D1YSF9 (D1YSF9_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Eph receptor tyrosine kinase, isoform F EMBL ACZ95093.1
EC=2.7.10.- EMBL ACZ95093.1
EC=2.7.10.1 EMBL ACZ95093.1

Gene names

Name:	Eph EMBL ACZ95093.1 FlyBase FBgn0025936
ORF Names:	Dmel_CG1511 EMBL ACZ95093.1

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome] EMBL ACZ95093.1

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	1005 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS009030
Sequence similarities	Contains 1 Eph LBD (Eph ligand-binding) domain. SAAS SAAS001090 Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS001090
Ligand	ATP-binding SAAS SAAS001090 Nucleotide-binding
Molecular function	Kinase Receptor SAAS SAAS001090 EMBL ACZ95093.1 Transferase Tyrosine-protein kinase SAAS SAAS009030
PTM	Phosphoprotein SAAS SAAS009030
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	melanotic encapsulation of foreign target Inferred from mutant phenotype PubMed 21947570. Source: FlyBase mushroom body development Inferred from mutant phenotype PubMed 16613832. Source: FlyBase peripheral nervous system development Inferred from mutant phenotype PubMed 22615969. Source: FlyBase
Cellular_component	integral to plasma membrane Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from sequence or structural similarity PubMed 10356296. Source: FlyBase
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ephrin receptor activity Inferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase activity Inferred from sequence or structural similarity PubMed 10356296. Source: FlyBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	D1YSF9 [UniParc]. Last modified February 9, 2010. Version 1. Checksum: 83F633A436873034	FASTA	1,005	112,949
	10 20 30 40 50 60 MTKSALKSAF YKNQAPISEQ NRSQIVSRMS LLRTILLIII SIHFKLAHAD QVVLLDTTRE 70 80 90 100 110 120 ATLEWTRYPY GPQAQTPGWV EESFTDFVKG INWRSYVVCD VAYHNVNNWL WSPFIDRGSA 130 140 150 160 170 180 NRLYIEIQFT IRDCSLFPGN ALSCKETFSL LFYEFDAATR EPPPWQTDSY RLIARIAAGE 190 200 210 220 230 240 GRFNQNSDVD INTEVKSIAV NKKGVYFAFR DQGACISVLA VKVYYITCPA VTENFAHFNE 250 260 270 280 290 300 TPTGREITII EKQNGTCVDN AEPYETPTYL CKGDGKWTIL TGGCRCKAGY EPNYTNKTCT 310 320 330 340 350 360 ECPLGTFKSP EVTKCTPCPP NSNASKTGSP FCKCASGFYR HPNDGRHMPC YSPPAAPTNL 370 380 390 400 410 420 TLLFVDQTSA IISWSAPAKN ESFSSETNSK IYHSDIVYKI KCNICSPNVV YNPSTDTFNE 430 440 450 460 470 480 TKITLTNLEP VTTYTVQIHA INSVSHINEF KRHSNESSLV AVSDIVFSNT SLLNIPLDLN 490 500 510 520 530 540 EVKTGQAEIV FTTESVLLST VFNLRILAIT NKDADLEWDK PVQSDFPLEF YEVRWFPKVE 550 560 570 580 590 600 LDAINKSALN TKETKAHIVG LLENTEYGFQ VRCKTNNGFG SYSNMIYAQT LQSVGSVYDD 610 620 630 640 650 660 SVQIRFIAGA IVTGVLFLVI FIIATVYFMR SKHQDDLDKK STNHLPLPLD YASNEVNSMD 670 680 690 700 710 720 TTPIVKKLHL NVTTPLFGNS RSYVDPHTYE DPNQAIREFA REIDANYITI EAIIGGGEFG 730 740 750 760 770 780 DVCRGRLKIP PNFVQDIDVA IKTLKPGSSE KARCDFLTEA SIMGQFDHPN VIYLQGVVTR 790 800 810 820 830 840 SNPVMIITEY MENGSLDTFL RVNDGKFQTL QLIVMLRGIA SGMSYLSDMN YVHRDLAARN 850 860 870 880 890 900 VLVNAQLICK IADFGLSREI ENASDAYTTR GGKIPVRWTA PEAIAFRKFT SASDVWSYGV 910 920 930 940 950 960 VLWEVMSYGE RPYWNWSNQD VIKSIEKGYR LPAPMDCPEA LYQLMLDCWQ KQRTHRPTFA 970 980 990 1000 SIVSTLDNLA RQPQSLLTTR PSPESDGNHI LDGQRGQNIF ISTDL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014135 Genomic DNA. Translation: ACZ95093.1.
RefSeq	NP_001162824.1. NM_001169353.2.
UniGene	Dm.6630.
3D structure databases
ProteinModelPortal	D1YSF9.
SMR	D1YSF9. Positions 49-445, 497-595, 637-973.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0301285; FBpp0290500; FBgn0025936.
GeneID	43803.
KEGG	dme:Dmel_CG1511.
Organism-specific databases
CTD	43803.
FlyBase	FBgn0025936. Eph.
Phylogenomic databases
GeneTree	ENSGT00700000104300.
KO	K05110.
Gene expression databases
Bgee	D1YSF9.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR001090. Ephrin_rcpt_lig-bd_dom. IPR003961. Fibronectin_type3. IPR008979. Galactose-bd-like. IPR009030. Growth_fac_rcpt. IPR013783. Ig-like_fold. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR016257. Tyr_kinase_ephrin_rcpt. IPR001426. Tyr_kinase_rcpt_V_CS. [Graphical view]
Pfam	PF01404. Ephrin_lbd. 1 hit. PF00041. fn3. 2 hits. PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PIRSF	PIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTS	PR00109. TYRKINASE.
SMART	SM00615. EPH_lbd. 1 hit. SM00060. FN3. 2 hits. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 2 hits. SSF49785. Gal_bind_like. 1 hit. SSF57184. Grow_fac_recept. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS51550. EPH_LBD. 1 hit. PS50853. FN3. 2 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	43803.
NextBio	835935.

Entry information

Entry name

D1YSF9_DROME

Accession

Primary (citable) accession number: D1YSF9

Entry history

Integrated into UniProtKB/TrEMBL:	February 9, 2010
Last sequence update:	February 9, 2010
Last modified:	May 1, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)