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D1GSS9

- D1GSS9_STAA0

UniProt

D1GSS9 - D1GSS9_STAA0

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Staphylococcus aureus (strain TW20 / 0582)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (19 Jan 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotationSAAS annotation

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei11 – 111SubstrateUniRule annotation
    Binding sitei32 – 321SubstrateUniRule annotation
    Active sitei61 – 611Proton donorUniRule annotation
    Binding sitei118 – 1181SubstrateUniRule annotation
    Binding sitei180 – 1801SubstrateUniRule annotation
    Binding sitei189 – 1891SubstrateUniRule annotation
    Binding sitei209 – 2091Substrate; via amide nitrogenUniRule annotation
    Binding sitei210 – 2101SubstrateUniRule annotation

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotation, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesisUniRule annotation

    Enzyme and pathway databases

    BioCyciSAUR663951:GLKU-1235-MONOMER.
    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
    Alternative name(s):
    OMP decarboxylaseUniRule annotation
    Gene namesi
    Name:pyrFUniRule annotationImported
    Ordered Locus Names:SATW20_11980Imported
    OrganismiStaphylococcus aureus (strain TW20 / 0582)Imported
    Taxonomic identifieri663951 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000632: Chromosome

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD1GSS9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni59 – 6810Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    KOiK01591.
    OMAiRPITQSA.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01200_B. OMPdecase_type1_B.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01740. pyrF. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D1GSS9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMKDLPIIAL DFESKEKVNQ FLDLFDESLF VKVGMELFYQ EGPQLINEIK    50
    ERGHDVFLDL KLHDIPNTVG KAMEGLAKLN VDLVNVHAAG GVKMMSEAIK 100
    GLRKHNQDTK IIAVTQLTST TEDMLRHEQN IQTSIEEAVL NYAKLANAAG 150
    LDGVVCSPLE SRMLTEKLGT SFLKVTPGIR PKGASQNDQH RITTPEEARQ 200
    LGSTHIVVGR PITKSDNPVE SYHKIKESWL V 231
    Length:231
    Mass (Da):25,728
    Last modified:January 19, 2010 - v1
    Checksum:i36BE199EEAFB9911
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN433596 Genomic DNA. Translation: CBI49077.1.
    RefSeqiYP_005731206.1. NC_017331.1.

    Genome annotation databases

    EnsemblBacteriaiCBI49077; CBI49077; SATW20_11980.
    GeneIDi12860670.
    KEGGisuw:SATW20_11980.
    PATRICi43215563. VBIStaAur147706_1278.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN433596 Genomic DNA. Translation: CBI49077.1 .
    RefSeqi YP_005731206.1. NC_017331.1.

    3D structure databases

    ProteinModelPortali D1GSS9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBI49077 ; CBI49077 ; SATW20_11980 .
    GeneIDi 12860670.
    KEGGi suw:SATW20_11980.
    PATRICi 43215563. VBIStaAur147706_1278.

    Phylogenomic databases

    KOi K01591.
    OMAi RPITQSA.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .
    BioCyci SAUR663951:GLKU-1235-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01200_B. OMPdecase_type1_B.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01740. pyrF. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW)."
      Holden M.T., Lindsay J.A., Corton C., Quail M.A., Cockfield J.D., Pathak S., Batra R., Parkhill J., Bentley S.D., Edgeworth J.D.
      J. Bacteriol. 192:888-892(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW20 / 0582Imported.

    Entry informationi

    Entry nameiD1GSS9_STAA0
    AccessioniPrimary (citable) accession number: D1GSS9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 19, 2010
    Last sequence update: January 19, 2010
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3