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D2BKG6 (D2BKG6_LACLK) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Amidophosphoribosyltransferase PIRNR PIRNR000485

Short name=ATase PIRNR PIRNR000485
EC=2.4.2.14 PIRNR PIRNR000485
Alternative name(s):
Glutamine phosphoribosylpyrophosphate amidotransferase PIRNR PIRNR000485
Gene names
Name:purF EMBL ADA65272.1
Ordered Locus Names:LLKF_1649 EMBL ADA65272.1
OrganismLactococcus lactis subsp. lactis (strain KF147) [Complete proteome] [HAMAP] EMBL ADA65272.1
Taxonomic identifier684738 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

Protein attributes

Sequence length499 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O. PIRNR PIRNR000485

Cofactor

Binds 1 magnesium ion per subunit By similarity. PIRNR PIRNR000485

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2. PIRNR PIRNR000485

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. PIRNR PIRNR000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site391For GATase activity By similarity PIRSR PIRSR000485-1

Sequences

Sequence LengthMass (Da)Tools
D2BKG6 [UniParc].

Last modified February 9, 2010. Version 1.
Checksum: 8CBAA401909E7722

FASTA49954,774
        10         20         30         40         50         60 
MFGKEQTLDL RVLGKNSSNE NSWWQQHPDD ERSHLNEECG LFGVWGHPDA ARLTYFGLHA 

        70         80         90        100        110        120 
LQHRGQEGAG ILVNNNGKLN RHRGLGLVTE VFRDEKDLEE LTGSSAIGHV RYATAGSANI 

       130        140        150        160        170        180 
NNIQPFQFEF HDGALGLAHN GNLTNAQSLR CELEKSGAIF SSNSDTEILM HLIRRSHHPE 

       190        200        210        220        230        240 
FMGRVKEALN TVKGGFAYLI MTENSIVAAL DPNGFRPLSI GKMSNGALVV ASETCAFDVV 

       250        260        270        280        290        300 
GATWIQDVQP GEIIEINDVG IHVDQFTDST NMTICSMEYI YFARPDSNIA GVNVHTARKR 

       310        320        330        340        350        360 
SGKILAQEAQ IDADIVIGVP NSSLSAASGY AEESGLPYEM GLIKNQYVAR TFIQPTQELR 

       370        380        390        400        410        420 
EQGVRMKLSA VRGVVEGKRV IMVDDSIVRG TTSRRIVKLL KDAGAAEVHV AIASPALKYP 

       430        440        450        460        470        480 
CFYGIDIQDR DELIAATHTT DEIRKAIGAD SLTYLSQSGL VEAIGHDKLC LSYFDGEYPT 

       490 
PLYDYEADYL ESLAKNSVK 

« Hide

References

[1]"Genome-scale genotype-phenotype matching of two Lactococcus lactis isolates from plants identifies mechanisms of adaptation to the plant niche."
Siezen R.J., Starrenburg M.J., Boekhorst J., Renckens B., Molenaar D., van Hylckama Vlieg J.E.
Appl. Environ. Microbiol. 74:424-436(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KF147 EMBL ADA65272.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001834 Genomic DNA. Translation: ADA65272.1.
RefSeqYP_003354072.1. NC_013656.1.

3D structure databases

ProteinModelPortalD2BKG6.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADA65272; ADA65272; LLKF_1649.
GeneID8679077.
KEGGllk:LLKF_1649.
PATRIC32251797. VBILacLac141273_1666.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000033688.
KOK00764.
OMARIIDACE.
OrthoDBEOG6KT2Q1.

Enzyme and pathway databases

BioCycLLAC684738:GI3F-1696-MONOMER.
UniPathwayUPA00074; UER00124.

Family and domain databases

Gene3D3.40.50.2020. 1 hit.
3.60.20.10. 1 hit.
InterProIPR005854. Amd_phspho_trans.
IPR017932. GATase_2_dom.
IPR029055. Ntn_hydrolases_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
PIRSFPIRSF000485. Amd_phspho_trans. 1 hit.
SUPFAMSSF53271. SSF53271. 1 hit.
SSF56235. SSF56235. 1 hit.
TIGRFAMsTIGR01134. purF. 1 hit.
PROSITEPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD2BKG6_LACLK
AccessionPrimary (citable) accession number: D2BKG6
Entry history
Integrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: June 11, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)