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D1GP06 (D1GP06_STAA0) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase HAMAP-Rule MF_00061
Short name=CMK HAMAP-Rule MF_00061
EC=2.7.1.148 HAMAP-Rule MF_00061
Alternative name(s):
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase HAMAP-Rule MF_00061
Gene names
Name:ispE HAMAP-Rule MF_00061 EMBL CBI48442.1
Ordered Locus Names:SATW20_05630 EMBL CBI48442.1
OrganismStaphylococcus aureus (strain TW20 / 0582) [Complete proteome] [HAMAP] EMBL CBI48442.1
Taxonomic identifier663951 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus ›

Protein attributes

Sequence length282 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol By similarity. HAMAP-Rule MF_00061 SAAS SAAS004424

Catalytic activity

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP-Rule MF_00061 SAAS SAAS004424

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. HAMAP-Rule MF_00061 SAAS SAAS004424

Sequence similarities

Belongs to the GHMP kinase family. IspE subfamily. HAMAP-Rule MF_00061

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding93 – 10311ATP By similarity HAMAP-Rule MF_00061

Sites

Active site91 By similarity HAMAP-Rule MF_00061
Active site1351 By similarity HAMAP-Rule MF_00061

Sequences

Sequence LengthMass (Da)Tools
D1GP06 [UniParc].

Last modified January 19, 2010. Version 1.
Checksum: C8A851AFCC4385AE

FASTA28231,442
        10         20         30         40         50         60 
MIYETAPAKI NFTLDTLFKR NDGYHEIEMI MTTVDLNDRL TFHKRKDRKI VVEIEHNYVP 

        70         80         90        100        110        120 
SNHKNLAYRA AQLFIEQYQL KQGVTISIDK EIPVSAGLAG GSADAAATLR GLNRLFDIGA 

       130        140        150        160        170        180 
SLEELALLGS KIGTDIPFCI YNKTALCTGR GEKIEFLNKP PSAWVILAKP NLGISSPDIF 

       190        200        210        220        230        240 
KLINLDKRYD VHTKMCYEAL ENRDYQQLCQ SLSNRLEPIS VSKHPQIDKL KNNMLKSGAD 

       250        260        270        280 
GALMSGSGPT VYGLARKESQ AKNIYNAVNG CCNEVYLVRL LG

« Hide

References

[1]"Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW)."
Holden M.T., Lindsay J.A., Corton C., Quail M.A., Cockfield J.D., Pathak S., Batra R., Parkhill J., Bentley S.D., Edgeworth J.D.
J. Bacteriol. 192:888-892(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TW20 / 0582.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FN433596 Genomic DNA. Translation: CBI48442.1.
RefSeqYP_005730576.1. NC_017331.1.

3D structure databases

ProteinModelPortalD1GP06.
SMRD1GP06. Positions 6-250.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCBI48442; CBI48442; SATW20_05630.
GeneID12862260.
KEGGsuw:SATW20_05630.
PATRIC43214174. VBIStaAur147706_0591.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00919.
OMALMGVNEL.

Enzyme and pathway databases

UniPathwayUPA00056; UER00094.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
HAMAPMF_00061. IspE.
InterProIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR004424. IspE.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERPTHR20861:SF2. PTHR20861:SF2. 1 hit.
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF010376. IspE. 1 hit.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00154. ispE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD1GP06_STAA0
AccessionPrimary (citable) accession number: D1GP06
Entry history
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: May 1, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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