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Protein

D-inositol 3-phosphate glycosyltransferase

Gene

mshA

Organism
Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate = UDP + 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei25 – 2511D-inositol 3-phosphateUniRule annotation
Binding sitei39 – 391UDP-GlcNAc; via amide nitrogenUniRule annotation
Binding sitei94 – 9411D-inositol 3-phosphateUniRule annotation
Binding sitei127 – 12711D-inositol 3-phosphateUniRule annotation
Binding sitei151 – 15111D-inositol 3-phosphateUniRule annotation
Binding sitei171 – 17111D-inositol 3-phosphateUniRule annotation
Binding sitei245 – 2451UDP-GlcNAcUniRule annotation
Binding sitei250 – 2501UDP-GlcNAcUniRule annotation
Metal bindingi320 – 3201Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi321 – 3211Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi323 – 3231Magnesium; via carbonyl oxygenUniRule annotation
Binding sitei333 – 3331UDP-GlcNAcUniRule annotation
Binding sitei341 – 3411UDP-GlcNAcUniRule annotation
Metal bindingi347 – 3471MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSROS479432:GI0V-966-MONOMER.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
D-inositol 3-phosphate glycosyltransferase (EC:2.4.1.250UniRule annotation)
Alternative name(s):
N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferaseUniRule annotation
Short name:
GlcNAc-Ins-P N-acetylglucosaminyltransferaseUniRule annotation
Gene namesi
Name:mshAUniRule annotation
Ordered Locus Names:Sros_0956
OrganismiStreptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
Taxonomic identifieri479432 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptosporangialesStreptosporangiaceaeStreptosporangium
Proteomesi
  • UP000002029 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435D-inositol 3-phosphate glycosyltransferasePRO_0000400164Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi479432.Sros_0956.

Structurei

3D structure databases

ProteinModelPortaliD2B9F4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni31 – 322UDP-GlcNAc bindingUniRule annotation
Regioni36 – 4161D-inositol 3-phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family. MshA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077288.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiPOG091H0AO3.

Family and domain databases

HAMAPiMF_01695. MshA. 1 hit.
InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.

Sequencei

Sequence statusi: Complete.

D2B9F4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVISPSEVVS VRRRRVSRVA TISMHTSPLD QPGTGDAGGM NVYIVEAARR
60 70 80 90 100
LAQLGVEVEI FTRQTSRDLP PVAEIAPGVS VRHVTAGPYE ELDKGDLPGQ
110 120 130 140 150
LCGFLSGVLR TEAMYEPGRY DVIHSHYWLS GQVGWLAKER WGVPLVHTMH
160 170 180 190 200
TMAKVKNLLL AEDDRPEPTA RVLGEEQVVQ VADRLVANTP TEAQELIDLY
210 220 230 240 250
GAAPGRVEVV NPGVNLNVFQ PASKGAARHR LDLPQDAHVL LFVGRVQPLK
260 270 280 290 300
APDVLLRAAA RMLIDDPSLR SRLVVVCVGG PSGNGLARPS YLTDVAASLG
310 320 330 340 350
ISDVVRIVPP APQHELADWY RAADVTVVPS HNESFGLVAL ESQACGTPVA
360 370 380 390 400
AASVGGLRTA VADGVSGVLV EGHDPQDWAR VLSRFVHRPA WRDALAAGAV
410 420 430
AQAAAFGWSA TAARLADVYA GAMANLHHVP IAVSS
Length:435
Mass (Da):46,352
Last modified:February 9, 2010 - v1
Checksum:i4C5C7591A813D5F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001814 Genomic DNA. Translation: ACZ83960.1.

Genome annotation databases

EnsemblBacteriaiACZ83960; ACZ83960; Sros_0956.
KEGGisro:Sros_0956.
PATRICi32463844. VBIStrRos112010_0926.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001814 Genomic DNA. Translation: ACZ83960.1.

3D structure databases

ProteinModelPortaliD2B9F4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi479432.Sros_0956.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACZ83960; ACZ83960; Sros_0956.
KEGGisro:Sros_0956.
PATRICi32463844. VBIStrRos112010_0926.

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077288.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiPOG091H0AO3.

Enzyme and pathway databases

BioCyciSROS479432:GI0V-966-MONOMER.

Family and domain databases

HAMAPiMF_01695. MshA. 1 hit.
InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMSHA_STRRD
AccessioniPrimary (citable) accession number: D2B9F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: February 9, 2010
Last modified: September 7, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.