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D1Z9B4

- DAPB_SORMK

UniProt

D1Z9B4 - DAPB_SORMK

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Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei768 – 7681Charge relay systemPROSITE-ProRule annotation
Active sitei845 – 8451Charge relay systemPROSITE-ProRule annotation
Active sitei878 – 8781Charge relay systemPROSITE-ProRule annotation

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:SMAC_05958
OrganismiSordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
Taxonomic identifieri771870 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeSordaria
ProteomesiUP000001881: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 111111CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei112 – 13221Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini133 – 924792VacuolarSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuole Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 924924Probable dipeptidyl-aminopeptidase BPRO_0000412163Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi364 – 3641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi827 – 8271N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliD1Z9B4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiD1Z9B4.
KOiK01282.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D1Z9B4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPPFTYSDDT LRSGRDRFRD HSPSQHRRSM SQETDSSAST TSIVFDRIQE
60 70 80 90 100
RLDTKEFTPR GTDGDDDGSL KDELNNDDLE TGPFLGNADS SSRSDQRSPG
110 120 130 140 150
DGQRMDRSLR RWLFIVSGVL VATWVIGLFV FVSSKAYKPS SSFAHDPQAT
160 170 180 190 200
VTHGTGKKVT LDQVLNNQWR AKSHSISWIA GANGEDGLLL EKEGVGKDYL
210 220 230 240 250
VVEDVRAQNP SSVQASKSKA LIKEKLFEFA NKTYWPSITV PSRDLKKVLL
260 270 280 290 300
ATDVKNNWRH SYYAVYWIFD VETQQVEPLV PYDVEARLQL ASWSPTSDAI
310 320 330 340 350
VYTRDNNMFL RKLGSDKIVQ ITRDGSADVF NGVPDWVYEE EVLASGVATW
360 370 380 390 400
WSEDGQYVAF LRTNETGVPE YPIQYFVSRP SGEEPKPGEE NYPEVRQIKY
410 420 430 440 450
PKAGAHNPIV DLKFYDVKRG DVFSVDISGR FADDDRLITE VVWAGKQVLI
460 470 480 490 500
KETNRVSDVM RVVLVDVGSR TGKAVRTVDV NAIDGGWFEI SHKTKFIPAD
510 520 530 540 550
PVNGRPDDGY VDTIIHDNGD HLAYFTPLDN PEPIMLTSGD YEVVDAPSAV
560 570 580 590 600
DLQRNLVYFV STKESSIQRH VYQVKLTGED MTPVTDTSKE GYYAISFSTG
610 620 630 640 650
AGYAMVSYQG PDIPWQKVIS TPSNPDKYEY VVEENKDLAE AAKKHELPIN
660 670 680 690 700
IYGTINVDGV DLNYVERRPP HFDKNKKYPV LFQQYSGPVS QTVKKTFAVD
710 720 730 740 750
FQSFVAAGLG YICVTVDGRG TGFIGRKNRV IIRGDLGHWE SHDQIAAAKH
760 770 780 790 800
WAQKDYIDED RLAIWGWSYG GYMTLKTLEQ DAGQTFKYGM AVAPVTDWRF
810 820 830 840 850
YDSIYTERYM RTPQTNLEGY DSAAVTNATA LSQNVRFLLM HGVADDNVHM
860 870 880 890 900
QNSLTLLDAL DQRSVENYDV HVFPDSDHGI YFHNANRIVF DKLTNWLVNA
910 920
FNGEWLKIAN AQPNGMKKRA APTA
Length:924
Mass (Da):104,058
Last modified:February 9, 2010 - v1
Checksum:i70999F5B74E9B34C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABT02000006 Genomic DNA. Translation: CCC08602.1.
RefSeqiXP_003351079.1. XM_003351031.1.

Genome annotation databases

GeneIDi10808655.
KEGGismp:SMAC_05958.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABT02000006 Genomic DNA. Translation: CCC08602.1 .
RefSeqi XP_003351079.1. XM_003351031.1.

3D structure databases

ProteinModelPortali D1Z9B4.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 10808655.
KEGGi smp:SMAC_05958.

Phylogenomic databases

InParanoidi D1Z9B4.
KOi K01282.
OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "De novo assembly of a 40 Mb eukaryotic genome from short sequence reads: Sordaria macrospora, a model organism for fungal morphogenesis."
    Nowrousian M., Stajich J.E., Chu M., Engh I., Espagne E., Halliday K., Kamerewerd J., Kempken F., Knab B., Kuo H.-C., Osiewacz H.D., Poeggeler S., Read N.D., Seiler S., Smith K.M., Zickler D., Kueck U., Freitag M.
    PLoS Genet. 6:E1000891-E1000891(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-333 / DSM 997 / K(L3346) / K-hell.

Entry informationi

Entry nameiDAPB_SORMK
AccessioniPrimary (citable) accession number: D1Z9B4
Secondary accession number(s): F7VTE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: February 9, 2010
Last modified: October 29, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3