D1GSU1 (D1GSU1_STAA0) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Methionyl-tRNA formyltransferase HAMAP-Rule MF_00182
EC=2.1.2.9 HAMAP-Rule MF_00182

Gene names

Name:	fmt HAMAP-Rule MF_00182
Ordered Locus Names:	SATW20_12100 EMBL CBI49089.1

Organism

Staphylococcus aureus (strain TW20 / 0582) [Complete proteome] [HAMAP] EMBL CBI49089.1

Taxonomic identifier

663951 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus subsp. aureus

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP By similarity. HAMAP-Rule MF_00182 SAAS SAAS005794
Catalytic activity	10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet). HAMAP-Rule MF_00182 SAAS SAAS005794
Sequence similarities	Belongs to the fmt family. HAMAP-Rule MF_00182

Ontologies

Keywords
Biological process	Protein biosynthesis HAMAP-Rule MF_00182 SAAS SAAS005794
Molecular function	Methyltransferase HAMAP-Rule MF_00182 SAAS SAAS005794 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	translational initiation Inferred from electronic annotation. Source: GOC
Molecular_function	methionyl-tRNA formyltransferase activity Inferred from electronic annotation. Source: HAMAP methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	109 – 112	4	Tetrahydrofolate (THF) binding By similarity HAMAP-Rule MF_00182

Sequences

	Sequence		Length	Mass (Da)
	D1GSU1 [UniParc]. Last modified January 19, 2010. Version 1. Checksum: FC45A768EA61D5CA	FASTA	311	34,211
	10 20 30 40 50 60 MTKIIFMGTP DFSTTVLEML IAEHDVIAVV TQPDRPVGRK RVMTPPPVKK VAMKYDLPVY 70 80 90 100 110 120 QPEKLSGSEE LEQLLQLDVD LIVTAAFGQL LPESLLALPN LGAINVHASL LPKYRGGAPI 130 140 150 160 170 180 HQAIIDGEQE TGITIMYMVK KLDAGNIISQ QAIKIEENDN VGTMHDKLSV LGADLLKETL 190 200 210 220 230 240 PSIIEGTNES VPQDDTQATF ASNIRREDER ISWNKPGRQV FNQIRGLSPW PVAYTTMDDT 250 260 270 280 290 300 NLKIYDAELV ETNKINEPGT IIETTKKAII VATNDNEAVA IKDMQLAGKK RMLAANYLSG 310 AQNTLVGKKL I

References

[1]

"Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW)." Holden M.T., Lindsay J.A., Corton C., Quail M.A., Cockfield J.D., Pathak S., Batra R., Parkhill J., Bentley S.D., Edgeworth J.D. J. Bacteriol. 192:888-892(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW20 / 0582.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FN433596 Genomic DNA. Translation: CBI49089.1.
RefSeq	YP_005731218.1. NC_017331.1.
3D structure databases
ProteinModelPortal	D1GSU1.
SMR	D1GSU1. Positions 3-299.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CBI49089; CBI49089; SATW20_12100.
GeneID	12860682.
KEGG	suw:SATW20_12100.
PATRIC	43215589. VBIStaAur147706_1291.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K00604.
OMA	DWNKSAR.
Enzyme and pathway databases
BioCyc	SAUR663951:GLKU-1247-MONOMER.
Family and domain databases
Gene3D	3.10.25.10. 1 hit. 3.40.50.170. 1 hit.
HAMAP	MF_00182. Formyl_trans.
InterPro	IPR005794. Fmt. IPR005793. Formyl_trans_C. IPR002376. Formyl_transf_N. IPR011034. Formyl_transferase_C-like. IPR001555. GART_AS. IPR015518. Met_tRNA_Form_TA-like. [Graphical view]
PANTHER	PTHR11138. PTHR11138. 1 hit.
Pfam	PF02911. Formyl_trans_C. 1 hit. PF00551. Formyl_trans_N. 1 hit. [Graphical view]
SUPFAM	SSF50486. FMT_C_like. 1 hit. SSF53328. formyl_transf. 1 hit.
TIGRFAMs	TIGR00460. fmt. 1 hit.
PROSITE	PS00373. GART. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

D1GSU1_STAA0

Accession

Primary (citable) accession number: D1GSU1

Entry history

Integrated into UniProtKB/TrEMBL:	January 19, 2010
Last sequence update:	January 19, 2010
Last modified:	May 29, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)