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D2B6P9

- D2B6P9_STRRD

UniProt

D2B6P9 - D2B6P9_STRRD

Protein

DNA polymerase IV

Gene

dinB

Organism
Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (09 Feb 2010)
      Previous versions | rss
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    Functioni

    Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.UniRule annotation

    Catalytic activityi

    Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotationSAAS annotation

    Cofactori

    Binds 2 magnesium ions per subunit.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi21 – 211MagnesiumUniRule annotation
    Sitei26 – 261Substrate discriminationUniRule annotation
    Metal bindingi115 – 1151MagnesiumUniRule annotation
    Active sitei116 – 1161UniRule annotation

    GO - Molecular functioni

    1. damaged DNA binding Source: InterPro
    2. DNA-directed DNA polymerase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA repair Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    DNA-directed DNA polymeraseUniRule annotationSAAS annotationImported, Mutator proteinUniRule annotation, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    DNA damage, DNA repairUniRule annotationSAAS annotation, DNA replicationUniRule annotationSAAS annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciSROS479432:GI0V-2878-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA polymerase IVUniRule annotation (EC:2.7.7.7UniRule annotation)
    Short name:
    Pol IVUniRule annotation
    Gene namesi
    Name:dinBUniRule annotation
    Ordered Locus Names:Sros_2856Imported
    OrganismiStreptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)Imported
    Taxonomic identifieri479432 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptosporangineaeStreptosporangiaceaeStreptosporangium
    ProteomesiUP000002029: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Monomer.UniRule annotationSAAS annotation

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini17 – 197181UmuCUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the DNA polymerase type-Y family.UniRule annotation
    Contains 1 umuC domain.UniRule annotation
    Contains umuC domain.SAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000082707.
    KOiK02346.
    OMAiLWIFANG.
    OrthoDBiEOG6FZ4D8.

    Family and domain databases

    Gene3Di3.30.1490.100. 1 hit.
    HAMAPiMF_01113. DNApol_IV.
    InterProiIPR017961. DNA_pol_Y-fam_little_finger.
    IPR001126. DNA_repair_prot_UmuC-like.
    IPR017963. DNA_repair_prot_UmuC-like_N.
    IPR022880. DNApol_IV.
    IPR024728. PolY_HhH_motif.
    [Graphical view]
    PfamiPF00817. IMS. 1 hit.
    PF11799. IMS_C. 1 hit.
    PF11798. IMS_HHH. 1 hit.
    [Graphical view]
    SUPFAMiSSF100879. SSF100879. 1 hit.
    PROSITEiPS50173. UMUC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D2B6P9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRPGSDLGA DDTGCPILHV DMDAFYASVE LRERPELRGT PVVIGAPGAR    50
    GVVLSATYEA RRFGVHSAMP MTRARRLCPQ AVIIPPSRGK YAEVSRGVME 100
    IFHTFTPEVE PIASDEAFLD VGGARKRLGP PAAIAAMIRE QVVRKHGITC 150
    SVGVANSKFV AKLASQHCKP DGLLVVPAGR VVDFLHPLPV GALWGVGERT 200
    EQSLVRLGIR TVGDLAGVPV ATLQRQLGQA AGAHLAALAW GRDERPVTPH 250
    APDKSIGAEE TFATDIGDPV KIRVELLRLS ERVAARLREG GHVGRTVSVK 300
    LRRADFSTIS RSRTLREPTD VAQTLYATAC DLYAAAGLDR DRLRLVGVRV 350
    ENLSPAGEAT RQLGLGERET GWREAEQAMD RAARRFGRDV VLPASLVRPP 400
    FDGMAP 406
    Length:406
    Mass (Da):43,698
    Last modified:February 9, 2010 - v1
    Checksum:i1C7DB6439C0935BA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001814 Genomic DNA. Translation: ACZ85813.1.
    RefSeqiYP_003338556.1. NC_013595.1.

    Genome annotation databases

    EnsemblBacteriaiACZ85813; ACZ85813; Sros_2856.
    GeneIDi8666142.
    KEGGisro:Sros_2856.
    PATRICi32467683. VBIStrRos112010_2835.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001814 Genomic DNA. Translation: ACZ85813.1 .
    RefSeqi YP_003338556.1. NC_013595.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACZ85813 ; ACZ85813 ; Sros_2856 .
    GeneIDi 8666142.
    KEGGi sro:Sros_2856.
    PATRICi 32467683. VBIStrRos112010_2835.

    Phylogenomic databases

    HOGENOMi HOG000082707.
    KOi K02346.
    OMAi LWIFANG.
    OrthoDBi EOG6FZ4D8.

    Enzyme and pathway databases

    BioCyci SROS479432:GI0V-2878-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.100. 1 hit.
    HAMAPi MF_01113. DNApol_IV.
    InterProi IPR017961. DNA_pol_Y-fam_little_finger.
    IPR001126. DNA_repair_prot_UmuC-like.
    IPR017963. DNA_repair_prot_UmuC-like_N.
    IPR022880. DNApol_IV.
    IPR024728. PolY_HhH_motif.
    [Graphical view ]
    Pfami PF00817. IMS. 1 hit.
    PF11799. IMS_C. 1 hit.
    PF11798. IMS_HHH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF100879. SSF100879. 1 hit.
    PROSITEi PS50173. UMUC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100Imported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100Imported.

    Entry informationi

    Entry nameiD2B6P9_STRRD
    AccessioniPrimary (citable) accession number: D2B6P9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 9, 2010
    Last sequence update: February 9, 2010
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3