SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

D1ZG13

- CBPYA_SORMK

UniProt

D1ZG13 - CBPYA_SORMK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Carboxypeptidase Y homolog A
Gene
CPYA, SMAC_01911
Organism
Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei278 – 2781 By similarity
Active sitei470 – 4701 By similarity
Active sitei529 – 5291 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
ORF Names:SMAC_01911
OrganismiSordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
Taxonomic identifieri771870 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeSordaria
ProteomesiUP000001881: Unassembled WGS sequence

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. vacuole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Propeptidei18 – 137120 By similarity
PRO_0000407478Add
BLAST
Chaini138 – 554417Carboxypeptidase Y homolog A
PRO_0000407479Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi191 ↔ 431 By similarity
Glycosylationi222 – 2221N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi325 ↔ 339 By similarity
Disulfide bondi349 ↔ 372 By similarity
Disulfide bondi356 ↔ 365 By similarity
Disulfide bondi394 ↔ 401 By similarity
Glycosylationi518 – 5181N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal

Phylogenomic databases

KOiK13289.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D1ZG13-1 [UniParc]FASTAAdd to Basket

« Hide

MRISASTVLL GAASAASAAS FQNQAQQVLA DNFHKAHDAI KPVADSFAHT    50
TLESFEEAFN GMNSQAKALW DEIKLLVPES AFDKPTWFSK PKAAKRRKDW 100
DHVVKGADVQ KLWVKGADGE KHREVGGQLD NFNLRVKSVD PSKLGVDKVK 150
QYSGYLDDEA NDKHLFYWFF ESRNDPKNDP VVLWLNGGPG CSSLTGLFLE 200
LGPSSIDKKL KVINNEYAWN NNASVIFLDQ PVNVGYSYSG NAVSNTVAAG 250
KDVYALLTLF FHQFPEYAKQ DFHIAGESYA GHYIPVFASE ILSHKDRNIN 300
LKSVLIGNGL TDPLTQYEHY RPMACGEGGY PAVLSESECR SMDNALPRCQ 350
SLIRNCYESG SVWSCVPAAI YCNNQFIGPY QRTGQNVYDI RGKCEDDNNL 400
CYSALGWISD YLNQKDVMDA LGVEVESYDS CNFDINRNFL FQGDWMQPFH 450
RLVPGILKEI PVLIYAGDAD FICNWLGNKA WSEALEWPGK KGFNKAELED 500
LSLPEADKEY GKVKSSGNFT FMQIYQAGHM VPMDQPENSL DFLNRWLGGE 550
WFEQ 554
Length:554
Mass (Da):62,144
Last modified:February 9, 2010 - v1
Checksum:iF12D1F1AB69EFF3D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CABT02000005 Genomic DNA. Translation: CCC08363.1.
RefSeqiXP_003348887.1. XM_003348839.1.

Genome annotation databases

GeneIDi10806348.
KEGGismp:SMAC_01911.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CABT02000005 Genomic DNA. Translation: CCC08363.1 .
RefSeqi XP_003348887.1. XM_003348839.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 10806348.
KEGGi smp:SMAC_01911.

Phylogenomic databases

KOi K13289.
OrthoDBi EOG7XDBR1.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "De novo assembly of a 40 Mb eukaryotic genome from short sequence reads: Sordaria macrospora, a model organism for fungal morphogenesis."
    Nowrousian M., Stajich J.E., Chu M., Engh I., Espagne E., Halliday K., Kamerewerd J., Kempken F., Knab B., Kuo H.-C., Osiewacz H.D., Poeggeler S., Read N.D., Seiler S., Smith K.M., Zickler D., Kueck U., Freitag M.
    PLoS Genet. 6:E1000891-E1000891(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-333 / DSM 997 / K(L3346) / K-hell.

Entry informationi

Entry nameiCBPYA_SORMK
AccessioniPrimary (citable) accession number: D1ZG13
Secondary accession number(s): F7VS77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: February 9, 2010
Last modified: June 11, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi