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Protein

Pyruvate kinase

Gene

Tnap_0838

Organism
Thermotoga naphthophila (strain ATCC BAA-489 / DSM 13996 / JCM 10882 / RKU-10)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (apgM)
  4. Enolase (eno)
  5. Pyruvate kinase (Tnap_0838)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processGlycolysisUniRule annotation
LigandMagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

BioCyciTNAP590168:GC5O-851-MONOMER.
UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Ordered Locus Names:Tnap_0838Imported
OrganismiThermotoga naphthophila (strain ATCC BAA-489 / DSM 13996 / JCM 10882 / RKU-10)Imported
Taxonomic identifieri590168 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000000940 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD2C7J4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 338PKInterPro annotationAdd BLAST338
Domaini351 – 463PK_CInterPro annotationAdd BLAST113

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021558.
KOiK00873.
OMAiGSYEDHA.

Family and domain databases

Gene3Di3.40.1380.20. 1 hit.
InterProiView protein in InterPro
IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiView protein in Pfam
PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.

Sequencei

Sequence statusi: Complete.

D2C7J4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNTKIVCTV GPRTDSYEMI EKMIDLGVNV FRINTSHGDW NEQEQKILKI
60 70 80 90 100
KELREKKKKP VAVLIDLAGP KIRTGYLEKE FVELKEGQIF TLTTKEILGN
110 120 130 140 150
EHMVSVNLSS LPQDVKKGDT ILLSDGEIVL EVIETTDTEV KTVVKVGGKI
160 170 180 190 200
THRRGVNVPT ADLSVESITD RDREFIKLGT LHNVEFFALS FVRKPEDVLK
210 220 230 240 250
AKEEIRKHGS EIPVISKIET KKALERLEEI IKVSDGIMVA RGDLGVEIPI
260 270 280 290 300
EEVPIVQKEI IKLSKYYSKP VIVATQILES MIENPFPTRA EVTDIANAIF
310 320 330 340 350
DGADALLLTA ETAVGKHPLE AIKVLSKVAE EAEKKLEFFR TIEYDTSDIS
360 370 380 390 400
EAISHACWQL SESLNAKLII TPTISGSTAI RVSKYNVSQP IVALTPEEKT
410 420 430 440 450
YYRLSLVRKV IPVLAEKCSQ ELEFIEKGLK KVEEMGLAEK GDLVVLTSGV
460
PGKVGTTNTI RVLRVD
Length:466
Mass (Da):51,938
Last modified:February 9, 2010 - v1
Checksum:iB347E016E3AA046E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001839 Genomic DNA. Translation: ADA66930.1.
RefSeqiWP_011943319.1. NC_013642.1.

Genome annotation databases

EnsemblBacteriaiADA66930; ADA66930; Tnap_0838.
GeneIDi29652890.
KEGGitnp:Tnap_0838.

Similar proteinsi

Entry informationi

Entry nameiD2C7J4_THENR
AccessioniPrimary (citable) accession number: D2C7J4
Entry historyiIntegrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: June 7, 2017
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported