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D1J7E5

- D1J7E5_MYCHP

UniProt

D1J7E5 - D1J7E5_MYCHP

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Protein
Ribosomal RNA small subunit methyltransferase A
Gene
rsmA, ksgA, MHO_0080
Organism
Mycoplasma hominis (strain ATCC 23114 / NBRC 14850 / NCTC 10111 / PG21)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits By similarity.UniRule annotationSAAS annotations

Catalytic activityi

4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNA.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111S-adenosyl-L-methionine; via carbonyl oxygen By similarityUniRule annotation
Binding sitei13 – 131S-adenosyl-L-methionine; via amide nitrogen By similarityUniRule annotation
Binding sitei37 – 371S-adenosyl-L-methionine; via carbonyl oxygen By similarityUniRule annotation
Binding sitei58 – 581S-adenosyl-L-methionine By similarityUniRule annotation
Binding sitei82 – 821S-adenosyl-L-methionine By similarityUniRule annotation
Binding sitei99 – 991S-adenosyl-L-methionine By similarityUniRule annotation

GO - Molecular functioni

  1. 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity Source: UniProtKB-EC
  2. RNA binding Source: UniProtKB-KW
  3. rRNA (adenine-N6,N6-)-dimethyltransferase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    MethyltransferaseUniRule annotationSAAS annotations, Transferase

    Keywords - Biological processi

    rRNA processingUniRule annotationSAAS annotations

    Keywords - Ligandi

    RNA-bindingUniRule annotationSAAS annotations, S-adenosyl-L-methionineUniRule annotationSAAS annotations

    Enzyme and pathway databases

    BioCyciMHOM347256:GBZD-8-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal RNA small subunit methyltransferase AUniRule annotation (EC:2.1.1.182UniRule annotation)
    Alternative name(s):
    16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase
    16S rRNA dimethyladenosine transferase
    16S rRNA dimethylase
    S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase
    Gene namesi
    Name:rsmAUniRule annotation
    Synonyms:ksgAUniRule annotationImported
    Ordered Locus Names:MHO_0080Imported
    OrganismiMycoplasma hominis (strain ATCC 23114 / NBRC 14850 / NCTC 10111 / PG21)Imported
    Taxonomic identifieri347256 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000002631: Chromosome

    Subcellular locationi

    Cytoplasm By similarity UniRule annotationSAAS annotations

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotations

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000227962.
    KOiK02528.
    OMAiQPLIEIK.
    OrthoDBiEOG66F08Z.

    Family and domain databases

    Gene3Di1.10.8.100. 1 hit.
    3.40.50.150. 1 hit.
    HAMAPiMF_00607. 16SrRNA_methyltr_A.
    InterProiIPR023165. rRNA_Ade_diMease-like.
    IPR020596. rRNA_Ade_Mease_Trfase_CS.
    IPR001737. rRNA_Ade_methylase_transferase.
    IPR020598. rRNA_Ade_methylase_Trfase_N.
    IPR011530. rRNA_adenine_dimethylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR11727. PTHR11727. 1 hit.
    PfamiPF00398. RrnaAD. 1 hit.
    [Graphical view]
    SMARTiSM00650. rADc. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00755. ksgA. 1 hit.
    PROSITEiPS01131. RRNA_A_DIMETH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D1J7E5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKALKSLGQ NFLSNKNIQK EIVKAANVVG KNIIEIGPGM GAITDQMADV    50
    VNRLVCIEFD KRLYEFLLQK NYSSNVEILN QDFLQTDLLK YTDFEVIGNI 100
    PYNITSDIIF KLLDNAKNIN KITLMVQKEV ADRICCGAGN SQYSKLAASI 150
    QLLYEPKYLF TVKAKEFNPA PKVDSAVIQL NLIKNNDFIW NNQVEILKFI 200
    KQMFQYKRKT LLNNFPSNLK QKISDFLKSN ELDLNIRAEK ITKEISINLF 250
    KFINNKN 257
    Length:257
    Mass (Da):29,513
    Last modified:January 19, 2010 - v1
    Checksum:iBD6EDED4667893CA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FP236530 Genomic DNA. Translation: CAX37142.1.
    RefSeqiWP_012855289.1. NC_013511.1.
    YP_003302545.1. NC_013511.1.

    Genome annotation databases

    EnsemblBacteriaiCAX37142; CAX37142; MHO_0080.
    GeneIDi8595423.
    KEGGimho:MHO_0080.
    PATRICi32273075. VBIMycHom120329_0008.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FP236530 Genomic DNA. Translation: CAX37142.1 .
    RefSeqi WP_012855289.1. NC_013511.1.
    YP_003302545.1. NC_013511.1.

    3D structure databases

    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAX37142 ; CAX37142 ; MHO_0080 .
    GeneIDi 8595423.
    KEGGi mho:MHO_0080.
    PATRICi 32273075. VBIMycHom120329_0008.

    Phylogenomic databases

    HOGENOMi HOG000227962.
    KOi K02528.
    OMAi QPLIEIK.
    OrthoDBi EOG66F08Z.

    Enzyme and pathway databases

    BioCyci MHOM347256:GBZD-8-MONOMER.

    Family and domain databases

    Gene3Di 1.10.8.100. 1 hit.
    3.40.50.150. 1 hit.
    HAMAPi MF_00607. 16SrRNA_methyltr_A.
    InterProi IPR023165. rRNA_Ade_diMease-like.
    IPR020596. rRNA_Ade_Mease_Trfase_CS.
    IPR001737. rRNA_Ade_methylase_transferase.
    IPR020598. rRNA_Ade_methylase_Trfase_N.
    IPR011530. rRNA_adenine_dimethylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR11727. PTHR11727. 1 hit.
    Pfami PF00398. RrnaAD. 1 hit.
    [Graphical view ]
    SMARTi SM00650. rADc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00755. ksgA. 1 hit.
    PROSITEi PS01131. RRNA_A_DIMETH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Life on arginine for Mycoplasma hominis: clues from its minimal genome and comparison with other human urogenital mycoplasmas."
      Pereyre S., Sirand-Pugnet P., Beven L., Charron A., Renaudin H., Barre A., Avenaud P., Jacob D., Couloux A., Barbe V., de Daruvar A., Blanchard A., Bebear C.
      PLoS Genet. 5:E1000677-E1000677(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 23114 / NBRC 14850 / NCTC 10111 / PG21.

    Entry informationi

    Entry nameiD1J7E5_MYCHP
    AccessioniPrimary (citable) accession number: D1J7E5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 19, 2010
    Last sequence update: January 19, 2010
    Last modified: September 3, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    External Data

    Dasty 3

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