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D1ZEM2 (KEX1_SORMK) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
ORF Names:SMAC_05571
OrganismSordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell) [Complete proteome]
Taxonomic identifier771870 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeSordaria

Protein attributes

Sequence length654 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 654625Pheromone-processing carboxypeptidase KEX1
PRO_0000411946

Regions

Topological domain30 – 524495Lumenal Potential
Transmembrane525 – 54521Helical; Potential
Topological domain546 – 654109Cytoplasmic Potential
Compositional bias645 – 6484Poly-Ser

Sites

Active site1871 By similarity
Active site3901 By similarity
Active site4521 By similarity

Amino acid modifications

Glycosylation3451N-linked (GlcNAc...) Potential
Glycosylation4411N-linked (GlcNAc...) Potential
Glycosylation4491N-linked (GlcNAc...) Potential
Glycosylation5021N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
D1ZEM2 [UniParc].

Last modified January 25, 2012. Version 2.
Checksum: BDC128358A4D8EB2

FASTA65472,418
        10         20         30         40         50         60 
MAATTNAGRS MASWRRLPTL IAAFTLSWAS SFVAAAGSAD YFVHDLPGAP DGPLVKMHAG 

        70         80         90        100        110        120 
HIEVNPENNG NLFFWHFQNK HIANKQRTVI WLNGGPGCSS EDGALMEIGP YRLKDENTLV 

       130        140        150        160        170        180 
YNDGAWNEFA NVLFVDNPVG TGFSYVDTNA YIHELTEMAS NFITFLERWF ALFPEYEHDD 

       190        200        210        220        230        240 
LYIAGESYAG QYIPYIAQAI IERNKNAGPV NHKWNLAGLL IGNGWISPKE QYEAYLQFAY 

       250        260        270        280        290        300 
EKGIVKKGTD LATRLENPTA LCQLKITESP DKIDYTECEE ILQDMLQQTA GGVGASGKPQ 

       310        320        330        340        350        360 
CYNMYDVRLK DDYPSCGMAW PPDLKSVTPY LRKKEVIKAL NINENKSTGW TECNGQVGLN 

       370        380        390        400        410        420 
FHPKTKPSIT LLPDILSSGV PILLFSGAED LICNHLGTEA LISNMEWNGG KGFELTPGTW 

       430        440        450        460        470        480 
ATRRDWTFEG EPAGFWQQAR NLTYVLFYNS SHMAPFDYPR RTRDMLDRFM GVDISSIGGQ 

       490        500        510        520        530        540 
PTDSRLDGEK LPETTVGGAA GNSTSNQAAE KAKLEMAKWE AYRKSGELVL VIVIVAAAIW 

       550        560        570        580        590        600 
GWFVWKDRRK TAGQGYMGVA TGERHSISTN PSGSRQGNVS GRTRGQGLEG FRNKRSGRRD 

       610        620        630        640        650 
VEAQDFDESE LDDLHLSKPE DPHADSRYSI GDASDDEDGQ KPEKSSSSGQ AGRS 

« Hide

References

[1]"De novo assembly of a 40 Mb eukaryotic genome from short sequence reads: Sordaria macrospora, a model organism for fungal morphogenesis."
Nowrousian M., Stajich J.E., Chu M., Engh I., Espagne E., Halliday K., Kamerewerd J., Kempken F., Knab B., Kuo H.-C., Osiewacz H.D., Poeggeler S., Read N.D., Seiler S., Smith K.M., Zickler D., Kueck U., Freitag M.
PLoS Genet. 6:E1000891-E1000891(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-333 / DSM 997 / K(L3346) / K-hell.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CABT02000026 Genomic DNA. Translation: CCC12394.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

OrthoDBEOG7TJ3SJ.

Family and domain databases

InterProIPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_SORMK
AccessionPrimary (citable) accession number: D1ZEM2
Secondary accession number(s): F7W440
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: January 25, 2012
Last modified: February 19, 2014
This is version 22 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries