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D1CBZ1

- D1CBZ1_THET1

UniProt

D1CBZ1 - D1CBZ1_THET1

Protein

Probable DNA ligase

Gene

lig

Organism
Thermobaculum terrenum (strain ATCC BAA-798 / YNP1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (19 Jan 2010)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei249 – 2491ATPUniRule annotation
    Active sitei251 – 2511N6-AMP-lysine intermediateUniRule annotation
    Binding sitei256 – 2561ATPUniRule annotation
    Binding sitei271 – 2711ATPUniRule annotation
    Binding sitei301 – 3011ATPUniRule annotation
    Binding sitei341 – 3411ATPUniRule annotation
    Binding sitei416 – 4161ATPUniRule annotation
    Binding sitei422 – 4221ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTTER525904:GHMJ-1441-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Tter_1400Imported
    OrganismiThermobaculum terrenum (strain ATCC BAA-798 / YNP1)Imported
    Taxonomic identifieri525904 [NCBI]
    Taxonomic lineageiBacteriaThermobaculum
    ProteomesiUP000000323: Chromosome 1

    Structurei

    3D structure databases

    ProteinModelPortaliD1CBZ1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000036008.
    KOiK10747.
    OMAiCTDIGEL.
    OrthoDBiEOG6Q8HXT.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D1CBZ1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLFSKLAEYF EQLDHTTSRN TLVAILADLY SQCDQSEVRP ITYLLQGRLA    50
    PFFKPIEIGM GINYVADAIG KAFGVDRKHV MQVFDRVGDI GTAARQVQQE 100
    AGKELSMEET PTVLEIFNQL MAISQVSGQG SIEKKIGMFA DILQKLDPRS 150
    VTYICRIPVG TLRLGVGDPT ILDALSFAKS GDKSLRKPLE RAYNETSDLG 200
    LIAETLWKDG IEGVEKLSIM PGNPVRPALA ERLPTPEAII NRMGQCAVEK 250
    KYDGFRCQVH KIGNEVKIFS RNLEDMTGMF PEITSGTLAM VDAETAIFEG 300
    EALAYHPLSG EFLPFQVTTK RRRKHKIEEA AQELPLKLFA FDILYKNGEN 350
    LMGMKYVDRR EILANTIKGE DSLIVSDWVI ADNVEKLMEV FNEAIESGLE 400
    GIVAKRLDSP YQAGARNFNW VKLKRTHAGQ LQDTVDCVIV GYIYGRGKRA 450
    QLGAGALLVA VYNPDKDTFQ TITKIGTGLT DEEWKEVVER CKPYVTEEKP 500
    ARVESIIQPS VWVEPAVVIE VLADEITRSP VHTAGMNGEK QGYALRFPRL 550
    VSFRESDKRP EDATTVQEII EMYQQQAIKQ VAS 583
    Length:583
    Mass (Da):65,106
    Last modified:January 19, 2010 - v1
    Checksum:i8544A91BE3F310BE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001825 Genomic DNA. Translation: ACZ42306.1.
    RefSeqiYP_003323128.1. NC_013525.1.

    Genome annotation databases

    EnsemblBacteriaiACZ42306; ACZ42306; Tter_1400.
    GeneIDi8645896.
    KEGGittr:Tter_1400.
    PATRICi32503032. VBITheTer68767_1496.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001825 Genomic DNA. Translation: ACZ42306.1 .
    RefSeqi YP_003323128.1. NC_013525.1.

    3D structure databases

    ProteinModelPortali D1CBZ1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACZ42306 ; ACZ42306 ; Tter_1400 .
    GeneIDi 8645896.
    KEGGi ttr:Tter_1400.
    PATRICi 32503032. VBITheTer68767_1496.

    Phylogenomic databases

    HOGENOMi HOG000036008.
    KOi K10747.
    OMAi CTDIGEL.
    OrthoDBi EOG6Q8HXT.

    Enzyme and pathway databases

    BioCyci TTER525904:GHMJ-1441-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-798 / YNP1Imported.

    Entry informationi

    Entry nameiD1CBZ1_THET1
    AccessioniPrimary (citable) accession number: D1CBZ1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 19, 2010
    Last sequence update: January 19, 2010
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3