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D1C9J4

- D1C9J4_SPHTD

UniProt

D1C9J4 - D1C9J4_SPHTD

Protein

Alanine racemase

Gene

Sthe_3087

Organism
Sphaerobacter thermophilus (strain DSM 20745 / S 6022)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (19 Jan 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei47 – 471Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei145 – 1451SubstrateUniRule annotation
    Active sitei279 – 2791Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei327 – 3271Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciSTHE479434:GHJN-3148-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:Sthe_3087Imported
    OrganismiSphaerobacter thermophilus (strain DSM 20745 / S 6022)Imported
    Taxonomic identifieri479434 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiSphaerobacteridaeSphaerobacteralesSphaerobacterineaeSphaerobacteraceaeSphaerobacter
    ProteomesiUP000002027: Chromosome 2

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei47 – 471N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD1C9J4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiLWQLEAI.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D1C9J4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIEPFAARLA AAQGGAHALI DLDAFAGNIA YVRSQLPEGA EVIAVIKANA    50
    YGHGLVPCGR AALAAGASRL AVARIEEALL LRAAGVVAPI LVLSPANPAL 100
    ARQAAESGIA LAVGSATGLN RLLDALGDDL PPLPVHLKVD TGMHRFGVEP 150
    EGVVELARAL AREPRVRVEG VFTHFATADA ADDRVLQEQT RRFAAAVQAL 200
    AAAGLQPPLV HMANSAAILR GVVEIPAPRA TIAVRAGLIL YGLNPSRELP 250
    LPAPIRPVLR LVTRVGQVFT VPPGEGISYG WSYIAERPIR CANLPIGYAD 300
    GLVRLLSNQG WAVVGGAVCP IRGRICMDQT VIEVEAAPDV AEGDEAVLLS 350
    DGRDGAMTAD QAAALAGTIN YEIVSALAAR IPRVYLRGGR PVAVLDLLGL 400
    VEDPSAAC 408
    Length:408
    Mass (Da):42,280
    Last modified:January 19, 2010 - v1
    Checksum:i8B8E0701C04629F4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001824 Genomic DNA. Translation: ACZ40487.1.
    RefSeqiYP_003321309.1. NC_013524.1.

    Genome annotation databases

    EnsemblBacteriaiACZ40487; ACZ40487; Sthe_3087.
    GeneIDi8647026.
    KEGGisti:Sthe_3087.
    PATRICi32429012. VBISphThe120955_3112.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001824 Genomic DNA. Translation: ACZ40487.1 .
    RefSeqi YP_003321309.1. NC_013524.1.

    3D structure databases

    ProteinModelPortali D1C9J4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACZ40487 ; ACZ40487 ; Sthe_3087 .
    GeneIDi 8647026.
    KEGGi sti:Sthe_3087.
    PATRICi 32429012. VBISphThe120955_3112.

    Phylogenomic databases

    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi LWQLEAI.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci STHE479434:GHJN-3148-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 20745 / S 6022Imported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 20745 / S 6022Imported.

    Entry informationi

    Entry nameiD1C9J4_SPHTD
    AccessioniPrimary (citable) accession number: D1C9J4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 19, 2010
    Last sequence update: January 19, 2010
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3