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Protein

Bifunctional lycopene cyclase/phytoene synthase

Gene

putative al2

Organism
Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase).By similarity

Catalytic activityi

Carotenoid psi-end group = carotenoid beta-end group.
2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathwayi: beta-carotene biosynthesis

This protein is involved in the pathway beta-carotene biosynthesis, which is part of Carotenoid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway beta-carotene biosynthesis and in Carotenoid biosynthesis.

Pathwayi: phytoene biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes all-trans-phytoene from geranylgeranyl diphosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional lycopene cyclase/phytoene synthase (putative al2)
This subpathway is part of the pathway phytoene biosynthesis, which is itself part of Carotenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes all-trans-phytoene from geranylgeranyl diphosphate, the pathway phytoene biosynthesis and in Carotenoid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Multifunctional enzyme, Transferase
Biological processCarotenoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00799; UER00773
UPA00802

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional lycopene cyclase/phytoene synthase
Including the following 2 domains:
Lycopene beta-cyclase (EC:5.5.1.19)
Alternative name(s):
Lycopene cyclase
Phytoene synthase (EC:2.5.1.32)
Gene namesi
Name:putative al2
ORF Names:SMAC_01277
OrganismiSordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
Taxonomic identifieri771870 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeSordaria
Proteomesi
  • UP000001881 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:SMAC_01277

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004092431 – 602Bifunctional lycopene cyclase/phytoene synthaseAdd BLAST602

Proteomic databases

PRIDEiD1Z4K7

Interactioni

Protein-protein interaction databases

STRINGi771870.XP_003352443.1

Structurei

3D structure databases

ProteinModelPortaliD1Z4K7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 241Lycopene beta-cyclaseAdd BLAST241
Regioni248 – 602Phytoene synthaseAdd BLAST355

Sequence similaritiesi

In the N-terminal section; belongs to the lycopene beta-cyclase family.Curated
In the C-terminal section; belongs to the phytoene/squalene synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFST Eukaryota
COG1562 LUCA
InParanoidiD1Z4K7
KOiK17841
OrthoDBiEOG092C1GQ8

Family and domain databases

CDDicd00683 Trans_IPPS_HH, 1 hit
Gene3Di1.10.600.10, 1 hit
InterProiView protein in InterPro
IPR008949 Isoprenoid_synthase_dom_sf
IPR017825 Lycopene_cyclase_dom
IPR002060 Squ/phyt_synthse
IPR019845 Squalene/phytoene_synthase_CS
IPR033904 Trans_IPPS_HH
PfamiView protein in Pfam
PF00494 SQS_PSY, 1 hit
SUPFAMiSSF48576 SSF48576, 1 hit
TIGRFAMsiTIGR03462 CarR_dom_SF, 2 hits
PROSITEiView protein in PROSITE
PS01044 SQUALEN_PHYTOEN_SYN_1, 1 hit
PS01045 SQUALEN_PHYTOEN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

D1Z4K7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYDYAFVHLK FTIPLAVLLT AIAYPVLNRI HVIQTGCLIF IAFTAALPWD
60 70 80 90 100
AYLIEQKVWS YPPEAIVGPR LLGIPFEELF FFVIQTYITA LVYILFNKPV
110 120 130 140 150
LHALHLNNQR NPPAWMRIAK VTGQLILVAL SVWGWKAAQV NQKTTYLGLI
160 170 180 190 200
LVWACPFLLA IWTLAGRFIL SLPWFVTVLP VVLPTFYLWA VDELALHRGT
210 220 230 240 250
WSIGSGTKLE YCLFGKLDIE EATFFLVTNM LIVSGMAVFD QYLAVIYAFP
260 270 280 290 300
TLFPKVNRYP TPLMLVQSRL VNTTKYDLER IEGLREAVER LRLKSRSFYL
310 320 330 340 350
ANSLFSGRLR IDLILLYSFC RLADDLVDDA KSRLEVLSWT AKLNHFLDQH
360 370 380 390 400
YGDSDATEDP KQKAERIDAY IKEAFPPFAY QALHLLPTHI LPPKPLYELI
410 420 430 440 450
KGFEMDSQFT FHGSSDSTNL KFPIAHDKDL KTYAIRVAGT VGELCIALII
460 470 480 490 500
HHCLPDMSDS QKRRLESAAC RMGIALQYVN IARDILVDAQ IGRVYLPTSW
510 520 530 540 550
LKEEGLTHKA VLDNPEGPEV IEKMRRRLLD NAFELYREAR PEMQQIPSEA
560 570 580 590 600
RGPMIGAVEN YMEIGRVLRE KKVGQVFVRK EGRATVPKQR RLRTLLRALY

EQ
Length:602
Mass (Da):68,953
Last modified:February 9, 2010 - v1
Checksum:iD691CC1ED7B51622
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABT02000004 Genomic DNA Translation: CCC07710.1
RefSeqiXP_003352443.1, XM_003352395.1

Genome annotation databases

EnsemblFungiiCCC07710; CCC07710; SMAC_01277
GeneIDi10810077
KEGGismp:SMAC_01277

Similar proteinsi

Entry informationi

Entry nameiLCPS_SORMK
AccessioniPrimary (citable) accession number: D1Z4K7
Secondary accession number(s): F7VQC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: February 9, 2010
Last modified: May 23, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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