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Protein

D-inositol 3-phosphate glycosyltransferase

Gene

mshA

Organism
Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate = UDP + 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei251D-inositol 3-phosphateUniRule annotation1
Binding sitei39UDP-GlcNAc; via amide nitrogenUniRule annotation1
Binding sitei941D-inositol 3-phosphateUniRule annotation1
Binding sitei1271D-inositol 3-phosphateUniRule annotation1
Binding sitei1511D-inositol 3-phosphateUniRule annotation1
Binding sitei1711D-inositol 3-phosphateUniRule annotation1
Binding sitei245UDP-GlcNAcUniRule annotation1
Binding sitei250UDP-GlcNAcUniRule annotation1
Metal bindingi320Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi321Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi323Magnesium; via carbonyl oxygenUniRule annotation1
Binding sitei333UDP-GlcNAcUniRule annotation1
Binding sitei341UDP-GlcNAcUniRule annotation1
Metal bindingi347MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandMagnesium, Metal-binding

Protein family/group databases

CAZyiGT4 Glycosyltransferase Family 4

Names & Taxonomyi

Protein namesi
Recommended name:
D-inositol 3-phosphate glycosyltransferase (EC:2.4.1.250UniRule annotation)
Alternative name(s):
N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferaseUniRule annotation
Short name:
GlcNAc-Ins-P N-acetylglucosaminyltransferaseUniRule annotation
Gene namesi
Name:mshAUniRule annotation
Ordered Locus Names:Sros_0956
OrganismiStreptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
Taxonomic identifieri479432 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptosporangialesStreptosporangiaceaeStreptosporangium
Proteomesi
  • UP000002029 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004001641 – 435D-inositol 3-phosphate glycosyltransferaseAdd BLAST435

Proteomic databases

PRIDEiD2B9F4

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi479432.Sros_0956

Structurei

3D structure databases

ProteinModelPortaliD2B9F4
SMRiD2B9F4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni31 – 32UDP-GlcNAc bindingUniRule annotation2
Regioni36 – 411D-inositol 3-phosphate bindingUniRule annotation6

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family. MshA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R5M Bacteria
COG0438 LUCA
HOGENOMiHOG000077288
KOiK15521
OMAiHTMAKVK
OrthoDBiPOG091H0AO3

Family and domain databases

HAMAPiMF_01695 MshA, 1 hit
InterProiView protein in InterPro
IPR001296 Glyco_trans_1
IPR028098 Glyco_trans_4-like_N
IPR017814 Mycothiol_biosynthesis_MshA
PfamiView protein in Pfam
PF13439 Glyco_transf_4, 1 hit
PF00534 Glycos_transf_1, 1 hit
TIGRFAMsiTIGR03449 mycothiol_MshA, 1 hit

Sequencei

Sequence statusi: Complete.

D2B9F4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVISPSEVVS VRRRRVSRVA TISMHTSPLD QPGTGDAGGM NVYIVEAARR
60 70 80 90 100
LAQLGVEVEI FTRQTSRDLP PVAEIAPGVS VRHVTAGPYE ELDKGDLPGQ
110 120 130 140 150
LCGFLSGVLR TEAMYEPGRY DVIHSHYWLS GQVGWLAKER WGVPLVHTMH
160 170 180 190 200
TMAKVKNLLL AEDDRPEPTA RVLGEEQVVQ VADRLVANTP TEAQELIDLY
210 220 230 240 250
GAAPGRVEVV NPGVNLNVFQ PASKGAARHR LDLPQDAHVL LFVGRVQPLK
260 270 280 290 300
APDVLLRAAA RMLIDDPSLR SRLVVVCVGG PSGNGLARPS YLTDVAASLG
310 320 330 340 350
ISDVVRIVPP APQHELADWY RAADVTVVPS HNESFGLVAL ESQACGTPVA
360 370 380 390 400
AASVGGLRTA VADGVSGVLV EGHDPQDWAR VLSRFVHRPA WRDALAAGAV
410 420 430
AQAAAFGWSA TAARLADVYA GAMANLHHVP IAVSS
Length:435
Mass (Da):46,352
Last modified:February 9, 2010 - v1
Checksum:i4C5C7591A813D5F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001814 Genomic DNA Translation: ACZ83960.1

Genome annotation databases

EnsemblBacteriaiACZ83960; ACZ83960; Sros_0956
KEGGisro:Sros_0956

Similar proteinsi

Entry informationi

Entry nameiMSHA_STRRD
AccessioniPrimary (citable) accession number: D2B9F4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: February 9, 2010
Last modified: May 23, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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