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D1GSS9

- D1GSS9_STAA0

UniProt

D1GSS9 - D1GSS9_STAA0

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Protein

Orotidine 5'-phosphate decarboxylase

Gene
pyrF, SATW20_11980
Organism
Staphylococcus aureus (strain TW20 / 0582)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity.UniRule annotationSAAS annotations

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111Substrate By similarityUniRule annotation
Binding sitei32 – 321Substrate By similarityUniRule annotation
Active sitei61 – 611Proton donor By similarityUniRule annotation
Binding sitei118 – 1181Substrate By similarityUniRule annotation
Binding sitei180 – 1801Substrate By similarityUniRule annotation
Binding sitei189 – 1891Substrate By similarityUniRule annotation
Binding sitei209 – 2091Substrate; via amide nitrogen By similarityUniRule annotation
Binding sitei210 – 2101Substrate By similarityUniRule annotation

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Biological processi

Pyrimidine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciSAUR663951:GLKU-1235-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylase
Gene namesi
Name:pyrFUniRule annotationImported
Ordered Locus Names:SATW20_11980Imported
OrganismiStaphylococcus aureus (strain TW20 / 0582)Imported
Taxonomic identifieri663951 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000632: Chromosome

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliD1GSS9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni59 – 6810Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK01591.
OMAiRPITQSA.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D1GSS9-1 [UniParc]FASTAAdd to Basket

« Hide

MMKDLPIIAL DFESKEKVNQ FLDLFDESLF VKVGMELFYQ EGPQLINEIK    50
ERGHDVFLDL KLHDIPNTVG KAMEGLAKLN VDLVNVHAAG GVKMMSEAIK 100
GLRKHNQDTK IIAVTQLTST TEDMLRHEQN IQTSIEEAVL NYAKLANAAG 150
LDGVVCSPLE SRMLTEKLGT SFLKVTPGIR PKGASQNDQH RITTPEEARQ 200
LGSTHIVVGR PITKSDNPVE SYHKIKESWL V 231
Length:231
Mass (Da):25,728
Last modified:January 19, 2010 - v1
Checksum:i36BE199EEAFB9911
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN433596 Genomic DNA. Translation: CBI49077.1.
RefSeqiYP_005731206.1. NC_017331.1.

Genome annotation databases

EnsemblBacteriaiCBI49077; CBI49077; SATW20_11980.
GeneIDi12860670.
KEGGisuw:SATW20_11980.
PATRICi43215563. VBIStaAur147706_1278.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN433596 Genomic DNA. Translation: CBI49077.1 .
RefSeqi YP_005731206.1. NC_017331.1.

3D structure databases

ProteinModelPortali D1GSS9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBI49077 ; CBI49077 ; SATW20_11980 .
GeneIDi 12860670.
KEGGi suw:SATW20_11980.
PATRICi 43215563. VBIStaAur147706_1278.

Phylogenomic databases

KOi K01591.
OMAi RPITQSA.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci SAUR663951:GLKU-1235-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW)."
    Holden M.T., Lindsay J.A., Corton C., Quail M.A., Cockfield J.D., Pathak S., Batra R., Parkhill J., Bentley S.D., Edgeworth J.D.
    J. Bacteriol. 192:888-892(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW20 / 0582.

Entry informationi

Entry nameiD1GSS9_STAA0
AccessioniPrimary (citable) accession number: D1GSS9
Entry historyi
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: June 11, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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