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Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei768Charge relay systemPROSITE-ProRule annotation1
Active sitei845Charge relay systemPROSITE-ProRule annotation1
Active sitei878Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

ESTHERineucr-q7shu8 DPP4N_Peptidase_S9

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:SMAC_05958
OrganismiSordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
Taxonomic identifieri771870 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeSordaria
Proteomesi
  • UP000001881 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:SMAC_05958

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 111CytoplasmicSequence analysisAdd BLAST111
Transmembranei112 – 132Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini133 – 924VacuolarSequence analysisAdd BLAST792

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004121631 – 924Probable dipeptidyl-aminopeptidase BAdd BLAST924

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi231N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi364N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi827N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiD1Z9B4

Interactioni

Protein-protein interaction databases

STRINGi771870.XP_003351079.1

Structurei

3D structure databases

ProteinModelPortaliD1Z9B4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2100 Eukaryota
COG1506 LUCA
InParanoidiD1Z9B4
KOiK01282
OrthoDBiEOG092C0PZJ

Family and domain databases

Gene3Di2.140.10.30, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002471 Pept_S9_AS
IPR001375 Peptidase_S9
IPR002469 Peptidase_S9B_N
IPR038554 Peptidase_S9B_N_sf
PfamiView protein in Pfam
PF00930 DPPIV_N, 1 hit
PF00326 Peptidase_S9, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00708 PRO_ENDOPEP_SER, 1 hit

Sequencei

Sequence statusi: Complete.

D1Z9B4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPFTYSDDT LRSGRDRFRD HSPSQHRRSM SQETDSSAST TSIVFDRIQE
60 70 80 90 100
RLDTKEFTPR GTDGDDDGSL KDELNNDDLE TGPFLGNADS SSRSDQRSPG
110 120 130 140 150
DGQRMDRSLR RWLFIVSGVL VATWVIGLFV FVSSKAYKPS SSFAHDPQAT
160 170 180 190 200
VTHGTGKKVT LDQVLNNQWR AKSHSISWIA GANGEDGLLL EKEGVGKDYL
210 220 230 240 250
VVEDVRAQNP SSVQASKSKA LIKEKLFEFA NKTYWPSITV PSRDLKKVLL
260 270 280 290 300
ATDVKNNWRH SYYAVYWIFD VETQQVEPLV PYDVEARLQL ASWSPTSDAI
310 320 330 340 350
VYTRDNNMFL RKLGSDKIVQ ITRDGSADVF NGVPDWVYEE EVLASGVATW
360 370 380 390 400
WSEDGQYVAF LRTNETGVPE YPIQYFVSRP SGEEPKPGEE NYPEVRQIKY
410 420 430 440 450
PKAGAHNPIV DLKFYDVKRG DVFSVDISGR FADDDRLITE VVWAGKQVLI
460 470 480 490 500
KETNRVSDVM RVVLVDVGSR TGKAVRTVDV NAIDGGWFEI SHKTKFIPAD
510 520 530 540 550
PVNGRPDDGY VDTIIHDNGD HLAYFTPLDN PEPIMLTSGD YEVVDAPSAV
560 570 580 590 600
DLQRNLVYFV STKESSIQRH VYQVKLTGED MTPVTDTSKE GYYAISFSTG
610 620 630 640 650
AGYAMVSYQG PDIPWQKVIS TPSNPDKYEY VVEENKDLAE AAKKHELPIN
660 670 680 690 700
IYGTINVDGV DLNYVERRPP HFDKNKKYPV LFQQYSGPVS QTVKKTFAVD
710 720 730 740 750
FQSFVAAGLG YICVTVDGRG TGFIGRKNRV IIRGDLGHWE SHDQIAAAKH
760 770 780 790 800
WAQKDYIDED RLAIWGWSYG GYMTLKTLEQ DAGQTFKYGM AVAPVTDWRF
810 820 830 840 850
YDSIYTERYM RTPQTNLEGY DSAAVTNATA LSQNVRFLLM HGVADDNVHM
860 870 880 890 900
QNSLTLLDAL DQRSVENYDV HVFPDSDHGI YFHNANRIVF DKLTNWLVNA
910 920
FNGEWLKIAN AQPNGMKKRA APTA
Length:924
Mass (Da):104,058
Last modified:February 9, 2010 - v1
Checksum:i70999F5B74E9B34C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABT02000006 Genomic DNA Translation: CCC08602.1
RefSeqiXP_003351079.1, XM_003351031.1

Genome annotation databases

EnsemblFungiiCCC08602; CCC08602; SMAC_05958
GeneIDi10808655
KEGGismp:SMAC_05958

Similar proteinsi

Entry informationi

Entry nameiDAPB_SORMK
AccessioniPrimary (citable) accession number: D1Z9B4
Secondary accession number(s): F7VTE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: February 9, 2010
Last modified: May 23, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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