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D2B6P9

- D2B6P9_STRRD

UniProt

D2B6P9 - D2B6P9_STRRD

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Protein
DNA polymerase IV
Gene
dinB, Sros_2856
Organism
Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII By similarity.UniRule annotation

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotationSAAS annotations

Cofactori

Binds 2 magnesium ions per subunit By similarity.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi21 – 211Magnesium By similarityUniRule annotation
Sitei26 – 261Substrate discrimination By similarityUniRule annotation
Metal bindingi115 – 1151Magnesium By similarityUniRule annotation
Active sitei116 – 1161 By similarityUniRule annotation

GO - Molecular functioni

  1. DNA-directed DNA polymerase activity Source: UniProtKB-HAMAP
  2. damaged DNA binding Source: InterPro
  3. magnesium ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. DNA repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymeraseUniRule annotationSAAS annotationsImported, Mutator proteinUniRule annotation, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA damage, DNA repairUniRule annotationSAAS annotations, DNA replicationUniRule annotationSAAS annotations

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciSROS479432:GI0V-2878-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase IVUniRule annotation (EC:2.7.7.7UniRule annotation)
Short name:
Pol IVUniRule annotation
Gene namesi
Name:dinBUniRule annotation
Ordered Locus Names:Sros_2856Imported
OrganismiStreptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)Imported
Taxonomic identifieri479432 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptosporangineaeStreptosporangiaceaeStreptosporangium
ProteomesiUP000002029: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 197181UmuC By similarityUniRule annotation
Add
BLAST

Sequence similaritiesi

Belongs to the DNA polymerase type-Y family.UniRule annotation
Contains 1 umuC domain.UniRule annotation
Contains umuC domain.SAAS annotations

Phylogenomic databases

HOGENOMiHOG000082707.
KOiK02346.
OMAiLWIFANG.
OrthoDBiEOG6FZ4D8.

Family and domain databases

Gene3Di3.30.1490.100. 1 hit.
HAMAPiMF_01113. DNApol_IV.
InterProiIPR017961. DNA_pol_Y-fam_little_finger.
IPR001126. DNA_repair_prot_UmuC-like.
IPR017963. DNA_repair_prot_UmuC-like_N.
IPR022880. DNApol_IV.
IPR024728. PolY_HhH_motif.
[Graphical view]
PfamiPF00817. IMS. 1 hit.
PF11799. IMS_C. 1 hit.
PF11798. IMS_HHH. 1 hit.
[Graphical view]
SUPFAMiSSF100879. SSF100879. 1 hit.
PROSITEiPS50173. UMUC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2B6P9-1 [UniParc]FASTAAdd to Basket

« Hide

MPRPGSDLGA DDTGCPILHV DMDAFYASVE LRERPELRGT PVVIGAPGAR    50
GVVLSATYEA RRFGVHSAMP MTRARRLCPQ AVIIPPSRGK YAEVSRGVME 100
IFHTFTPEVE PIASDEAFLD VGGARKRLGP PAAIAAMIRE QVVRKHGITC 150
SVGVANSKFV AKLASQHCKP DGLLVVPAGR VVDFLHPLPV GALWGVGERT 200
EQSLVRLGIR TVGDLAGVPV ATLQRQLGQA AGAHLAALAW GRDERPVTPH 250
APDKSIGAEE TFATDIGDPV KIRVELLRLS ERVAARLREG GHVGRTVSVK 300
LRRADFSTIS RSRTLREPTD VAQTLYATAC DLYAAAGLDR DRLRLVGVRV 350
ENLSPAGEAT RQLGLGERET GWREAEQAMD RAARRFGRDV VLPASLVRPP 400
FDGMAP 406
Length:406
Mass (Da):43,698
Last modified:February 9, 2010 - v1
Checksum:i1C7DB6439C0935BA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001814 Genomic DNA. Translation: ACZ85813.1.
RefSeqiYP_003338556.1. NC_013595.1.

Genome annotation databases

EnsemblBacteriaiACZ85813; ACZ85813; Sros_2856.
GeneIDi8666142.
KEGGisro:Sros_2856.
PATRICi32467683. VBIStrRos112010_2835.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001814 Genomic DNA. Translation: ACZ85813.1 .
RefSeqi YP_003338556.1. NC_013595.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACZ85813 ; ACZ85813 ; Sros_2856 .
GeneIDi 8666142.
KEGGi sro:Sros_2856.
PATRICi 32467683. VBIStrRos112010_2835.

Phylogenomic databases

HOGENOMi HOG000082707.
KOi K02346.
OMAi LWIFANG.
OrthoDBi EOG6FZ4D8.

Enzyme and pathway databases

BioCyci SROS479432:GI0V-2878-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.100. 1 hit.
HAMAPi MF_01113. DNApol_IV.
InterProi IPR017961. DNA_pol_Y-fam_little_finger.
IPR001126. DNA_repair_prot_UmuC-like.
IPR017963. DNA_repair_prot_UmuC-like_N.
IPR022880. DNApol_IV.
IPR024728. PolY_HhH_motif.
[Graphical view ]
Pfami PF00817. IMS. 1 hit.
PF11799. IMS_C. 1 hit.
PF11798. IMS_HHH. 1 hit.
[Graphical view ]
SUPFAMi SSF100879. SSF100879. 1 hit.
PROSITEi PS50173. UMUC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100.

Entry informationi

Entry nameiD2B6P9_STRRD
AccessioniPrimary (citable) accession number: D2B6P9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: June 11, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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