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D1C5A3 (D1C5A3_SPHTD) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Sthe_1990 EMBL ACZ39420.1
OrganismSphaerobacter thermophilus (strain DSM 20745 / S 6022) [Complete proteome] [HAMAP] EMBL ACZ39420.1
Taxonomic identifier479434 [NCBI]
Taxonomic lineageBacteriaChloroflexiSphaerobacteridaeSphaerobacteralesSphaerobacterineaeSphaerobacteraceaeSphaerobacter

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain154 – 360207ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding187 – 24256ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3131Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3271Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3271Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3291Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
D1C5A3 [UniParc].

Last modified January 19, 2010. Version 1.
Checksum: FD30FF4D1BB3C3E6

FASTA37540,785
        10         20         30         40         50         60 
MAQGARKIRV GVIFGGRSGE HDVSLRSAQA ILRAIDRERF EVVPIGITRE GRWLSGGDPL 

        70         80         90        100        110        120 
RQLAATSRLA LAPGDDPPAE ESDLGSALAV PETGHAVEVA GAGVVQQLDV VFPVLHGPYG 

       130        140        150        160        170        180 
EDGTVQGLLE LADVPYVGAG VLGSAVSMDK VVAKQLFERE GLPVAPWLWV TRRQWERDPE 

       190        200        210        220        230        240 
GVAARVEREL GYPCFVKPAN LGSSVGVSKV HHPGELPGAM EEAARYDRKL VVERGIDARE 

       250        260        270        280        290        300 
LEVSVLGNDE PITSVVGEIR PVNEFYDYQA KYVDEGSELL VPAPITQEQS DTVREMAVRA 

       310        320        330        340        350        360 
FKVVDAAGMA RVDFFLERNT GTIYINEINT IPGFTQISMY PILWEASGLS FRELVSRLIE 

       370 
LALERHAERR DGSGV 

« Hide

References

[1]"The complete chromosome 1 of Sphaerobacter thermophilus DSM 20745."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N., Mikhailova N., LaButti K.M., Clum A., Sun H.I., Brettin T., Detter J.C. expand/collapse author list , Han C., Larimer F., Land M., Hauser L., Markowitz V., Cheng J.F., Hugenholtz P., Woyke T., Wu D., Steenblock K., Schneider S., Pukall R., Goeker M., Klenk H.P., Eisen J.A.
Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 20745 / S 6022.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001823 Genomic DNA. Translation: ACZ39420.1.
RefSeqYP_003320242.1. NC_013523.1.

3D structure databases

ProteinModelPortalD1C5A3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACZ39420; ACZ39420; Sthe_1990.
GeneID8639417.
KEGGsti:Sthe_1990.
PATRIC32426793. VBISphThe120955_2009.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011593.
KOK01921.
OMAQIDVIFP.
OrthoDBEOG64BQ73.

Enzyme and pathway databases

BioCycSTHE479434:GHJN-2045-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD1C5A3_SPHTD
AccessionPrimary (citable) accession number: D1C5A3
Entry history
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: June 11, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)