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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei187PROSITE-ProRule annotation1
Active sitei390PROSITE-ProRule annotation1
Active sitei452PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:SMAC_05571
OrganismiSordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
Taxonomic identifieri771870 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeSordaria
Proteomesi
  • UP000001881 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 524LumenalSequence analysisAdd BLAST495
Transmembranei525 – 545HelicalSequence analysisAdd BLAST21
Topological domaini546 – 654CytoplasmicSequence analysisAdd BLAST109

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000041194630 – 654Pheromone-processing carboxypeptidase KEX1Add BLAST625

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi345N-linked (GlcNAc...)Sequence analysis1
Glycosylationi441N-linked (GlcNAc...)Sequence analysis1
Glycosylationi449N-linked (GlcNAc...)Sequence analysis1
Glycosylationi502N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi771870.XP_003349288.1.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi645 – 648Poly-Ser4

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
InParanoidiD1ZEM2.
OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D1ZEM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATTNAGRS MASWRRLPTL IAAFTLSWAS SFVAAAGSAD YFVHDLPGAP
60 70 80 90 100
DGPLVKMHAG HIEVNPENNG NLFFWHFQNK HIANKQRTVI WLNGGPGCSS
110 120 130 140 150
EDGALMEIGP YRLKDENTLV YNDGAWNEFA NVLFVDNPVG TGFSYVDTNA
160 170 180 190 200
YIHELTEMAS NFITFLERWF ALFPEYEHDD LYIAGESYAG QYIPYIAQAI
210 220 230 240 250
IERNKNAGPV NHKWNLAGLL IGNGWISPKE QYEAYLQFAY EKGIVKKGTD
260 270 280 290 300
LATRLENPTA LCQLKITESP DKIDYTECEE ILQDMLQQTA GGVGASGKPQ
310 320 330 340 350
CYNMYDVRLK DDYPSCGMAW PPDLKSVTPY LRKKEVIKAL NINENKSTGW
360 370 380 390 400
TECNGQVGLN FHPKTKPSIT LLPDILSSGV PILLFSGAED LICNHLGTEA
410 420 430 440 450
LISNMEWNGG KGFELTPGTW ATRRDWTFEG EPAGFWQQAR NLTYVLFYNS
460 470 480 490 500
SHMAPFDYPR RTRDMLDRFM GVDISSIGGQ PTDSRLDGEK LPETTVGGAA
510 520 530 540 550
GNSTSNQAAE KAKLEMAKWE AYRKSGELVL VIVIVAAAIW GWFVWKDRRK
560 570 580 590 600
TAGQGYMGVA TGERHSISTN PSGSRQGNVS GRTRGQGLEG FRNKRSGRRD
610 620 630 640 650
VEAQDFDESE LDDLHLSKPE DPHADSRYSI GDASDDEDGQ KPEKSSSSGQ

AGRS
Length:654
Mass (Da):72,418
Last modified:January 25, 2012 - v2
Checksum:iBDC128358A4D8EB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABT02000026 Genomic DNA. Translation: CCC12394.1.

Genome annotation databases

EnsemblFungiiCCC12394; CCC12394; SMAC_05571.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABT02000026 Genomic DNA. Translation: CCC12394.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi771870.XP_003349288.1.

Protein family/group databases

MEROPSiS10.007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCCC12394; CCC12394; SMAC_05571.

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
InParanoidiD1ZEM2.
OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKEX1_SORMK
AccessioniPrimary (citable) accession number: D1ZEM2
Secondary accession number(s): F7W440
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: January 25, 2012
Last modified: November 30, 2016
This is version 34 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.