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D1C584 (D1C584_SPHTD) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3,4-dihydroxy-2-butanone 4-phosphate synthase HAMAP-Rule MF_00180
Short name=DHBP synthase HAMAP-Rule MF_00180
EC=4.1.99.12 HAMAP-Rule MF_00180
Gene names
Name:ribB HAMAP-Rule MF_00180
Ordered Locus Names:Sthe_1970 EMBL ACZ39401.1
OrganismSphaerobacter thermophilus (strain DSM 20745 / S 6022) [Complete proteome] [HAMAP] EMBL ACZ39401.1
Taxonomic identifier479434 [NCBI]
Taxonomic lineageBacteria › Chloroflexi › Sphaerobacteridae › Sphaerobacterales › Sphaerobacterineae › Sphaerobacteraceae › Sphaerobacter ›

Protein attributes

Sequence length230 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate By similarity. HAMAP-Rule MF_00180 SAAS SAAS017945

Catalytic activity

D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate. HAMAP-Rule MF_00180 SAAS SAAS017945

Cofactor

Binds 2 divalent metal cations per subunit. Magnesium or manganese By similarity. HAMAP-Rule MF_00180 SAAS SAAS017945

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1. RuleBase RU003843 HAMAP-Rule MF_00180 SAAS SAAS017945

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00180 SAAS SAAS017945

Sequence similarities

Belongs to the DHBP synthase family. RuleBase RU003843 HAMAP-Rule MF_00180

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region27 – 282Substrate binding By similarity HAMAP-Rule MF_00180
Region142 – 1465Substrate binding By similarity HAMAP-Rule MF_00180

Sites

Metal binding281Magnesium or manganese 1 By similarity HAMAP-Rule MF_00180
Metal binding281Magnesium or manganese 2 By similarity HAMAP-Rule MF_00180
Binding site321Substrate By similarity HAMAP-Rule MF_00180
Binding site1661Substrate By similarity HAMAP-Rule MF_00180
Site1281Essential for catalytic activity By similarity HAMAP-Rule MF_00180
Site1661Essential for catalytic activity By similarity HAMAP-Rule MF_00180

Sequences

Sequence LengthMass (Da)Tools
D1C584 [UniParc].

Last modified January 19, 2010. Version 1.
Checksum: 3E5AC3CC147F1D70

FASTA23024,299
        10         20         30         40         50         60 
MPLATIEQAI AALRAGRFVI IVDGPDRENE GDLCIAGQFI TPEAVNFIVR EARGLLCAAM 

        70         80         90        100        110        120 
APEWVDRLRL PLMVDPASNS APFGTAFTVS VEARQGVTTG ISAHDRARTI RTLADPASTP 

       130        140        150        160        170        180 
ADFAMPGHVF PLRARPGGVL ERPGQTEAAV DLARLAGLHP VVAICEIMAD DGTMARLPEL 

       190        200        210        220        230 
ERFATRHDIP IISVADLAAV RRAQADRHPA GVADHSPAGT AAREGTAYGC

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References

[1]"The complete chromosome 1 of Sphaerobacter thermophilus DSM 20745."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N., Mikhailova N., LaButti K.M., Clum A., Sun H.I., Brettin T., Detter J.C. expand/collapse author list , Han C., Larimer F., Land M., Hauser L., Markowitz V., Cheng J.F., Hugenholtz P., Woyke T., Wu D., Steenblock K., Schneider S., Pukall R., Goeker M., Klenk H.P., Eisen J.A.
Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 20745 / S 6022.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001823 Genomic DNA. Translation: ACZ39401.1.
RefSeqYP_003320223.1. NC_013523.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACZ39401; ACZ39401; Sthe_1970.
GeneID8639397.
KEGGsti:Sthe_1970.
PATRIC32426755. VBISphThe120955_1990.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000115444.
KOK14652.
OMAQMAKLIR.

Enzyme and pathway databases

UniPathwayUPA00275; UER00399.

Family and domain databases

Gene3D3.90.870.10. 1 hit.
HAMAPMF_00180. RibB.
InterProIPR017945. DHBP_synth_RibB-like_a/b_dom.
IPR000422. DHBP_synthase_RibB.
[Graphical view]
PfamPF00926. DHBP_synthase. 1 hit.
[Graphical view]
SUPFAMSSF55821. DHBP_synth_RibB-like_a/b_dom. 1 hit.
TIGRFAMsTIGR00506. ribB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD1C584_SPHTD
AccessionPrimary (citable) accession number: D1C584
Entry history
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: May 1, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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