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D2C5X8 (D2C5X8_THENR) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tyrosine--tRNA ligase HAMAP-Rule MF_02007
EC=6.1.1.1 HAMAP-Rule MF_02007
Alternative name(s):
Tyrosyl-tRNA synthetase HAMAP-Rule MF_02007
Gene names
Name:tyrS HAMAP-Rule MF_02007
Ordered Locus Names:Tnap_0260
OrganismThermotoga naphthophila (strain ATCC BAA-489 / DSM 13996 / JCM 10882 / RKU-10) [Complete proteome] [HAMAP] EMBL ADA66364.1
Taxonomic identifier590168 [NCBI]
Taxonomic lineageBacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga ›

Protein attributes

Sequence length401 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) By similarity. HAMAP-Rule MF_02007 SAAS SAAS002307

Catalytic activity

ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr). HAMAP-Rule MF_02007 SAAS SAAS002307

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_02007 SAAS SAAS002307

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_02007.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. HAMAP-Rule MF_02007

Contains 1 S4 RNA-binding domain. HAMAP-Rule MF_02007 SAAS SAAS002307

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain334 – 39562S4 RNA-binding By similarity HAMAP-Rule MF_02007
Motif41 – 5010"HIGH" region By similarity HAMAP-Rule MF_02007
Motif225 – 2295"KMSKS" region By similarity HAMAP-Rule MF_02007

Sites

Binding site2281ATP By similarity HAMAP-Rule MF_02007

Sequences

Sequence LengthMass (Da)Tools
D2C5X8 [UniParc].

Last modified February 9, 2010. Version 1.
Checksum: D09E6F2764C5E0F3

FASTA40146,165
        10         20         30         40         50         60 
MTPEEQVKIL KRNVVDFVSE EELLDRIKRK GKLRVKLGVD PSRPDLHLGH AVVLRKLREF 

        70         80         90        100        110        120 
QDLGHTVVLI IGDFTARIGD PSGRNETRPM LTREEVLENA KTYQEQAFKI LDPERTELRF 

       130        140        150        160        170        180 
NGEWLDRMTF ADVIVLASKY TVARMLERDD FAKRFKEGIP ITISEFLYPL AQAYDSVAIQ 

       190        200        210        220        230        240 
ADVELGGTDQ LFNLLVGRKI QEEYGQEPQI VMTMPIIEGT DGKLKMSKSY GNYIAFNDPP 

       250        260        270        280        290        300 
EEMYGKLMSI PDELIIKYMR LLTDVPEERI EEYERKMKEK TINPRDVKMV LAYEITRFFH 

       310        320        330        340        350        360 
GEENAKKAQE QFVKVFQKKE IPDEMPIVEI SQEKNIVDLL VEIGAVSSKS EAKRLVAQGG 

       370        380        390        400 
VYIDGERIED IKFTVKPVGE QVLKVGKRKF YRISGGETKK L

« Hide

References

[1]"Complete sequence of Thermotoga petrophila RKU-1."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Mikhailova N., Nelson K.E., Gogarten J.P., Noll K.M.
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-489 / DSM 13996 / JCM 10882 / RKU-10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001839 Genomic DNA. Translation: ADA66364.1.
RefSeqYP_003345778.1. NC_013642.1.

3D structure databases

ProteinModelPortalD2C5X8.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADA66364; ADA66364; Tnap_0260.
GeneID8674389.
KEGGtnp:Tnap_0260.
PATRIC32520271. VBITheNap72244_0265.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000242791.
KOK01866.
OMADRPLNIK.

Family and domain databases

Gene3D3.10.290.10. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_02007. Tyr_tRNA_synth_type2.
InterProIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002942. S4_RNA-bd.
IPR002307. Tyr-tRNA-ligase.
IPR024088. Tyr-tRNA-ligase_bac-type.
IPR024108. Tyr-tRNA-ligase_bac_2.
[Graphical view]
PANTHERPTHR11766. PTHR11766. 1 hit.
PfamPF01479. S4. 1 hit.
PF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01040. TRNASYNTHTYR.
SMARTSM00363. S4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00234. tyrS. 1 hit.
PROSITEPS50889. S4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD2C5X8_THENR
AccessionPrimary (citable) accession number: D2C5X8
Entry history
Integrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: May 1, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info