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Protein

Xylose isomerase

Gene

xylA

Organism
Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei55 – 551UniRule annotation
Active sitei58 – 581UniRule annotation
Metal bindingi179 – 1791Magnesium 1UniRule annotation
Metal bindingi215 – 2151Magnesium 1UniRule annotation
Metal bindingi215 – 2151Magnesium 2UniRule annotation
Metal bindingi218 – 2181Magnesium 2UniRule annotation
Metal bindingi243 – 2431Magnesium 1UniRule annotation
Metal bindingi253 – 2531Magnesium 2UniRule annotation
Metal bindingi255 – 2551Magnesium 2UniRule annotation
Metal bindingi285 – 2851Magnesium 1UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Pentose shuntUniRule annotation, Xylose metabolismUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciSROS479432:GI0V-359-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
Gene namesi
Name:xylAUniRule annotation
Ordered Locus Names:Sros_0353Imported
OrganismiStreptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)Imported
Taxonomic identifieri479432 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptosporangialesStreptosporangiaceaeStreptosporangium
ProteomesiUP000002029 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi479432.Sros_0353.

Structurei

3D structure databases

ProteinModelPortaliD2B0X8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000022596.
KOiK01805.
OMAiYDIRFAI.
OrthoDBiEOG62NX4R.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2B0X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDYTPKPED RFTFGLWTVG WQARDQFGDA SRAPLDPVES VHRLAELGAY
60 70 80 90 100
GVTFHDDDLL AVEPDRDKAV ERFKKALAET GLKVPMATTN LFTHPVFKDG
110 120 130 140 150
GFTSNDRDVR RYALRKVMRN VDLAAELGAT TYVCWGGREG AESGAAKDIR
160 170 180 190 200
AALSRYKEGM DLLTSYVIDR GYDIRFAIEP KPNEPRGDIL LPTVGHALAF
210 220 230 240 250
INELEHSERV GLNPEVGHEE MAGLNFAHGI AQALWHGKLF HIDLNGQHGP
260 270 280 290 300
RFDQDLVFGH GDVKNSFFLV DLLENGGYDG PRHFDYKPLR TEDAEDVWVS
310 320 330 340 350
AAANMRTYLI LKEKVKAFHA DPEVVEARAA SRVAELSEPT LAPGETLEDL
360 370 380
HRDDFDVDRA AARGFHFSRL NQLALEHLLG VRG
Length:383
Mass (Da):42,749
Last modified:February 9, 2010 - v1
Checksum:iDDF6DA2E5CEAD8E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001814 Genomic DNA. Translation: ACZ83385.1.
RefSeqiWP_012887131.1. NC_013595.1.

Genome annotation databases

EnsemblBacteriaiACZ83385; ACZ83385; Sros_0353.
KEGGisro:Sros_0353.
PATRICi32462666. VBIStrRos112010_0342.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001814 Genomic DNA. Translation: ACZ83385.1.
RefSeqiWP_012887131.1. NC_013595.1.

3D structure databases

ProteinModelPortaliD2B0X8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi479432.Sros_0353.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACZ83385; ACZ83385; Sros_0353.
KEGGisro:Sros_0353.
PATRICi32462666. VBIStrRos112010_0342.

Phylogenomic databases

HOGENOMiHOG000022596.
KOiK01805.
OMAiYDIRFAI.
OrthoDBiEOG62NX4R.

Enzyme and pathway databases

BioCyciSROS479432:GI0V-359-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100Imported.

Entry informationi

Entry nameiD2B0X8_STRRD
AccessioniPrimary (citable) accession number: D2B0X8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: July 22, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.