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D1Z9B4

- DAPB_SORMK

UniProt

D1Z9B4 - DAPB_SORMK

Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (09 Feb 2010)
      Previous versions | rss
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    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei768 – 7681Charge relay systemPROSITE-ProRule annotation
    Active sitei845 – 8451Charge relay systemPROSITE-ProRule annotation
    Active sitei878 – 8781Charge relay systemPROSITE-ProRule annotation

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:DAPB
    ORF Names:SMAC_05958
    OrganismiSordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
    Taxonomic identifieri771870 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeSordaria
    ProteomesiUP000001881: Unassembled WGS sequence

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 924924Probable dipeptidyl-aminopeptidase BPRO_0000412163Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi364 – 3641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi827 – 8271N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliD1Z9B4.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 111111CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini133 – 924792VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei112 – 13221Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK01282.
    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR002471. Pept_S9_AS.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D1Z9B4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPFTYSDDT LRSGRDRFRD HSPSQHRRSM SQETDSSAST TSIVFDRIQE    50
    RLDTKEFTPR GTDGDDDGSL KDELNNDDLE TGPFLGNADS SSRSDQRSPG 100
    DGQRMDRSLR RWLFIVSGVL VATWVIGLFV FVSSKAYKPS SSFAHDPQAT 150
    VTHGTGKKVT LDQVLNNQWR AKSHSISWIA GANGEDGLLL EKEGVGKDYL 200
    VVEDVRAQNP SSVQASKSKA LIKEKLFEFA NKTYWPSITV PSRDLKKVLL 250
    ATDVKNNWRH SYYAVYWIFD VETQQVEPLV PYDVEARLQL ASWSPTSDAI 300
    VYTRDNNMFL RKLGSDKIVQ ITRDGSADVF NGVPDWVYEE EVLASGVATW 350
    WSEDGQYVAF LRTNETGVPE YPIQYFVSRP SGEEPKPGEE NYPEVRQIKY 400
    PKAGAHNPIV DLKFYDVKRG DVFSVDISGR FADDDRLITE VVWAGKQVLI 450
    KETNRVSDVM RVVLVDVGSR TGKAVRTVDV NAIDGGWFEI SHKTKFIPAD 500
    PVNGRPDDGY VDTIIHDNGD HLAYFTPLDN PEPIMLTSGD YEVVDAPSAV 550
    DLQRNLVYFV STKESSIQRH VYQVKLTGED MTPVTDTSKE GYYAISFSTG 600
    AGYAMVSYQG PDIPWQKVIS TPSNPDKYEY VVEENKDLAE AAKKHELPIN 650
    IYGTINVDGV DLNYVERRPP HFDKNKKYPV LFQQYSGPVS QTVKKTFAVD 700
    FQSFVAAGLG YICVTVDGRG TGFIGRKNRV IIRGDLGHWE SHDQIAAAKH 750
    WAQKDYIDED RLAIWGWSYG GYMTLKTLEQ DAGQTFKYGM AVAPVTDWRF 800
    YDSIYTERYM RTPQTNLEGY DSAAVTNATA LSQNVRFLLM HGVADDNVHM 850
    QNSLTLLDAL DQRSVENYDV HVFPDSDHGI YFHNANRIVF DKLTNWLVNA 900
    FNGEWLKIAN AQPNGMKKRA APTA 924
    Length:924
    Mass (Da):104,058
    Last modified:February 9, 2010 - v1
    Checksum:i70999F5B74E9B34C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CABT02000006 Genomic DNA. Translation: CCC08602.1.
    RefSeqiXP_003351079.1. XM_003351031.1.

    Genome annotation databases

    GeneIDi10808655.
    KEGGismp:SMAC_05958.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CABT02000006 Genomic DNA. Translation: CCC08602.1 .
    RefSeqi XP_003351079.1. XM_003351031.1.

    3D structure databases

    ProteinModelPortali D1Z9B4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 10808655.
    KEGGi smp:SMAC_05958.

    Phylogenomic databases

    KOi K01282.
    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR002471. Pept_S9_AS.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "De novo assembly of a 40 Mb eukaryotic genome from short sequence reads: Sordaria macrospora, a model organism for fungal morphogenesis."
      Nowrousian M., Stajich J.E., Chu M., Engh I., Espagne E., Halliday K., Kamerewerd J., Kempken F., Knab B., Kuo H.-C., Osiewacz H.D., Poeggeler S., Read N.D., Seiler S., Smith K.M., Zickler D., Kueck U., Freitag M.
      PLoS Genet. 6:E1000891-E1000891(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-333 / DSM 997 / K(L3346) / K-hell.

    Entry informationi

    Entry nameiDAPB_SORMK
    AccessioniPrimary (citable) accession number: D1Z9B4
    Secondary accession number(s): F7VTE6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: February 9, 2010
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3