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D1Z4K7 (LCPS_SORMK) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional lycopene cyclase/phytoene synthase

Including the following 2 domains:

  1. Lycopene beta-cyclase
    EC=5.5.1.19
    Alternative name(s):
    Lycopene cyclase
  2. Phytoene synthase
    EC=2.5.1.32
Gene names
Name:putative al2
ORF Names:SMAC_01277
OrganismSordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell) [Complete proteome]
Taxonomic identifier771870 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeSordaria

Protein attributes

Sequence length602 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase) By similarity.

Catalytic activity

Carotenoid psi-end group = carotenoid beta-end group.

2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathway

Carotenoid biosynthesis; beta-carotene biosynthesis.

Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

In the N-terminal section; belongs to the lycopene beta-cyclase family.

In the C-terminal section; belongs to the phytoene/squalene synthase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 602602Bifunctional lycopene cyclase/phytoene synthase
PRO_0000409243

Regions

Transmembrane6 – 2621Helical; Potential
Transmembrane30 – 5021Helical; Potential
Transmembrane76 – 9621Helical; Potential
Transmembrane118 – 13821Helical; Potential
Transmembrane146 – 16621Helical; Potential
Transmembrane168 – 18821Helical; Potential
Transmembrane230 – 25021Helical; Potential
Region1 – 241241Lycopene beta-cyclase
Region248 – 602355Phytoene synthase

Sequences

Sequence LengthMass (Da)Tools
D1Z4K7 [UniParc].

Last modified February 9, 2010. Version 1.
Checksum: D691CC1ED7B51622

FASTA60268,953
        10         20         30         40         50         60 
MYDYAFVHLK FTIPLAVLLT AIAYPVLNRI HVIQTGCLIF IAFTAALPWD AYLIEQKVWS 

        70         80         90        100        110        120 
YPPEAIVGPR LLGIPFEELF FFVIQTYITA LVYILFNKPV LHALHLNNQR NPPAWMRIAK 

       130        140        150        160        170        180 
VTGQLILVAL SVWGWKAAQV NQKTTYLGLI LVWACPFLLA IWTLAGRFIL SLPWFVTVLP 

       190        200        210        220        230        240 
VVLPTFYLWA VDELALHRGT WSIGSGTKLE YCLFGKLDIE EATFFLVTNM LIVSGMAVFD 

       250        260        270        280        290        300 
QYLAVIYAFP TLFPKVNRYP TPLMLVQSRL VNTTKYDLER IEGLREAVER LRLKSRSFYL 

       310        320        330        340        350        360 
ANSLFSGRLR IDLILLYSFC RLADDLVDDA KSRLEVLSWT AKLNHFLDQH YGDSDATEDP 

       370        380        390        400        410        420 
KQKAERIDAY IKEAFPPFAY QALHLLPTHI LPPKPLYELI KGFEMDSQFT FHGSSDSTNL 

       430        440        450        460        470        480 
KFPIAHDKDL KTYAIRVAGT VGELCIALII HHCLPDMSDS QKRRLESAAC RMGIALQYVN 

       490        500        510        520        530        540 
IARDILVDAQ IGRVYLPTSW LKEEGLTHKA VLDNPEGPEV IEKMRRRLLD NAFELYREAR 

       550        560        570        580        590        600 
PEMQQIPSEA RGPMIGAVEN YMEIGRVLRE KKVGQVFVRK EGRATVPKQR RLRTLLRALY 


EQ 

« Hide

References

[1]"De novo assembly of a 40 Mb eukaryotic genome from short sequence reads: Sordaria macrospora, a model organism for fungal morphogenesis."
Nowrousian M., Stajich J.E., Chu M., Engh I., Espagne E., Halliday K., Kamerewerd J., Kempken F., Knab B., Kuo H.-C., Osiewacz H.D., Poeggeler S., Read N.D., Seiler S., Smith K.M., Zickler D., Kueck U., Freitag M.
PLoS Genet. 6:E1000891-E1000891(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-333 / DSM 997 / K(L3346) / K-hell.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CABT02000004 Genomic DNA. Translation: CCC07710.1.
RefSeqXP_003352443.1. XM_003352395.1.

3D structure databases

ProteinModelPortalD1Z4K7.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID10810077.
KEGGsmp:SMAC_01277.

Phylogenomic databases

KOK17841.
OrthoDBEOG7RBZJ2.

Enzyme and pathway databases

UniPathwayUPA00799; UER00773.
UPA00802.

Family and domain databases

Gene3D1.10.600.10. 1 hit.
InterProIPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMSSF48576. SSF48576. 1 hit.
TIGRFAMsTIGR03462. CarR_dom_SF. 2 hits.
PROSITEPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLCPS_SORMK
AccessionPrimary (citable) accession number: D1Z4K7
Secondary accession number(s): F7VQC8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: February 9, 2010
Last modified: February 19, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways