ID   D2A4V3_TRICA            Unreviewed;      1114 AA.
AC   D2A4V3;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   24-JAN-2024, entry version 44.
DE   SubName: Full=Integrator complex subunit 2-like Protein {ECO:0000313|EMBL:EFA05171.1};
GN   Name=AUGUSTUS-3.0.2_15300 {ECO:0000313|EMBL:EFA05171.1};
GN   ORFNames=TcasGA2_TC015300 {ECO:0000313|EMBL:EFA05171.1};
OS   Tribolium castaneum (Red flour beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX   NCBI_TaxID=7070 {ECO:0000313|EMBL:EFA05171.1, ECO:0000313|Proteomes:UP000007266};
RN   [1] {ECO:0000313|EMBL:EFA05171.1, ECO:0000313|Proteomes:UP000007266}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA05171.1,
RC   ECO:0000313|Proteomes:UP000007266};
RX   PubMed=18362917; DOI=10.1038/nature06784;
RG   Tribolium Genome Sequencing Consortium;
RA   Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA   Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA   Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA   Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA   Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA   Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA   Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA   Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA   Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA   Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA   Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA   Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA   Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA   Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA   Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA   Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA   Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA   Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA   Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA   Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA   Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA   Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA   Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA   Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA   Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA   Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA   Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA   Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA   Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA   Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA   Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA   Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA   Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA   Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA   Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA   Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA   Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA   Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA   Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA   Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA   Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT   "The genome of the model beetle and pest Tribolium castaneum.";
RL   Nature 452:949-955(2008).
RN   [2] {ECO:0000313|EMBL:EFA05171.1, ECO:0000313|Proteomes:UP000007266}
RP   GENOME REANNOTATION.
RC   STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA05171.1,
RC   ECO:0000313|Proteomes:UP000007266};
RX   PubMed=19820115; DOI=10.1093/nar/gkp807;
RA   Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA   Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT   "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT   for Tribolium castaneum.";
RL   Nucleic Acids Res. 38:D437-D442(2010).
CC   -!- SIMILARITY: Belongs to the Integrator subunit 2 family.
CC       {ECO:0000256|ARBA:ARBA00006705}.
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DR   EMBL; KQ971344; EFA05171.1; -; Genomic_DNA.
DR   RefSeq; XP_008194516.1; XM_008196294.2.
DR   AlphaFoldDB; D2A4V3; -.
DR   STRING; 7070.D2A4V3; -.
DR   EnsemblMetazoa; TC015300_001; TC015300_001; TC015300.
DR   GeneID; 661595; -.
DR   KEGG; tca:661595; -.
DR   eggNOG; ENOG502QSP2; Eukaryota.
DR   HOGENOM; CLU_007707_0_0_1; -.
DR   InParanoid; D2A4V3; -.
DR   OMA; IISNYPH; -.
DR   OrthoDB; 2881275at2759; -.
DR   PhylomeDB; D2A4V3; -.
DR   Proteomes; UP000007266; Linkage group 6.
DR   GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR   GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR   InterPro; IPR026236; Int2_metazoa.
DR   InterPro; IPR029321; INTS2.
DR   PANTHER; PTHR28608; INTEGRATOR COMPLEX SUBUNIT 2; 1.
DR   PANTHER; PTHR28608:SF1; INTEGRATOR COMPLEX SUBUNIT 2; 1.
DR   Pfam; PF14750; INTS2; 1.
DR   PRINTS; PR02105; INTSUBUNIT2.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007266}.
SQ   SEQUENCE   1114 AA;  125874 MW;  26C2524395FC5818 CRC64;
     MSFKKGVDPK VFRAIQNVDM HQLSECTEVE IRPVLPCLVR MGLISPLDTS KKCTTMKVDI
     LTIVSGMELV NSIVALLSID FHRLETEVKK EQQLRQKGVA LQNDSILIGN LSNTSMALEY
     ERSDMTRRLS ILLGELLYVQ SQIQDENSDT SYIKPSELFD NDIFAEELSD IICIALAELP
     ITLNILTITE TLLHLHNGPP IICRIVANFP DCFREVCTYL IQTGEKQEET KLSTVRAATI
     SLLCKMNPSQ ALTIRSKCVE LCRMPALAIT LSLDGGEGDM VAFISGLLLG NDQTIRNWIA
     LFIRTGQKKK GEISSTALLQ LREELLRRLH VILAASVEGH LLDSLVVQGS ALLRLYCALR
     GIAAIKFQED EVTALVRLLT SHPSPTPAGV RFVSIGLCML IACPSLISLQ EHERRSIEWV
     QWLVKEEAYF ESASGVTASF GEMLLLMAIH FHSNQLSAIC DLVCATLGMK IPIRHNNMTR
     MKQVFTQEIF TEQVVTAHAV KVPVTNSLSA NMTGFLPIHC IHQLLKSRAF AKHNVNIKNW
     IYKQICTSVS PLHPVLPMLV EVYVNSVIMP TSRNTETNKP LSENEIRRVF QSSIFGQYFD
     HKKSIFTMDF DLNSENQDVV VDGTSLTPQL LLLYYLLLYE DCRLVNAHIL AAFNRKIKLY
     SSEFLSELPI KYLLHHAQKD QSSYSGLFGP LLKLLATHFP HLTLVEDWLD DMSIKTEHKP
     THVTQISVIE AFNDLDTNPS KCAKLMQTLL KQQAIDIWPF AEIFTQFARK ILNDNVPRYL
     QDLYRDVWLR FNTVLPRRLW VLTVKNLVDD FSNLTRIDVA EDPLQIMRCD ERVFRCAPLY
     AIVLRVLRAS LASSRSQLMQ HLQANPRLDH AGQVLNESDR EEMCRATIAA QESAAVQMLL
     ETCIETDEDR TIGGQKWALQ EVRSLVCSYL HQVFIADTML AKLVHFQGYP SELIEVMVKG
     VPSMHICLDF LQELMQQPSL DKQIFAIQLL SHLCIQYALP KSLNLCVAAL NLLYALLGSL
     SSSQRVRLFR PILPALVRIS EAFPPLVDDI VNLMMQLAKV CKSQASLASH FDVHLGKELE
     VSAEESKELC VLVQETFSDI LDRAVFKSKI YKQE
//