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Protein

Bifunctional enzyme Fae/Hps

Gene

fae

Organism
Methanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 / SANAE)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H4MPT) to 5,10-methylenetetrahydromethanopterin.UniRule annotation
Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.UniRule annotation

Catalytic activityi

5,6,7,8-tetrahydromethanopterin + formaldehyde = 5,10-methylenetetrahydromethanopterin + H2O.UniRule annotation
D-arabino-hex-3-ulose 6-phosphate = D-ribulose 5-phosphate + formaldehyde.UniRule annotation

Pathwayi: D-ribose 5-phosphate biosynthesis

This protein is involved in the pathway D-ribose 5-phosphate biosynthesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway D-ribose 5-phosphate biosynthesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei17Proton donorUniRule annotation1
Binding sitei19SubstrateUniRule annotation1
Binding sitei48Substrate; via carbonyl oxygenUniRule annotation1
Binding sitei66SubstrateUniRule annotation1
Binding sitei68SubstrateUniRule annotation1
Binding sitei83SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolismUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00293.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional enzyme Fae/HpsUniRule annotation
Gene namesi
Name:faeImported
Synonyms:fae-hpsUniRule annotation, hpsImported
Ordered Locus Names:MCP_2904Imported
OrganismiMethanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 / SANAE)Imported
Taxonomic identifieri304371 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanocellalesMethanocellaceaeMethanocella
Proteomesi
  • UP000001882 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi304371.MCP_2904.

Structurei

3D structure databases

ProteinModelPortaliD1Z2Q4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini174 – 378OMPdecaseInterPro annotationAdd BLAST205

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 161Formaldehyde-activating enzymeUniRule annotationAdd BLAST161
Regioni162 – 3963-hexulose-6-phosphate synthaseUniRule annotationAdd BLAST235

Sequence similaritiesi

In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.UniRule annotation
In the N-terminal section; belongs to the formaldehyde-activating enzyme family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00053. Archaea.
arCOG00103. Archaea.
COG0269. LUCA.
COG1795. LUCA.
HOGENOMiHOG000286408.
KOiK13812.
OMAiLWDPPYL.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
3.30.230.60. 1 hit.
HAMAPiMF_01268. Fae_Hps. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR020868. Fae/Hps.
IPR014826. HCHO-activating_enzyme.
IPR001754. OMPdeCOase_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF08714. Fae. 1 hit.
PF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
SSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR03126. one_C_fae. 1 hit.

Sequencei

Sequence statusi: Complete.

D1Z2Q4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLVGEALIG EGNEVAHIDL LVGDKAGPVG MAFANGMTNM SAGHTPLLAV
60 70 80 90 100
VRPNLIPKPA TLIVPKVTVK NLEQAAQIFG PAQAAVAKAV ADAVEEGIIP
110 120 130 140 150
KDQVESIVII VSVFVHPAAK DYTRIYKYNY GATRLALVRA MESFPPVDKV
160 170 180 190 200
TFEKDRGTHA IMGYKIMRLW DPPYLQIAID APDLGVVERV LMQAPKNDHI
210 220 230 240 250
IIEAGTPLIK RYGLEVISKI RAIKKDAFIV ADLKTLDTGN LEARMAADAT
260 270 280 290 300
ADAVVCSGLA PLETIEKFCE EARKVGIYSI IDMLNVDNPA KVVEALKHKP
310 320 330 340 350
DIVELHRGID TEGQKAEHAW GNIAGIKKAA GGKKLLVAVA GGVKVENVEV
360 370 380 390
AMKGGADILV VGRAITNAKD IEGATRAFLR AMHKDEIDQY RIMTDF
Length:396
Mass (Da):42,680
Last modified:February 9, 2010 - v1
Checksum:i956B14C37D4C77E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011532 Genomic DNA. Translation: BAI62976.1.

Genome annotation databases

EnsemblBacteriaiBAI62976; BAI62976; MCP_2904.
KEGGimpd:MCP_2904.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011532 Genomic DNA. Translation: BAI62976.1.

3D structure databases

ProteinModelPortaliD1Z2Q4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi304371.MCP_2904.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAI62976; BAI62976; MCP_2904.
KEGGimpd:MCP_2904.

Phylogenomic databases

eggNOGiarCOG00053. Archaea.
arCOG00103. Archaea.
COG0269. LUCA.
COG1795. LUCA.
HOGENOMiHOG000286408.
KOiK13812.
OMAiLWDPPYL.

Enzyme and pathway databases

UniPathwayiUPA00293.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
3.30.230.60. 1 hit.
HAMAPiMF_01268. Fae_Hps. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR020868. Fae/Hps.
IPR014826. HCHO-activating_enzyme.
IPR001754. OMPdeCOase_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF08714. Fae. 1 hit.
PF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
SSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR03126. one_C_fae. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiD1Z2Q4_METPS
AccessioniPrimary (citable) accession number: D1Z2Q4
Entry historyi
Integrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: November 2, 2016
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzymeUniRule annotation, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.