D1ZKF3 (AMPP1_SORMK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase P
Short name=AMPP
Short name=Aminopeptidase P
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	AMPP
ORF Names:	SMAC_08089

Organism

Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell) [Complete proteome]

Taxonomic identifier

771870 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Sordaria › Sordaria macrospora

Protein attributes

Sequence length	614 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 614	614	Probable Xaa-Pro aminopeptidase P		PRO_0000411810
Sites
	Metal binding	411	1	Manganese 2 By similarity
	Metal binding	422	1	Manganese 1 By similarity
	Metal binding	422	1	Manganese 2 By similarity
	Metal binding	520	1	Manganese 1 By similarity
	Metal binding	534	1	Manganese 1 By similarity
	Metal binding	534	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	D1ZKF3 [UniParc]. Last modified February 9, 2010. Version 1. Checksum: 719F8EB7E20C2AF8	FASTA	614	67,883
	10 20 30 40 50 60 MTVNTTDRLA ALRSLMKERS VDIYVVPSED SHASEYITDC DARRTFISGF SGSAGTAVVT 70 80 90 100 110 120 LDKAALATDG RYFNQASKQL DENWHLLKTG LQDVPTWQEW TADESAGGKT VGIDPTLISP 130 140 150 160 170 180 AVAEKLNGDI KKHGGSGLKA VTENLVDLVW GESRPPRPSE PVFLLGAKYA GKGAAEKLTD 190 200 210 220 230 240 LRKELEKKKA AAFVVSMLDE IAWLFNLRGN DITYNPVFFS YAIVTKDSAT LYVDESKLTD 250 260 270 280 290 300 EVKQYLAENG TEIKPYTDLF KDTEVLANAA KSTSESEKPT KYLVSNKASW ALKLALGGEK 310 320 330 340 350 360 HVDEVRSPIG DAKAIKNETE LEGMRKCHIR DGAALIKYFA WLEDQLVNKK AKLNEVEAAD 370 380 390 400 410 420 QLEKFRSEQS DFVGLSFDTI SSTGPNGAII HYKPERGACS VIDPNAIYLC DSGAQFYDGT 430 440 450 460 470 480 TDVTRTLHFG QPTAAEKKSY TLVLKGNIAL DTAVFPKGTS GFALDALARQ FLWKYGLDYR 490 500 510 520 530 540 HGTGHGVGSF LNVHEGPIGI GTRKAYIDVP LAPGNVLSIE PGYYEDGNYG IRIENLAIVR 550 560 570 580 590 600 EVKTEHQFGD KPYLGFEHIT MVPYCRKLID ESLLTQEEKD WLNKSNEEIR KNMAGYFDGD 610 QLTTDWLLRE TSPF

References

[1]

"De novo assembly of a 40 Mb eukaryotic genome from short sequence reads: Sordaria macrospora, a model organism for fungal morphogenesis." Nowrousian M., Stajich J.E., Chu M., Engh I., Espagne E., Halliday K., Kamerewerd J., Kempken F., Knab B., Kuo H.-C., Osiewacz H.D., Poeggeler S., Read N.D., Seiler S., Smith K.M., Zickler D., Kueck U., Freitag M. PLoS Genet. 6:E1000891-E1000891(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC MYA-333 / DSM 997 / K(L3346) / K-hell.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CABT02000052 Genomic DNA. Translation: CCC13968.1.
RefSeq	XP_003347197.1. XM_003347149.1.
3D structure databases
ProteinModelPortal	D1ZKF3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	10804617.
KEGG	smp:SMAC_08089.
Phylogenomic databases
KO	K01262.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR000587. Creatinase. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF01321. Creatinase_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP1_SORMK

Accession

Primary (citable) accession number: D1ZKF3
Secondary accession number(s): F7W9H7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	February 9, 2010
Last modified:	March 6, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program