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D1C584

- D1C584_SPHTD

UniProt

D1C584 - D1C584_SPHTD

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Protein
3,4-dihydroxy-2-butanone 4-phosphate synthase
Gene
ribB, Sthe_1970
Organism
Sphaerobacter thermophilus (strain DSM 20745 / S 6022)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate By similarity.UniRule annotationSAAS annotations

Catalytic activityi

D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate.UniRule annotationSAAS annotations

Cofactori

Binds 2 divalent metal cations per subunit. Magnesium or manganese By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi28 – 281Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi28 – 281Magnesium or manganese 2 By similarityUniRule annotation
Binding sitei32 – 321Substrate By similarityUniRule annotation
Sitei128 – 1281Essential for catalytic activity By similarityUniRule annotation
Binding sitei166 – 1661Substrate By similarityUniRule annotation
Sitei166 – 1661Essential for catalytic activity By similarityUniRule annotation

GO - Molecular functioni

  1. 3,4-dihydroxy-2-butanone-4-phosphate synthase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. manganese ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. riboflavin biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotations

Keywords - Biological processi

Riboflavin biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotations, ManganeseUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciSTHE479434:GHJN-2025-MONOMER.
UniPathwayiUPA00275; UER00399.

Names & Taxonomyi

Protein namesi
Recommended name:
3,4-dihydroxy-2-butanone 4-phosphate synthaseUniRule annotation (EC:4.1.99.12UniRule annotation)
Short name:
DHBP synthaseUniRule annotation
Gene namesi
Name:ribBUniRule annotation
Ordered Locus Names:Sthe_1970Imported
OrganismiSphaerobacter thermophilus (strain DSM 20745 / S 6022)Imported
Taxonomic identifieri479434 [NCBI]
Taxonomic lineageiBacteriaChloroflexiSphaerobacteridaeSphaerobacteralesSphaerobacterineaeSphaerobacteraceaeSphaerobacter
ProteomesiUP000002027: Chromosome 1

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni27 – 282Substrate binding By similarityUniRule annotation
Regioni142 – 1465Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Belongs to the DHBP synthase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000115444.
KOiK14652.
OMAiQMAKLIR.
OrthoDBiEOG679TK8.

Family and domain databases

Gene3Di3.90.870.10. 1 hit.
HAMAPiMF_00180. RibB.
InterProiIPR017945. DHBP_synth_RibB-like_a/b_dom.
IPR000422. DHBP_synthase_RibB.
[Graphical view]
PfamiPF00926. DHBP_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF55821. SSF55821. 1 hit.
TIGRFAMsiTIGR00506. ribB. 1 hit.

Sequencei

Sequence statusi: Complete.

D1C584-1 [UniParc]FASTAAdd to Basket

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MPLATIEQAI AALRAGRFVI IVDGPDRENE GDLCIAGQFI TPEAVNFIVR    50
EARGLLCAAM APEWVDRLRL PLMVDPASNS APFGTAFTVS VEARQGVTTG 100
ISAHDRARTI RTLADPASTP ADFAMPGHVF PLRARPGGVL ERPGQTEAAV 150
DLARLAGLHP VVAICEIMAD DGTMARLPEL ERFATRHDIP IISVADLAAV 200
RRAQADRHPA GVADHSPAGT AAREGTAYGC 230
Length:230
Mass (Da):24,299
Last modified:January 19, 2010 - v1
Checksum:i3E5AC3CC147F1D70
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001823 Genomic DNA. Translation: ACZ39401.1.
RefSeqiYP_003320223.1. NC_013523.1.

Genome annotation databases

EnsemblBacteriaiACZ39401; ACZ39401; Sthe_1970.
GeneIDi8639397.
KEGGisti:Sthe_1970.
PATRICi32426755. VBISphThe120955_1990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001823 Genomic DNA. Translation: ACZ39401.1 .
RefSeqi YP_003320223.1. NC_013523.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACZ39401 ; ACZ39401 ; Sthe_1970 .
GeneIDi 8639397.
KEGGi sti:Sthe_1970.
PATRICi 32426755. VBISphThe120955_1990.

Phylogenomic databases

HOGENOMi HOG000115444.
KOi K14652.
OMAi QMAKLIR.
OrthoDBi EOG679TK8.

Enzyme and pathway databases

UniPathwayi UPA00275 ; UER00399 .
BioCyci STHE479434:GHJN-2025-MONOMER.

Family and domain databases

Gene3Di 3.90.870.10. 1 hit.
HAMAPi MF_00180. RibB.
InterProi IPR017945. DHBP_synth_RibB-like_a/b_dom.
IPR000422. DHBP_synthase_RibB.
[Graphical view ]
Pfami PF00926. DHBP_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF55821. SSF55821. 1 hit.
TIGRFAMsi TIGR00506. ribB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 20745 / S 6022.

Entry informationi

Entry nameiD1C584_SPHTD
AccessioniPrimary (citable) accession number: D1C584
Entry historyi
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: June 11, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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