Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

D1C584

- D1C584_SPHTD

UniProt

D1C584 - D1C584_SPHTD

Protein

3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene

ribB

Organism
Sphaerobacter thermophilus (strain DSM 20745 / S 6022)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (19 Jan 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.UniRule annotationSAAS annotation

    Catalytic activityi

    D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate.UniRule annotationSAAS annotation

    Cofactori

    Binds 2 divalent metal cations per subunit. Magnesium or manganese.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi28 – 281Magnesium or manganese 1UniRule annotation
    Metal bindingi28 – 281Magnesium or manganese 2UniRule annotation
    Binding sitei32 – 321SubstrateUniRule annotation
    Sitei128 – 1281Essential for catalytic activityUniRule annotation
    Binding sitei166 – 1661SubstrateUniRule annotation
    Sitei166 – 1661Essential for catalytic activityUniRule annotation

    GO - Molecular functioni

    1. 3,4-dihydroxy-2-butanone-4-phosphate synthase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. riboflavin biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LyaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Riboflavin biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciSTHE479434:GHJN-2025-MONOMER.
    UniPathwayiUPA00275; UER00399.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3,4-dihydroxy-2-butanone 4-phosphate synthaseUniRule annotation (EC:4.1.99.12UniRule annotation)
    Short name:
    DHBP synthaseUniRule annotation
    Gene namesi
    Name:ribBUniRule annotation
    Ordered Locus Names:Sthe_1970Imported
    OrganismiSphaerobacter thermophilus (strain DSM 20745 / S 6022)Imported
    Taxonomic identifieri479434 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiSphaerobacteridaeSphaerobacteralesSphaerobacterineaeSphaerobacteraceaeSphaerobacter
    ProteomesiUP000002027: Chromosome 1

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni27 – 282Substrate bindingUniRule annotation
    Regioni142 – 1465Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the DHBP synthase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000115444.
    KOiK14652.
    OMAiQMAKLIR.
    OrthoDBiEOG679TK8.

    Family and domain databases

    Gene3Di3.90.870.10. 1 hit.
    HAMAPiMF_00180. RibB.
    InterProiIPR017945. DHBP_synth_RibB-like_a/b_dom.
    IPR000422. DHBP_synthase_RibB.
    [Graphical view]
    PfamiPF00926. DHBP_synthase. 1 hit.
    [Graphical view]
    SUPFAMiSSF55821. SSF55821. 1 hit.
    TIGRFAMsiTIGR00506. ribB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D1C584-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLATIEQAI AALRAGRFVI IVDGPDRENE GDLCIAGQFI TPEAVNFIVR    50
    EARGLLCAAM APEWVDRLRL PLMVDPASNS APFGTAFTVS VEARQGVTTG 100
    ISAHDRARTI RTLADPASTP ADFAMPGHVF PLRARPGGVL ERPGQTEAAV 150
    DLARLAGLHP VVAICEIMAD DGTMARLPEL ERFATRHDIP IISVADLAAV 200
    RRAQADRHPA GVADHSPAGT AAREGTAYGC 230
    Length:230
    Mass (Da):24,299
    Last modified:January 19, 2010 - v1
    Checksum:i3E5AC3CC147F1D70
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001823 Genomic DNA. Translation: ACZ39401.1.
    RefSeqiYP_003320223.1. NC_013523.1.

    Genome annotation databases

    EnsemblBacteriaiACZ39401; ACZ39401; Sthe_1970.
    GeneIDi8639397.
    KEGGisti:Sthe_1970.
    PATRICi32426755. VBISphThe120955_1990.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001823 Genomic DNA. Translation: ACZ39401.1 .
    RefSeqi YP_003320223.1. NC_013523.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACZ39401 ; ACZ39401 ; Sthe_1970 .
    GeneIDi 8639397.
    KEGGi sti:Sthe_1970.
    PATRICi 32426755. VBISphThe120955_1990.

    Phylogenomic databases

    HOGENOMi HOG000115444.
    KOi K14652.
    OMAi QMAKLIR.
    OrthoDBi EOG679TK8.

    Enzyme and pathway databases

    UniPathwayi UPA00275 ; UER00399 .
    BioCyci STHE479434:GHJN-2025-MONOMER.

    Family and domain databases

    Gene3Di 3.90.870.10. 1 hit.
    HAMAPi MF_00180. RibB.
    InterProi IPR017945. DHBP_synth_RibB-like_a/b_dom.
    IPR000422. DHBP_synthase_RibB.
    [Graphical view ]
    Pfami PF00926. DHBP_synthase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55821. SSF55821. 1 hit.
    TIGRFAMsi TIGR00506. ribB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 20745 / S 6022Imported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 20745 / S 6022Imported.

    Entry informationi

    Entry nameiD1C584_SPHTD
    AccessioniPrimary (citable) accession number: D1C584
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 19, 2010
    Last sequence update: January 19, 2010
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3