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Protein

Calcium-transporting ATPase

Gene

Atp2b4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.UniRule annotation

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calcium-transporting ATPase activity Source: MGI
  3. calmodulin binding Source: MGI
  4. metal ion binding Source: InterPro
  5. nitric-oxide synthase binding Source: MGI
  6. nitric-oxide synthase inhibitor activity Source: MGI
  7. protein phosphatase 2B binding Source: MGI

GO - Biological processi

  1. calcium ion transmembrane transport Source: MGI
  2. calcium ion transport Source: MGI
  3. cellular calcium ion homeostasis Source: MGI
  4. cellular response to epinephrine stimulus Source: MGI
  5. negative regulation of adrenergic receptor signaling pathway involved in heart process Source: MGI
  6. negative regulation of arginine catabolic process Source: MGI
  7. negative regulation of calcineurin-NFAT signaling cascade Source: MGI
  8. negative regulation of cardiac muscle hypertrophy in response to stress Source: MGI
  9. negative regulation of citrulline biosynthetic process Source: MGI
  10. negative regulation of nitric oxide biosynthetic process Source: MGI
  11. negative regulation of nitric oxide mediated signal transduction Source: MGI
  12. negative regulation of nitric-oxide synthase activity Source: MGI
  13. negative regulation of the force of heart contraction Source: MGI
  14. positive regulation of cAMP-dependent protein kinase activity Source: MGI
  15. positive regulation of peptidyl-serine phosphorylation Source: MGI
  16. regulation of transcription from RNA polymerase II promoter Source: MGI
  17. response to hydrostatic pressure Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Calcium transportUniRule annotation, Ion transport, Transport

