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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Sphaerobacter thermophilus (strain DSM 20745 / S 6022)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTHE479434:GHJN-2667-MONOMER.
UniPathwayiUPA00071.

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:Sthe_2612
OrganismiSphaerobacter thermophilus (strain DSM 20745 / S 6022)
Taxonomic identifieri479434 [NCBI]
Taxonomic lineageiBacteriaChloroflexiSphaerobacteridaeSphaerobacteralesSphaerobacterineaeSphaerobacteraceaeSphaerobacter
Proteomesi
  • UP000002027 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2072072-phospho-L-lactate guanylyltransferasePRO_0000398714Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi479434.Sthe_2612.

Structurei

3D structure databases

ProteinModelPortaliD1C883.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105YV1. Bacteria.
COG1920. LUCA.
HOGENOMiHOG000223639.
KOiK14941.
OMAiWITADEI.
OrthoDBiEOG6W19MQ.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_02114. CofC.
InterProiIPR002835. Coenzyme_F420_CofC.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01983. CofC. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR03552. F420_cofC. 1 hit.

Sequencei

Sequence statusi: Complete.

D1C883-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTIAVVPVQ RLSTAKSRLA ARLAPDERRT LVLSLLDHVL TALNAARQVD
60 70 80 90 100
AVILVSPDPE VLEHAARRGA IALLQPGVGL NEGLRLGRDE ALRRGADTLL
110 120 130 140 150
IVLADLPWIT ADEIDALVAA LPERGIALAP DRHDHGTNAA ALRPPDAIEP
160 170 180 190 200
AFGAGSFARH QAQARSRGLP LRELRVQGLA FDIDTPADLE ELAGHAPVGA

SSDESGT
Length:207
Mass (Da):21,837
Last modified:January 19, 2010 - v1
Checksum:i258F3587E0BE8F3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001824 Genomic DNA. Translation: ACZ40026.1.
RefSeqiWP_012873064.1. NC_013524.1.

Genome annotation databases

EnsemblBacteriaiACZ40026; ACZ40026; Sthe_2612.
KEGGisti:Sthe_2612.
PATRICi32428038. VBISphThe120955_2631.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001824 Genomic DNA. Translation: ACZ40026.1.
RefSeqiWP_012873064.1. NC_013524.1.

3D structure databases

ProteinModelPortaliD1C883.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi479434.Sthe_2612.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACZ40026; ACZ40026; Sthe_2612.
KEGGisti:Sthe_2612.
PATRICi32428038. VBISphThe120955_2631.

Phylogenomic databases

eggNOGiENOG4105YV1. Bacteria.
COG1920. LUCA.
HOGENOMiHOG000223639.
KOiK14941.
OMAiWITADEI.
OrthoDBiEOG6W19MQ.

Enzyme and pathway databases

UniPathwayiUPA00071.
BioCyciSTHE479434:GHJN-2667-MONOMER.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_02114. CofC.
InterProiIPR002835. Coenzyme_F420_CofC.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01983. CofC. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR03552. F420_cofC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 20745 / S 6022.

Entry informationi

Entry nameiCOFC_SPHTD
AccessioniPrimary (citable) accession number: D1C883
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: January 19, 2010
Last modified: November 11, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.