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Protein

3-deoxy-manno-octulosonate cytidylyltransferase

Gene

kdsB

Organism
Veillonella parvula (strain ATCC 10790 / DSM 2008 / JCM 12972 / Te3) (Veillonella alcalescens)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.UniRule annotationSAAS annotation

Catalytic activityi

CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate.UniRule annotationSAAS annotation

Pathwayi

GO - Molecular functioni

  1. 3-deoxy-manno-octulosonate cytidylyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Source: UniProtKB-UniPathway
  2. keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

NucleotidyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciVPAR479436:GHOS-559-MONOMER.
UniPathwayiUPA00030.
UPA00358; UER00476.

Names & Taxonomyi

Protein namesi
Recommended name:
3-deoxy-manno-octulosonate cytidylyltransferaseUniRule annotationSAAS annotation (EC:2.7.7.38UniRule annotationSAAS annotation)
Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthaseUniRule annotation
Gene namesi
Name:kdsBUniRule annotation
Ordered Locus Names:Vpar_0542Imported
OrganismiVeillonella parvula (strain ATCC 10790 / DSM 2008 / JCM 12972 / Te3) (Veillonella alcalescens)Imported
Taxonomic identifieri479436 [NCBI]
Taxonomic lineageiBacteriaFirmicutesNegativicutesSelenomonadalesVeillonellaceaeVeillonella
ProteomesiUP000007968 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliD1BLG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KdsB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000007602.
KOiK00979.
OMAiNSGTERC.
OrthoDBiEOG6KT2SK.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_00057. CMP_KDO_synth.
InterProiIPR003329. Cytidylyl_trans.
IPR004528. KdsB.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR21485:SF4. PTHR21485:SF4. 1 hit.
PfamiPF02348. CTP_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR00466. kdsB. 1 hit.

Sequencei

Sequence statusi: Complete.

D1BLG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFGCVIPAR YGSTRLPGKP LADIAGKPMI ERVYARVSQA TKTVCTIVAT
60 70 80 90 100
DDNRVYSAVQ QFGGTVMMTD PNHPTGTDRL AEVASHYTDL DVVINVQGDE
110 120 130 140 150
PMIDPNLIDD LARLFEEDPN LQMATVATPL LEEEYEEPSA VKVILNNRND
160 170 180 190 200
AMYFSRSLIP YPRHDFVRPP LKHIGIYAYR REFLLNYAKM EPTPAERTES
210 220 230 240
LEQLRALENG YTIRVILTNK RFIGVDTPED LARVNAIYEQ EEK
Length:243
Mass (Da):27,522
Last modified:January 19, 2010 - v1
Checksum:i76A172FD72E43C3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001820 Genomic DNA. Translation: ACZ24225.1.
RefSeqiYP_003311505.1. NC_013520.1.

Genome annotation databases

EnsemblBacteriaiACZ24225; ACZ24225; Vpar_0542.
GeneIDi8635999.
KEGGivpr:Vpar_0542.
PATRICi32530378. VBIVeiPar80537_0528.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001820 Genomic DNA. Translation: ACZ24225.1.
RefSeqiYP_003311505.1. NC_013520.1.

3D structure databases

ProteinModelPortaliD1BLG8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACZ24225; ACZ24225; Vpar_0542.
GeneIDi8635999.
KEGGivpr:Vpar_0542.
PATRICi32530378. VBIVeiPar80537_0528.

Phylogenomic databases

HOGENOMiHOG000007602.
KOiK00979.
OMAiNSGTERC.
OrthoDBiEOG6KT2SK.

Enzyme and pathway databases

UniPathwayiUPA00030.
UPA00358; UER00476.
BioCyciVPAR479436:GHOS-559-MONOMER.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_00057. CMP_KDO_synth.
InterProiIPR003329. Cytidylyl_trans.
IPR004528. KdsB.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR21485:SF4. PTHR21485:SF4. 1 hit.
PfamiPF02348. CTP_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR00466. kdsB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10790 / DSM 2008 / JCM 12972 / Te3Imported.

Entry informationi

Entry nameiD1BLG8_VEIPT
AccessioniPrimary (citable) accession number: D1BLG8
Entry historyi
Integrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: March 4, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.