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Protein

Thymidine kinase

Gene

Sros_6597

Organism
Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei98Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSROS479432:GI0V-6294-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Ordered Locus Names:Sros_6597Imported
OrganismiStreptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)Imported
Taxonomic identifieri479432 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptosporangialesStreptosporangiaceaeStreptosporangium
Proteomesi
  • UP000002029 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi479432.Sros_6597.

Structurei

3D structure databases

ProteinModelPortaliD2B3M4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107W53. Bacteria.
COG1435. LUCA.
HOGENOMiHOG000076391.
KOiK00857.
OMAiRATHNAR.
OrthoDBiPOG091H0659.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiView protein in Pfam
PF00265. TK. 1 hit.
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

D2B3M4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTELSALSAV PVGSRDGVLR FYFGPMDCGK STLALQMNYN HRRQGRRGLV
60 70 80 90 100
LTKHDRSGGP QVTSRIGLGS EAIEVVDDLD LVALVREHER VDYVICDEAC
110 120 130 140 150
FYTVAQIEQL ADLTDHFGVD VYAFGLASDF RSQMFPAAQR LFELADEISR
160 170 180 190 200
LQVEVLCWCG RPGRLNARVV GDRLVRTGEQ VMIGDTGDAP VRYQVLCRRH
210
HRAGDLGAAG
Length:210
Mass (Da):23,240
Last modified:February 9, 2010 - v1
Checksum:iA3D9645073F7746F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001814 Genomic DNA. Translation: ACZ89309.1.

Genome annotation databases

EnsemblBacteriaiACZ89309; ACZ89309; Sros_6597.
KEGGisro:Sros_6597.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiD2B3M4_STRRD
AccessioniPrimary (citable) accession number: D2B3M4
Entry historyiIntegrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: July 5, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported