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D1FNM8

- D1FNM8_MOUSE

UniProt

D1FNM8 - D1FNM8_MOUSE

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Protein
Calcium-transporting ATPase
Gene
Atp2b4
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium By similarity.UniRule annotation

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calcium-transporting ATPase activity Source: InterPro
  3. metal ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. calcium ion transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotations

Keywords - Biological processi

Calcium transportUniRule annotation, Ion transport, Transport

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Calcium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPaseUniRule annotation (EC:3.6.3.8UniRule annotation)
Gene namesi
Name:Atp2b4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88111. Atp2b4.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Family & Domainsi

Sequence similaritiesi

Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIB subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotations

Phylogenomic databases

HOGENOMiHOG000265623.
KOiK05850.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR022141. ATP_Ca_trans_C.
IPR006408. ATPase_P-typ_Ca-transp_plasma.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF12424. ATP_Ca_trans_C. 1 hit.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D1FNM8-1 [UniParc]FASTAAdd to Basket

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MTNPPGQSVS ANTVAESHEG EFGCTLMDLR KLMELRGADA VAQISAHYGG     50
VQEICTRLKT SPIEGLSGNP ADLEKRRLVF GKNVIPPKRP KTFLELVWEA 100
LQDVTLIILE IAAVISLVLS FYRPPGGDNE ICGHIASSPE EEEEGETGWI 150
EGAAILASVI IVVLVTAFND WSKEKQFRGL QSRIELEQKF SIIRNGQLIQ 200
LPVAEIVVGD IAQIKYGDLL PADGILIQGN DLKIDESSLT GESDHVKKTL 250
DKDPMLLSGT HVMEGSGRMV VTAVGVNSQT GIIFTLLGAS EEEDDDDKKK 300
KGKKQGAPEN RNKAKTQDGV ALEIQPLNSQ EGLDSEDKEK KIARIPKKEK 350
SVLQGKLTRL AVQIGKAGLI MSVLTVVILI LYFVVDNFVI QRREWLPECT 400
PVYIQYFVKF FIIGVTVLVV AVPEGLPLAV TISLAYSVKK MMKDNNLVRH 450
LDACETMGNA TAICSDKTGT LTMNRMTVVQ AYIGGTHYRQ IPQPDVFPPK 500
VLELIVNGIS INCAYTSKIQ PPEKEGGLPR QVGNKTECGL LGFVTDLKQD 550
YQAVRNEVPE EKLFKVYTFN SVRKSMSTVI RKPEGGFRMF SKGASEIMLR 600
RCDRILNKEG EIKSFRSKDR DNMVRNVIEP MASEGLRTIC LAYRDFDGTE 650
PSWDIEGEIL TSLICIAVVG IEDPVRPEVP DAIAKCKRAG ITVRMVTGDN 700
VNTARAIATK CGILTPKDDF LCLEGKEFNS LIRNEKGEVE QEKLDKIWPK 750
LRVLARSSPT DKHTLVKGII DSTAGEQRQV VAVTGDGTND GPALKKADVG 800
FAMGIAGTDV AKEASDIILT DDNFTSIVKA VMWGRNVYDS ISKFLQFQLT 850
VNVVAVIVAF TGACITQDSP LKAVQMLWVN LIMDTFASLA LATEPPTESL 900
LRRRPYGRNK PLISRTMMKN ILGHAVYQLL IVFLLVFAGD TLFDIDSGRK 950
APLNSPPSQH YTIVFNTFVL MQLFNEINAR KIHGEKNVFA GVYRNIIFCT 1000
VVLGTFFCQI MIVELGGKPF SCTSLTMEQW MWCLFIGIGE LLWGQVISAI 1050
PTKSLKFLKE AGHGSDKEDI SRDTEGMDEI DLAEMELRRG QILWVRGLNR 1100
IQTQIDVINK FQTEAPLKRV RENMTQHLDV KLVPSSYSAA VASLRTCPSI 1150
SSAISSAVTS PPVGSE 1166
Length:1,166
Mass (Da):128,548
Last modified:March 21, 2012 - v2
Checksum:i1A9DA75973DC88D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU493094 mRNA. Translation: ACC91879.2.
RefSeqiNP_001161421.1. NM_001167949.2.
UniGeneiMm.188617.

Genome annotation databases

GeneIDi381290.
KEGGimmu:381290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU493094 mRNA. Translation: ACC91879.2 .
RefSeqi NP_001161421.1. NM_001167949.2.
UniGenei Mm.188617.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 381290.
KEGGi mmu:381290.

Organism-specific databases

CTDi 493.
MGIi MGI:88111. Atp2b4.

Phylogenomic databases

HOGENOMi HOG000265623.
KOi K05850.

Miscellaneous databases

NextBioi 401842.
SOURCEi Search...

Family and domain databases

Gene3Di 1.20.1110.10. 3 hits.
InterProi IPR022141. ATP_Ca_trans_C.
IPR006408. ATPase_P-typ_Ca-transp_plasma.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF12424. ATP_Ca_trans_C. 1 hit.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Regulated Alternative Splicing of a Novel and a Classical Exon-20 of PMCA4."
    Afroze T., Yang G., Khoshbin A., Tanwir M., Tabish T., Momen A., Elias C., Backx P., Husain M.
    Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.
    Tissue: BrainImported.

Entry informationi

Entry nameiD1FNM8_MOUSE
AccessioniPrimary (citable) accession number: D1FNM8
Entry historyi
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: March 21, 2012
Last modified: September 3, 2014
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

External Data

Dasty 3

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