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D2BKG6

- D2BKG6_LACLK

UniProt

D2BKG6 - D2BKG6_LACLK

Protein

Amidophosphoribosyltransferase

Gene

purF

Organism
Lactococcus lactis subsp. lactis (strain KF147)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (09 Feb 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei39 – 391For GATase activityUniRule annotation

    GO - Molecular functioni

    1. amidophosphoribosyltransferase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
    2. nucleoside metabolic process Source: InterPro
    3. purine nucleobase biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    GlycosyltransferaseUniRule annotationImported, Transferase

    Keywords - Biological processi

    Purine biosynthesisUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciLLAC684738:GI3F-1696-MONOMER.
    UniPathwayiUPA00074; UER00124.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AmidophosphoribosyltransferaseUniRule annotation (EC:2.4.2.14UniRule annotation)
    Short name:
    ATaseUniRule annotation
    Alternative name(s):
    Glutamine phosphoribosylpyrophosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:purFImported
    Ordered Locus Names:LLKF_1649Imported
    OrganismiLactococcus lactis subsp. lactis (strain KF147)Imported
    Taxonomic identifieri684738 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
    ProteomesiUP000001886: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliD2BKG6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000033688.
    KOiK00764.
    OMAiRIIDACE.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    3.60.20.10. 1 hit.
    InterProiIPR005854. Amd_phspho_trans.
    IPR017932. GATase_2_dom.
    IPR029055. Ntn_hydrolases_N.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view]
    PfamiPF00156. Pribosyltran. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000485. Amd_phspho_trans. 1 hit.
    SUPFAMiSSF53271. SSF53271. 1 hit.
    SSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01134. purF. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D2BKG6-1 [UniParc]FASTAAdd to Basket

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    MFGKEQTLDL RVLGKNSSNE NSWWQQHPDD ERSHLNEECG LFGVWGHPDA    50
    ARLTYFGLHA LQHRGQEGAG ILVNNNGKLN RHRGLGLVTE VFRDEKDLEE 100
    LTGSSAIGHV RYATAGSANI NNIQPFQFEF HDGALGLAHN GNLTNAQSLR 150
    CELEKSGAIF SSNSDTEILM HLIRRSHHPE FMGRVKEALN TVKGGFAYLI 200
    MTENSIVAAL DPNGFRPLSI GKMSNGALVV ASETCAFDVV GATWIQDVQP 250
    GEIIEINDVG IHVDQFTDST NMTICSMEYI YFARPDSNIA GVNVHTARKR 300
    SGKILAQEAQ IDADIVIGVP NSSLSAASGY AEESGLPYEM GLIKNQYVAR 350
    TFIQPTQELR EQGVRMKLSA VRGVVEGKRV IMVDDSIVRG TTSRRIVKLL 400
    KDAGAAEVHV AIASPALKYP CFYGIDIQDR DELIAATHTT DEIRKAIGAD 450
    SLTYLSQSGL VEAIGHDKLC LSYFDGEYPT PLYDYEADYL ESLAKNSVK 499
    Length:499
    Mass (Da):54,774
    Last modified:February 9, 2010 - v1
    Checksum:i8CBAA401909E7722
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001834 Genomic DNA. Translation: ADA65272.1.
    RefSeqiYP_003354072.1. NC_013656.1.

    Genome annotation databases

    EnsemblBacteriaiADA65272; ADA65272; LLKF_1649.
    GeneIDi8679077.
    KEGGillk:LLKF_1649.
    PATRICi32251797. VBILacLac141273_1666.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001834 Genomic DNA. Translation: ADA65272.1 .
    RefSeqi YP_003354072.1. NC_013656.1.

    3D structure databases

    ProteinModelPortali D2BKG6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADA65272 ; ADA65272 ; LLKF_1649 .
    GeneIDi 8679077.
    KEGGi llk:LLKF_1649.
    PATRICi 32251797. VBILacLac141273_1666.

    Phylogenomic databases

    HOGENOMi HOG000033688.
    KOi K00764.
    OMAi RIIDACE.
    OrthoDBi EOG6KT2Q1.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00124 .
    BioCyci LLAC684738:GI3F-1696-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    3.60.20.10. 1 hit.
    InterProi IPR005854. Amd_phspho_trans.
    IPR017932. GATase_2_dom.
    IPR029055. Ntn_hydrolases_N.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view ]
    Pfami PF00156. Pribosyltran. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000485. Amd_phspho_trans. 1 hit.
    SUPFAMi SSF53271. SSF53271. 1 hit.
    SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01134. purF. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-scale genotype-phenotype matching of two Lactococcus lactis isolates from plants identifies mechanisms of adaptation to the plant niche."
      Siezen R.J., Starrenburg M.J., Boekhorst J., Renckens B., Molenaar D., van Hylckama Vlieg J.E.
      Appl. Environ. Microbiol. 74:424-436(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KF147Imported.

    Entry informationi

    Entry nameiD2BKG6_LACLK
    AccessioniPrimary (citable) accession number: D2BKG6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 9, 2010
    Last sequence update: February 9, 2010
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3