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Protein

Bifunctional lycopene cyclase/phytoene synthase

Gene

putative al2

Organism
Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase).By similarity

Catalytic activityi

Carotenoid psi-end group = carotenoid beta-end group.
2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathway: beta-carotene biosynthesis

This protein is involved in the pathway beta-carotene biosynthesis, which is part of Carotenoid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway beta-carotene biosynthesis and in Carotenoid biosynthesis.

Pathway: phytoene biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes all-trans-phytoene from geranylgeranyl diphosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional lycopene cyclase/phytoene synthase (putative al2)
This subpathway is part of the pathway phytoene biosynthesis, which is itself part of Carotenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes all-trans-phytoene from geranylgeranyl diphosphate, the pathway phytoene biosynthesis and in Carotenoid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Transferase

Keywords - Biological processi

Carotenoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00799; UER00773.
UPA00802.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional lycopene cyclase/phytoene synthase
Including the following 2 domains:
Lycopene beta-cyclase (EC:5.5.1.19)
Alternative name(s):
Lycopene cyclase
Phytoene synthase (EC:2.5.1.32)
Gene namesi
Name:putative al2
ORF Names:SMAC_01277
OrganismiSordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
Taxonomic identifieri771870 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeSordaria
ProteomesiUP000001881 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:SMAC_01277.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalSequence AnalysisAdd
BLAST
Transmembranei30 – 5021HelicalSequence AnalysisAdd
BLAST
Transmembranei76 – 9621HelicalSequence AnalysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence AnalysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence AnalysisAdd
BLAST
Transmembranei168 – 18821HelicalSequence AnalysisAdd
BLAST
Transmembranei230 – 25021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 602602Bifunctional lycopene cyclase/phytoene synthasePRO_0000409243Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi771870.XP_003352443.1.

Structurei

3D structure databases

ProteinModelPortaliD1Z4K7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 241241Lycopene beta-cyclaseAdd
BLAST
Regioni248 – 602355Phytoene synthaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the lycopene beta-cyclase family.Curated
In the C-terminal section; belongs to the phytoene/squalene synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiD1Z4K7.
KOiK17841.
OrthoDBiEOG7RBZJ2.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR008949. Isoprenoid_synthase_dom.
IPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.
PROSITEiPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D1Z4K7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYDYAFVHLK FTIPLAVLLT AIAYPVLNRI HVIQTGCLIF IAFTAALPWD
60 70 80 90 100
AYLIEQKVWS YPPEAIVGPR LLGIPFEELF FFVIQTYITA LVYILFNKPV
110 120 130 140 150
LHALHLNNQR NPPAWMRIAK VTGQLILVAL SVWGWKAAQV NQKTTYLGLI
160 170 180 190 200
LVWACPFLLA IWTLAGRFIL SLPWFVTVLP VVLPTFYLWA VDELALHRGT
210 220 230 240 250
WSIGSGTKLE YCLFGKLDIE EATFFLVTNM LIVSGMAVFD QYLAVIYAFP
260 270 280 290 300
TLFPKVNRYP TPLMLVQSRL VNTTKYDLER IEGLREAVER LRLKSRSFYL
310 320 330 340 350
ANSLFSGRLR IDLILLYSFC RLADDLVDDA KSRLEVLSWT AKLNHFLDQH
360 370 380 390 400
YGDSDATEDP KQKAERIDAY IKEAFPPFAY QALHLLPTHI LPPKPLYELI
410 420 430 440 450
KGFEMDSQFT FHGSSDSTNL KFPIAHDKDL KTYAIRVAGT VGELCIALII
460 470 480 490 500
HHCLPDMSDS QKRRLESAAC RMGIALQYVN IARDILVDAQ IGRVYLPTSW
510 520 530 540 550
LKEEGLTHKA VLDNPEGPEV IEKMRRRLLD NAFELYREAR PEMQQIPSEA
560 570 580 590 600
RGPMIGAVEN YMEIGRVLRE KKVGQVFVRK EGRATVPKQR RLRTLLRALY

EQ
Length:602
Mass (Da):68,953
Last modified:February 9, 2010 - v1
Checksum:iD691CC1ED7B51622
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABT02000004 Genomic DNA. Translation: CCC07710.1.
RefSeqiXP_003352443.1. XM_003352395.1.

Genome annotation databases

GeneIDi10810077.
KEGGismp:SMAC_01277.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABT02000004 Genomic DNA. Translation: CCC07710.1.
RefSeqiXP_003352443.1. XM_003352395.1.

3D structure databases

ProteinModelPortaliD1Z4K7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi771870.XP_003352443.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi10810077.
KEGGismp:SMAC_01277.

Organism-specific databases

EuPathDBiFungiDB:SMAC_01277.

Phylogenomic databases

InParanoidiD1Z4K7.
KOiK17841.
OrthoDBiEOG7RBZJ2.

Enzyme and pathway databases

UniPathwayiUPA00799; UER00773.
UPA00802.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR008949. Isoprenoid_synthase_dom.
IPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.
PROSITEiPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "De novo assembly of a 40 Mb eukaryotic genome from short sequence reads: Sordaria macrospora, a model organism for fungal morphogenesis."
    Nowrousian M., Stajich J.E., Chu M., Engh I., Espagne E., Halliday K., Kamerewerd J., Kempken F., Knab B., Kuo H.-C., Osiewacz H.D., Poeggeler S., Read N.D., Seiler S., Smith K.M., Zickler D., Kueck U., Freitag M.
    PLoS Genet. 6:E1000891-E1000891(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-333 / DSM 997 / K(L3346) / K-hell.

Entry informationi

Entry nameiLCPS_SORMK
AccessioniPrimary (citable) accession number: D1Z4K7
Secondary accession number(s): F7VQC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: February 9, 2010
Last modified: June 24, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.