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D1YDL7 (D1YDL7_PROAA) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP phosphoribosyltransferase HAMAP-Rule MF_00079
Short name=ATP-PRT HAMAP-Rule MF_00079
Short name=ATP-PRTase HAMAP-Rule MF_00079
EC=2.4.2.17 HAMAP-Rule MF_00079
Gene names
Name:hisG HAMAP-Rule MF_00079 EMBL EFB87526.1
ORF Names:HMPREF9206_0013 EMBL EFB87526.1
OrganismPropionibacterium acnes J139 EMBL EFB87526.1
Taxonomic identifier679194 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Propionibacteriaceae › Propionibacterium ›

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity By similarity. HAMAP-Rule MF_00079

Catalytic activity

1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00079 SAAS SAAS018198

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00079

Enzyme regulation

Feedback inhibited by histidine By similarity. HAMAP-Rule MF_00079

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. HAMAP-Rule MF_00079 SAAS SAAS018198

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00079.

Sequence similarities

Belongs to the ATP phosphoribosyltransferase family. Long subfamily. HAMAP-Rule MF_00079

Sequences

Sequence LengthMass (Da)Tools
D1YDL7 [UniParc].

Last modified February 9, 2010. Version 1.
Checksum: 9FE2A1C27AE641CF

FASTA28430,661
        10         20         30         40         50         60 
MSDLLRIAVP NKGALSEAAS SLLAEAGYRQ RTDHKDLTLV DEENGVEFFY LRPRDIAVYV 

        70         80         90        100        110        120 
GEGTLDIGIT GRDLLLDSNA DATEIKGLGF GHSRFRFAAP KSPQNTIEGL AGKRIATSYP 

       130        140        150        160        170        180 
GLLSAFLTER GIDAHLIHLD GAVESSIRLG VADVIADVVE TGTTLRRAGL EIFGDVILES 

       190        200        210        220        230        240 
EAVLVQRRDF AGSTTFDHFM RRIDGVQVAR TYVMVDYDVP AEALDAATAL TPGLEAPTVS 

       250        260        270        280 
PLSKDGWYAV RAMVPRIVVQ GLMDQLWDAG ARAILSTELS ACRL

« Hide

References

[1]"Genome Sequence of Propionibacterium acnes J139."
Durkin A.S., Madupu R., Torralba M., Methe B., Sutton G., Strausberg R.L., Nelson K.E.
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: J139 EMBL EFB87526.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		ADFS01000003 Genomic DNA. Translation: EFB87526.1.

3D structure databases

ProteinModelPortalD1YDL7.
SMRD1YDL7. Positions 4-284.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEFB87526; EFB87526; HMPREF9206_0013.
PATRIC36448870. VBIProAcn138375_1437.

Enzyme and pathway databases

UniPathwayUPA00031; UER00006.

Family and domain databases

Gene3D3.30.70.120. 1 hit.
HAMAPMF_00079. HisG_Long.
InterProIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view]
PANTHERPTHR21403. PTHR21403. 1 hit.
PfamPF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view]
SUPFAMSSF54913. N-reg_PII-like_a/b. 1 hit.
TIGRFAMsTIGR00070. hisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
PROSITEPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD1YDL7_PROAA
AccessionPrimary (citable) accession number: D1YDL7
Entry history
Integrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: April 3, 2013
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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