Skip Header

Contribute Send feedback
Read comments (?) or add your own

D1R094 (D1R094_STAAU) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--poly(phosphoribitol) ligase subunit 1 HAMAP-Rule MF_00593
EC=6.1.1.13 HAMAP-Rule MF_00593
Alternative name(s):
D-alanine-D-alanyl carrier protein ligase HAMAP-Rule MF_00593
D-alanine-activating enzyme HAMAP-Rule MF_00593
Gene names
Name:dltA HAMAP-Rule MF_00593
ORF Names:SGAG_01310 EMBL EFC03574.1
OrganismStaphylococcus aureus A8117 EMBL EFC03574.1
Taxonomic identifier553574 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus ›

Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp By similarity. HAMAP-Rule MF_00593 SAAS SAAS010071

Catalytic activity

ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate). HAMAP-Rule MF_00593 SAAS SAAS010071

Pathway

Cell wall biogenesis; lipoteichoic acid biosynthesis. HAMAP-Rule MF_00593 SAAS SAAS010071

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00593 SAAS SAAS010071.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily. HAMAP-Rule MF_00593

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. EMBL EFC03574.1

Sequences

Sequence LengthMass (Da)Tools
D1R094 [UniParc].

Last modified February 9, 2010. Version 1.
Checksum: 3E2DB528D8211794

FASTA48554,644
        10         20         30         40         50         60 
MTDIINKLQA FADANPQSIA VRHTTDELTY QQLMDESSKL AHRLQGSKKP MILFGHMSPY 

        70         80         90        100        110        120 
MIVGMIGAIK AGCGYVPVDT SIPEDRIKMI INKVQPEFVF NTTDESFESL EGEVFTIEDI 

       130        140        150        160        170        180 
KTSQDPVIFD SQIKDNDTVY TIFTSGSTGE PKGVQIEYAS LVQFTEWMLE LNKSGNKQQW 

       190        200        210        220        230        240 
LNQAPFSFDL SVMAIYPCLA SGGTLNLVDK NMINKPKLLN EMLTATPINI WVSTPSFMEM 

       250        260        270        280        290        300 
CLLLPTLNEE QYGSLNEFFF CGEILPHRAA KALVSRFPSA TIYNTYGPTE ATVAVTSIQI 

       310        320        330        340        350        360 
TQEILDQYPT LPVGVERLGA RLSTTDDGEL VIEGQSVSLG YLKNDQKTAE VFNFDDGIRT 

       370        380        390        400        410        420 
YHTGDKAKFE NGQWFIQGRI DFQIKLNGYR MELEEIETQL RQSEFVKEAI VVPVYKNDKV 

       430        440        450        460        470        480 
IHLIGAIVPT TEVTDNAEMT KNIKNDLKSR LPEYMIPRKF EWMEQLPLTS NGKIDRKKIA 


EVING

« Hide

References

[1]"The Genome Sequence of Staphylococcus aureus strain A8117."
The Broad Institute Genome Sequencing Platform
Ward D., Peleg A.Y., Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D., Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D. expand/collapse author list , Hepburn T., Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.
Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: A8117 EMBL EFC03574.1.
[2]"Serine/threonine phosphatase Stp1 contributes to reduced susceptibility to vancomycin and virulence in Staphylococcus aureus."
Cameron D.R., Ward D.V., Kostoulias X., Howden B.P., Moellering R.C.Jr., Eliopoulos G.M., Peleg A.Y.
J. Infect. Dis. 205:1677-1687(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: A8117 EMBL EFC03574.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		ACYO01000005 Genomic DNA. Translation: EFC03574.1.

3D structure databases

ProteinModelPortalD1R094.
SMRD1R094. Positions 4-483.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEFC03574; EFC03574; SGAG_01310.
PATRIC35909734. VBIStaAur72157_1294.

Enzyme and pathway databases

UniPathwayUPA00556.

Family and domain databases

HAMAPMF_00593. DltA.
InterProIPR010071. AA_adenyl_domain.
IPR000873. AMP-dep_Synth/Lig.
IPR010072. D_ala_DACP_lig.
IPR025110. DUF4009.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
PF13193. DUF4009. 1 hit.
[Graphical view]
TIGRFAMsTIGR01733. AA-adenyl-dom. 1 hit.
TIGR01734. D-ala-DACP-lig. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD1R094_STAAU
AccessionPrimary (citable) accession number: D1R094
Entry history
Integrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: May 1, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info