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D1GSS9

- D1GSS9_STAA0

UniProt

D1GSS9 - D1GSS9_STAA0

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Staphylococcus aureus (strain TW20 / 0582)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotationSAAS annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111SubstrateUniRule annotation
Binding sitei32 – 321SubstrateUniRule annotation
Active sitei61 – 611Proton donorUniRule annotation
Binding sitei118 – 1181SubstrateUniRule annotation
Binding sitei180 – 1801SubstrateUniRule annotation
Binding sitei189 – 1891SubstrateUniRule annotation
Binding sitei209 – 2091Substrate; via amide nitrogenUniRule annotation
Binding sitei210 – 2101SubstrateUniRule annotation

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Biological processi

Pyrimidine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciSAUR663951:GLKU-1235-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotationSAAS annotation (EC:4.1.1.23UniRule annotationSAAS annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotationImported
Ordered Locus Names:SATW20_11980Imported
OrganismiStaphylococcus aureus (strain TW20 / 0582)Imported
Taxonomic identifieri663951 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000632: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliD1GSS9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni59 – 6810Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

KOiK01591.
OMAiRPITQSA.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D1GSS9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMKDLPIIAL DFESKEKVNQ FLDLFDESLF VKVGMELFYQ EGPQLINEIK
60 70 80 90 100
ERGHDVFLDL KLHDIPNTVG KAMEGLAKLN VDLVNVHAAG GVKMMSEAIK
110 120 130 140 150
GLRKHNQDTK IIAVTQLTST TEDMLRHEQN IQTSIEEAVL NYAKLANAAG
160 170 180 190 200
LDGVVCSPLE SRMLTEKLGT SFLKVTPGIR PKGASQNDQH RITTPEEARQ
210 220 230
LGSTHIVVGR PITKSDNPVE SYHKIKESWL V
Length:231
Mass (Da):25,728
Last modified:January 19, 2010 - v1
Checksum:i36BE199EEAFB9911
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN433596 Genomic DNA. Translation: CBI49077.1.
RefSeqiYP_005731206.1. NC_017331.1.

Genome annotation databases

EnsemblBacteriaiCBI49077; CBI49077; SATW20_11980.
GeneIDi12860670.
KEGGisuw:SATW20_11980.
PATRICi43215563. VBIStaAur147706_1278.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN433596 Genomic DNA. Translation: CBI49077.1 .
RefSeqi YP_005731206.1. NC_017331.1.

3D structure databases

ProteinModelPortali D1GSS9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBI49077 ; CBI49077 ; SATW20_11980 .
GeneIDi 12860670.
KEGGi suw:SATW20_11980.
PATRICi 43215563. VBIStaAur147706_1278.

Phylogenomic databases

KOi K01591.
OMAi RPITQSA.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci SAUR663951:GLKU-1235-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW)."
    Holden M.T., Lindsay J.A., Corton C., Quail M.A., Cockfield J.D., Pathak S., Batra R., Parkhill J., Bentley S.D., Edgeworth J.D.
    J. Bacteriol. 192:888-892(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW20 / 0582Imported.

Entry informationi

Entry nameiD1GSS9_STAA0
AccessioniPrimary (citable) accession number: D1GSS9
Entry historyi
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: November 26, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3