Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alanine racemase

Gene

Sthe_3087

Organism
Sphaerobacter thermophilus (strain DSM 20745 / S 6022)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathway: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Sthe_3087)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei47 – 471Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei145 – 1451SubstrateUniRule annotation
Active sitei279 – 2791Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei327 – 3271Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSTHE479434:GHJN-3148-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Sthe_3087Imported
OrganismiSphaerobacter thermophilus (strain DSM 20745 / S 6022)Imported
Taxonomic identifieri479434 [NCBI]
Taxonomic lineageiBacteriaChloroflexiSphaerobacteridaeSphaerobacteralesSphaerobacterineaeSphaerobacteraceaeSphaerobacter
ProteomesiUP000002027 Componenti: Chromosome 2

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei47 – 471N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi479434.Sthe_3087.

Structurei

3D structure databases

ProteinModelPortaliD1C9J4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiPSDWVRP.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D1C9J4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEPFAARLA AAQGGAHALI DLDAFAGNIA YVRSQLPEGA EVIAVIKANA
60 70 80 90 100
YGHGLVPCGR AALAAGASRL AVARIEEALL LRAAGVVAPI LVLSPANPAL
110 120 130 140 150
ARQAAESGIA LAVGSATGLN RLLDALGDDL PPLPVHLKVD TGMHRFGVEP
160 170 180 190 200
EGVVELARAL AREPRVRVEG VFTHFATADA ADDRVLQEQT RRFAAAVQAL
210 220 230 240 250
AAAGLQPPLV HMANSAAILR GVVEIPAPRA TIAVRAGLIL YGLNPSRELP
260 270 280 290 300
LPAPIRPVLR LVTRVGQVFT VPPGEGISYG WSYIAERPIR CANLPIGYAD
310 320 330 340 350
GLVRLLSNQG WAVVGGAVCP IRGRICMDQT VIEVEAAPDV AEGDEAVLLS
360 370 380 390 400
DGRDGAMTAD QAAALAGTIN YEIVSALAAR IPRVYLRGGR PVAVLDLLGL

VEDPSAAC
Length:408
Mass (Da):42,280
Last modified:January 19, 2010 - v1
Checksum:i8B8E0701C04629F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001824 Genomic DNA. Translation: ACZ40487.1.
RefSeqiWP_012873522.1. NC_013524.1.
YP_003321309.1. NC_013524.1.

Genome annotation databases

EnsemblBacteriaiACZ40487; ACZ40487; Sthe_3087.
KEGGisti:Sthe_3087.
PATRICi32429012. VBISphThe120955_3112.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001824 Genomic DNA. Translation: ACZ40487.1.
RefSeqiWP_012873522.1. NC_013524.1.
YP_003321309.1. NC_013524.1.

3D structure databases

ProteinModelPortaliD1C9J4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi479434.Sthe_3087.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACZ40487; ACZ40487; Sthe_3087.
KEGGisti:Sthe_3087.
PATRICi32429012. VBISphThe120955_3112.

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiPSDWVRP.
OrthoDBiEOG6PP9NJ.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciSTHE479434:GHJN-3148-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 20745 / S 6022Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 20745 / S 6022Imported.

Entry informationi

Entry nameiD1C9J4_SPHTD
AccessioniPrimary (citable) accession number: D1C9J4
Entry historyi
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: June 24, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.