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D1C2Z5

- D1C2Z5_SPHTD

UniProt

D1C2Z5 - D1C2Z5_SPHTD

Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Sphaerobacter thermophilus (strain DSM 20745 / S 6022)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (19 Jan 2010)
      Previous versions | rss
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    Functioni

    Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP.UniRule annotationSAAS annotation

    Catalytic activityi

    10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. methionyl-tRNA formyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    TransferaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Protein biosynthesisUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciSTHE479434:GHJN-1202-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
    Gene namesi
    Name:fmtUniRule annotation
    Ordered Locus Names:Sthe_1176Imported
    OrganismiSphaerobacter thermophilus (strain DSM 20745 / S 6022)Imported
    Taxonomic identifieri479434 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiSphaerobacteridaeSphaerobacteralesSphaerobacterineaeSphaerobacteraceaeSphaerobacter
    ProteomesiUP000002027: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323 PotentialImportedAdd
    BLAST
    Chaini24 – 314291 PotentialImportedPRO_5000537677Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliD1C2Z5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni112 – 1154Tetrahydrofolate (THF) bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the Fmt family.UniRule annotation

    Keywords - Domaini

    SignalImported

    Phylogenomic databases

    HOGENOMiHOG000261177.
    KOiK00604.
    OMAiRGDWFTP.
    OrthoDBiEOG6B09WV.

    Family and domain databases

    Gene3Di3.10.25.10. 1 hit.
    3.40.50.170. 1 hit.
    HAMAPiMF_00182. Formyl_trans.
    InterProiIPR005794. Fmt.
    IPR005793. Formyl_trans_C.
    IPR002376. Formyl_transf_N.
    IPR011034. Formyl_transferase_C-like.
    IPR015518. Met_tRNA_Form_TA-like.
    [Graphical view]
    PANTHERiPTHR11138. PTHR11138. 1 hit.
    PfamiPF02911. Formyl_trans_C. 1 hit.
    PF00551. Formyl_trans_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50486. SSF50486. 1 hit.
    SSF53328. SSF53328. 1 hit.
    TIGRFAMsiTIGR00460. fmt. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    D1C2Z5-1 [UniParc]FASTAAdd to Basket

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    MAISVVFLGS PAFAVPSLRA LALDARFTIP LVVTQPDRPA GRGRRPRPPA    50
    VKDAAIELGL PVFQPETLRD PAAVERLAAA VPDVLVVVAY GEILRQSVLD 100
    LAPLGCLNVH PSLLPRYRGS SPVQAAILNG DTETGISIIK LVRRMDAGPI 150
    VAQRRVPLDG TETAGTLSER LANLAAEMLP DVVAAWVAGE LEAEPQDDAA 200
    ATYTRELTTA DARIDWGKDA AEIERLVRAM QPWPKAWSIL EGRRLAVLAC 250
    DISHKPSTEP PGTINVSARP PRVATGTTDL VLLRVQPEGK REMAAEDWAR 300
    GARLPHGARF APVE 314
    Length:314
    Mass (Da):33,662
    Last modified:January 19, 2010 - v1
    Checksum:i3BBACF9AA3D417ED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001823 Genomic DNA. Translation: ACZ38612.1.
    RefSeqiYP_003319434.1. NC_013523.1.

    Genome annotation databases

    EnsemblBacteriaiACZ38612; ACZ38612; Sthe_1176.
    GeneIDi8638573.
    KEGGisti:Sthe_1176.
    PATRICi32425101. VBISphThe120955_1190.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001823 Genomic DNA. Translation: ACZ38612.1 .
    RefSeqi YP_003319434.1. NC_013523.1.

    3D structure databases

    ProteinModelPortali D1C2Z5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACZ38612 ; ACZ38612 ; Sthe_1176 .
    GeneIDi 8638573.
    KEGGi sti:Sthe_1176.
    PATRICi 32425101. VBISphThe120955_1190.

    Phylogenomic databases

    HOGENOMi HOG000261177.
    KOi K00604.
    OMAi RGDWFTP.
    OrthoDBi EOG6B09WV.

    Enzyme and pathway databases

    BioCyci STHE479434:GHJN-1202-MONOMER.

    Family and domain databases

    Gene3Di 3.10.25.10. 1 hit.
    3.40.50.170. 1 hit.
    HAMAPi MF_00182. Formyl_trans.
    InterProi IPR005794. Fmt.
    IPR005793. Formyl_trans_C.
    IPR002376. Formyl_transf_N.
    IPR011034. Formyl_transferase_C-like.
    IPR015518. Met_tRNA_Form_TA-like.
    [Graphical view ]
    PANTHERi PTHR11138. PTHR11138. 1 hit.
    Pfami PF02911. Formyl_trans_C. 1 hit.
    PF00551. Formyl_trans_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50486. SSF50486. 1 hit.
    SSF53328. SSF53328. 1 hit.
    TIGRFAMsi TIGR00460. fmt. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 20745 / S 6022Imported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 20745 / S 6022Imported.

    Entry informationi

    Entry nameiD1C2Z5_SPHTD
    AccessioniPrimary (citable) accession number: D1C2Z5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 19, 2010
    Last sequence update: January 19, 2010
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3