ID   D2AZ32_STRRD            Unreviewed;       451 AA.
AC   D2AZ32;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   SubName: Full=Metal dependent phosphohydrolase {ECO:0000313|EMBL:ACZ90969.1};
GN   OrderedLocusNames=Sros_8321 {ECO:0000313|EMBL:ACZ90969.1};
OS   Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI
OS   9100).
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Streptosporangium.
OX   NCBI_TaxID=479432 {ECO:0000313|EMBL:ACZ90969.1, ECO:0000313|Proteomes:UP000002029};
RN   [1] {ECO:0000313|EMBL:ACZ90969.1, ECO:0000313|Proteomes:UP000002029}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100
RC   {ECO:0000313|Proteomes:UP000002029};
RX   PubMed=21304675; DOI=10.4056/sigs.631049;
RA   Nolan M., Sikorski J., Jando M., Lucas S., Lapidus A., Glavina Del Rio T.,
RA   Chen F., Tice H., Pitluck S., Cheng J.F., Chertkov O., Sims D., Meincke L.,
RA   Brettin T., Han C., Detter J.C., Bruce D., Goodwin L., Land M., Hauser L.,
RA   Chang Y.J., Jeffries C.D., Ivanova N., Mavromatis K., Mikhailova N.,
RA   Chen A., Palaniappan K., Chain P., Rohde M., Goker M., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Streptosporangium roseum type strain (NI
RT   9100).";
RL   Stand. Genomic Sci. 2:29-37(2010).
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DR   EMBL; CP001814; ACZ90969.1; -; Genomic_DNA.
DR   AlphaFoldDB; D2AZ32; -.
DR   STRING; 479432.Sros_8321; -.
DR   KEGG; sro:Sros_8321; -.
DR   eggNOG; COG2206; Bacteria.
DR   HOGENOM; CLU_000445_92_14_11; -.
DR   Proteomes; UP000002029; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR037522; HD_GYP_dom.
DR   PANTHER; PTHR43155:SF2; CYCLIC DI-GMP PHOSPHODIESTERASE PA4108; 1.
DR   PANTHER; PTHR43155; CYCLIC DI-GMP PHOSPHODIESTERASE PA4108-RELATED; 1.
DR   Pfam; PF13487; HD_5; 1.
DR   SMART; SM00471; HDc; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   PROSITE; PS51832; HD_GYP; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002029};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        13..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        44..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        73..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        108..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        145..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        180..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          229..424
FT                   /note="HD-GYP"
FT                   /evidence="ECO:0000259|PROSITE:PS51832"
FT   REGION          416..451
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   451 AA;  48290 MW;  E38F89CC5C0B33B4 CRC64;
     MAALRGLPWF AKVYLVAVIG AAFALLGYSV AVSGRLEQLD WSNLLVLALL FLVCESVPTL
     LNVKQAAVSV SFSAALAAVV LVGPEGAALV GMTAVFSVRP GLPLVKRLFN GAQFAVCGYV
     AGQVYEWLGG GVGLPTIAGF DDLIVPFVGA AAVFVPLNFI LIALVLALTG QADQVPLRGL
     AQFMVSYLGY ATFGLLIAGL WATVSSISAV LVLLPLFVAR WAFGQYHAQQ RSYDATIAAL
     CQAVETKDYY TRGHCTRVSL ASGMIAHEIG MGSERLRAIR YAGMLHDVGK LGVPTKVLQK
     DGPLTEEEFA AIQLHPMRGL EIVRGIDFLD EAFAGIMHHH ERQDGKGYPM GLAGDEIPEF
     ARIIAVADAF DSMTSDRSYR GARPVEVAMA ELRKGAGTQF DPVMVVAFIK AVDRDGWEPP
     RKVTTPPAGE AETTTKDHDD PTMPIQVVSE R
//