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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Sanguibacter keddieii (strain ATCC 51767 / DSM 10542 / NCFB 3025 / ST-74)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00071

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:Sked_24100
OrganismiSanguibacter keddieii (strain ATCC 51767 / DSM 10542 / NCFB 3025 / ST-74)
Taxonomic identifieri446469 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesSanguibacteraceaeSanguibacter
Proteomesi
  • UP000000322 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003987131 – 2842-phospho-L-lactate guanylyltransferaseAdd BLAST284

Proteomic databases

PRIDEiD1BJD0

Interactioni

Protein-protein interaction databases

STRINGi446469.Sked_24100

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105ME0 Bacteria
COG1920 LUCA
HOGENOMiHOG000223639
KOiK14941
OMAiAMLVDTI
OrthoDBiPOG091H0B3J

Family and domain databases

HAMAPiMF_02114 CofC, 1 hit
InterProiView protein in InterPro
IPR002835 Coenzyme_F420_CofC
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF01983 CofC, 1 hit
SUPFAMiSSF53448 SSF53448, 2 hits
TIGRFAMsiTIGR03552 F420_cofC, 1 hit

Sequencei

Sequence statusi: Complete.

D1BJD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAEQQAVVS AEQQAVVSAE QPAVVSADQP AVTWTVVVPV KVTSQAKTRL
60 70 80 90 100
AGDLSPTQRV ELVRAMVVDT VAAARATPTV DRVVVVTDDP DVVADLSADE
110 120 130 140 150
PAGTDAERRA DPSAENRAST SAQHPCLRAH LDVVPEPSPA AGLNAAIRAG
160 170 180 190 200
VASARSGGGL AAVSVAVLLG DLPALRPGDL GAALEAASAH HRAVVTDADG
210 220 230 240 250
SGTTLLTARS GVELYPAFGP GSAAEHAARG HVVLDVADVP AVSGLRQDVD
260 270 280
LARDLAAVAA LGPGPRTTEV LDRWARLGEG SSAA
Length:284
Mass (Da):28,596
Last modified:January 19, 2010 - v1
Checksum:i773E493E03FE7783
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001819 Genomic DNA Translation: ACZ22324.1

Genome annotation databases

EnsemblBacteriaiACZ22324; ACZ22324; Sked_24100
KEGGiske:Sked_24100

Similar proteinsi

Entry informationi

Entry nameiCOFC_SANKS
AccessioniPrimary (citable) accession number: D1BJD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: January 19, 2010
Last modified: May 23, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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