTPRDVSGL RDVKMVKKAK TMMKNAQKKM
610 620 630
NRLGKKGEAD RHVFDMKPKH LLSGKRKAGK KDRR
Length:634
Mass (Da):73,964
Last modified:February 9, 2010 - v1
Checksum:i0A05E65E65D6DB62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ496111 Genomic DNA. Translation: ABF55254.1.
RefSeqiNP_036473.2. NM_012341.2.
UniGeneiHs.215766.

Genome annotation databases

GeneIDi23560.
KEGGihsa:23560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ496111 Genomic DNA. Translation: ABF55254.1.
RefSeqiNP_036473.2. NM_012341.2.
UniGeneiHs.215766.

3D structure databases

ProteinModelPortaliD2CFK9.
SMRiD2CFK9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000354040.

Proteomic databases

PaxDbiD2CFK9.
PRIDEiD2CFK9.

Protocols and materials databases

DNASUi23560.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi23560.
KEGGihsa:23560.

Organism-specific databases

CTDi23560.
PharmGKBiPA134922009.

Phylogenomic databases

eggNOGiKOG1490. Eukaryota.
COG1084. LUCA.
KOiK06943.
OMAiDYRYMRW.
OrthoDBiEOG091G0476.
PhylomeDBiD2CFK9.

Miscellaneous databases

ChiTaRSiGTPBP4. human.
GenomeRNAii23560.

Gene expression databases

BgeeiENSG00000107937.
ExpressionAtlasiD2CFK9. baseline and differential.
GenevisibleiD2CFK9. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR031167. G_OBG.
IPR006073. GTP_binding_domain.
IPR024926. NOG1.
IPR010674. NOG1_Rossman_fold_dom.
IPR012973. NOG_C.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PfamiPF06858. NOG1. 1 hit.
PF08155. NOGCT. 1 hit.
[Graphical view]
PIRSFiPIRSF038919. NOG1. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD2CFK9_HUMAN
AccessioniPrimary (citable) accession number: D2CFK9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: November 2, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.