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D1C0N9 (D1C0N9_XYLCX) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine--tRNA ligase HAMAP-Rule MF_00176
EC=6.1.1.11 HAMAP-Rule MF_00176
Alternative name(s):
Seryl-tRNA synthetase HAMAP-Rule MF_00176
Seryl-tRNA(Ser/Sec) synthetase HAMAP-Rule MF_00176
Gene names
Name:serS HAMAP-Rule MF_00176
Ordered Locus Names:Xcel_3242
OrganismXylanimonas cellulosilytica (strain DSM 15894 / CECT 5975 / LMG 20990 / XIL07) [Complete proteome] [HAMAP]
Taxonomic identifier446471 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Promicromonosporaceae › Xylanimonas ›

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) By similarity. HAMAP-Rule MF_00176

Catalytic activity

ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec). HAMAP-Rule MF_00176

ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). HAMAP-Rule MF_00176

Pathway

Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1. HAMAP-Rule MF_00176

Subunit structure

Homodimer. The tRNA molecule binds across the dimer By similarity. HAMAP-Rule MF_00176

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00176.

Domain

Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding By similarity. HAMAP-Rule MF_00176

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. HAMAP-Rule MF_00176

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding260 – 2623ATP By similarity HAMAP-Rule MF_00176
Nucleotide binding347 – 3504ATP By similarity HAMAP-Rule MF_00176
Region229 – 2313Serine binding By similarity HAMAP-Rule MF_00176

Sites

Binding site2761ATP; via amide nitrogen and carbonyl oxygen By similarity HAMAP-Rule MF_00176
Binding site2831Serine By similarity HAMAP-Rule MF_00176
Binding site3821Serine By similarity HAMAP-Rule MF_00176

Sequences

Sequence LengthMass (Da)Tools
D1C0N9 [UniParc].

Last modified January 19, 2010. Version 1.
Checksum: 8F6A12F71D5D227A

FASTA42446,171
        10         20         30         40         50         60 
MIDLRLLRDN PDVVRESQVA RGDDPALVDA ALDADARRRA SLAAFEELRA EQKAMGKKVA 

        70         80         90        100        110        120 
QAQGDEKQAL LARTRHLSDE VKSRSKDADD AAAALDAALW KISNVVEGAP AGGEDDYVVI 

       130        140        150        160        170        180 
QHVGTPRDFA AEGFEPQDHL ALGEGLRAID TARGAKVSGT RFYFLTGIGA RLELAILNAA 

       190        200        210        220        230        240 
MDQAVQAGFT PVITPTLVKP ETMRGTGFLG AHADEVYRLE KDDLYLVGTS EVALAGYHAD 

       250        260        270        280        290        300 
EIIDLADGPA RYAGWSACYR REAGSAGRDT RGIIRVHQFH KVEMFSYCRP EDAAEEHQRL 

       310        320        330        340        350        360 
LAWEEAMLAK VELPYRVIDT AAGDLGSSAA RKFDCEAWLP TQNRWLELTS TSNCTTFQAR 

       370        380        390        400        410        420 
RLGVRERTAD GSTRNVATLN GTLGTTRWIV AILENHQQAD GSVRVPEGLR PYLGGLEVLE 


PFGG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001821 Genomic DNA. Translation: ACZ32242.1.
RefSeqYP_003327800.1. NC_013530.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACZ32242; ACZ32242; Xcel_3242.
GeneID8650798.
KEGGxce:Xcel_3242.
PATRIC32555551. VBIXylCel24446_3281.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000035937.
KOK01875.
OMAQTERNAN.

Enzyme and pathway databases

UniPathwayUPA00906; UER00895.

Family and domain databases

Gene3D1.10.287.40. 1 hit.
HAMAPMF_00176. Ser_tRNA_synth_type1.
InterProIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR002317. Ser-tRNA-ligase_type_1.
IPR015866. Ser-tRNA-synth_1_N.
IPR010978. tRNA-bd_arm.
[Graphical view]
PANTHERPTHR11778. PTHR11778. 1 hit.
PfamPF02403. Seryl_tRNA_N. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PIRSFPIRSF001529. Ser-tRNA-synth_IIa. 1 hit.
PRINTSPR00981. TRNASYNTHSER.
SUPFAMSSF46589. tRNA_binding_arm. 1 hit.
TIGRFAMsTIGR00414. serS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD1C0N9_XYLCX
AccessionPrimary (citable) accession number: D1C0N9
Entry history
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: May 1, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info