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D2ATV0

- PSA_STRRD

UniProt

D2ATV0 - PSA_STRRD

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Protein
Proteasome subunit alpha
Gene
prcA, Sros_5870
Organism
Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation By similarity.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationi

The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. proteolysis involved in cellular protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

BioCyciSROS479432:GI0V-5900-MONOMER.
UniPathwayiUPA00997.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha (EC:3.4.25.1)
Alternative name(s):
20S proteasome alpha subunit
Proteasome core protein PrcA
Gene namesi
Name:prcA
Ordered Locus Names:Sros_5870
OrganismiStreptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
Taxonomic identifieri479432 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptosporangineaeStreptosporangiaceaeStreptosporangium
ProteomesiUP000002029: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. proteasome core complex, alpha-subunit complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259Proteasome subunit alphaUniRule annotation
PRO_0000397179Add
BLAST

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC By similarity.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.

Phylogenomic databases

HOGENOMiHOG000245319.
KOiK03432.
OrthoDBiEOG6NKQZG.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00289_B. Proteasome_A_B.
InterProiIPR029055. Ntn_hydrolases_N.
IPR022296. Proteasome_asu_bac.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR03691. 20S_bact_alpha. 1 hit.
PROSITEiPS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D2ATV0-1 [UniParc]FASTAAdd to Basket

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MSMPFGYVSP EQQMRDKADY ARKGIARGRS VVVLQYEHGI LFVAPNPSRA    50
LHKISEIYDR IGFAAVGRYN EFEALRLGGI RYADINGYNY ARDDVTARGL 100
ANLYAQNLGQ IFTESMKPFE VEIVVAEVGD SSDEDHIYRL TFDGSVFDET 150
GLVAMGGQAE AVAGRLKERY RDGLPLAEAL EAALFALTEP GGERSPASQL 200
EVAVLDRNRP HRKFLRLAGP RLERLLAEGS ATSATSATPG EAEAPATAPE 250
GDVDTGSNG 259
Length:259
Mass (Da):28,099
Last modified:August 10, 2010 - v2
Checksum:i12584DF9AD920B71
GO

Sequence cautioni

The sequence ACZ88605.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001814 Genomic DNA. Translation: ACZ88605.1. Different initiation.
RefSeqiYP_003341348.1. NC_013595.1.

Genome annotation databases

EnsemblBacteriaiACZ88605; ACZ88605; Sros_5870.
GeneIDi8669164.
KEGGisro:Sros_5870.
PATRICi32473583. VBIStrRos112010_5777.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001814 Genomic DNA. Translation: ACZ88605.1 . Different initiation.
RefSeqi YP_003341348.1. NC_013595.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACZ88605 ; ACZ88605 ; Sros_5870 .
GeneIDi 8669164.
KEGGi sro:Sros_5870.
PATRICi 32473583. VBIStrRos112010_5777.

Phylogenomic databases

HOGENOMi HOG000245319.
KOi K03432.
OrthoDBi EOG6NKQZG.

Enzyme and pathway databases

UniPathwayi UPA00997 .
BioCyci SROS479432:GI0V-5900-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00289_B. Proteasome_A_B.
InterProi IPR029055. Ntn_hydrolases_N.
IPR022296. Proteasome_asu_bac.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR03691. 20S_bact_alpha. 1 hit.
PROSITEi PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100.

Entry informationi

Entry nameiPSA_STRRD
AccessioniPrimary (citable) accession number: D2ATV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: August 10, 2010
Last modified: June 11, 2014
This is version 28 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi