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Protein

Probable DNA ligase

Gene

lig

Organism
Thermobaculum terrenum (strain ATCC BAA-798 / YNP1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei249ATPUniRule annotation1
Active sitei251N6-AMP-lysine intermediateUniRule annotation1
Binding sitei256ATPUniRule annotation1
Binding sitei271ATPUniRule annotation1
Binding sitei301ATPUniRule annotation1
Binding sitei341ATPUniRule annotation1
Binding sitei416ATPUniRule annotation1
Binding sitei422ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTER525904:G1GGS-1436-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Tter_1400Imported
OrganismiThermobaculum terrenum (strain ATCC BAA-798 / YNP1)Imported
Taxonomic identifieri525904 [NCBI]
Taxonomic lineageiBacteriaThermobaculum
Proteomesi
  • UP000000323 Componenti: Chromosome 1

Interactioni

Protein-protein interaction databases

STRINGi525904.Tter_1400

Structurei

3D structure databases

ProteinModelPortaliD1CBZ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini329 – 462DNA_LIGASE_A3InterPro annotationAdd BLAST134

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107TRG Bacteria
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWIKYKRD
OrthoDBiPOG091H09SJ

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

D1CBZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFSKLAEYF EQLDHTTSRN TLVAILADLY SQCDQSEVRP ITYLLQGRLA
60 70 80 90 100
PFFKPIEIGM GINYVADAIG KAFGVDRKHV MQVFDRVGDI GTAARQVQQE
110 120 130 140 150
AGKELSMEET PTVLEIFNQL MAISQVSGQG SIEKKIGMFA DILQKLDPRS
160 170 180 190 200
VTYICRIPVG TLRLGVGDPT ILDALSFAKS GDKSLRKPLE RAYNETSDLG
210 220 230 240 250
LIAETLWKDG IEGVEKLSIM PGNPVRPALA ERLPTPEAII NRMGQCAVEK
260 270 280 290 300
KYDGFRCQVH KIGNEVKIFS RNLEDMTGMF PEITSGTLAM VDAETAIFEG
310 320 330 340 350
EALAYHPLSG EFLPFQVTTK RRRKHKIEEA AQELPLKLFA FDILYKNGEN
360 370 380 390 400
LMGMKYVDRR EILANTIKGE DSLIVSDWVI ADNVEKLMEV FNEAIESGLE
410 420 430 440 450
GIVAKRLDSP YQAGARNFNW VKLKRTHAGQ LQDTVDCVIV GYIYGRGKRA
460 470 480 490 500
QLGAGALLVA VYNPDKDTFQ TITKIGTGLT DEEWKEVVER CKPYVTEEKP
510 520 530 540 550
ARVESIIQPS VWVEPAVVIE VLADEITRSP VHTAGMNGEK QGYALRFPRL
560 570 580
VSFRESDKRP EDATTVQEII EMYQQQAIKQ VAS
Length:583
Mass (Da):65,106
Last modified:January 19, 2010 - v1
Checksum:i8544A91BE3F310BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001825 Genomic DNA Translation: ACZ42306.1
RefSeqiWP_012875341.1, NC_013525.1

Genome annotation databases

EnsemblBacteriaiACZ42306; ACZ42306; Tter_1400
KEGGittr:Tter_1400

Similar proteinsi

Entry informationi

Entry nameiD1CBZ1_THET1
AccessioniPrimary (citable) accession number: D1CBZ1
Entry historyiIntegrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: March 28, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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