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D1FNM8

- D1FNM8_MOUSE

UniProt

D1FNM8 - D1FNM8_MOUSE

Protein

Calcium-transporting ATPase

Gene

Atp2b4

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 2 (21 Mar 2012)
      Previous versions | rss
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    Functioni

    This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.UniRule annotation

    Catalytic activityi

    ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calcium-transporting ATPase activity Source: InterPro
    3. metal ion binding Source: InterPro

    GO - Biological processi

    1. calcium ion transport Source: MGI

    Keywords - Molecular functioni

    HydrolaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Calcium transportUniRule annotation, Ion transport, Transport

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Calcium, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium-transporting ATPaseUniRule annotation (EC:3.6.3.8UniRule annotation)
    Gene namesi
    Name:Atp2b4Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:88111. Atp2b4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. [View classification]UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000265623.
    KOiK05850.

    Family and domain databases

    Gene3Di1.20.1110.10. 3 hits.
    InterProiIPR022141. ATP_Ca_trans_C.
    IPR006408. ATPase_P-typ_Ca-transp_plasma.
    IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF12424. ATP_Ca_trans_C. 1 hit.
    PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SMARTiSM00831. Cation_ATPase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
    TIGR01494. ATPase_P-type. 3 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D1FNM8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNPPGQSVS ANTVAESHEG EFGCTLMDLR KLMELRGADA VAQISAHYGG     50
    VQEICTRLKT SPIEGLSGNP ADLEKRRLVF GKNVIPPKRP KTFLELVWEA 100
    LQDVTLIILE IAAVISLVLS FYRPPGGDNE ICGHIASSPE EEEEGETGWI 150
    EGAAILASVI IVVLVTAFND WSKEKQFRGL QSRIELEQKF SIIRNGQLIQ 200
    LPVAEIVVGD IAQIKYGDLL PADGILIQGN DLKIDESSLT GESDHVKKTL 250
    DKDPMLLSGT HVMEGSGRMV VTAVGVNSQT GIIFTLLGAS EEEDDDDKKK 300
    KGKKQGAPEN RNKAKTQDGV ALEIQPLNSQ EGLDSEDKEK KIARIPKKEK 350
    SVLQGKLTRL AVQIGKAGLI MSVLTVVILI LYFVVDNFVI QRREWLPECT 400
    PVYIQYFVKF FIIGVTVLVV AVPEGLPLAV TISLAYSVKK MMKDNNLVRH 450
    LDACETMGNA TAICSDKTGT LTMNRMTVVQ AYIGGTHYRQ IPQPDVFPPK 500
    VLELIVNGIS INCAYTSKIQ PPEKEGGLPR QVGNKTECGL LGFVTDLKQD 550
    YQAVRNEVPE EKLFKVYTFN SVRKSMSTVI RKPEGGFRMF SKGASEIMLR 600
    RCDRILNKEG EIKSFRSKDR DNMVRNVIEP MASEGLRTIC LAYRDFDGTE 650
    PSWDIEGEIL TSLICIAVVG IEDPVRPEVP DAIAKCKRAG ITVRMVTGDN 700
    VNTARAIATK CGILTPKDDF LCLEGKEFNS LIRNEKGEVE QEKLDKIWPK 750
    LRVLARSSPT DKHTLVKGII DSTAGEQRQV VAVTGDGTND GPALKKADVG 800
    FAMGIAGTDV AKEASDIILT DDNFTSIVKA VMWGRNVYDS ISKFLQFQLT 850
    VNVVAVIVAF TGACITQDSP LKAVQMLWVN LIMDTFASLA LATEPPTESL 900
    LRRRPYGRNK PLISRTMMKN ILGHAVYQLL IVFLLVFAGD TLFDIDSGRK 950
    APLNSPPSQH YTIVFNTFVL MQLFNEINAR KIHGEKNVFA GVYRNIIFCT 1000
    VVLGTFFCQI MIVELGGKPF SCTSLTMEQW MWCLFIGIGE LLWGQVISAI 1050
    PTKSLKFLKE AGHGSDKEDI SRDTEGMDEI DLAEMELRRG QILWVRGLNR 1100
    IQTQIDVINK FQTEAPLKRV RENMTQHLDV KLVPSSYSAA VASLRTCPSI 1150
    SSAISSAVTS PPVGSE 1166
    Length:1,166
    Mass (Da):128,548
    Last modified:March 21, 2012 - v2
    Checksum:i1A9DA75973DC88D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU493094 mRNA. Translation: ACC91879.2.
    RefSeqiNP_001161421.1. NM_001167949.2.
    UniGeneiMm.188617.

    Genome annotation databases

    GeneIDi381290.
    KEGGimmu:381290.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU493094 mRNA. Translation: ACC91879.2 .
    RefSeqi NP_001161421.1. NM_001167949.2.
    UniGenei Mm.188617.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 381290.
    KEGGi mmu:381290.

    Organism-specific databases

    CTDi 493.
    MGIi MGI:88111. Atp2b4.

    Phylogenomic databases

    HOGENOMi HOG000265623.
    KOi K05850.

    Miscellaneous databases

    NextBioi 401842.
    SOURCEi Search...

    Family and domain databases

    Gene3Di 1.20.1110.10. 3 hits.
    InterProi IPR022141. ATP_Ca_trans_C.
    IPR006408. ATPase_P-typ_Ca-transp_plasma.
    IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF12424. ATP_Ca_trans_C. 1 hit.
    PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SMARTi SM00831. Cation_ATPase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01517. ATPase-IIB_Ca. 1 hit.
    TIGR01494. ATPase_P-type. 3 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regulated Alternative Splicing of a Novel and a Classical Exon-20 of PMCA4."
      Afroze T., Yang G., Khoshbin A., Tanwir M., Tabish T., Momen A., Elias C., Backx P., Husain M.
      Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6Imported.
      Tissue: BrainImported.

    Entry informationi

    Entry nameiD1FNM8_MOUSE
    AccessioniPrimary (citable) accession number: D1FNM8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 19, 2010
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 40 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

    External Data

    Dasty 3