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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Thermobaculum terrenum (strain ATCC BAA-798 / YNP1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00071.

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:Tter_1863
OrganismiThermobaculum terrenum (strain ATCC BAA-798 / YNP1)
Taxonomic identifieri525904 [NCBI]
Taxonomic lineageiBacteriaThermobaculum
Proteomesi
  • UP000000323 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003987191 – 2302-phospho-L-lactate guanylyltransferaseAdd BLAST230

Interactioni

Protein-protein interaction databases

STRINGi525904.Tter_1863.

Structurei

3D structure databases

SMRiD1CDA4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105YV1. Bacteria.
COG1920. LUCA.
KOiK14941.
OMAiAMLVDTI.
OrthoDBiPOG091H0B3J.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_02114. CofC. 1 hit.
InterProiView protein in InterPro
IPR002835. Coenzyme_F420_CofC.
IPR029044. Nucleotide-diphossugar_trans.
PANTHERiPTHR40392. PTHR40392. 1 hit.
PfamiView protein in Pfam
PF01983. CofC. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR03552. F420_cofC. 1 hit.

Sequencei

Sequence statusi: Complete.

D1CDA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAMNIAVLV PVKKLDKAKM RMADTLDRSQ RRQLMMVTLR RVLSALQKAQ
60 70 80 90 100
IGDVYLVASD PQVKNIACDL CVKFIPDQGD ELNPSLELAR GELCQNYDAL
110 120 130 140 150
LVVFGDLPMI SDKDIKTIVR LGSSKPSCVI APDKRNVGTN VLFLHPPYLL
160 170 180 190 200
PFTFGGNSYE RFRSNCEKLG VQFLVYQSQN TALDLDYPQD ILDLAALRGH
210 220 230
KISGLEEILD PGVLAQISQV TSMSGAKMGA
Length:230
Mass (Da):25,358
Last modified:January 19, 2010 - v1
Checksum:i447DEF2FBBA9F924
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001825 Genomic DNA. Translation: ACZ42769.1.

Genome annotation databases

EnsemblBacteriaiACZ42769; ACZ42769; Tter_1863.
KEGGittr:Tter_1863.

Entry informationi

Entry nameiCOFC_THET1
AccessioniPrimary (citable) accession number: D1CDA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: January 19, 2010
Last modified: December 20, 2017
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families