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D1ZG13 (CBPYA_SORMK) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carboxypeptidase Y homolog A

EC=3.4.16.5
Gene names
Name:CPYA
ORF Names:SMAC_01911
OrganismSordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell) [Complete proteome]
Taxonomic identifier771870 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeSordaria

Protein attributes

Sequence length554 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activity

Release of a C-terminal amino acid with broad specificity.

Subcellular location

Vacuole By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Cellular componentVacuole
   DomainSignal
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentvacuole

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Propeptide18 – 137120 By similarity
PRO_0000407478
Chain138 – 554417Carboxypeptidase Y homolog A
PRO_0000407479

Sites

Active site2781 By similarity
Active site4701 By similarity
Active site5291 By similarity

Amino acid modifications

Glycosylation2221N-linked (GlcNAc...) Potential
Glycosylation5181N-linked (GlcNAc...) Potential
Disulfide bond191 ↔ 431 By similarity
Disulfide bond325 ↔ 339 By similarity
Disulfide bond349 ↔ 372 By similarity
Disulfide bond356 ↔ 365 By similarity
Disulfide bond394 ↔ 401 By similarity

Sequences

Sequence LengthMass (Da)Tools
D1ZG13 [UniParc].

Last modified February 9, 2010. Version 1.
Checksum: F12D1F1AB69EFF3D

FASTA55462,144
        10         20         30         40         50         60 
MRISASTVLL GAASAASAAS FQNQAQQVLA DNFHKAHDAI KPVADSFAHT TLESFEEAFN 

        70         80         90        100        110        120 
GMNSQAKALW DEIKLLVPES AFDKPTWFSK PKAAKRRKDW DHVVKGADVQ KLWVKGADGE 

       130        140        150        160        170        180 
KHREVGGQLD NFNLRVKSVD PSKLGVDKVK QYSGYLDDEA NDKHLFYWFF ESRNDPKNDP 

       190        200        210        220        230        240 
VVLWLNGGPG CSSLTGLFLE LGPSSIDKKL KVINNEYAWN NNASVIFLDQ PVNVGYSYSG 

       250        260        270        280        290        300 
NAVSNTVAAG KDVYALLTLF FHQFPEYAKQ DFHIAGESYA GHYIPVFASE ILSHKDRNIN 

       310        320        330        340        350        360 
LKSVLIGNGL TDPLTQYEHY RPMACGEGGY PAVLSESECR SMDNALPRCQ SLIRNCYESG 

       370        380        390        400        410        420 
SVWSCVPAAI YCNNQFIGPY QRTGQNVYDI RGKCEDDNNL CYSALGWISD YLNQKDVMDA 

       430        440        450        460        470        480 
LGVEVESYDS CNFDINRNFL FQGDWMQPFH RLVPGILKEI PVLIYAGDAD FICNWLGNKA 

       490        500        510        520        530        540 
WSEALEWPGK KGFNKAELED LSLPEADKEY GKVKSSGNFT FMQIYQAGHM VPMDQPENSL 

       550 
DFLNRWLGGE WFEQ 

« Hide

References

[1]"De novo assembly of a 40 Mb eukaryotic genome from short sequence reads: Sordaria macrospora, a model organism for fungal morphogenesis."
Nowrousian M., Stajich J.E., Chu M., Engh I., Espagne E., Halliday K., Kamerewerd J., Kempken F., Knab B., Kuo H.-C., Osiewacz H.D., Poeggeler S., Read N.D., Seiler S., Smith K.M., Zickler D., Kueck U., Freitag M.
PLoS Genet. 6:E1000891-E1000891(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-333 / DSM 997 / K(L3346) / K-hell.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CABT02000005 Genomic DNA. Translation: CCC08363.1.
RefSeqXP_003348887.1. XM_003348839.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID10806348.
KEGGsmp:SMAC_01911.

Phylogenomic databases

KOK13289.
OrthoDBEOG7XDBR1.

Family and domain databases

InterProIPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCBPYA_SORMK
AccessionPrimary (citable) accession number: D1ZG13
Secondary accession number(s): F7VS77
Entry history
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: February 9, 2010
Last modified: February 19, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries