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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Sanguibacter keddieii (strain ATCC 51767 / DSM 10542 / NCFB 3025 / ST-74)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSKED446469:GHD3-2406-MONOMER.
UniPathwayiUPA00071.

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:Sked_24100
OrganismiSanguibacter keddieii (strain ATCC 51767 / DSM 10542 / NCFB 3025 / ST-74)
Taxonomic identifieri446469 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesSanguibacteraceaeSanguibacter
Proteomesi
  • UP000000322 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2842842-phospho-L-lactate guanylyltransferasePRO_0000398713Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi446469.Sked_24100.

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105ME0. Bacteria.
COG1920. LUCA.
HOGENOMiHOG000223639.
KOiK14941.
OMAiAMLVDTI.
OrthoDBiPOG091H0B3J.

Family and domain databases

Gene3Di3.90.550.10. 2 hits.
HAMAPiMF_02114. CofC. 1 hit.
InterProiIPR002835. Coenzyme_F420_CofC.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01983. CofC. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 2 hits.
TIGRFAMsiTIGR03552. F420_cofC. 1 hit.

Sequencei

Sequence statusi: Complete.

D1BJD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAEQQAVVS AEQQAVVSAE QPAVVSADQP AVTWTVVVPV KVTSQAKTRL
60 70 80 90 100
AGDLSPTQRV ELVRAMVVDT VAAARATPTV DRVVVVTDDP DVVADLSADE
110 120 130 140 150
PAGTDAERRA DPSAENRAST SAQHPCLRAH LDVVPEPSPA AGLNAAIRAG
160 170 180 190 200
VASARSGGGL AAVSVAVLLG DLPALRPGDL GAALEAASAH HRAVVTDADG
210 220 230 240 250
SGTTLLTARS GVELYPAFGP GSAAEHAARG HVVLDVADVP AVSGLRQDVD
260 270 280
LARDLAAVAA LGPGPRTTEV LDRWARLGEG SSAA
Length:284
Mass (Da):28,596
Last modified:January 19, 2010 - v1
Checksum:i773E493E03FE7783
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001819 Genomic DNA. Translation: ACZ22324.1.
RefSeqiWP_012867393.1. NC_013521.1.

Genome annotation databases

EnsemblBacteriaiACZ22324; ACZ22324; Sked_24100.
KEGGiske:Sked_24100.
PATRICi32393276. VBISanKed123513_2381.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001819 Genomic DNA. Translation: ACZ22324.1.
RefSeqiWP_012867393.1. NC_013521.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi446469.Sked_24100.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACZ22324; ACZ22324; Sked_24100.
KEGGiske:Sked_24100.
PATRICi32393276. VBISanKed123513_2381.

Phylogenomic databases

eggNOGiENOG4105ME0. Bacteria.
COG1920. LUCA.
HOGENOMiHOG000223639.
KOiK14941.
OMAiAMLVDTI.
OrthoDBiPOG091H0B3J.

Enzyme and pathway databases

UniPathwayiUPA00071.
BioCyciSKED446469:GHD3-2406-MONOMER.

Family and domain databases

Gene3Di3.90.550.10. 2 hits.
HAMAPiMF_02114. CofC. 1 hit.
InterProiIPR002835. Coenzyme_F420_CofC.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01983. CofC. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 2 hits.
TIGRFAMsiTIGR03552. F420_cofC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOFC_SANKS
AccessioniPrimary (citable) accession number: D1BJD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: January 19, 2010
Last modified: September 7, 2016
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.