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D1Z9B4 (DAPB_SORMK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl-aminopeptidase B

Short name=DPAP B
EC=3.4.14.5
Gene names
Name:DAPB
ORF Names:SMAC_05958
OrganismSordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell) [Complete proteome]
Taxonomic identifier771870 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeSordaria

Protein attributes

Sequence length924 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 924924Probable dipeptidyl-aminopeptidase B
PRO_0000412163

Regions

Topological domain1 – 111111Cytoplasmic Potential
Transmembrane112 – 13221Helical; Signal-anchor for type II membrane protein; Potential
Topological domain133 – 924792Vacuolar Potential

Sites

Active site7681Charge relay system By similarity
Active site8451Charge relay system By similarity
Active site8781Charge relay system By similarity

Amino acid modifications

Glycosylation2311N-linked (GlcNAc...) Potential
Glycosylation3641N-linked (GlcNAc...) Potential
Glycosylation8271N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
D1Z9B4 [UniParc].

Last modified February 9, 2010. Version 1.
Checksum: 70999F5B74E9B34C

FASTA924104,058
        10         20         30         40         50         60 
MPPFTYSDDT LRSGRDRFRD HSPSQHRRSM SQETDSSAST TSIVFDRIQE RLDTKEFTPR 

        70         80         90        100        110        120 
GTDGDDDGSL KDELNNDDLE TGPFLGNADS SSRSDQRSPG DGQRMDRSLR RWLFIVSGVL 

       130        140        150        160        170        180 
VATWVIGLFV FVSSKAYKPS SSFAHDPQAT VTHGTGKKVT LDQVLNNQWR AKSHSISWIA 

       190        200        210        220        230        240 
GANGEDGLLL EKEGVGKDYL VVEDVRAQNP SSVQASKSKA LIKEKLFEFA NKTYWPSITV 

       250        260        270        280        290        300 
PSRDLKKVLL ATDVKNNWRH SYYAVYWIFD VETQQVEPLV PYDVEARLQL ASWSPTSDAI 

       310        320        330        340        350        360 
VYTRDNNMFL RKLGSDKIVQ ITRDGSADVF NGVPDWVYEE EVLASGVATW WSEDGQYVAF 

       370        380        390        400        410        420 
LRTNETGVPE YPIQYFVSRP SGEEPKPGEE NYPEVRQIKY PKAGAHNPIV DLKFYDVKRG 

       430        440        450        460        470        480 
DVFSVDISGR FADDDRLITE VVWAGKQVLI KETNRVSDVM RVVLVDVGSR TGKAVRTVDV 

       490        500        510        520        530        540 
NAIDGGWFEI SHKTKFIPAD PVNGRPDDGY VDTIIHDNGD HLAYFTPLDN PEPIMLTSGD 

       550        560        570        580        590        600 
YEVVDAPSAV DLQRNLVYFV STKESSIQRH VYQVKLTGED MTPVTDTSKE GYYAISFSTG 

       610        620        630        640        650        660 
AGYAMVSYQG PDIPWQKVIS TPSNPDKYEY VVEENKDLAE AAKKHELPIN IYGTINVDGV 

       670        680        690        700        710        720 
DLNYVERRPP HFDKNKKYPV LFQQYSGPVS QTVKKTFAVD FQSFVAAGLG YICVTVDGRG 

       730        740        750        760        770        780 
TGFIGRKNRV IIRGDLGHWE SHDQIAAAKH WAQKDYIDED RLAIWGWSYG GYMTLKTLEQ 

       790        800        810        820        830        840 
DAGQTFKYGM AVAPVTDWRF YDSIYTERYM RTPQTNLEGY DSAAVTNATA LSQNVRFLLM 

       850        860        870        880        890        900 
HGVADDNVHM QNSLTLLDAL DQRSVENYDV HVFPDSDHGI YFHNANRIVF DKLTNWLVNA 

       910        920 
FNGEWLKIAN AQPNGMKKRA APTA 

« Hide

References

[1]"De novo assembly of a 40 Mb eukaryotic genome from short sequence reads: Sordaria macrospora, a model organism for fungal morphogenesis."
Nowrousian M., Stajich J.E., Chu M., Engh I., Espagne E., Halliday K., Kamerewerd J., Kempken F., Knab B., Kuo H.-C., Osiewacz H.D., Poeggeler S., Read N.D., Seiler S., Smith K.M., Zickler D., Kueck U., Freitag M.
PLoS Genet. 6:E1000891-E1000891(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-333 / DSM 997 / K(L3346) / K-hell.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CABT02000006 Genomic DNA. Translation: CCC08602.1.
RefSeqXP_003351079.1. XM_003351031.1.

3D structure databases

ProteinModelPortalD1Z9B4.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID10808655.
KEGGsmp:SMAC_05958.

Phylogenomic databases

KOK01282.
OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
InterProIPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
PROSITEPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPB_SORMK
AccessionPrimary (citable) accession number: D1Z9B4
Secondary accession number(s): F7VTE6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: February 9, 2010
Last modified: April 16, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries