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Protein

Ribosomal RNA small subunit methyltransferase A

Gene

rsmA

Organism
Mycoplasma hominis (strain ATCC 23114 / NBRC 14850 / NCTC 10111 / PG21)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.UniRule annotation

Catalytic activityi

4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N6-dimethyladenine(1518)/N6-dimethyladenine(1519) in 16S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei11S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei13S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei37S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei58S-adenosyl-L-methionineUniRule annotation1
Binding sitei82S-adenosyl-L-methionineUniRule annotation1
Binding sitei99S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferaseUniRule annotationSAAS annotation, RNA-bindingUniRule annotationSAAS annotation, Transferase
Biological processrRNA processingUniRule annotationSAAS annotation
LigandS-adenosyl-L-methionineUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMHOM347256:G1GK4-8-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA small subunit methyltransferase AUniRule annotation (EC:2.1.1.182UniRule annotation)
Alternative name(s):
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferaseUniRule annotation
16S rRNA dimethyladenosine transferaseUniRule annotation
16S rRNA dimethylaseUniRule annotation
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferaseUniRule annotation
Gene namesi
Name:rsmAUniRule annotation
Synonyms:ksgAUniRule annotationImported
Ordered Locus Names:MHO_0080Imported
OrganismiMycoplasma hominis (strain ATCC 23114 / NBRC 14850 / NCTC 10111 / PG21)Imported
Taxonomic identifieri347256 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000002631 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi347256.MHO_0080

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 184rADcInterPro annotationAdd BLAST167

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105D1X Bacteria
COG0030 LUCA
HOGENOMiHOG000227962
KOiK02528
OMAiKRFGQHW
OrthoDBiPOG091H02E3

Family and domain databases

Gene3Di1.10.8.100, 1 hit
HAMAPiMF_00607 16SrRNA_methyltr_A, 1 hit
InterProiView protein in InterPro
IPR001737 KsgA/Erm
IPR023165 rRNA_Ade_diMease-like
IPR020596 rRNA_Ade_Mease_Trfase_CS
IPR020598 rRNA_Ade_methylase_Trfase_N
IPR011530 rRNA_adenine_dimethylase
IPR029063 SAM-dependent_MTases
PANTHERiPTHR11727 PTHR11727, 1 hit
PfamiView protein in Pfam
PF00398 RrnaAD, 1 hit
SMARTiView protein in SMART
SM00650 rADc, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00755 ksgA, 1 hit
PROSITEiView protein in PROSITE
PS01131 RRNA_A_DIMETH, 1 hit
PS51689 SAM_RNA_A_N6_MT, 1 hit

Sequencei

Sequence statusi: Complete.

D1J7E5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKALKSLGQ NFLSNKNIQK EIVKAANVVG KNIIEIGPGM GAITDQMADV
60 70 80 90 100
VNRLVCIEFD KRLYEFLLQK NYSSNVEILN QDFLQTDLLK YTDFEVIGNI
110 120 130 140 150
PYNITSDIIF KLLDNAKNIN KITLMVQKEV ADRICCGAGN SQYSKLAASI
160 170 180 190 200
QLLYEPKYLF TVKAKEFNPA PKVDSAVIQL NLIKNNDFIW NNQVEILKFI
210 220 230 240 250
KQMFQYKRKT LLNNFPSNLK QKISDFLKSN ELDLNIRAEK ITKEISINLF

KFINNKN
Length:257
Mass (Da):29,513
Last modified:January 19, 2010 - v1
Checksum:iBD6EDED4667893CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP236530 Genomic DNA Translation: CAX37142.1
RefSeqiWP_012855289.1, NC_013511.1

Genome annotation databases

EnsemblBacteriaiCAX37142; CAX37142; MHO_0080
GeneIDi25040385
KEGGimho:MHO_0080

Similar proteinsi

Entry informationi

Entry nameiD1J7E5_MYCHP
AccessioniPrimary (citable) accession number: D1J7E5
Entry historyiIntegrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: March 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health