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D1Z4K7

- LCPS_SORMK

UniProt

D1Z4K7 - LCPS_SORMK

Protein

Bifunctional lycopene cyclase/phytoene synthase

Gene

putative al2

Organism
Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (09 Feb 2010)
      Previous versions | rss
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    Functioni

    Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase).By similarity

    Catalytic activityi

    Carotenoid psi-end group = carotenoid beta-end group.
    2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

    Pathwayi

    GO - Molecular functioni

    1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB-EC
    2. intramolecular lyase activity Source: InterPro

    GO - Biological processi

    1. carotenoid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, Transferase

    Keywords - Biological processi

    Carotenoid biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00799; UER00773.
    UPA00802.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional lycopene cyclase/phytoene synthase
    Including the following 2 domains:
    Lycopene beta-cyclase (EC:5.5.1.19)
    Alternative name(s):
    Lycopene cyclase
    Phytoene synthase (EC:2.5.1.32)
    Gene namesi
    Name:putative al2
    ORF Names:SMAC_01277
    OrganismiSordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
    Taxonomic identifieri771870 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeSordaria
    ProteomesiUP000001881: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 602602Bifunctional lycopene cyclase/phytoene synthasePRO_0000409243Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliD1Z4K7.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei30 – 5021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei76 – 9621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei118 – 13821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei146 – 16621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei168 – 18821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei230 – 25021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 241241Lycopene beta-cyclaseAdd
    BLAST
    Regioni248 – 602355Phytoene synthaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the lycopene beta-cyclase family.Curated
    In the C-terminal section; belongs to the phytoene/squalene synthase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK17841.
    OrthoDBiEOG7RBZJ2.

    Family and domain databases

    Gene3Di1.10.600.10. 1 hit.
    InterProiIPR017825. Lycopene_cyclase_dom.
    IPR002060. Squ/phyt_synthse.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    [Graphical view]
    PfamiPF00494. SQS_PSY. 1 hit.
    [Graphical view]
    SUPFAMiSSF48576. SSF48576. 1 hit.
    TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.
    PROSITEiPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
    PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D1Z4K7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYDYAFVHLK FTIPLAVLLT AIAYPVLNRI HVIQTGCLIF IAFTAALPWD    50
    AYLIEQKVWS YPPEAIVGPR LLGIPFEELF FFVIQTYITA LVYILFNKPV 100
    LHALHLNNQR NPPAWMRIAK VTGQLILVAL SVWGWKAAQV NQKTTYLGLI 150
    LVWACPFLLA IWTLAGRFIL SLPWFVTVLP VVLPTFYLWA VDELALHRGT 200
    WSIGSGTKLE YCLFGKLDIE EATFFLVTNM LIVSGMAVFD QYLAVIYAFP 250
    TLFPKVNRYP TPLMLVQSRL VNTTKYDLER IEGLREAVER LRLKSRSFYL 300
    ANSLFSGRLR IDLILLYSFC RLADDLVDDA KSRLEVLSWT AKLNHFLDQH 350
    YGDSDATEDP KQKAERIDAY IKEAFPPFAY QALHLLPTHI LPPKPLYELI 400
    KGFEMDSQFT FHGSSDSTNL KFPIAHDKDL KTYAIRVAGT VGELCIALII 450
    HHCLPDMSDS QKRRLESAAC RMGIALQYVN IARDILVDAQ IGRVYLPTSW 500
    LKEEGLTHKA VLDNPEGPEV IEKMRRRLLD NAFELYREAR PEMQQIPSEA 550
    RGPMIGAVEN YMEIGRVLRE KKVGQVFVRK EGRATVPKQR RLRTLLRALY 600
    EQ 602
    Length:602
    Mass (Da):68,953
    Last modified:February 9, 2010 - v1
    Checksum:iD691CC1ED7B51622
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CABT02000004 Genomic DNA. Translation: CCC07710.1.
    RefSeqiXP_003352443.1. XM_003352395.1.

    Genome annotation databases

    GeneIDi10810077.
    KEGGismp:SMAC_01277.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CABT02000004 Genomic DNA. Translation: CCC07710.1 .
    RefSeqi XP_003352443.1. XM_003352395.1.

    3D structure databases

    ProteinModelPortali D1Z4K7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 10810077.
    KEGGi smp:SMAC_01277.

    Phylogenomic databases

    KOi K17841.
    OrthoDBi EOG7RBZJ2.

    Enzyme and pathway databases

    UniPathwayi UPA00799 ; UER00773 .
    UPA00802 .

    Family and domain databases

    Gene3Di 1.10.600.10. 1 hit.
    InterProi IPR017825. Lycopene_cyclase_dom.
    IPR002060. Squ/phyt_synthse.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    [Graphical view ]
    Pfami PF00494. SQS_PSY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48576. SSF48576. 1 hit.
    TIGRFAMsi TIGR03462. CarR_dom_SF. 2 hits.
    PROSITEi PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
    PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "De novo assembly of a 40 Mb eukaryotic genome from short sequence reads: Sordaria macrospora, a model organism for fungal morphogenesis."
      Nowrousian M., Stajich J.E., Chu M., Engh I., Espagne E., Halliday K., Kamerewerd J., Kempken F., Knab B., Kuo H.-C., Osiewacz H.D., Poeggeler S., Read N.D., Seiler S., Smith K.M., Zickler D., Kueck U., Freitag M.
      PLoS Genet. 6:E1000891-E1000891(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-333 / DSM 997 / K(L3346) / K-hell.

    Entry informationi

    Entry nameiLCPS_SORMK
    AccessioniPrimary (citable) accession number: D1Z4K7
    Secondary accession number(s): F7VQC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 31, 2011
    Last sequence update: February 9, 2010
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3