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Calcium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPaseUniRule annotation (EC:3.6.3.8UniRule annotation)
Gene namesi
Name:Atp2b4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88111. Atp2b4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei369 – 39022HelicalUniRule annotationAdd
BLAST
Transmembranei410 – 43627HelicalUniRule annotationAdd
BLAST
Transmembranei844 – 86522HelicalUniRule annotationAdd
BLAST
Transmembranei917 – 93822HelicalUniRule annotationAdd
BLAST
Transmembranei958 – 97518HelicalUniRule annotationAdd
BLAST
Transmembranei996 – 101722HelicalUniRule annotationAdd
BLAST
Transmembranei1029 – 105022HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
  2. membrane Source: MGI
  3. plasma membrane Source: MGI
  4. T-tubule Source: MGI
  5. Z disc Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000265623.
KOiK05850.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR030319. ATP2B4.
IPR022141. ATP_Ca_trans_C.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006408. P-type_ATPase_IIB.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF276. PTHR24093:SF276. 1 hit.
PfamiPF12424. ATP_Ca_trans_C. 1 hit.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D1FNM8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNPPGQSVS ANTVAESHEG EFGCTLMDLR KLMELRGADA VAQISAHYGG
60 70 80 90 100
VQEICTRLKT SPIEGLSGNP ADLEKRRLVF GKNVIPPKRP KTFLELVWEA
110 120 130 140 150
LQDVTLIILE IAAVISLVLS FYRPPGGDNE ICGHIASSPE EEEEGETGWI
160 170 180 190 200
EGAAILASVI IVVLVTAFND WSKEKQFRGL QSRIELEQKF SIIRNGQLIQ
210 220 230 240 250
LPVAEIVVGD IAQIKYGDLL PADGILIQGN DLKIDESSLT GESDHVKKTL
260 270 280 290 300
DKDPMLLSGT HVMEGSGRMV VTAVGVNSQT GIIFTLLGAS EEEDDDDKKK
310 320 330 340 350
KGKKQGAPEN RNKAKTQDGV ALEIQPLNSQ EGLDSEDKEK KIARIPKKEK
360 370 380 390 400
SVLQGKLTRL AVQIGKAGLI MSVLTVVILI LYFVVDNFVI QRREWLPECT
410 420 430 440 450
PVYIQYFVKF FIIGVTVLVV AVPEGLPLAV TISLAYSVKK MMKDNNLVRH
460 470 480 490 500
LDACETMGNA TAICSDKTGT LTMNRMTVVQ AYIGGTHYRQ IPQPDVFPPK
510 520 530 540 550
VLELIVNGIS INCAYTSKIQ PPEKEGGLPR QVGNKTECGL LGFVTDLKQD
560 570 580 590 600
YQAVRNEVPE EKLFKVYTFN SVRKSMSTVI RKPEGGFRMF SKGASEIMLR
610 620 630 640 650
RCDRILNKEG EIKSFRSKDR DNMVRNVIEP MASEGLRTIC LAYRDFDGTE
660 670 680 690 700
PSWDIEGEIL TSLICIAVVG IEDPVRPEVP DAIAKCKRAG ITVRMVTGDN
710 720 730 740 750
VNTARAIATK CGILTPKDDF LCLEGKEFNS LIRNEKGEVE QEKLDKIWPK
760 770 780 790 800
LRVLARSSPT DKHTLVKGII DSTAGEQRQV VAVTGDGTND GPALKKADVG
810 820 830 840 850
FAMGIAGTDV AKEASDIILT DDNFTSIVKA VMWGRNVYDS ISKFLQFQLT
860 870 880 890 900
VNVVAVIVAF TGACITQDSP LKAVQMLWVN LIMDTFASLA LATEPPTESL
910 920 930 940 950
LRRRPYGRNK PLISRTMMKN ILGHAVYQLL IVFLLVFAGD TLFDIDSGRK
960 970 980 990 1000
APLNSPPSQH YTIVFNTFVL MQLFNEINAR KIHGEKNVFA GVYRNIIFCT
1010 1020 1030 1040 1050
VVLGTFFCQI MIVELGGKPF SCTSLTMEQW MWCLFIGIGE LLWGQVISAI
1060 1070 1080 1090 1100
PTKSLKFLKE AGHGSDKEDI SRDTEGMDEI DLAEMELRRG QILWVRGLNR
1110 1120 1130 1140 1150
IQTQIDVINK FQTEAPLKRV RENMTQHLDV KLVPSSYSAA VASLRTCPSI
1160
SSAISSAVTS PPVGSE
Length:1,166
Mass (Da):128,548
Last modified:March 21, 2012 - v2
Checksum:i1A9DA75973DC88D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU493094 mRNA. Translation: ACC91879.2.
RefSeqiNP_001161421.1. NM_001167949.2.
UniGeneiMm.188617.

Genome annotation databases

GeneIDi381290.
KEGGimmu:381290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU493094 mRNA. Translation: ACC91879.2.
RefSeqiNP_001161421.1. NM_001167949.2.
UniGeneiMm.188617.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi381290.
KEGGimmu:381290.

Organism-specific databases

CTDi493.
MGIiMGI:88111. Atp2b4.

Phylogenomic databases

HOGENOMiHOG000265623.
KOiK05850.

Miscellaneous databases

NextBioi401842.
SOURCEiSearch...

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR030319. ATP2B4.
IPR022141. ATP_Ca_trans_C.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006408. P-type_ATPase_IIB.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF276. PTHR24093:SF276. 1 hit.
PfamiPF12424. ATP_Ca_trans_C. 1 hit.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Regulated Alternative Splicing of a Novel and a Classical Exon-20 of PMCA4."
    Afroze T., Yang G., Khoshbin A., Tanwir M., Tabish T., Momen A., Elias C., Backx P., Husain M.
    Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.
    Tissue: BrainImported.

Entry informationi

Entry nameiD1FNM8_MOUSE
AccessioniPrimary (citable) accession number: D1FNM8
Entry historyi
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: March 21, 2012
Last modified: February 4, 2015
This is version 44 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.