Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

D1GSS9 (D1GSS9_STAA0) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01200

EC=4.1.1.23 HAMAP-Rule MF_01200
Alternative name(s):
OMP decarboxylase HAMAP-Rule MF_01200
Gene names
Name:pyrF HAMAP-Rule MF_01200 EMBL CBI49077.1
Ordered Locus Names:SATW20_11980 EMBL CBI49077.1
OrganismStaphylococcus aureus (strain TW20 / 0582) [Complete proteome] [HAMAP] EMBL CBI49077.1
Taxonomic identifier663951 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length231 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity. HAMAP-Rule MF_01200 SAAS SAAS001754

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01200

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. HAMAP-Rule MF_01200

Subunit structure

Homodimer By similarity. SAAS SAAS001754 HAMAP-Rule MF_01200

Sequence similarities

Belongs to the OMP decarboxylase family. Type 1 subfamily. HAMAP-Rule MF_01200

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region59 – 6810Substrate binding By similarity HAMAP-Rule MF_01200

Sites

Active site611Proton donor By similarity HAMAP-Rule MF_01200
Binding site111Substrate By similarity HAMAP-Rule MF_01200
Binding site321Substrate By similarity HAMAP-Rule MF_01200
Binding site1181Substrate By similarity HAMAP-Rule MF_01200
Binding site1801Substrate By similarity HAMAP-Rule MF_01200
Binding site1891Substrate By similarity HAMAP-Rule MF_01200
Binding site2091Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01200
Binding site2101Substrate By similarity HAMAP-Rule MF_01200

Sequences

Sequence LengthMass (Da)Tools
D1GSS9 [UniParc].

Last modified January 19, 2010. Version 1.
Checksum: 36BE199EEAFB9911

FASTA23125,728
        10         20         30         40         50         60 
MMKDLPIIAL DFESKEKVNQ FLDLFDESLF VKVGMELFYQ EGPQLINEIK ERGHDVFLDL 

        70         80         90        100        110        120 
KLHDIPNTVG KAMEGLAKLN VDLVNVHAAG GVKMMSEAIK GLRKHNQDTK IIAVTQLTST 

       130        140        150        160        170        180 
TEDMLRHEQN IQTSIEEAVL NYAKLANAAG LDGVVCSPLE SRMLTEKLGT SFLKVTPGIR 

       190        200        210        220        230 
PKGASQNDQH RITTPEEARQ LGSTHIVVGR PITKSDNPVE SYHKIKESWL V 

« Hide

References

[1]"Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW)."
Holden M.T., Lindsay J.A., Corton C., Quail M.A., Cockfield J.D., Pathak S., Batra R., Parkhill J., Bentley S.D., Edgeworth J.D.
J. Bacteriol. 192:888-892(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TW20 / 0582.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FN433596 Genomic DNA. Translation: CBI49077.1.
RefSeqYP_005731206.1. NC_017331.1.

3D structure databases

ProteinModelPortalD1GSS9.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBI49077; CBI49077; SATW20_11980.
GeneID12860670.
KEGGsuw:SATW20_11980.
PATRIC43215563. VBIStaAur147706_1278.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01591.
OMARPITQSA.

Enzyme and pathway databases

BioCycSAUR663951:GLKU-1235-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01200_B. OMPdecase_type1_B.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD1GSS9_STAA0
AccessionPrimary (citable) accession number: D1GSS9
Entry history
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: June 11, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)