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D1C584

- D1C584_SPHTD

UniProt

D1C584 - D1C584_SPHTD

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Protein

3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene

ribB

Organism
Sphaerobacter thermophilus (strain DSM 20745 / S 6022)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.UniRule annotationSAAS annotation

Catalytic activityi

D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate.UniRule annotationSAAS annotation

Cofactori

Binds 2 divalent metal cations per subunit. Magnesium or manganese.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi28 – 281Magnesium or manganese 1UniRule annotation
Metal bindingi28 – 281Magnesium or manganese 2UniRule annotation
Binding sitei32 – 321SubstrateUniRule annotation
Sitei128 – 1281Essential for catalytic activityUniRule annotation
Binding sitei166 – 1661SubstrateUniRule annotation
Sitei166 – 1661Essential for catalytic activityUniRule annotation

GO - Molecular functioni

  1. 3,4-dihydroxy-2-butanone-4-phosphate synthase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. riboflavin biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Riboflavin biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSTHE479434:GHJN-2025-MONOMER.
UniPathwayiUPA00275; UER00399.

Names & Taxonomyi

Protein namesi
Recommended name:
3,4-dihydroxy-2-butanone 4-phosphate synthaseUniRule annotation (EC:4.1.99.12UniRule annotation)
Short name:
DHBP synthaseUniRule annotation
Gene namesi
Name:ribBUniRule annotation
Ordered Locus Names:Sthe_1970Imported
OrganismiSphaerobacter thermophilus (strain DSM 20745 / S 6022)Imported
Taxonomic identifieri479434 [NCBI]
Taxonomic lineageiBacteriaChloroflexiSphaerobacteridaeSphaerobacteralesSphaerobacterineaeSphaerobacteraceaeSphaerobacter
ProteomesiUP000002027: Chromosome 1

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni27 – 282Substrate bindingUniRule annotation
Regioni142 – 1465Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the DHBP synthase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000115444.
KOiK14652.
OMAiQMAKLIR.
OrthoDBiEOG679TK8.

Family and domain databases

Gene3Di3.90.870.10. 1 hit.
HAMAPiMF_00180. RibB.
InterProiIPR017945. DHBP_synth_RibB-like_a/b_dom.
IPR000422. DHBP_synthase_RibB.
[Graphical view]
PfamiPF00926. DHBP_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF55821. SSF55821. 1 hit.
TIGRFAMsiTIGR00506. ribB. 1 hit.

Sequencei

Sequence statusi: Complete.

D1C584 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLATIEQAI AALRAGRFVI IVDGPDRENE GDLCIAGQFI TPEAVNFIVR
60 70 80 90 100
EARGLLCAAM APEWVDRLRL PLMVDPASNS APFGTAFTVS VEARQGVTTG
110 120 130 140 150
ISAHDRARTI RTLADPASTP ADFAMPGHVF PLRARPGGVL ERPGQTEAAV
160 170 180 190 200
DLARLAGLHP VVAICEIMAD DGTMARLPEL ERFATRHDIP IISVADLAAV
210 220 230
RRAQADRHPA GVADHSPAGT AAREGTAYGC
Length:230
Mass (Da):24,299
Last modified:January 19, 2010 - v1
Checksum:i3E5AC3CC147F1D70
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001823 Genomic DNA. Translation: ACZ39401.1.
RefSeqiYP_003320223.1. NC_013523.1.

Genome annotation databases

EnsemblBacteriaiACZ39401; ACZ39401; Sthe_1970.
GeneIDi8639397.
KEGGisti:Sthe_1970.
PATRICi32426755. VBISphThe120955_1990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001823 Genomic DNA. Translation: ACZ39401.1 .
RefSeqi YP_003320223.1. NC_013523.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACZ39401 ; ACZ39401 ; Sthe_1970 .
GeneIDi 8639397.
KEGGi sti:Sthe_1970.
PATRICi 32426755. VBISphThe120955_1990.

Phylogenomic databases

HOGENOMi HOG000115444.
KOi K14652.
OMAi QMAKLIR.
OrthoDBi EOG679TK8.

Enzyme and pathway databases

UniPathwayi UPA00275 ; UER00399 .
BioCyci STHE479434:GHJN-2025-MONOMER.

Family and domain databases

Gene3Di 3.90.870.10. 1 hit.
HAMAPi MF_00180. RibB.
InterProi IPR017945. DHBP_synth_RibB-like_a/b_dom.
IPR000422. DHBP_synthase_RibB.
[Graphical view ]
Pfami PF00926. DHBP_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF55821. SSF55821. 1 hit.
TIGRFAMsi TIGR00506. ribB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 20745 / S 6022Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 20745 / S 6022Imported.

Entry informationi

Entry nameiD1C584_SPHTD
AccessioniPrimary (citable) accession number: D1C584
Entry historyi
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: October 29, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3