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D1Z2Q4

- D1Z2Q4_METPS

UniProt

D1Z2Q4 - D1Z2Q4_METPS

Protein

Bifunctional enzyme Fae/Hps

Gene

fae

Organism
Methanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 / SANAE)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (09 Feb 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H4MPT) to 5,10-methylenetetrahydromethanopterin.UniRule annotation
    Catalyzes the formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydromethanopterin = tetrahydromethanopterin + formaldehyde.UniRule annotation
    D-arabino-hex-3-ulose 6-phosphate = D-ribulose 5-phosphate + formaldehyde.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei17 – 171Proton donorUniRule annotation
    Binding sitei19 – 191SubstrateUniRule annotation
    Binding sitei48 – 481Substrate; via carbonyl oxygenUniRule annotation
    Binding sitei66 – 661SubstrateUniRule annotation
    Binding sitei68 – 681SubstrateUniRule annotation
    Binding sitei83 – 831SubstrateUniRule annotation

    GO - Molecular functioni

    1. aldehyde-lyase activity Source: UniProtKB-HAMAP
    2. carbon-nitrogen lyase activity Source: UniProtKB-HAMAP
    3. orotidine-5'-phosphate decarboxylase activity Source: InterPro

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. carbohydrate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LyaseUniRule annotation

    Keywords - Biological processi

    Carbohydrate metabolismUniRule annotation

    Enzyme and pathway databases

    BioCyciMPAL304371:GI7G-2965-MONOMER.
    UniPathwayiUPA00293.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional enzyme Fae/HpsUniRule annotation
    Gene namesi
    Name:faeImported
    Synonyms:fae-hpsUniRule annotation, hpsImported
    Ordered Locus Names:MCP_2904Imported
    OrganismiMethanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 / SANAE)Imported
    Taxonomic identifieri304371 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanocellalesMethanocellaceaeMethanocella
    ProteomesiUP000001882: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliD1Z2Q4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 161161Formaldehyde-activating enzymeUniRule annotationAdd
    BLAST
    Regioni162 – 3962353-hexulose-6-phosphate synthaseUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.UniRule annotation
    In the N-terminal section; belongs to the formaldehyde-activating enzyme family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000286408.
    KOiK13812.
    OMAiYNYGATK.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    3.30.230.60. 1 hit.
    HAMAPiMF_01268. Fae_Hps.
    InterProiIPR013785. Aldolase_TIM.
    IPR020868. Bifunctional_enzyme_fae/hps.
    IPR014826. HCHO-activating_enzyme.
    IPR001754. OMPdeCOase_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF08714. Fae. 1 hit.
    PF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    SSF54211. SSF54211. 1 hit.
    TIGRFAMsiTIGR03126. one_C_fae. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D1Z2Q4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYLVGEALIG EGNEVAHIDL LVGDKAGPVG MAFANGMTNM SAGHTPLLAV    50
    VRPNLIPKPA TLIVPKVTVK NLEQAAQIFG PAQAAVAKAV ADAVEEGIIP 100
    KDQVESIVII VSVFVHPAAK DYTRIYKYNY GATRLALVRA MESFPPVDKV 150
    TFEKDRGTHA IMGYKIMRLW DPPYLQIAID APDLGVVERV LMQAPKNDHI 200
    IIEAGTPLIK RYGLEVISKI RAIKKDAFIV ADLKTLDTGN LEARMAADAT 250
    ADAVVCSGLA PLETIEKFCE EARKVGIYSI IDMLNVDNPA KVVEALKHKP 300
    DIVELHRGID TEGQKAEHAW GNIAGIKKAA GGKKLLVAVA GGVKVENVEV 350
    AMKGGADILV VGRAITNAKD IEGATRAFLR AMHKDEIDQY RIMTDF 396
    Length:396
    Mass (Da):42,680
    Last modified:February 9, 2010 - v1
    Checksum:i956B14C37D4C77E4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011532 Genomic DNA. Translation: BAI62976.1.
    RefSeqiYP_003357959.1. NC_013665.1.

    Genome annotation databases

    EnsemblBacteriaiBAI62976; BAI62976; MCP_2904.
    GeneIDi8682577.
    KEGGimpd:MCP_2904.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011532 Genomic DNA. Translation: BAI62976.1 .
    RefSeqi YP_003357959.1. NC_013665.1.

    3D structure databases

    ProteinModelPortali D1Z2Q4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAI62976 ; BAI62976 ; MCP_2904 .
    GeneIDi 8682577.
    KEGGi mpd:MCP_2904.

    Phylogenomic databases

    HOGENOMi HOG000286408.
    KOi K13812.
    OMAi YNYGATK.

    Enzyme and pathway databases

    UniPathwayi UPA00293 .
    BioCyci MPAL304371:GI7G-2965-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    3.30.230.60. 1 hit.
    HAMAPi MF_01268. Fae_Hps.
    InterProi IPR013785. Aldolase_TIM.
    IPR020868. Bifunctional_enzyme_fae/hps.
    IPR014826. HCHO-activating_enzyme.
    IPR001754. OMPdeCOase_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF08714. Fae. 1 hit.
    PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    SSF54211. SSF54211. 1 hit.
    TIGRFAMsi TIGR03126. one_C_fae. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of a mesophilic hydrogenotrophic methanogen Methanocella paludicola, the first cultivated representative of the order Methanocellales."
      Sakai S., Takaki Y., Shimamura S., Sekine M., Tajima T., Kosugi H., Ichikawa N., Tasumi E., Hiraki A.T., Shimizu A., Kato Y., Nishiko R., Mori K., Fujita N., Imachi H., Takai K.
      PLoS ONE 6:E22898-E22898(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17711 / JCM 13418 / NBRC 101707 / SANAEImported.

    Entry informationi

    Entry nameiD1Z2Q4_METPS
    AccessioniPrimary (citable) accession number: D1Z2Q4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 9, 2010
    Last sequence update: February 9, 2010
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzymeUniRule annotation, Reference proteomeImported

    External Data

    Dasty 3