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D1CBZ1

- D1CBZ1_THET1

UniProt

D1CBZ1 - D1CBZ1_THET1

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Protein

Probable DNA ligase

Gene

lig

Organism
Thermobaculum terrenum (strain ATCC BAA-798 / YNP1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Note: Divalent metal cations.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei249 – 2491ATPUniRule annotation
Active sitei251 – 2511N6-AMP-lysine intermediateUniRule annotation
Binding sitei256 – 2561ATPUniRule annotation
Binding sitei271 – 2711ATPUniRule annotation
Binding sitei301 – 3011ATPUniRule annotation
Binding sitei341 – 3411ATPUniRule annotation
Binding sitei416 – 4161ATPUniRule annotation
Binding sitei422 – 4221ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTER525904:GHMJ-1441-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Tter_1400Imported
OrganismiThermobaculum terrenum (strain ATCC BAA-798 / YNP1)Imported
Taxonomic identifieri525904 [NCBI]
Taxonomic lineageiBacteriaThermobaculum
ProteomesiUP000000323: Chromosome 1

Structurei

3D structure databases

ProteinModelPortaliD1CBZ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.
OMAiCTDIGEL.
OrthoDBiEOG6Q8HXT.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D1CBZ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLFSKLAEYF EQLDHTTSRN TLVAILADLY SQCDQSEVRP ITYLLQGRLA
60 70 80 90 100
PFFKPIEIGM GINYVADAIG KAFGVDRKHV MQVFDRVGDI GTAARQVQQE
110 120 130 140 150
AGKELSMEET PTVLEIFNQL MAISQVSGQG SIEKKIGMFA DILQKLDPRS
160 170 180 190 200
VTYICRIPVG TLRLGVGDPT ILDALSFAKS GDKSLRKPLE RAYNETSDLG
210 220 230 240 250
LIAETLWKDG IEGVEKLSIM PGNPVRPALA ERLPTPEAII NRMGQCAVEK
260 270 280 290 300
KYDGFRCQVH KIGNEVKIFS RNLEDMTGMF PEITSGTLAM VDAETAIFEG
310 320 330 340 350
EALAYHPLSG EFLPFQVTTK RRRKHKIEEA AQELPLKLFA FDILYKNGEN
360 370 380 390 400
LMGMKYVDRR EILANTIKGE DSLIVSDWVI ADNVEKLMEV FNEAIESGLE
410 420 430 440 450
GIVAKRLDSP YQAGARNFNW VKLKRTHAGQ LQDTVDCVIV GYIYGRGKRA
460 470 480 490 500
QLGAGALLVA VYNPDKDTFQ TITKIGTGLT DEEWKEVVER CKPYVTEEKP
510 520 530 540 550
ARVESIIQPS VWVEPAVVIE VLADEITRSP VHTAGMNGEK QGYALRFPRL
560 570 580
VSFRESDKRP EDATTVQEII EMYQQQAIKQ VAS
Length:583
Mass (Da):65,106
Last modified:January 19, 2010 - v1
Checksum:i8544A91BE3F310BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001825 Genomic DNA. Translation: ACZ42306.1.
RefSeqiYP_003323128.1. NC_013525.1.

Genome annotation databases

EnsemblBacteriaiACZ42306; ACZ42306; Tter_1400.
GeneIDi8645896.
KEGGittr:Tter_1400.
PATRICi32503032. VBITheTer68767_1496.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001825 Genomic DNA. Translation: ACZ42306.1 .
RefSeqi YP_003323128.1. NC_013525.1.

3D structure databases

ProteinModelPortali D1CBZ1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACZ42306 ; ACZ42306 ; Tter_1400 .
GeneIDi 8645896.
KEGGi ttr:Tter_1400.
PATRICi 32503032. VBITheTer68767_1496.

Phylogenomic databases

HOGENOMi HOG000036008.
KOi K10747.
OMAi CTDIGEL.
OrthoDBi EOG6Q8HXT.

Enzyme and pathway databases

BioCyci TTER525904:GHMJ-1441-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-798 / YNP1Imported.

Entry informationi

Entry nameiD1CBZ1_THET1
AccessioniPrimary (citable) accession number: D1CBZ1
Entry historyi
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: November 26, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3