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Protein
Submitted name:

NAD-dependent epimerase/dehydratase

Gene

Vpar_0111

Organism
Veillonella parvula (strain ATCC 10790 / DSM 2008 / JCM 12972 / Te3) (Veillonella alcalescens)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351NADPCombined sources
Binding sitei40 – 401NADPCombined sources
Binding sitei58 – 581NADPCombined sources
Binding sitei80 – 801NADPCombined sources
Binding sitei84 – 841NADPCombined sources
Binding sitei128 – 1281NADPCombined sources
Binding sitei154 – 1541NADP; via amide nitrogenCombined sources
Binding sitei179 – 1791NADPCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 143NADPCombined sources

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

NADPCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BioCyciVPAR479436:GHOS-114-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
NAD-dependent epimerase/dehydrataseImported
Gene namesi
Ordered Locus Names:Vpar_0111Imported
OrganismiVeillonella parvula (strain ATCC 10790 / DSM 2008 / JCM 12972 / Te3) (Veillonella alcalescens)Imported
Taxonomic identifieri479436 [NCBI]
Taxonomic lineageiBacteriaFirmicutesNegativicutesSelenomonadalesVeillonellaceaeVeillonella
ProteomesiUP000007968 Componenti: Chromosome

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3R6DX-ray1.25A2-218[»]
4HNGX-ray1.50A1-218[»]
4HNHX-ray1.58A/B1-218[»]
4IPTX-ray1.55A1-218[»]
ProteinModelPortaliD1BQI7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiD1BQI7.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000262431.
OMAiYELATWT.
OrthoDBiEOG6R5C9T.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D1BQI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKYITILGA AGQIAQKLTA TLLTYTDMHI TLYGRQLKTR IPPEIIDHER
60 70 80 90 100
VTVIEGSFQN PGKLEQAVTN AEVVFVGAME SGSDMASIVK ALSRKNIRRV
110 120 130 140 150
IGVSMAGLSG EFPVALEKWT FDNLPISYVQ GERQARNVLR ESNLNYTILR
160 170 180 190 200
LTWLYNDPEK TDYELIPEGA QFNDAQVSRE AVVKAIFDIL HAADETPFHR
210
TSIGVGEPGT HYDKPSFH
Length:218
Mass (Da):24,384
Last modified:January 19, 2010 - v1
Checksum:i28C9D22E9D952388
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001820 Genomic DNA. Translation: ACZ23800.1.
RefSeqiYP_003311080.1. NC_013520.1.

Genome annotation databases

EnsemblBacteriaiACZ23800; ACZ23800; Vpar_0111.
KEGGivpr:Vpar_0111.
PATRICi32529510. VBIVeiPar80537_0107.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001820 Genomic DNA. Translation: ACZ23800.1.
RefSeqiYP_003311080.1. NC_013520.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3R6DX-ray1.25A2-218[»]
4HNGX-ray1.50A1-218[»]
4HNHX-ray1.58A/B1-218[»]
4IPTX-ray1.55A1-218[»]
ProteinModelPortaliD1BQI7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACZ23800; ACZ23800; Vpar_0111.
KEGGivpr:Vpar_0111.
PATRICi32529510. VBIVeiPar80537_0107.

Phylogenomic databases

HOGENOMiHOG000262431.
OMAiYELATWT.
OrthoDBiEOG6R5C9T.

Enzyme and pathway databases

BioCyciVPAR479436:GHOS-114-MONOMER.

Miscellaneous databases

EvolutionaryTraceiD1BQI7.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10790 / DSM 2008 / JCM 12972 / Te3Imported.
  2. "Crystal structure of NAD-dependent epimerase/dehydratase from Veillonella parvula DSM 2008 with Cz-methylated lysine."
    Chang C., Hatzos-Skintges C., Clancy S., Joachimiak A.
    Submitted (MAR-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS) OF 2-218.
  3. "The crystal structure of a short-chain dehydrogenases/reductase (wide type) from Veillonella parvula DSM 2008 in complex with NADP."
    Tan K., Hatzos-Skintges C., Clancy S., Joachimiak A.
    Submitted (OCT-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.58 ANGSTROMS) IN COMPLEX WITH NADP.
  4. "The crystal structure of a short-chain dehydrogenases/reductase (wide type) from Veillonella parvula DSM 2008."
    Tan K., Hatzos-Skintges C., Clancy S., Joachimiak A.
    Submitted (OCT-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS).
  5. "The crystal structure of a short-chain dehydrogenases/reductase (ethylated) from Veillonella parvula DSM 2008."
    Tan K., Hatzos-Skintges C., Clancy S., Joachimiak A.
    Submitted (JAN-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS).

Entry informationi

Entry nameiD1BQI7_VEIPT
AccessioniPrimary (citable) accession number: D1BQI7
Entry historyi
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: April 1, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.