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Protein

Alanine racemase

Gene

Sthe_3087

Organism
Sphaerobacter thermophilus (strain DSM 20745 / S 6022)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Sthe_3087)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei47Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei145SubstrateUniRule annotation1
Active sitei279Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei327Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSTHE479434:G1GGR-3101-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Sthe_3087Imported
OrganismiSphaerobacter thermophilus (strain DSM 20745 / S 6022)Imported
Taxonomic identifieri479434 [NCBI]
Taxonomic lineageiBacteriaChloroflexiSphaerobacteridaeSphaerobacteralesSphaerobacterineaeSphaerobacteraceaeSphaerobacter
Proteomesi
  • UP000002027 Componenti: Chromosome 2

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi479434.Sthe_3087

Structurei

3D structure databases

ProteinModelPortaliD1C9J4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini258 – 386Ala_racemase_CInterPro annotationAdd BLAST129

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031444
KOiK01775
OMAiWEILCGF
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 1 hit
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

D1C9J4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEPFAARLA AAQGGAHALI DLDAFAGNIA YVRSQLPEGA EVIAVIKANA
60 70 80 90 100
YGHGLVPCGR AALAAGASRL AVARIEEALL LRAAGVVAPI LVLSPANPAL
110 120 130 140 150
ARQAAESGIA LAVGSATGLN RLLDALGDDL PPLPVHLKVD TGMHRFGVEP
160 170 180 190 200
EGVVELARAL AREPRVRVEG VFTHFATADA ADDRVLQEQT RRFAAAVQAL
210 220 230 240 250
AAAGLQPPLV HMANSAAILR GVVEIPAPRA TIAVRAGLIL YGLNPSRELP
260 270 280 290 300
LPAPIRPVLR LVTRVGQVFT VPPGEGISYG WSYIAERPIR CANLPIGYAD
310 320 330 340 350
GLVRLLSNQG WAVVGGAVCP IRGRICMDQT VIEVEAAPDV AEGDEAVLLS
360 370 380 390 400
DGRDGAMTAD QAAALAGTIN YEIVSALAAR IPRVYLRGGR PVAVLDLLGL

VEDPSAAC
Length:408
Mass (Da):42,280
Last modified:January 19, 2010 - v1
Checksum:i8B8E0701C04629F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001824 Genomic DNA Translation: ACZ40487.1
RefSeqiWP_012873522.1, NC_013524.1

Genome annotation databases

EnsemblBacteriaiACZ40487; ACZ40487; Sthe_3087
KEGGisti:Sthe_3087

Similar proteinsi

Entry informationi

Entry nameiD1C9J4_SPHTD
AccessioniPrimary (citable) accession number: D1C9J4
Entry historyiIntegrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: February 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health